Articles Related to AZ
Radiological Assessment of Rock Samples from Asir mountain in Abha and Al-Baha region, Saudi Arabia
This study investigates the natural radioactivity levels in the Abha and Al-Baha region, a mountain range with a variety of
rock types, ranging from calcareous to granitic. Thirty rock samples were collected, 15 from the Abha mountains and 15
from the Al-Baha mountains
The Role of Complementary and Alternative Medicine in the Treatment of Insomnia
Insomnia is a frequent condition that can be acute, intermittent, or chronic. It is an unpleasant feeling that makes it difficult to fall asleep. The main aim of the review is to determine the adverse effects of Insomnia drugs and the need to opt for Complementary and alternative medicine (CAM) approach as an adjuvant in treating Insomnia condition with lesser- known side effects. The Methodology involved a detailed literature survey which was performed through an online database, such as Science Direct, Google Scholar, Scopus, Cochrane, and PubMed. The study included original research and book chapters conducted on relation with Insomnia in particular with various therapies used currently and aimed to find possible alternative source which will be effective in treatment as well as with less burden of side effects
Leptin Receptor Gene Variant Rs1137101 and Ghrelin Gene Variant Rs696217 are Associated with Body Mass Index in Brazilian Population: A Case-Control Study
Introduction: Obesity is a multifactorial condition influenced by environment and genetic factors. Controlling appetite
and satiety involves complex interactions between the hypothalamus, which is responsible for homeostasis regulation
energy, and hormones that regulate appetite including leptin and ghrelin. Leptin plays an important role in the regulation
of food intake and energy expenditure, generating an increase in energy burning and decreasing food intake. And ghrelin
is directly involved in the regulation of short-term energy balance.
Objectives: To verify frequency, biochemical profile and Body Mass Index (BMI) variations according to SNPs in LEPR
and GHRL gene.
Subjects and Methods: 163 both genders subjects were classified into Study Group (SG): 103 subjects with obesity; Control Group (CG): 60 non-obese. Blood samples were collected to perform DNA extraction and biochemical profile analysis. Statistical significance was established at p < 0.05.
Results: The genotype and allele frequency were similar between groups for both polymorphisms. The _/A genotype of
the GHRL rs696217 polymorphism was associated to increased BMI in SG compared CG (p = 0.003) and increased triglycerides (TG) and very low density lipoprotein (VLDLc) values in CG (p < 0, 05). The _/A genotype was also associated
with increased fasting glucose compared to CC genotype only in CG (p = 0.031). Considering the LEPR rs1137101 polymorphism, AA genotype subjects presented higher BMI compared to _/G genotype subjects (p = 0.024). No difference
between biochemical profile variables related to LEPR rs1137101 polymorphism was found.
Conclusion: AA genotypes of the LEPR rs1137101 polymorphism and _/A of the GHRL rs696217 polymorphism suggest
being risk factors for BMI and the latter is associated with fasting glucose, VLDLc and TG variation.
Reversed-Phase High Performance Liquid Chromatography Procedure for the Determination of Isavuconazole in Human Plasma
Introduction: Isavuconazole is an antifungal drug used for treating patients with invasive fungal infections. Efficacy and safety of isavuconazole is monitored by measuring plasma isavuconazole concentration using LCMS which is a non-affordable method. We used the HPLC system with a UV detector to measure plasma Isavuconazole concentration.
Objective: Improved Reversed-phase high performance liquid chromatography procedure with UV detection is described which is cost effective, simple, precise and easily processed for the measurement of Isavuconazole, a drug used to treat the patients with invasive fungal infections, in blood plasma. Method: The method involves protein precipitation, addition of ammonium dihydrogen phosphate and chromatographic separation on a Hypurity C18 Column using an isocratic mobile phase of acetonitrile and ammonium acetate buffer (pH 8.0, 10 mM) (55:45, v/v). The UV detection was performed at 285 nm. The method provides rapid resolution of Isavuconazole in a 50 uL injection.
Result: Lower limit of Quantification (LLOQ) is 0.25 μg/ml in a 50 uL injection volume for Isavuconazole with a recovery consistently > 100 %. The assay is validated over linear range of 0.25 to 10 μg/ml. The intra-assay precision is < 3.53 % and inter-assay is <6.38% relative standard deviation of Isavuconazole. The method demonstrated clean separation, clinically acceptable detection limit and a linear range upto 25 ug/mL.
Conclusion: The assay demonstrated applicability in quantifying the drug level and monitoring the therapeutic dose for maintaining effective biological level to have better response in fungal infected patients. The method is cheaper as compared to LC-MS/MS and Tandem Mass spectrometry and the results are reportable on the same day of blood collection.
The Combined Effect of 2,4-Epibrassinolide and Chilling Stress on Tomato Cultivars Differing in Maturity
Low temperature (but above-freezing) during germination and early seedling growth of chilling-sensitive crop is one of the most significant limiting factors in the productivity. 2,4-Epibrassinolide (24-EB) is one of the most active forms of brassinosteroids are multifunctional plant hormones that can regulate development and respond to abiotic stresses. The effect of seed-pretreatment with 24-EB (12.5 μg/L) on photosynthetic characteristics, membrane permeability, lipid peroxidation and antioxidant activities under chilling stress were investigated in tomato (Lycopersicon esculentum Mill.) cultivars: Kulon (early ripening) and Yakhont (mid-early). Results showed that the use of 24-EB led to more pronounced changes in the pigment composition in Yakhont in the absence of a stress factor, whereas in Kulon under chilling stress (2 o C for 24 h). 24-EB pretreatment minimized the damage to cell membranes in tomato plants caused by chilling stress. The tolerance to chilling stress in Yakhont was higher than Kulon (by electrolyte leakage and content of malondialdehyde assay). Under these conditions, oxidative processes in plants of Yakhont did not show significant difference. We have not established the effect of 24-EB on the level of low molecular weight antioxidants in tomato cultivars (measured by inhibition of 2,2-diphenyl-1-picrylhydrazyl free radical method). The antioxidant activity of leaf extracts in Yakhont was
twice as high as in Kulon under all experimental conditions (with/without 24-EB, 22/2 o C). It was concluded that the less pronounced reaction of plants of Yakhont to the use of 24-EB and chilling stress is due to their genetically determined higher cold resistance than that of Kulon.
Evaluation of Weather Conditions as Well as NO2 and PM 2.5 Levels in the Urban Areas of South Brazil in Different Seasons
Due to the ever-increasing importance of studying pollution effects on environment and population, the development of methodologies for the evaluation of atmospheric pollutants has allowed great advances concerning air quality monitoring. Nitrogen dioxide (NO2) and fine particulate matters (PM2.5) have as major sources vehicle engine exhausts and industrial processes. In the municipality of Pelotas, the economical and industrial growth allied to the expansion of the local vehicle fleet have brought several impacts on human health and environment. For this region, there are few studies concerning air pollution monitoring and dispersion. Data were collected seasonally (summer, autumn, winter and spring) in eight points (Porto, Areal, Centro, Fragata, Simões Lopes, Três Vendas, Laranjal,and Capão do Leão) over the city area, aiming to have a picture of the city as a whole. Annual mean ± standard deviation of the PM2.5 measurements are: Porto 48.95±6.28, Areal 3.29±4.56, Centro 39.56±7.05, Fragata 30.28±3.59,Simões Lopes9.5±.9, Três Vendas 3.4±3.80, Laranjal 29.79±2.34, Capão do Leão 24.25±3.2 and annual mean ±standard deviation for NO2 were: Porto 9.06±.5, Areal 0.49±0.94, Centro 4.3±0.89, Fragata 2.44±0.56, Trem 7.20±0.99, Três Vendas 2.94±.22, Laranjal 8.83±.97, Capão do Leão 6.77±0.76. We conclude that there are significant differences in different places of the city, mainly due to traffic and human activities characteristics of each point. On the other hand, meteorological factors act similarly in all sites concerning the pollution dispersion.
Knowledge, Attitude, Acceptance and Utilization of the Female Condom Among Population in Brazzaville
Introduction: Knowledge and use of the male condom is not uncommon. This study sought to fill this gap by exploring Female Condom knowledge, attitude, acceptance and use in a sample of population to inform intervention measures aimed at increasing the acceptability and usage of the Female Condom taking into cognizance its safety and effectiveness.
Method Study: A cross-sectional survey conducted between May and July 2019, was used to explore knowledge, attitudes and practices on the female condom targeting Congolese population at Brazzaville, Republic of Congo. To allow the participants to respond to the questionnaire at a time comfortable to him/her.
Results: Seven hundred and twenty questionnaires were administered and 567 questionnaires were included in the final analysis giving a response rate of 81%. In total, 277 men and 290 women aged 14 to 63 participated in the study. Among the participants who have already seen the female condom, 80 have already used it, i.e. 21.3%. Of the 80 individuals who reported ever using a female condom, 43 (53.7%) used the female condom with a usual partner and 17 (21.3%) used it with a new partner. Concerning factors contributing to low usage of the female condom, the majority either had difficulty installing (26.3%); great difficulty in fitting (17.5%); the use of the female condom was simply uncomfortable (25%).
Discussion: Our study population included 68.3% of participants with higher education, which explains the fact that there is (93.8%) has heard talk about the female condom and among them 66.3% have already seen the female condom. Only 66.3% of people have ever seen a female condom, on the other hand very few people have used it. The majority of people had difficulty using the female condom, including difficulty in inserting the female condom. Difficulties related to the female condom insertion were reported by the majority of the respondents.
Conclusion: This study revealed critical gaps in knowledge, condom use, and negotiation skills and highlights the unmet need for interventions to further educate and empower women with and without HIV to prevent spread of HIV in this high-prevalence, high-risk population.
Hierarchical Analysis of The Factors Associated with the Consumption of Fruits and Vegetables: Cohort of Universities of Minas Gerais, Brazil (Cume Project)
The objective of this study was to assess which factors, at hierarchical levels, are associated with adequate consumption of fruits and vegetables (FV) in undergraduate and graduate students. This is a cross-sectional analysis of the baseline of the Cohort of Universities of Minas Gerais (CUME Project), with alumni from Universities of Minas Gerais, Brazil, in the years 2016 and 2018. The outcome variable was adequate consumption of FV (≥400 g/day). The exposure variables were divided into: block 1, socioeconomic (marital status, education, professional status, individual and family income); block 2, behavioral (physical activity, alcohol consumption, tobacco use, and consumption of legumes, natural juices, ultra-processed foods, soft drinks and industrialized juices, and fast foods); block 3, individual (gender, age, skin color, self-perception of health and presence of obesity, systemic arterial hypertension, diabetes mellitus, and depression). To verify the associations, hierarchical multiple logistic regression was used. The sample consisted of 4,124 individuals with a median age of 34 years and Interquartile Range (IQ) of 12 years, 68.1% women, with a high frequency (62.2%) of adequate consumption of FV. This adequate consumption of FV was associated with being a woman (OR=1.41; 95%CI 1.21-1.64; p<0.001), advancing in age and being physically active (OR=2.10; 95%CI 1.78-2.47; p<0.001), having regular consumption of natural fruit juice (OR=2.00; 95%CI 1.70-2.34, p<0.001), or consumption of ultra-processed foods (OR=0.96; 95%CI 0.95-0.97; p<0.001). In conclusion, individual and behavioral factors are associated with adequate consumption of FV in highly educated individuals.
Therapy-related Myeloid Neoplasms after Pediatric Solid Cancer in a Single Reference Cancer Center in Brazil
Pediatric cancer overall survival has increased due to improvements in treatment. However, long-term adverse effects are a challenge for this population. Secondary myeloid neoplasm (MN) is one of the complications of solid tumor treatment. Therapy-related myeloid neoplasms (t-MN), therapy-related acute myeloid leukemia (t-AML), and therapy-related myelodysplastic syndrome (t-MDS) are the most common events. The aim of this study was to report a large pediatric sample and the relevance of t-MN after pediatric solid tumor therapy. We conducted a retrospective study between 2000-2016 in a cohort of pediatric patients treated for solid tumors who developed a secondary MN by medical records review and analysis. Seven from 2178 pediatric patients who were previously treated for solid tumors, were diagnosed with t-MN in a reference cancer center in Brazil. The median age at primary tumor diagnosis was 12.8 years old. Osteosarcoma, atypical primitive neuroectodermal tumor (PNET), Ewing sarcoma, and retinoblastoma were the most frequent solid tumors associated with t-MN. Three patients had a story of familiar cancer, and one patient with osteosarcoma had Li-Fraumeni syndrome confirmed. The median latency period to secondary MN was ten months and the prevalence rate was 0.32%. Two patients developed t-MDS and five, t-AML. All these patients received cytotoxic agents’ high doses that may have been associated with t-MN development. t-MN initial control, as well as unfavorable cytogenetic abnormalities, may have contributed to the poor outcome. We described the rarity of t-MN related to previous solid tumor therapy in a large pediatric sample in a Brazilian Cancer Center and their poor prognosis.
Profiling of Benzodiazepines using Fluoroscence Spectrofluorometry: A Systematic Review
Benzodiazepines (BZDs) are one of the most widely used psychoactive drugs for the treatment of anxiety and panic
disorders, insomnia, muscle relaxation, epilepsy among other purposes. Given its rampant consumption worldwide,
BZDs are used in a number of drug facilitated sexual assaults (DFSA),
Rape, Child and Abortion: from Ideologization to Rights Violation in Brazil
Analyze the abortion of a pregnant 10-year-old girl who was repeatedly raped by her uncle in the state of Espirito Santo paralyzed Brazil. Pregnancy was revealed on the 7th of August, when the girl went to a local hospital suffering from abdominal pain. The girl claimed that she has been raped by the relative since she was 6 years old and that she did not report him to the authorities before, due to the fear caused by the uncle’s threats.
Sero-Prevalence and Associated Factors of Hepatitis B Virus Infection among Health Professionals in Adama Town, Oromia, Central Ethiopia
Hepatitis B is an infectious disease that caused by hepatitis B virus infection. Hepatitis B virus replicates in the liver and causes both acute and chronic hepatitis. The virus predominantly transmitted through a blood and sexual contact from potential sources. Healthcare professionals are at great risk of occupational exposure to this virus.
The Consciousness Energy Healing Treatment and Its Impact on the Structural Properties and the Isotopic Abundance Ratio of Cefazolin Sodium
Cefazolin sodium is a broad-spectrum antibiotic useful for the treatment of many Gram-positive and some Gram-negative bacterial
infections. This study was designed to investigate the impact of the Trivedi Effect® on the structural properties and the isotopic abundance
ratio of cefazolin sodium using LC-MS and GC-MS spectroscopy. Cefazolin sodium sample was divided into two parts, one part of
cefazolin sodium was considered as control
Enteric Pathogens in Patients with Acquired Immunodeficiency Syndrome from Porto Velho City, Rondonia State, Western Amazon, Brazil
Patients with human immunodeficiency virus (HIV), mainly those who live under poor sanitary and socioeconomic conditions, are often diagnosed with Gastrointestinal (GI) tract diseases. The lowest CD4+ T-cell counts are not found in the plasma, but in the GI tract, the biggest HIV source, thus allowing opportunistic infections. Therefore, the aim of the present study was to identify the epidemiological factors of GI infections and the prevalent pathogens in HIV patients from Porto Velho City, Rondônia State.
Comparative Bioequivalence Studies of Pantoprazole 40 mg Delayed-Release Tablet Formulations in Healthy Thai Volunteers
Pantoprazole is a H+,K+-ATPase enzyme inhibitor for the treatment of acid-related gastrointestinal diseases. The Government Pharmaceutical Organization (GPO), Thailand had developed Pantoprazole GPO® (pantoprazole 40 mg delayed-release tablets) as a generic substitute for the corresponding innovator product, CONTROLOC® 40 mg.
Editorial Board Members Related to AZ
Abolfazl Dohaei
Researcher
Department of Cardiology
Mayo Clinic in Rochester
United States
Department of Cardiology
Mayo Clinic in Rochester
United States
Ozlem Altindag
Department of Physical Medicine and Rehabilitation
University of Gaziantep
Turkey
University of Gaziantep
Turkey
RAMTEKE KULDEEP HEMRAJ
Associate Professor
Department of pharmaceutics
Modern College of Pharmacy
India
Department of pharmaceutics
Modern College of Pharmacy
India
FAZAL KHAWAJA
Chief of Gastroenterology and Hepatology
Director of GI Endoscopy Unit
Dr. Hamid S. Al-Ahmady Hospital
Saudi Arabia
Director of GI Endoscopy Unit
Dr. Hamid S. Al-Ahmady Hospital
Saudi Arabia
Mehdi Razzaghi-Abyaneh
Professor and Head
Department of Mycology
Pasteur Institute of Iran
Iran
Department of Mycology
Pasteur Institute of Iran
Iran
Eman Mohamed Zaghloul Al-Rafah
Professor
Department of Oral and Maxillofacial Rehabilitation
Faculty of Dentistry
King Abdulaziz University
Saudi Arabia
Department of Oral and Maxillofacial Rehabilitation
Faculty of Dentistry
King Abdulaziz University
Saudi Arabia
Leonard E Gerber
Associate Professor
Department of Nutrition and Food Sciences
University of Rhode Island
United States
Department of Nutrition and Food Sciences
University of Rhode Island
United States
JUAN CARLOS SALAZAR
Professor and Chair, Department of Pediatrics
University of Connecticut School of Medicine
Physician in Chief Connecticut Children’s Medical Center
Academic Director, Division of Pediatric Infectious Diseases and
Director of the Pediatric and Youth HIV Program
United States
University of Connecticut School of Medicine
Physician in Chief Connecticut Children’s Medical Center
Academic Director, Division of Pediatric Infectious Diseases and
Director of the Pediatric and Youth HIV Program
United States
Moinuddin Sarker
Natural State Research Inc.
Stamford, Connecticut
United States
Stamford, Connecticut
United States
Abolfazl Dohaei
Researcher
Department of Cardiology
Mayo Clinic
United States
Department of Cardiology
Mayo Clinic
United States