Paraneoplastic Urticarial Vasculitis and Recurrence of Prostatic Adenocarcinoma

Volume 6 | Issue 5 Paraneoplastic Urticarial Vasculitis and Recurrence of Prostatic Adenocarcinoma Marsaudon E*1, Ksiyer S1, Louarn A2 and Ilardo C2 1Medical Doctor, Internal Medicine Service, Hospital Alphonse Guerin, Ploermel, France 2Primary Care Resident, Internal Medicine Service, Hospital Alphonse Guerin, Ploermel, France *Corresponding author: Marsaudon E, Internal medicine service, Hospital Alphonse Guerin, 7 rue du roi Arthur, 56800 Ploermel, France, Tel: +33297732416, E-mail: marsaudon.eric@orange.fr Case report Open Access


Introduction
Chronic urticarial defined by skin lesions evolving for more than 6 weeks, can persist for months or years before finding an etiology that can remain unknown in 50% of cases.Many causes of urticaria have been reported, as alimentary, infections, drugs, dysthyroidism or autoimmune disease.Until now, 41 cases of malignancies have been associated with urticaria and reported with thyroid carcinomas, seminoma, astrocytoma, lymphoreticular system malignancies, lung cancer or renal carcinoma (Table 1).Description with prostate cancer is rare, justifying our case report regarding a man whose skin lesion testified the recurrence of his cancer.

Abstract
Chronic urticaria is a common condition but its etiology can sometimes be serious.A variety of causes has been reported to induce urticaria, like food, infections, drugs or environmental factors.Although an association between chronic urticarial and malignancy has been occasionally reported, such association remains controversial because it's difficult to demonstrate it's not just coincidental.However, various cancers have been described in connection with this skin pathology such as thyroid, pulmonary or renal carcinoma.In all of these cases, treatment of the tumor led to prompt resolution of the urticarial lesions, thus suggesting a pathogenetic relationship between the two.We report the case of a man treated for several months without success for chronic urticaria whose treatment of the recurrence of his prostate cancer has removed the skin lesions.(first 0.5 mg/kg/day during 6 month then 1 mg/kg/day) and antihistamines (dexchlorphéniramine then levocetirizne).He was arrhythmic, carried a valvular heart disease and benefited from coronary angioplasty for a myocardial infarction.In 2003, he underwent surgery for a prostatic adenocarcinoma classified as pT3NxM1 and treated with anti-androgenic.Treatment was stopped in 2010 while the PSA level was 0.09 ng/ml.Clinical examination is satisfactory except a 38 °C fever, a systolic murmur and resting dyspnea.The urticarial lesions are slightly pruriginous and spread throughout the body, trunk and 4 limbs (Figure 1).Biological investigations found hemoglobin at 8.7 g/l, CRP at 180 mg/l, PSA at 36.29 ng/l.Ionic balance is normal while clearance of creatinine is at 73 ml/min.Thyroid blood control, complement C3 and C4, C1 inhibitor antigenic level, antithyroid autoantibodies, antinuclear antibodies, cryoglobulin, rheumatoid factor, serum immunoglobulins level, circulating immune complexes, stool screening for blood parasites and yeast, serum electrophoresis, total immunoglobulin E are all normal.The patient receives antibiotic treatment by ceftriaxone (1g/day during 7 days) improving the respiratory infection and normalizing his CRP.In a second time treatment both oral bicalutamide (50 mg/day) and leuprorelin injection (subcutaneous implant 3.6 mg every 28 days) is proposed for its prostatic adenocarcinoma.Two months later, all the skin lesions disappeared (Figure 2).Journal of Case Reports and Studies Paraneoplastic dermatoses are not metastatic spreads but accompany the natural history of cancers for about 8% of them [1].Usually disappearing during curative treatment and reappearing at relapses, they are expressed by variable clinical signs: acanthosis nigricans, Bazex acrokeratosis, palmar fasciitis, lanuginous hypertrichosis, erythema gyratum repens, paraneoplastic pemphigus dermatomyositis [2].
Its link with prostatic cancer is very rare, the international literature reporting so far only one case allowing as in our presentation, to discover the disease [12].It was a 63-year-old patient suffering from 6 months of chronic urticaria whose treatment with both oral antihistamine and systemic and topical corticosteroid therapies were ineffective.Prostate biopsies confirming a prostate adenocarcinoma, he underwent a radical prostatectomy and after a few weeks, urticaria spontaneously disappeared.In the two years following prostatectomy no new episode of urticaria reappeared.
Currently etiopathogenic mechanisms responsible for this paraneoplastic vasculitis aren't still fully understood although the explanation is probably based on vascular hypersensitivity to cytokines produced by neoplastic cells.For practice however, notice that the main specific of this cutaneous reaction is a weakly pruriginous nature and a poor sensitivity to the corticosteroid/ antihistaminic association usually proposed in front of the appearance of urticarial plaques.

Figure 1 :
Figure 1: chronic urticarial vasculitis Endoscopy finds gastric atrophy and colonoscopy discovers sigmoid diverticulosis.The myelogram is normal.The chest CT scan shows a bilateral pleural effusion of low abundance and interstitial pneumopathy of the right lower lobe.Bronchial fibroscopy and staged biopsies are reassuring.The abdominal CT revealed multiple parenchymal hepatic nodules (the largest was 17 mm) with intraperitoneal effusion and infiltration of superior mesenteric fat.Cardiac ultrasonography exclude endocarditis but shows dilated cardiomyopathy with an ejection fraction of 28%.Scintigraphy shows diffuse bone metastases in the pelvis and skin biopsy find pericapillary inflammatory infiltrate without vascular necrosis confirming leukocytoplasic vasculitis and excluding mastocytosis.

1 Prostate Table 1 :
Chronic urticaria and cancer published between 1928 and 2018 A 84-year-old man was admitted for weakness, anemia and chronic urticarial plaques treated for 9 months with corticosteroids Received Date: August 03, 2018 Accepted Date: October 29, 2018 Published Date: October 31, 2018