Articles Related to Amyotrophic Lateral Sclerosis
A Case Report of Rapidly Progressing Amyotrophic Lateral Sclerosis in 31 Year Old Patient with Sympathovagal Imbalance
ALS is a fatal neurodegenerative condition characterized by degeneration of upper and lower motor neuron in cerebral cortex, cranial nerve nuclei and anterior horn cells of spinal cord. Three drugs are FDA approved, Riluzole, Edaravone and
AMX0035 (recently approved), which can only prolong survival time by 2-3 months.
Clinical Stabilization of a Patient with Amyotrophic Lateral Sclerosis Due to Comprehensive Management
Amyotrophic lateral sclerosis (ALS) is a progressive nervous system disease that affects nerve cells in the brain and spinal cord, resulting in paralysis, inevitably, death. We herein report a case of a 67-year-old woman diagnosed with Amyotrophic Lateral Sclerosis (ALS) for one year presented with type II respiratory failure who has been under comprehensive management and kept using Non-Invasive Ventilator (NIV) for more than four months in a stable condition. In this report, we try to discuss the multidisciplinary approach to optimize the functioning of the patients and to care the patients with ALS in order to improve their quality of life (QOL).
A Case of Bulbar Amyotrophic Lateral Sclerosis with Mild Cognitive Impairment
It is still contentious whether amyotrophic lateral sclerosis (ALS)-Alzheimer’s disease (AD) cases comprise a combined disease or
represent a coincidental association. We describe the case of a 78-year-old white male with a 12-month history of bulbar muscle
weakness and mild cognitive impairment. Hallmarks of AD pathology were present and associated with diffuse congophilic
angiopathy. The motor cortex did not show a loss of motoneurons. The anterior horns of the medulla oblongata and hypoglossal nuclei
showed skein-like cytoplasmic inclusions and ubiquitin and TDP43 phosphate positive staining. No signs of FTLD were detected. The
pathological results suggest that, in this case, ALS and AD pathology appeared to be independent.
A Highly Efficient Culture Technique for Derivation of Motor Neurons from Human Umbilical Cord Derived Mesenchymal Stem Cells
Motor Neuron Diseases (MND) are a group of progressive neurological disorders that destroy motor neurons, cells that control essential muscle activity. Despite the advances in treatment modalities, the overall survival rate has not changed for decades. This is mainly due to the lack of effective methods.
Editorial Board Members Related to Amyotrophic Lateral Sclerosis
DEBORAH F GELINAS
Associate Professor
Department of Neuro-ophthalmology
Michigan State University
United States
Department of Neuro-ophthalmology
Michigan State University
United States