Articles Related to Carcinogenesis

Compartmentalization Modules of Inflammatory Response are Centered on the Epithelial-Mesenchymal Transition of Transforming Cells in Carcinogenesis

The epithelial-mesenchymal transition (EMT) event in carcinogenesis is dependent on multiple operant pathways of master transcription as proposed for NF-kappaB and in terms of the initiated progression of malignant transformation. Inflammation is a primarily compartmentalized series of distinct and overlapping systems that induce and enhance multifocal operabilities within both the nucleus and cytoplasm by systems of enhancer/inhibitory modes of modulation of multi-gene transcription.

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IL-8 Regulates Epithelial-Mesenchymal Transition through pERK1/2 in AGS Cells

The aim of this project was to evaluate the influence of inflammatory cytokines IL-1β and IL-8 on gastric epithelial-mesenchymal transition in gastric epithelial cells.

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Duodenal Contents Reflux can Induce Esophageal Squamous Cell Carcinoma as Well as Adenocarcinoma

Esophageal carcinoma is the eighth most common cancer, and the sixth most common cause of cancer-related deaths worldwide. Esophageal carcinomas in developing nations account for more than 80% of the total cases and deaths. Esophageal cancer can arise as esophageal squamous cell carcinoma (ESCC) or esophageal adenocarcinoma (EAC), which have distinct etiological and pathological characteristics. ESCC is the most common histological type of esophageal cancer in the Eastern world, and its incidence remains stable. In contrast, the epidemiology of esophageal cancer in developed nations has dramatically changed over the past 40 years. Forty years ago, ESCC accounted for more than 90% of esophageal cancer cases in the United States. However, adenocarcinoma has now become the leading type of esophageal cancer in the United States, representing 80% of cases.

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