Articles Related to Antioxidants

Monodora Myristica Protects Against Oxidative Stress in the Drosophila Melanogaster Model of Lead-Induced Neurotoxicity

Background to Study: Lead (Pb) is ubiquitous in the environment and toxic. It has many negative effects on many organs and induces biochemical, physiological, and behavioural alterations on the brain. Monodora myristica is a calabash nutmeg belonging to the family of Annonaceae.It is a rich source of flavonoids which have been shown to exhibit both antioxi-dant and anti-inflammatory properties. We evaluated the protective role of Monodora myristica on lead-induced toxicity in D. melanogaster in this study

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The Simultaneous Activation of Nrf2 and Antioxidant Compounds may reduce the Risk, Progression, and Improve the Management of Diabetes by Reducing Oxidative and Inflammatory Damages

Despite extensive research, the incidence of diabetes continues to increase, and the management of diabetes needs improvement, because in 2016, more than 100,000 patients had lower extremity amputated, suffered ischemic heart disease and stroke. Analysis of investigations indicates that increased oxidative stress and chronic inflammation enhance the risk, progression, diabetic–related complications, and reduce effectiveness of drug therapy. Therefore, simultaneously attenuation of these cellular abnormalities may help in reducing the risk of development, progression, and prolonging the effectiveness of drug therapy.

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Neurobiochemical Roles of Low Molecular Weight Antioxidants on Oxidative Stress Biomarkers and Severity of Ischemic Stroke in Wistar Rats

Purpose: To evaluate the neurobiochemical role(s) of low molecular weight (LMWA) antioxidants in the treatment of surgically- induced ischemic stroke (IS) in wistar rats.Methods: Ischemic stroke was induced in wistar rats using middle cerebral artery occlusion (MCAO). Neurological assessments were carried out using stair case, cylinder test and modified neurological severity score (mnss) methods. Low molecular weight antioxidants (vitamins C, E, α-lipoic acid, dimethyl sulfoxide and mannitol) were orally administered to the rats for two weeks in three different doses (22.5, 45 and 67.5 mg/kg).

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The Role of Nutrition in Fighting Free Radicals

This paper aims to review in literature the main mechanisms of oxidative stress, pointing out the major formed metabolites, the mechanisms of cell damage and major antioxidants. Oxygen is essential to human life. The formation of free radicals (FR) is closely related to oxygen consumption, a mechanism that occurs with an incomplete reduction of this molecule.

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