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Articles Related to Blood Pressure

Effects of Gabapentin Enacarbil on Cortical Arousals, Heart Rate, Blood Pressure and Anterior Tibialis EMG Responses Associated with PLMs in Restless Legs Syndrome

Objective: This study was conducted to investigate the effects of gabapentin enacarbil (GEn) on sleep EEG, heart rate (HR), blood presssure, anterior tibialis EMG activity (PLMs power) and subjective complaints in subjects with moderate to severe RLS and disturbed sleep. Methods: This was a single site, single-blind, placebo run-in, fixed dose single group polysomnography (PSG) study. Eligible subjects (age 24-66 years) were treated with placebo for one week and GEn (600 mg/day) for 4 weeks. Two in-laboratory PSGs were collected for adaptation and baseline at the end of the placebo run-in period and for re-adaptation and efficacy assessment at the end of the 4-week treatment period. The primary endpoint was the difference in PSG derived cortical arousal intensity (arousal scale, 0-9) associated with PLMs between 4 weeks of treatment with GEn and placebo. Secondary endpoints included changes in HR responses (ΔHR), nocturnal systolic blood pressure (SBP) changes (>10 mmHg) secondary to PLMs and PLMs power. Other PSG and subjective measures were assessed. Results: Of 20 subjects enrolled, 18 completed the study. Subjects treated with GEn did not show significant improvements in cortical arousal intensity and ΔHR. However, subjects showed reduced PLMs power (p= 0.013) and associated reductions in nocturnal SBP per hour of sleep (p= 0.041) GEn showed significant improvement in other PSG parameters and subjective endpoints. Conclusion: The data suggests that GEn reduces the frequency and power of PLMs and the corresponding SBP changes in subjects with RLS. Despite reducing the total number of PLM associated arousals and nocturnal HR, the study did not demonstrate consistent effects of GEn on cortical arousal intensity and corresponding HR changes associated with PLMs. Clinical Trial Registration: ClinicalTrials.gov identifier: NCT02424695
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Effects of Ramadan Fasting on Anthropometric Measures, Blood Pressure and Glucose Level among Type 2 Diabetic Patients on Metformin Treatment

Fasting from dawn to dusk during Ramadan is obligatory for all healthy adult Muslims.
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The ACAI (Euterpe oleracea Mart.) Pulp Consumption Improves Blood Pressure Levels in Women with Higher Concentrations of Interferon-Gamma

Interferon-gamma (IFN-γ) is associated with the inflammatory responses modulation, which could culminate in chronic metabolic diseases. In this context, the aim of the present study was to evaluate the effect of the acai (Euterpe oleracea Mart. mart.) pulp consumption on the anthropometric, clinical and biochemical parameters in women clinically healthy, with IFN-γ, respectively, smaller and higher than 5 pg/mL. Twenty four women in G1 (with IFN-γ concentrations smaller than 5 pg/mL) and sixteen in G2 (with IFN-γ concentrations greater than 5 pg / mL), consumed 200g per day of acai pulp during four weeks. Anthropometric and body composition measurements, biochemical and clinical data were evaluated before and after the intervention
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Labetalol in Comparison to Methyl Dopa in Treatment of Gestational Hypertension, A Randomized Trial

To evaluate the value and safety of labetalol in comparison to Alfa methyldopa in treatment of pregnant women with pregnancy-induced hypertension (PIH). 264 patients with PIH were randomly distributed to take either methyldopa (group 1) labetalol (group 2). or Intake of medications with respect to Age, gravidity, Blood Pressure measurement, albumin in urine measurement Levels, Side Effects, dose of the drug, increasing duration of pregnancy, mode of delivery, Perinatal safety and APGAR scores were studied. The statistical level of significance was taken at P<0.05.
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How Should we Screen Overweight and Obese Adolescents for Risk of Type 2 Diabetes in Large Public Health Initiatives?

To develop a valid method to identify insulin resistance (IR) in overweight and obese adolescents without requiring a fasting blood sample.
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Hemodynamic and Autonomic Reactivity to Mental and Physical Stress in Lean, Overweight and Obese Subjects

There could be progressive changes in hemodynamic and autonomic parameters causing cardiovascular damage from lean to morbid obesity. We aim to study resting and reactivity of hemodynamic and autonomic parameters to physical and mental stress in lean, overweight and obese subjects of the Oman Family Study (OFS).
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DNA Methylation Status of the Methylenetetrahydrofolate Reductase Gene is associated with Depressive Symptoms in Japanese Workers: A Cross-Sectional Study

Polymorphisms in methylenetetrahydrofolate reductase (MTHFR) gene, that is considered to be the most important genetic determinant of blood homocysteine concentration, are associated with various diseases, including psychiatric disorders. However, the epigenetic factors influencing on the transcription and expression of this gene are unclear.
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Early Postnatal Stunting Increases Risk of Hypertension among Young Rural Adults from India- Pune Rural Cohort

As stunting in early postnatal life is prudent in developing countries, investigating its long term effect on adult blood pressure is necessary.
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Anthropometric Predictors for Multiple Risk Factor Aggregation in Adults from Maracaibo City

There are several anthropometric measures that are useful for diagnosis obesity and also are related to the development of different cardiovascular risk factors. The purpose of this study was to determine the predictive ability of various anthropometric parameters for the multiple risk factors aggregation (MRFA) in the adult population of the city of Maracaibo-Venezuela.
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Dermatophytosis in a Dog Seropositive for Ehrlichia Spp

In this report, we present a case of dermatophytosis in a dog seropositive for Ehrlichia spp.Mild annular skin lesions observed on initial presentation persisted and became worse during the course of antibiotic therapy. Microscopic examination of the fungal culture of skin scrapings revealed infection with Microsporum gypseum. The patient fully recovered following treatment with topical 1% clotrimazole and antifungal shampoo.
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Pharmacy Compounding Quality Control and Pharmaceutical Development Strategies for Seventeen alpha Hydroxyprogesterone Caproate in Prevention of Preterm Delivery

Seventeen alpha hydroxyprogesterone caproate (17-OHPC) is the only FDA-approved drug labeled for prevention of preterm delivery. This drug is also available as a compounded product from licensed compounding pharmacies. This article reviews the FDA approval history and pharmacy compounding quality control data of 17-OHPC, as well as briefly discusses possible future pharmaceutical development strategies for 17-OHPC.
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Editorial Board Members Related to Blood Pressure

Akira Sugawara

Department of Molecular Endocrinology
Tohoku University Graduate School of Medicine
Japan

Kawther Alquadan

Assistant Professor of Medicine
Division of Nephrology, Hypertension and Transplantation
University of Florida
USA

Chandan Saha

Associate Professor
Department of Biostatistics
School of Medicine
Indiana University
United states

DAVID R. BLACK

Professor Emeritus
Department of Health and Kinesiology
Purdue University
United States
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