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Articles Related to Breast Cancer

Radiation Dose to Oesophagus in Breast Cancer Patients Receiving Radiation Therapy: A Retrospective Study

Background: Breast cancer is the most common cancer in women worldwide. Management of Breast cancer requires multidisciplinary team approach (viz, Surgery, Chemotherapy, Radiation therapy, Hormonal therapy & Targeted therapy). Radiotherapy reduces the risk of breast cancer mortality for women after breast conserving surgery and for women after mastectomy for node-positive disease. One of the organs at risk in breast cancer therapy is esophagus. As such, there is potential to expose greater volumes of esophagus to radiation. This may result in increased frequency and severity of acute radiation esophagitis during treatment. Aims and Objectives: To evaluate dosimetric parameters such as mean dose (Dmean) maximum dose (Dmax) which may influence the incidence and severity of esophagitis in breast cancer patients receiving radiotherapy. Material and Methods: Treatment plans of post mastectomy patients who had already received adjuvant RT of dose 50 Gy in 25 # over 5 weeks to the chest wall along with Supraclavicular field (SCF) using 3-Dimensional Conformal Radiation Therapy (3D CRT) and Intensity Modulated Radiation Therapy (IMRT) were selected. Mean dose (Dmean) and maximum dose (Dmax) to esophagus was assessed. Results: Dosimetric parameters assessed are Dmean and Dmax. Dmean assessed up to less than or equal to 11Gy and Dmax assessed upto less than or equal to 34Gy. The average of Dmean in this study is 8.34Gy which is within normal limits of prescribed dose. The mean Of Dmax in this study is 24.80Gy which is in limits of prescribed dose. Conclusion: Increased dose to esophagus in observed when IMRT is used especially when supraclavicular or internal mammary nodes are involved. Routine contouring of esophagus and planning accordingly may reduce oesophageal dose and acute oesophageal toxicity.
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Drug Therapy Problems and Clinical Outcomes Among Patients with Human Epidermal Growth Factor Receptor 2 (HER2) Positive Breast Cancer on Trastuzumab-Based Therapy in a Kenyan Tertiary Health Facility

Breast cancer ranks first among the most commonly diagnosed cancers in Kenyan females and globally. Treatment is challenging because it is a heterogeneous disease with several subtypes. There has been a significant change in the treatment of Human Epidermal Growth Factor Receptor 2 (HER2) positive breast cancer subtypes following the introduction and widespread use of HER2 targeted therapies.
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Cost-Effectiveness and Budget Impact Analysis of Recombinant Tumor Necrosis Factor-Thymosin Alpha 1 in a Complex Treatment of Metastatic Breast Cancer

Recombinant tumor necrosis factor -thymosin alpha 1 (TNF-T) has been used in Russian oncological practice for a number of years.
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Profile of Tumor-Associated Cytokines among Breast Cancer Patients: A Preliminary Study

The link between disease and the oral cavity represent clinically important factors that have given rise to the interest in using saliva as a diagnostic fluid for systemic diseases. The objective of this study was to detect and quantify cancer related cytokines in the saliva of women with breast cancer and compare their concentrations to a healthy cohort.
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Recent Advancements Involving Immunoliposomes to Target Breast Cancer

Breast cancer is caused by genetic abnormalities resulting in uncontrolled growth of breast cells, and is the most commonly diagnosed cancer amongst women. The clinical use of liposomal-based drugs to treat solid tumors such as breast cancer has been shown to improve the overall pharmacological properties of otherwise “unencapsulated” cytotoxic agents.
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Screening & Awareness of Breast Cancer in an Urban Slum of Pakistan: A Pilot Study

Background: Breast cancer is the most common cancer in women across the world with low survival rates in less developed countries. Low survival rates in less developed countries can be explained mainly by the lack of early detection programs and lack of adequate diagnosis and treatment facilities.
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The Influence of Faith and Religiosity in Coping with Breast Cancer

The study researches the influence of faith and religiosity in coping with breast cancer based on the analysis of spiritual well-being and the association of spirituality/religiosity and its practices with the acceptance of diagnosis, treatment adherence and future prospects for the patient. A descriptive and field research carried out with patients diagnosed with breast cancer resulted in the evident conclusion that faith and religiosity present themselves as the determinant, potent and active factors in their clinical treatments and in their lives.
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Advances in the Treatment of Breast Cancer-Emphasis on fertility preservationA Case Report

With the recent advances in breast cancer treatment the 5 year survival rates have increased significantly with overall 20yrs survival in developed countries like USA. With further improvement being designed in the treatment of breast cancers with more and more sophisticated models to study breast cancer in human beings using the modern microfluidic models one expects more and younger breast cancer survivors to be needing fertility treatments. Here we review the modern advances in breast cancer treatments and the need for emphasizing on fertility preservation before starting any chemotherapeutic or other management as recommended by both ASO and ASRM.
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Late Cerebellar Vermis Metastasis of Breast Cancer Presenting as Pseudo-Benign Paroxysmal Positional Vertigo

Benign paroxysmal positional vertigo (BPPV) is a common peripheral vestibular disease; however intracranial lesions can mimic it. Intractable, not self-limiting paroxysmal positional vertigo sustained by intracranial tumors is called malignant paroxysmal positional vertigo (MPPV) while, when radiological imaging shows vascular cerebellar vermis lesions and there are atypical findings on the Dix-Hallpike maneuver, we speak about pseudo-benign paroxysmal type (pseudo-BPPV).
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Breast Cancer Detection by Determination of Optical Properties of Non-Malignant and Malignant Breast Tissues

Breast cancer being one of the most frequent form of cancer, is the leading cause of cancer deaths in women worldwide. Early detection can greatly improve a woman`s chances for survival. In this paper we introduce an economic and accurate optical system for breast cancer detection.
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Historical Concepts of Ovarian Dermoid Cysts

A study of the history of the dermoid cyst of the ovary suggests that the old masters were only conversant with large tumors. The relatively smaller dermoid cyst with its typical greasy matter and hairs only came into recognition during the second half of the 19th century. Therefore, the purpose of this paper is to document how the medical masters of yester years became acquainted with this distinct disease.
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Editorial Board Members Related to Breast Cancer

WEN ZHOU

Associate Faculty
Women's Health Faculty
Columbia University
United States

P. S. SURESH

Assistant Professor
Department of Bio-Sciences
Mangalore University
India

Khaldon Bodoor

Associate Professor
Department of Biotechnology and Genetic Engineering
Jordan University of Science and Technology
Jordan

Qifeng Yang

Professor
Department of Breast Surgery
Director, Pathology Tissue Bank
Qilu Hospital, Shandong University
China

Anuradha Ratna

Department of Medicine
University of Massachusetts Medical School
USA

Peter Lobie

Principal Investigator
Cancer Science Institute of Singapore
National University of Singapore
Singapore

SAN MING WANG

Associate Professor
Department of Genomics
University of Nebraska Medical Center
United States

Fatemeh Baghbani

Faculty of Biomedical Engineering
Amirkabir University of Technology
Iran

Nallasivam Palanisamy

Associate Professor
Michigan Center for Translational Pathology
University of Michigan
United States

Lizhong Wang

Associate Professor
Department of Genetics
University of Alabama
USA
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