Articles Related to Asymptomatic Hyperparathyroidism

Background: Primary hyperparathyroidism (PHPT) is a frequently diagnosed endocrine disease and nowadays it is asymptomatic in the majority of patients. The management of asymptomatic PHPT is still debated in some cases, although there are evidences that asymptomatic patients may have improved outcomes after curative surgery. In this paper we show one of the longest follow-ups of surgically treated asymptomatic PHPT, focusing on skeletal long-term effects of surgery. Methods: We included in the study 21 patients that underwent parathyroidectomy for asymptomatic PHPT at our Institution from 2006 to 2010 with a complete follow-up at 10 years. Data about age, BMI, preoperative serum and urinary calcium, vitamin D, alkaline phosphatase parathormone, bone densitometry, surgical procedure and histological examination were collected and analyzed. Results: At follow-up we observed a normalization of PTH, serum calcium and alkaline phosphatase in all patients. Moreover, in all cases the T-score at 1 year increased significantly both at lumbar spine and femoral neck and this is maintained at long-term follow-up. Conclusions: Parathyroidectomy can be proposed as a safe therapeutical option in the majority of cases of asymptomatic PHPT considering the good results of surgery in terms of bone demineralization reduction

View complete article: PDF  |  Full-text