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Articles Related to CRP

Detection of a Rheumatic Factor (RF,) Anti- Cyclic Citrullinated Peptides (Anti CCP) Antibodies and C- Reactive Protein (CRP) in Diagnosis and Prognosis of Rheumatoid Arthritis

Introduction: Rheumatoid arthritis ( RA)is an autoimmune and inflammatory disease. It is characterized by arthrosynovitis with resultant joint destruction . So, an early clinical diagnosis along with simple serological tests like anti CCP antibodies, C –reactive protein ( CRP) and Rheumatoid factor (RF) play an important role .An attempt was made to study and compare these parameters in OPD and IPD RA patients in our hospital setup, VMMC and Safdarjung Hospital , New Delhi. Aims and Objectives: To study the role of RF , Anti-CCP antibodies and CRP in early detection and prognosis of Rheu- matoid arthritis. Materials and Methods: A Total of 440 samples were studied from January 2018 to December 2020 (3years). Correlation between Rheumatoid factor(RF) ,anti CCP antibodies and CRP in suspected RA patients from various departments like PMR , Orthopaedics , Medicine, Obstetrics and Gynaecology and Paediatrics was attempted. RF and CRP was performed using latex agglutination test and anti CCP antibody by ELISA. Results and Conclusion: Of 440 samples tested, all the factors were positive in 87 patients . Anti CCP and RF alone was seen in 32 patients. RF and CRP positive in 49 patients, RF alone in 22 patients. In 250 patients all the tests were negative. So, Anti CCP along with RF and CRP showed a better positive predictive value in patients of Rheumatoid arthritis. But positivity of these parameters even in patients who lack sign and symptoms also aids in better diagnosis, treatment and prognosis.
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Infective Endocarditis at Tricuspid Valve in CHD: What are its Characteristics? What is the Pathophysiology?

Infective endocarditis (IE) is a serious infectious disease that carries a high mortality rate. We report the case of 74-year-old female who is a chronic hemodialysis patient, and was presented with tricuspid valve endocarditis (TVIE) with central venous catheter, due to an Enterobacter Cloacae, which is a non-HACEK Gram-negative bacilli (GNB) and has been reported to be an extremely rare pathogen of IE. The patient was treated with imipenem and teicoplanin for a four-week period, with negative Blood culture and normal C reactive protein (CRP) levels at the end. The aim of our study is to understand the pathophysiology of the IE in chronic renal failure (CRF) especially at the tricuspid valve (TV), and to determine the clinical, biological characteristics and therapeutic modalities.
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Late Cerebellar Vermis Metastasis of Breast Cancer Presenting as Pseudo-Benign Paroxysmal Positional Vertigo

Benign paroxysmal positional vertigo (BPPV) is a common peripheral vestibular disease; however intracranial lesions can mimic it. Intractable, not self-limiting paroxysmal positional vertigo sustained by intracranial tumors is called malignant paroxysmal positional vertigo (MPPV) while, when radiological imaging shows vascular cerebellar vermis lesions and there are atypical findings on the Dix-Hallpike maneuver, we speak about pseudo-benign paroxysmal type (pseudo-BPPV).
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Clinical Utility of Triglyceride: HDL-Cholesterol Ratio as a Surrogate Marker of Inflammation in Pediatric Obesity

The prognostic utility of the triglyceride: HDL-cholesterol (TG:HDL-C) ratio, a marker for insulin resistance, is unknown among high-risk children and adolescents. We examined the clinical utility of TG:HDL-C ratio as a marker of insulin resistance and chronic inflammation in obese youth.
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How Should we Screen Overweight and Obese Adolescents for Risk of Type 2 Diabetes in Large Public Health Initiatives?

To develop a valid method to identify insulin resistance (IR) in overweight and obese adolescents without requiring a fasting blood sample.
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ESBL-Producing E. Coli in a Patient on Automated Peritoneal Dialysis

Peritoneal Dialysis (PD) is one of the 3 well-established modalities of renal replacement therapy used in patients with renal failure. Despite its significant role as a successful method of renal replacement therapy, PD is highly associated with peritonitis and catheter-related infections.
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The Roles of Procalcitonin, C-Reactive Protein and Erythrocyte Sedimentation Rate in Predicting Bacteremia

The early differentiation between infectious and non-infectious sepsis remains a challenge due to the lack of a reliable, ready available and quick biomarker of bacterial sepsis. This study aims to determine the diagnostic accuracies of procalcitonin (PCT), C-reactive protein (CRP) and erythrocyte sedimentation rate (ESR) as individual and combined predictors of bacterial sepsis, when compared to the gold standard microbiological cultures
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Canakinumab in the Treatment of Erosive Hand Osteoarthritis: A Case Series

Erosive hand Osteoarthritis (EOA) is a common and debilitating form of hand OA for which there are no proven or efficacious therapies. Interleukin-1 beta (IL-1β) plays a prominent role in OA joint inflammation. Canakinumab is a selective IL-1β inhibitor.
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Anti-Inflammatory Effects of β-Glucan in Cancer Related Fatigue

Immune-mediated inflammatory diseases are among the exhausting diseases which are often difficult to diagnose. Fatigue is the most common syndrome accompanying cancer diseases and treatment. In cancer patients, fatigue is not only a manifestation of treatment, but also reflects biological effects of the tumor.
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Development of Severe Hypophosphatemia from Acquired Fanconi Syndrome during Treatment with Abiraterone

The first patient was a 77 year old man who had been on abiraterone for 12 months before his phosphorous was checked. At that point, it was 0.6 mg/dl, which is severely decreased. A full work up for hypophosphatemia showed normal parathyroid hormone and 25-hydroxyvitamin D. A urine study showed inappropriate excretion of phosphorous along with aminoaciduria and normoglycemic glucosuria.
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Procalcitonin versus C-Reactive Protein in Neonatal Sepsis

Urinary tract infection (UTI) is the most common serious bacterial infection in febrile children younger than 3 months, with reported rates ranging from 5% to 20% depending on different series. Neonates and infants up to age 2 months who have pyelonephritis usually do not have symptoms localized to the urinary tract.
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Editorial Board Members Related to CRP

ASIF ALI

Assistant Professor
Academy of Scientific & Innovative Research (AcSIR)
India

Jianfei Qi

Assistant Professor
Biochemistry and Molecular Biology
University of Maryland School of Medicine
United States
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