ANNEX PUBLISHERS

Journal of Neurology and Neurological Disorders

Editorial Board Member - JNND

RAJNISH S. DAVE

Associate Scientist
Department of Neuroscience
Temple University
United States
BIOGRAPHY:

Dr Dave was born and grew up in Mumbai, India. He received his Ph.D. degree from University of Mumbai in 1998. Dr. Dave for his postdoctoral training in molecular virology at Columbia University and subsequently continued his training in neuroAIDS and molecular virology at Thomas Jefferson University. Dr Dave joined the Center for neuroAIDS Research in the Department of Neuroscience in 2008 where his research is focused on elucidating role of miRNAs in HIV-induced brain diseases in opiate-abusers.



RESEARCH INTERESTS:

His interest is focused on investigating the role of small non-coding RNAs, in HIV-1 neuropathogenesis. Small non-coding RNAs, such as microRNAs (miRNAs) and small interfering RNAs (siRNAs) possess the ability to regulate gene expression through post-transcriptional gene silencing mechanisms. Both miRNAs and siRNAs have an integral role in disease etiology and host-virus interactions. Alterations in miRNA expression often correlate with onset of cancers, viral infections or mental disorders. Several human viruses also express miRNAs. HIV-1 infection of the Central Nervous System (CNS) often leads to HIV-1-associated dementia (HAD) and HIV-1-associated minor cognitive motor disorder (HMCMD). HIV-1 infection is associated with macrophage infiltration, formation of microglial nodules and multinucleated giant cells, astrocyte activation and neuronal loss. Perivascular macrophages and microglia present in the hippocampus and basal ganglia are predominantly infected. However, the role of miRNAs and siRNAs in HIV-1 infection of CNS remains unclear. Currently, we are investigating alterations in miRNA expression profiles and how they might affect the course of disease progression in HIV-1-infected opiate abusers. This cohort is of interest as it often exhibits an accelerated form of HIV-1 associated dementia and enhanced neurological dysfunction.





Other Editorial Board Members - JNND

Glen Jickling

Assistant Professor
Department of Neurology
University of California
United States

Allan Siegel

Professor
Department of Neurology & Neurosciences
Rutgers University
United States

Walter J. Lukiw

Professor
Neurology, Neuroscience and Ophthalmology
Louisiana State University
United States

J Vernon Odom

Professor
Department of Ophthalmology
West Virginia University
United States

Tatjana Rundek

Professor
Miller School of Medicine
University of Miami
United States

Robert H. Rosenwasser

Professor
Department of Neurological Surgery
Thomas Jefferson University
United States

GIHAN INDRAGITH TENNEKOON

Professor
Departments of Neurology and Pediatrics
University of Pennsylvania
United States

Yan Zhou

Associate Professor
Department of Pharmacology
Guangxi Medical University
China

Sheila Crewther

Professor
School of Psychological Science
Univerity of La Trobe
Australia

Hongbin Fang

Associate Professor
Department of Biostatistics, Bioinformatics & Biomathematics
Georgetown University
United States
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