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Articles Related to Arthritis

Long-Term Outcome of Juvenile Idiopathic Arthritis in Early Adulthood: Clinical Experience from a Saudi Tertiary Hospital

To report the long-term outcome including disease activity, damage and social status, quality of life at the last follow-up visit in a Saudi cohort of adults with juvenile idiopathic arthritis (JIA), and to determine the predictive factors.
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Ultrasound as a New Imaging Tool to Assess Pathological Change of Joints in Preclinical Mouse Models of Osteoarthritis

Murine osteoarthritis (OA) models are important for exploring OA pathology and treatment in the pre-clinical study. Longitudinal in vivo imaging modalities, including X-ray, computed tomography, and magnetic resonance imaging, are commonly used diagnostic tools in OA clinic, while end-point histomorphometry analysis is the major outcome measurement in the pre-clinical study because clinical imaging modalities have limited resolution for small animals.
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Dawn of the Biofilm Disease: Highlights about Biofilm in Bone and Joint & Prosthetic Joint Infections Pathogenesis, Diagnosis and Treatment

I present some key considerations of the biofilm disease as part of two complex pathologies such as bone and joint infections and prosthetic joint infections, taking into account the bacterial pathogenic factors to understand the particular nature of these infections, and to achieve an accurate diagnosis and management beyond the antimicrobial therapy. I mention some personal experience of many years in the medical microbiology laboratory and next to the patient’s bed.
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Comparative Study for Efficacy and Safety of Biosimilar Infliximab in Patients with Active Rheumatoid Arthritis on a stable Dose of Methotrexate

The present study evaluated the efficacy and safety of biosimilar infliximab in patients with active rheumatoid arthritis on a stable dose of methotrexate. Subjects were assigned randomly to either study infliximab or reference infliximab product in an approved dose of 3 mg/kg as an intravenous infusion at week 0, followed by similar doses at Weeks 2, 6 and 14. Primary efficacy endpoint was the proportion of subjects achieving ACR20 criteria at week 16 and secondary efficacy assessment included proportion of subjects achieving ACR20, ACR50 and ACR70 at week 16. In the open-label phase, all responders were followed till week 54. The non-responders entered a follow-up phase for immunogenicity and safety for an additional 3 months.
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Osteoid Osteoma of the Ribs - Is Image Intensifier or Bone Scintigraphy a Mandatory Diagnostic Tool - A Case report with Review of Literature

Osteoid osteoma (OO) is a benign bone tumour. In 1935, the jaffe reported it first. The fifty percent of OOs occur in long bones of the lower extremities but it may affect any bone. Only 1 % OOs affects the ribs and surgical excision was reported only in 14 cases in the literature. Complete surgical excision is the standard treatment method for osteoid osteoma is complete surgical excision which is reserved for the patients not responding to conservative treatment. In this report, we present a case of osteoid osteoma of the posterior part of the shaft of the sixth rib affecting a 30-year-old male, who had presented with symptoms of severe pain over the affected area and underwent surgical resection. Excised rib segment showed no osteosclerotic lesion on X-ray so immediately extended resection of the sixth rib was done. Here we have tried to evaluate the importance of the presence of the skeletal scintigraphy or C Arm image intensifier intraoperatively by comparing our experience with the available literature.
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Relationship of YWHAH Single Nucleotide Polymorphisms to Markers of Rheumatoid Arthritis Disease Severity

Introduction: Serum 14-3-3 eta provides diagnostic and prognostic information in Rheumatoid Arthritis (RA). It is coded by the YWHAH gene with single nucleotide polymorphisms (SNPs) linked to bipolar disorder and schizophrenia. It was hypothesized that 6 previously described YWHAH SNPs might relate to markers of RA disease severity such as seropositivity or erosive changes. Association study performed at an academic hospital Rheumatology Clinic. Subjects studied were 18 years of age or older with RA. TaqMan analysis screened for YWHAH SNPs rs2246704, rs2853884, rs3747158, rs4820059, rs7291050, rs933226. Primary endpoint was presence of at least one copy of the YWHAH SNPs with the markers of RA disease severity.
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MRI of the Psoas Major Muscle: Origin, Attachment, Anatomical Variants and Correlation with the Lumbar Disc Extrusion

To verify the psoas major muscle (PMM) anatomical origin and variants, to evaluate the PMM attachment to the lumbar disc and variants, and to search for correlation between the anatomic variants of PMM attachment to the disc and disc extrusion.
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Sjögren’s Syndrome - Oral Changes, Advanced Diagnosis, and Management - A Case Report

Sjögren syndrome (SS) is chronic, systemic autoimmune disease characterized by lymphocytic infiltration of the exocrine glands. It is an elaborate involvement of the lacrimal and salivary glands, which eventually lead to keratoconjunctivitis sicca and xerostomia.
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Septic Shock Secondary to Salmonella Enterica Ssp. Arizonae in an Immunocompetent Albanian Male

Salmonella-associated diarrhea is a common cause of community-acquired gastroenteritis. Some species of salmonella are associated with invasive diseases like meningitis, endocarditis and septicemia.
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Canakinumab in the Treatment of Erosive Hand Osteoarthritis: A Case Series

Erosive hand Osteoarthritis (EOA) is a common and debilitating form of hand OA for which there are no proven or efficacious therapies. Interleukin-1 beta (IL-1β) plays a prominent role in OA joint inflammation. Canakinumab is a selective IL-1β inhibitor.
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The Effect of Interleukin-6-Type Cytokines and Adiponectin on MAPK Activation in the Immortalized Human Chondrocyte C28/I2 Line and Normal Human Chondrocytes

The C28/I2 line of immortalized juvenile human chondrocytes was employed to determine the extent to which recombinant human (rh) interleukin-6 (rhIL-6), the interleukin-6-like cytokine, rh-oncostatin M, and the adipokine, rh-adiponectin, activated extracellularsignal regulated kinase (ERK1/2), p38α mitogen-activated protein kinase (p38α MAPK) and c-Jun-amino-terminal kinase (JNK).
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Food Energy Cost of Overweight and Obesity: A Model to Estimate the Amount of Food Expended for Excess Body Weight in a Community

Over-consumption of food energy entails body fat accumulation, overweight, obesity and increased risks of diseases. It is also indirectly associated with poor body condition followed by forced rest periods and limitations of activities and tasks. At community or global level, excess body weight could indirectly influence the environment by advancing food demand and the pressure on food production resources.
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Evaluation of Luffa Aegyptica Mill Powder: A Novel Superdisintegrant in Delayed Release Tablets

The current research in the field of drug delivery by which pulsatile release can be achieved has been intensified. The objective of the present study was to evaluate Luffa aegyptica mill powder as a novel superdisintegrant in the development of pulsatile drug delivery system (PDDS).
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Salmonella Septic Arthritis of the Knee in a Child

Infection with Salmonella spp can result in a variety of presentations such as enteric fever, septicemia, gastroenteritis, and septic arthritis. The common organisms seen in septic arthritis are Staphylococcus aureus and Streptococci which accounts for about 67% and 20% respectively. Salmonella spp however is less commonly seen in septic arthritis and it is usually associated with immunosuppression conditions and underlying chronic debilitating diseases such as malignancy, hemoglobinopathy, diabetes mellitus, and HIV.
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Croscarmellose Sodium Efficiency in the Development of a Generic Capsule Formulation of Piroxicam, Comparable Dissolution Profile to the Innovator Product, Feldene

The objective of this study was to evaluate the encapsulation performance of Croscarmellose sodium, a superdisintegrant in a low-dose, poor-solubility drug formulation and the in-vitro dissolution performance of the Piroxicam capsules. Preparation, characterization and evaluation of the effects of the different concentrations of carmellose sodium and the amount of dried starch on in-vitro dissolution of Piroxicam capsules. Piroxicam was chosen for its very low solubility in biological fluids, which result in poor systemic bioavailability after oral administration. Piroxicam can be categorized as Class II drugs according to the Biopharmaceutics Classification System.
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Editorial Board Members Related to Arthritis

Osama Mohamed Ahmed

Professor of Physiology
Physiology Division
Zoology Department
Faculty of Science, Beni-Suef University
Egypt

Charles J. Malemud

Professor
Department of Medicine and Anatomy
Case Western Reserve University
United States

Xueqin Gao

Department of Orthopaedic Surgery
University of Texas Health Science Center
USA

Muhammad Nasir Afzal

Professor & Director
Department of physiology
College of Medicine, Alfaisal University
Saudi Arabia
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