Articles Related to CMV

Several viruses are often believed to be associated with acquired aplastic anemia. There is paucity of literature proving the association between viruses and aplastic anemia. We aimed to study the association of aplastic anemia with Human Parvovirus B19 (B19V), Epstein Barr virus (EBV), Cytomegalovirus (CMV), Hepatitis viruses, Measles virus (MV), Varicella Zoster virus (VZV) and Adenovirus (AdV). Between January 2020 to December 2020, confirmed cases of aplastic anemia and age and sex matched controls of iron deficiency anemia were enrolled in the study. They were tested for the above- mentioned viruses for antigen and/or IgM antibody by ELISA and/or nucleic acid by Real Time PCR in serum samples. Relevant history was collected. Cases were followed up at 3, 6 and 12 months after enrollment for recording the outcome. Total 68 cases and 34 controls were included in the study of which 61(89.70%) cases and 12(38.23%) controls were positive for markers of at-least one of the 10 viruses studied. B19V, EBV, CMV and Hepatitis B virus were found to be significantly associated with aplastic anemia. Five patients died within 12 months. Mortality was not associated with viral infections. Viral infections may play a role in pathogenesis of acquired aplastic anemia.

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Immunosenescence describes the decrease in immune function with advancing age, a phenomenon that is associated with changes in the B and T lymphocyte populations. CD8+ T cells display the most dramatic phenotypical and functional changes within the T cell compartment whereby the cohorts of effector and memory T cells expand while the total population and diversity of naive T cells both decline.

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