Articles Related to gene
Comparative Assessment of De Novo Genome Assemblers for Generating Eukaryotic Primary Genome Assembly from Short Reads
Ameya Santhosh, Rani Alex, Vikas Vohra (2023) Comparative Assessment of De Novo Genome Assemblers for Generating Eukaryotic Primary Genome Assembly from Short Reads. J Comp Sys Bio 6(1): 101
Evolutionary Analysis of the TLR Genes in Ten Fishes
Fish are a commonly available type of vertebrate that rely on both congenital and acquired immunity to protect against
pathogens. Congenital immunity acts as their first line of defense, while acquired immunity is crucial in defending against
specific pathogenic infections. Toll-like receptor (TLR) genes play a significant role in their innate immunity and are essential to their immune system. To better understand the evolutionary status of TLRs in fish and their adaptive immune defense characteristics, researchers analyzed ten fish species' TLR7 and TLR13 gene sequences using the NCBI and Ensembl
databases
Association of ACE I/D rs4646994 and ACE2 rs2285666 Receptor Gene Polymorphisms with SARS-CoV-2 Infection in Bangladeshi People
Covid-19 caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which hit the world
in December 2019 is one of the worst medical emergencies people have ever encountered. Human angiotensin I converting
enzyme 2 (ACE2) is the entry path of this virus to the host that regulates the renin-angiotensin-aldosterone system (RAAS).
Hypothesis: Susceptibility to SARS-CoV-2 infection may be affected by ACE rs4646994 and ACE2 rs2285666 polymorphisms.
Adherence to Antiretroviral Medication and Factors Affecting it Among HIV-- Positive Patients Receiving it at Adama General Hospital
Before the development of highly active antiretroviral medication, AIDS and related illnesses caused a great deal of suffering and death. All of the AIDS-related morbidities and mortality have considerably decreased thanks to modern medication, especially in industrialized nations. However, this accomplishment is still elusive in underdeveloped nations, particularly in those in sub-Saharan Africa. This failure can be attributed to a number of factors. Poverty, ignorance about the treatment, and inadequate therapy adherence are at the top of this list.
Leptin Receptor Gene Variant Rs1137101 and Ghrelin Gene Variant Rs696217 are Associated with Body Mass Index in Brazilian Population: A Case-Control Study
Introduction: Obesity is a multifactorial condition influenced by environment and genetic factors. Controlling appetite
and satiety involves complex interactions between the hypothalamus, which is responsible for homeostasis regulation
energy, and hormones that regulate appetite including leptin and ghrelin. Leptin plays an important role in the regulation
of food intake and energy expenditure, generating an increase in energy burning and decreasing food intake. And ghrelin
is directly involved in the regulation of short-term energy balance.
Objectives: To verify frequency, biochemical profile and Body Mass Index (BMI) variations according to SNPs in LEPR
and GHRL gene.
Subjects and Methods: 163 both genders subjects were classified into Study Group (SG): 103 subjects with obesity; Control Group (CG): 60 non-obese. Blood samples were collected to perform DNA extraction and biochemical profile analysis. Statistical significance was established at p < 0.05.
Results: The genotype and allele frequency were similar between groups for both polymorphisms. The _/A genotype of
the GHRL rs696217 polymorphism was associated to increased BMI in SG compared CG (p = 0.003) and increased triglycerides (TG) and very low density lipoprotein (VLDLc) values in CG (p < 0, 05). The _/A genotype was also associated
with increased fasting glucose compared to CC genotype only in CG (p = 0.031). Considering the LEPR rs1137101 polymorphism, AA genotype subjects presented higher BMI compared to _/G genotype subjects (p = 0.024). No difference
between biochemical profile variables related to LEPR rs1137101 polymorphism was found.
Conclusion: AA genotypes of the LEPR rs1137101 polymorphism and _/A of the GHRL rs696217 polymorphism suggest
being risk factors for BMI and the latter is associated with fasting glucose, VLDLc and TG variation.
Italian Survey on Perception of Obesity and Bariatric and Metabolic Surgery: A Comparison between General Practitioners and Obese Patients
Obesity is a pandemic, chronic and relapsing disease with several treatment options.
The aim of this work was to investigate the level of awareness that people with obesity (PwO) have of their own condition and
the level of knowledge regarding possible treatments available. To compare and contrast collected data on PwO with data
obtained from general practitioners (GPs)
A Review of General Policies and Regulations of Solid Waste Management in Saudi Arabia
Municipal or household solid wastes are generated from several sources in Saudi Arabia and more than 80% of population is concentered
in different urban areas and solid waste generation in three largest cities in Saudi Arabia such as Riyadh, Jeddah and Dammam where
variable human activities are encountered.
Comparison of Balance Coefficient Methods in Efficient Fractional Factorial Design Using Generalized Minimum Aberration (GMA) and Minimum Moment Aberration (MMA)
Efficient orthogonal arrays with three factors having two, three and four levels were constructed with balance and orthogonal property
for lowest common multiples of runs. The two forms of balance coefficient were used for classifying the designs into two; and minimum
aberration criteria were used to determine designs with less aberration. The designs constructed using the maximum form of balance
coefficient has the less aberration in both the Generalized Minimum Aberration and Minimum Moment Aberration criteria.
A Novel Hemizygous Mutation of HCFC1 Causes X-Linked Recessive Gene Inherited Developmental Delay in a Chinese Family
Developmental delay (DD) / intellectual disability (ID) is considered one of the most genetically heterogeneous human diseases.
Herein, we described a Chinese boy affected by DD/ID with 3-methylcrotonyl-CoA carboxylase deficiency (MCCD) and 3-hydroxy3-methylglutaric aciduria (3-HMG), which associated with a novel missense hemizygous mutation, c.4442C>T, within the acidic
domain of HCFC1 gene identified by whole exon sequencing (WES) and validated by Sanger sequencing.
Prevalence and Genetic Profile of β-Thalassemia Associated Mutations in a Mauritanian Population
Although common in the Mediterranean populations, β-thalassemia are present in various other parts of the world including
south Asia and Africa. This study was aimed to re-evaluate the prevalence of β thalassemia, the specific underlying β globin gene
mutations and their associated haplotypes in the Mauritanian population.
Behavior and Genetics: Confounding Effects on Adolescent BMI
Despite persistently high rates of obesity among American children and adults, the complex interplay between behavior, genetics and weight outcomes is not well understood.
Case Report of Novel LAMB2 Gene Mutation in Palestinian Infant with Pierson (Microcoria-Congenital Nephrosis) Syndrome
Laminin β2 (LAMB2) gene mutation typically causes a rare autosomal recessive inherited disorder called Pierson syndrome (PS) that present in the neonatal period and progressively affecting renal and ocular functions in the form of congenital nephrotic syndrome (CNS) combined with bilateral microcoria.
Editorial Board Members Related to gene
VILMA E. ORTIZ
Associate Anesthetist
Department of Anesthesia, Critical Care & Pain Medicine
Massachusetts General Hospital
United States
Department of Anesthesia, Critical Care & Pain Medicine
Massachusetts General Hospital
United States
JIANYE GE
Assistant Professor
Department of Forensics and Investigative Genetics
University of North Texas Health Science Center
United States
Department of Forensics and Investigative Genetics
University of North Texas Health Science Center
United States
Nallasivam Palanisamy
Associate Professor
Michigan Center for Translational Pathology
University of Michigan
United States
Michigan Center for Translational Pathology
University of Michigan
United States
Isik Yulug
Associate professor
Department of Molecular Biology and Genetics
Bilkent University
Turkey
Department of Molecular Biology and Genetics
Bilkent University
Turkey
Jorge Cerezal Garrido
Associate Professor
Department of Surgery
Medical school of the University Miguel Hernandez
Spain
Department of Surgery
Medical school of the University Miguel Hernandez
Spain
Yao Olive Li
Assistant Professor
Department of Human Nutrition & Food Science
California State Polytechnic University
United States
Department of Human Nutrition & Food Science
California State Polytechnic University
United States