Articles Related to AUC

Purpose: We aimed to create mechanic optic nerve injury model in rats and investigate the neuroprotective effects of ripasudil on retinal ganglion cells. Study Design: Experimental study Methods: Mechanic optic nerve injury model was created in the right eyes of male Wistar rats (n=15). Rats were divided into three groups: glaucoma model with sham treatment (group1) and 20 µM intravitreal ripasudil treatment (group 2) and 50 µM intravitreal ripasudil treatment (group 3). Treatment was applied intravitreally and rats were sacrificed at the end of 4 weeks. Glial fibrillary acidic protein (GFAP), Brn-3a antibody,anti- Iba1 was examined by immunohistochemistry. Results: The number of Brn-3a positive RGC in the mechanical optic nerve injury model was 5.33 ± 2.08 (min: 3, max: 7) in sham group, 10.25 ± 2.63 (min: 8, max: 14) in 20 µM group and 16.75 ± 5.43 (min:9, max: 21) in 50 µM group (p <0.05). GFAP positive RGC counts were recorded as 24.33 ± 2.08 (min: 22, max: 26) in sham group, 16.75 ± 1.70 (min: 15, max: 19) in 20 µM group and 13.00 ± 4.08 (min:10 , max: 19) in 50 µM group (p <0.05). Ripasudil treatment also decreased Iba1 expression in the retina of mechanic optic nerve injury groups. In addition, ripasudil treatment prevented apoptotic cell death by increasing Bcl-xL protein expression and preserved Tfam protein expression in the retina. Conclusions: Our experimental study has shown that ripasudil is neuropreotective in mechanical optic nerve injury model.

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Purpose:This study aimed to assess contrast sensitivity and acquired color vision deficiency in patients with primary open-angle glaucoma and to evaluate their correlations with visual field parameters. Methods: The current study included 100 patients with primary open-angle glaucoma and 40 healthy control subjects. The 100 glaucoma patients were divided into 3 groups (mild, moderate and sever). Ophthalmic examination included best corrected visual acuity (BCVA), gonioscopy, slit lamp biomicroscopy, visual field assessment by perimetry and intraocular pressure was measured using Goldmann applanation tonometry. Contrast Sensitivity evaluated by the Pelli-Robson chart and the Mesotest II b. Color vision was evaluated by the Farnsworth- panel D15. Results: The mean age of the studied cases was 52.61±14.86 years with male to female ratio 50.2/49.8. Cup-To-Disc (C/D) ratio was statistically significant increase in severe cases followed by moderate and lastly mild glaucoma subgroups. There was highly statistically significant increase in the mean C/D ratio among cases with glaucomatous eyes compared to normal .There was a significant correlation between worsening visual field indeces and decreased contrast sensitivity. Color vision was demonstrated to be significantly correlated according to severity, duration of affection, age and uncontrolled IOP. Conclusion: Mesotest II b is a better alternative to conventional reliable and reproducible Pelli Robson chart test for assessment of contrast sensitivity in patients with glaucoma.

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The endeavor of this research accounts for a superficial green route scheme by using an extract of leaves of Smilax aspera as a stabilizing and capping agent. Zinc Oxide nanoparticles (ZnO-NPs) were examined through UV-visible Spectrophotometer, X-Ray Diffraction (XRD), EDX (Energy Dispersive X-rays spectroscopy), Scanning Electron Microscopy (SEM), Transmission Electron Microscopy (TEM). The NPs demonstrates potential photo catalytic activity for the degradation of Methyl Orange (MO) and Methylene Blue (MB) dyes upon exposure to sunlight.

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A glaucoma is a group of eye conditions that damage the optic nerve, which is vital to good vision and if not detected early eventually leads to irreversible blindness. Primary open-angle glaucoma the most common type of glaucoma which occurs due to an imbalance of the eye liquid drainage and production. Although, Primary open-angle glaucoma’s optic neuropathic nature which features retinal ganglionic cell loss representing the most prevalent form of glaucoma, its exact a etiology and pathogenesis are unknown.

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The aim of this study was to assess the potential acute adverse effects associated with the use of anti-glaucoma medications among glaucoma patients with Glucose-6-Phosphate Dehydrogenase deficiency.

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The prognostic utility of the triglyceride: HDL-cholesterol (TG:HDL-C) ratio, a marker for insulin resistance, is unknown among high-risk children and adolescents. We examined the clinical utility of TG:HDL-C ratio as a marker of insulin resistance and chronic inflammation in obese youth.

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Malleus ankylosis known as House syndrome is very rare. It represents 38.1% of congenital malformation of the middle ear [1] if stapes ankylosis is associated.

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The early differentiation between infectious and non-infectious sepsis remains a challenge due to the lack of a reliable, ready available and quick biomarker of bacterial sepsis. This study aims to determine the diagnostic accuracies of procalcitonin (PCT), C-reactive protein (CRP) and erythrocyte sedimentation rate (ESR) as individual and combined predictors of bacterial sepsis, when compared to the gold standard microbiological cultures

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Dialysis patients are known to tolerate high potassium due to the chronic hyperkalemia that is inherent in their disease. Despite this, most reports of extremely high potassium (>9 mmol/L) are in the setting of cardiac arrest. We describe the case of a 57-year-old Caucasian male with past medical history significant for end stage renal disease known to be non-adherent to a low potassium diet as well as missed dialysis appointments.

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There are several anthropometric measures that are useful for diagnosis obesity and also are related to the development of different cardiovascular risk factors. The purpose of this study was to determine the predictive ability of various anthropometric parameters for the multiple risk factors aggregation (MRFA) in the adult population of the city of Maracaibo-Venezuela.

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Given the greater incidence and severity of obesity in Southern African American (SAAW) than Southern Caucasian women (SCW), it is important to determine factors contributing to this metabolic, racial disparity. Traditional Southern foods contribute to dietary patterns high in fat.

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The Congenital Rubella Syndrome is a multisystemic disease and CNS involvement occurs in the form of microcephaly, mental/motor disabilities, leptomeningitis, encephalitis, vascular damage and retardation of myelination. We report a case of gross non-communicating hydrocephalus in a neonate of Congenital Rubella Syndrome which is a rare presentation.

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Nanotechnology manipulates and creates matter to formulate nanometer scale materials and objects. It is an interdisciplinary field that involves a wide range of scientific and engineering disciplines, and has societal implications.

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Cavernous haemangiomas of the optic nerve, optic chiasm or optic tract are rare. Usually they present with acute onset of symptoms such as acute decline of visual acuity, headaches, nausea or even decline of the level of consciousness which suggests haemorrhage in or even out of the lesion. Otherwise, they have an insidious clinical pattern with subacute or chronic visual disturbance, diplopia and retro- orbital pain.

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This study investigated comparative concentrations of individual amino acids, total amino acids (TAA), non-essential amino acids (NEA) and essential amino acids (EAA) in the blood after the administration of Rice Protein Isolate (RPI) compared to Whey Protein Isolate (WPI).

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