Articles Related to Availability
A Bioequivalence Study of Two Formulations of Lacosamide
This study was conducted to compare the bioavailability of two tablet formulations containing 200 mg Lacosamide (one Lacosamide 200 mg film-coated tablet marketed in Italy as Ollat®, one Vimpat® coated tablet). 20 healthy subjects were enrolled in a single-center, randomized, single-dose, laboratory-blinded, 2-period, 2-sequence, crossover study, with a minimum washout period of 7 days. All the 20 subjects completed the study. Plasma samples were collected up to 72.0 hours post-dosing. Lacosamide levels were determined using a validated high-performance liquid chromatography
with tandem mass spectrometry (HPLC/MS/MS) method
Review on Transdermal Drug Delivery System-Focus on Innovative 2 Transdermal Dosage Forms
The transdermal drug delivery system is technique that provides drug through the intact skin. Skin penetration enhancement techniques have been developed to increase the bioavailability of drug substance. These review describes various transdermal patches available in market, types of patches, basic components, polymer used in formulation. The novel drug delivery method do well and complete with those already on the market the main problem that requires consideration include device design and safety, efficacy, ease of handling and economical. Transdermal drug delivery system represent the most attractive method among these because of its low rejection rate, magnificent, ease of administration and better convenience and compliance with patient. This review article provide an overview of transdermal drug delivery system contains various innovative dosage forms. In comparison transdermal patch are effective due to its easy to apply and non-invasive.
PSII Photosystem Protection by Soil Amendment with Biochar and Adequate Nitrogen Fertilizer Availability Attenuate Cadmium Induced-Photoinhibition and Phytotoxicity in Solanum Lycopersicon
The aim of this research was to assess the biochar ability to protect the photosynthesis process face to Cd contamination, especially, when nitrogen fertilizer was added at adequate amount. Culture of tomato seedlings was conducted on pots containing soil added with different portion of biochar (0, 3.5 and 7%) and nitrogen (3 or 6g NH4NO3). Irrigation was done by water (control condition) or Cd solution (150µM). Data showed that regardless presence of Cd, synchronously addition of high nitrogen fertilizer (6g) and biochar (7%) in the culture medium resulted in fresh matter production, photosynthetic pigment (Chlorophyll a) and mineral elements content enhancement. Similar observation was shown concerning the mineral nutrition (nitrogen, phosphorus and potassium contents).
Pharmacokinetics Bridging Study of a 400 Mg Extended Release Formulation of the Novel Fumaric Acid Ester PPC-06 (Tepilamide Fumarate) in Healthy Male Volunteers
Tepilamide fumarate (PPC-06) is a new, patented prodrug of monomethyl fumarate (MMF), belonging to the fumaric acid esters
(FAEs) class of drugs. The efficacy and safety of a 400 mg PPC-06 dose administered twice daily, achieved thus far through concomitant
intake of two tablets of 200 mg, was demonstrated previously in two Phase 2 clinical trials on patients with moderate to severe chronic
plaque-type psoriasis.
Availability and Knowledge of Iodized Salt at Household Level and Associated Factors at Debre Tabor Town, Northwest Ethiopia
IDDs are among the major public health problems of the world. Nearly two billion individuals worldwide and about 350 million Africans are at risk of iodine deficiency and face many risks from its deficiency and complications. Poor knowledge related to iodine diet and iodized salt utilization were some of the factors. Poor Educational status, Occupation and Sources of Information were frequently cited factors related to Knowledge on iodized salt consumption. Iodized salt is an effective and cheap method to prevent and
control iodine deficiency in the community.
Pharmacokinetics of a 1,000 mg Disintegrating Aspirin Tablet Formulation
Migraine is a global disorder and considerably affecting people`s quality of life. Treatments include nonsteroidal anti-inflammatory drugs-containing medicinal products among whom acetylsalicylic acid-containing Aspirin® has been proven effectively to relief migraine headache. Early treatment is recommended for patients with migraine attacks.
Biological Availability of Phosphorus in Raw and Acidulated Sinda and Chilembwe Rock Phosphates in Broiler Chickens
A 14 day broiler chickens feeding trial was conducted to determine bio-availability and relative biological values (RBV) of phosphorus in raw and acidulated local rock phosphates (RPs) as potential replacements for imported and more expensive di-calcium phosphate (DCP). Treatments included Raw, Sulphuric acid and Phosphoric acid acidulated Sinda and Chilembwe RPs. Bio-availability was assessed based on feed intake, body weight gains, feed conversion ratios, phosphorus retention and mineralization of tibia bones and blood serum. RBVs were calculated on the same parameters using DCP as a reference standard. Phosphorus contents in local RPs were significantly (P ≥ 0.05) lower than in DCP, but acidulating RPs with Phosphoric acid significantly increased phosphorus, but reduced calcium contents. Other minerals were comparable with what was in DCP. Acidulating RPs significantly (P ≥ 0.05) increased body weight gains and feed conversion ratios, but not feed intake. Phosphorus retentions, weights and ash contents of tibia bones were significantly (P ≥ 0.05) lower in chickens fed diets based on raw than that of those fed diets based on acidulated RPs and DCP; an indication that acidulating the RPs improved phosphorus bio-availability in broiler chickens. There were however; no statistical differences (P ≥ 0.05) among treatments in calcium and phosphorus contents in both tibia bones and blood serum.
Paediatric Radiotherapy in Morocco
In Morocco, through the finding of the Casablanca population-based registry, all cancers are estimated at 35000 new cases par year and 3.2% are aged less or equal 20 years.
Bioequivalence Study of Two Oral-Capsule Formulations of Omeprazole 20 mg in Combination with Sodium Bicarbonate in Healthy Mexican Adult Volunteers
In Mexico, the immediate-release formulation of omeprazole 20 mg in combination with 1100 mg of sodium bicarbonate (oral capsules) is indicated for patients over 18 years for the treatment of gastritis, reflux, heartburn and the sensation of emptiness caused by the excessive acid production.
Bioequivalence Study of Two Oral-Capsule Formulations of Pregabalin 300 mg in Healthy Mexican Adult Volunteers
Pregabalin is a ligand for the alpha-2-delta subunit of voltage-gated calcium channels in the central nervous system. It has anticonvulsant, analgesic, and anxiolytic activity. The bioequivalence of a test formulation was evaluated with respect to its corresponding reference drug formulation of oral pregabalin 300 mg, administered as a capsule. This randomized-sequence, single-dose, single-blind, two-period crossover design under fasting conditions was done on 25 healthy Mexican adult subjects including both genders. There was a seven-day washout period.
Relative Bioavailability of Ciprofloxacin Doses (750 and 1000) mg in Healthy Male Volunteers by Using HPLC Method
A new, stable and accurate high performance liquid chromatography ultraviolet spectrophotometric method for quantitation of Ciprofloxacin in human plasma was developed and validated.
Availability of Adequate Iodized Salt at Household Level and Associated Factors in Rural Communities in Laelay Maychew District, Northern Ethiopia: A Cross Sectional Study
Universal salt iodization is cost-effective, safe and sustainable strategy to ensure adequate intake of iodine by all populations. Worldwide the proportion of people consuming iodized salt dramatically increased while, the coverage of universal salt iodization is still low in Ethiopia.
Croscarmellose Sodium Efficiency in the Development of a Generic Capsule Formulation of Piroxicam, Comparable Dissolution Profile to the Innovator Product, Feldene
The objective of this study was to evaluate the encapsulation performance of Croscarmellose sodium, a superdisintegrant in a low-dose, poor-solubility drug formulation and the in-vitro dissolution performance of the Piroxicam capsules. Preparation, characterization and evaluation of the effects of the different concentrations of carmellose sodium and the amount of dried starch on in-vitro dissolution of Piroxicam capsules. Piroxicam was chosen for its very low solubility in biological fluids, which result in poor systemic bioavailability after oral administration. Piroxicam can be categorized as Class II drugs according to the Biopharmaceutics Classification System.
Reduction of Bitterness and Enhancing Palatability of Cetirizine Oral Liquid Dosage Forms by Cyclodextrins
The aim of this manuscript is to study cyclodextrins (CDs) as a potential excipient to suppress bitterness and enhance palatability of pediatric liquid preparations for Cetirizine, an extremely bitter drug. Natural α, β and γ CDs; and β CD derivatives such as hydroxyl propyl (HP), randomly methylated (RM) and sulfobutyl ether (SBE) β-CDs were screened in different molar ratios of 1:1, 1:2 and 1:3 for their inhibition of the extremely bitter taste of Cetirizine using the human gustatory sensation test.
Editorial Board Members Related to Availability
Kit-Lam Chan
Professor
School of Pharmaceutical Sciences
Universiti Sains Malaysia
Malaysia
School of Pharmaceutical Sciences
Universiti Sains Malaysia
Malaysia
Sohail Mushtaq
Senior Lecturer
Department of Clinical Sciences
University of Chester
United Kingdom
Department of Clinical Sciences
University of Chester
United Kingdom
Suzanne M. Miller
Professor
Division of Cancer
Fox Chase Cancer Center
United States
Division of Cancer
Fox Chase Cancer Center
United States
Angela Myracle
Assistant Professor
School of Food and Agriculture
University of Maine
United States
School of Food and Agriculture
University of Maine
United States
R. SURESHKUMAR
Assistant professor
Department of Pharmaceutics
JSS College of Pharmacy
India
Department of Pharmaceutics
JSS College of Pharmacy
India
ALAA EL-DEEN BAKRY YASSIN
Associate Professor
Department of Pharmaceutical Sciences
King Saud bin Abdulaziz University for Health Sciences
Saudi Arabia
Department of Pharmaceutical Sciences
King Saud bin Abdulaziz University for Health Sciences
Saudi Arabia
Pierre Deviche
Professor of Environmental Physiology
School of Life Sciences
Arizona State University
USA
School of Life Sciences
Arizona State University
USA