Articles Related to Center
A Single-Center Experience in Alport Syndrome
Alport Syndrome is a hereditary condition that affects the collagen in the basement membrane and is characterized by microscopic hematuria, sensorineural hearing loss, increasing renal dysfunction, and ocular abnormalities. It is
more common between the ages of 20 and 30. Men and women are equally affected. However, the prognosis of men is
worse than women due to renal failure. The purpose of this study is to evaluate the demographic and clinical findings of patients with Alport Syndrome in our center
Study to Find Clinical Characteristics of ABPA in Patients of Severe Bronchial Asthma and Its Relation with Serum Ige Level at Teriary Care Center North India
Allergic bronchopulmonary aspergillosis (ABPA) is an idiopathic inflammatory disease of the lung, characterized by an allergic inflammatory response to colonization of the airways by Aspergillus fumigatus or other fungi. Untreated
or inadequatetreatment may lead to poor outcome in patients. Raised level of serum IgE of more than 1000 IU/ML have
been considered as one if theimportant diagnostic criteria for ABPA, however relation of serum IgE withs severity ofdiseases is lacking. This study was conducted to find out level of serum IgE in patients ofABPA and to find out corelation of
Serum IgE with duration of symptoms and diseasesseverity.
Histomorphological Features of Sarcoidosis - 4 Year Study in a Tertiary Care Center, South Kerala
Pathologists are frequently involved in the diagnosis of sarcoidosis on conventional biopsies and cytology specimens. Histology generally does not pose difficult tasks in the correct clinical and imaging scenario, but atypical forms of sarcoidosis exist, and in these cases, the diagnosis may become difficult. The final diagnosis always requires the careful integration of the histology with the clinical, laboratory, and radiologic findings. The differential diagnoses of sarcoidosis includes granulomatous infections, hypersensitivity pneumonitis, pneumoconiosis, autoimmune diseases, drug reactions, chronic aspiration, and even diffuse fibrosing diseases. In this study, we discuss the histomorphological aspects of Sarcoidosis, along with radiological, biochemical and clinical aspects. The most important finding is the presence of non caseating granulomas by histology which needs to be interpreted in the light of appropriate clinico-radiological and laboratory findings. This study emphasises the role of the pathologist and discusses the differential diagnosis.
Anti-Infectives do not Impact Treatment Response to Immune Checkpoint Inhibitors: a Single Center Retrospective Analysis
Immune-checkpoint inhibitors (ICI) have provided groundbreaking advancements for a
variety of malignancies. It has been of recent interest to identify predictive indicators of response to improve cancer
management using immunotherapy. The intestinal microbiome has been recognized as a potential predictor of ICI anti-
tumor activity. Antibiotics reduce diversity the overall composition of the gut microbiota, with effects seen as quickly as in
a single day. Post-antibiotic dysbiosis recovery varies depending on type and duration of exposure. Preclinical studies in
mice with advanced cancer treated with broad spectrum antibiotics have been associated with resistance to ICI treatment.
Factors Influencing Adherence to Hydroxyurea Treatment Among Children with Sickle Cell Disease at the Mother and Child Center of the Chantal Biya Foundation
Introduction: Sickle cell disease (SCD) is a genetic hemoglobin disease for which there are many treatment options. Evidence supports the efficacy and cost-effectiveness of hydroxyurea (HU). Nevertheless, its use and adherence to treatment remain suboptimal, hence, the necessity to assess the factors influencing this observance.
Objectives: The objective was to evaluate the factors influencing observance to HU in children with sickle cell disease from the Mother and Child Center of the Chantal Biya Foundation (MCC of the CBF).
Materials and Methods: This was a descriptive and analytical cross-sectional study from January to June 2020. Children on HU for at least six months, and followed up at MCC of the CBF were included. Data collection was done using a pre-tested questionnaire. The level of compliance was assessed using the Morisky’s observance grid, where 8 points was considered as “good”; 6-7 points as “fair”, and <6 as “poor”. Data were stored in CSPro version 7.0 software, and subsequently analyzed using the SPSS version 20.0 software.
Results: Of 142 patients recruited, the level of patient observance was considered “good” in 2.1%, fair in 26.1% and poor in 71.8%. Logistic regression analyses suggested that using hydroxyurea to prevent complications was the only factor that favored good medical adherence [OR=0.37; CI (0.14-0.987)] (p=0.047). Poor compliance was mainly associated with the fear of infertility and and other sides effects associated with the use of HU.
Conclusion: Children with SCD in this study have poor compliance with HU. Implementing IEC sessions would make it possible to raise patient/parent awareness and reverse this trend.
Therapy-related Myeloid Neoplasms after Pediatric Solid Cancer in a Single Reference Cancer Center in Brazil
Pediatric cancer overall survival has increased due to improvements in treatment. However, long-term adverse effects are a challenge for this population. Secondary myeloid neoplasm (MN) is one of the complications of solid tumor treatment. Therapy-related myeloid neoplasms (t-MN), therapy-related acute myeloid leukemia (t-AML), and therapy-related myelodysplastic syndrome (t-MDS) are the most common events. The aim of this study was to report a large pediatric sample and the relevance of t-MN after pediatric solid tumor therapy. We conducted a retrospective study between 2000-2016 in a cohort of pediatric patients treated for solid tumors who developed a secondary MN by medical records review and analysis. Seven from 2178 pediatric patients who were previously treated for solid tumors, were diagnosed with t-MN in a reference cancer center in Brazil. The median age at primary tumor diagnosis was 12.8 years old. Osteosarcoma, atypical primitive neuroectodermal tumor (PNET), Ewing sarcoma, and retinoblastoma were the most frequent solid tumors associated with t-MN. Three patients had a story of familiar cancer, and one patient with osteosarcoma had Li-Fraumeni syndrome confirmed. The median latency period to secondary MN was ten months and the prevalence rate was 0.32%. Two patients developed t-MDS and five, t-AML. All these patients received cytotoxic agents’ high doses that may have been associated with t-MN development. t-MN initial control, as well as unfavorable cytogenetic abnormalities, may have contributed to the poor outcome. We described the rarity of t-MN related to previous solid tumor therapy in a large pediatric sample in a Brazilian Cancer Center and their poor prognosis.
Comparison of Hemodialysis Patients and Healthy Individuals Attitudes towards Organ Donation: A Descriptive Study
The research is comparative descriptive type. The sample of the study consisted of a total of 167 people, including 82 hemodialysis patients and 85 healthy individuals who applied to the Family Health Center. The data of the study were obtained using the questionnaire and organ donation attitude scale. SPSS 25 was used in the analysis of the data.
Hand Washing: A Proposed Scoring Scale to Grade the Level of Practice of Mothers in the Community
History of hand washing as an intervention to reduce morbidity and mortality in hospitals dates back to early 1800’s and the practise has
yielded good results. Increasing evidence suggesting that hand washing significantly reduced the risk of respiratory tract infections and
diarrhoeal diseases, lead to the promotion of hand washing in homes as a public health intervention of choice with well documented impact.
Assessment of the Microbiological Quality of the Medico-Technical Equipment, Surfaces, Premises and Staff Hands in the Department of Neonatology of the Departmental University Hospital Center of Ouémé-Plateau in Benin in 2018
Hospital hygiene is a set of preventive measures essential to ensure the quality of care in health facilities
Is the Emergency Bag of the Doctor of a Rural Medical Capacity Ready for Emergencies? A Quality Improvement Project (QIP) in a Greek Rural Health Center
This article describes the procedure we followed in a small rural medical capacity in Greece, to improve a crucial aspect of the everyday clinical practice and adopt a culture of auto-regulation through the procedure of Audit. As Doctors of the Amfiklia Health Center we are often called to leave the office and deal with emergency cases out of the Health Center. It was common ground that the maintenance of the Emergency Bag we use in these cases is neglected. We audited our practice using certain standards, analyzed the findings, recommended regulations, implemented the changes and re-audited our practice. At the end of this project we managed to ensure that the Emergency Bag has almost all of the necessary drugs and consumables which will be in-date. We also managed to improve our practice with regards to the appropriate recording of the Controlled Drugs used during such cases.
Clinical and Paraclinical Profile of Patients in First Nephrology Consultation at the Aristide Le Dantec University Hospital Center (ALD-UHC) About 542 Cases
Late recourse to nephrology consultation remains a topical issue which concerns both developed and developing countries such that a majority of the patients are seen to be at an advanced stage of chronic kidney diseases. The aim of this study is to
assess the clinical and paraclinical profile of patients referred for primary nephrological consultation.
Liquid-Based Cytology Compared to Conventional Cytology for Diagnosis of Cervical Intraepithelial Neoplasia: A Single-Center Experience
Cervical carcinoma is the fourth most common gynecologic cancer. Screening assays that include the conventional cytology (CC) have a sensitivity and specificity far from optimal; however, liquid-based cytology (LBC) may overcome some limitations. The objective is to compare the screening accuracy of LBC and CC in individuals suspected of having precancerous lesions. A prospective, single center study, recruited individuals from a tertiary-level center. In all participants, CC and LBC were performed. Clinical, cytologic and histopathologic results were collected. Bethesda System was used and agreement of two of three cytopathologists was necessary to assign a positive or negative result. Cervical biopsy was performed in participants with abnormal findings.
Compartmentalization Modules of Inflammatory Response are Centered on the Epithelial-Mesenchymal Transition of Transforming Cells in Carcinogenesis
The epithelial-mesenchymal transition (EMT) event in carcinogenesis is dependent on multiple operant pathways of master transcription as proposed for NF-kappaB and in terms of the initiated progression of malignant transformation. Inflammation is a primarily compartmentalized series of distinct and overlapping systems that induce and enhance multifocal operabilities within both the nucleus and cytoplasm by systems of enhancer/inhibitory modes of modulation of multi-gene transcription.
Perceived Barriers to Maintaining Healthy Body Weight among Saudi Women of Reproductive Age in Jeddah City
Maintaining a healthy body weight is important for overall health and can help prevent and control many chronic conditions. However, the information surrounding the barriers to healthy eating (HE) and physical activity (PA) for weight maintenance among Saudi women of reproductive age is insufficient to design and develop intervention programs. To explore personal, social, and physical environmental factors that act as barriers to maintaining a healthy weight and how these barriers vary by socio-demographic and weight status. A cross-sectional study was conducted in 2014 using a stratified two-stage cluster sampling design comprising 408 Saudi women attending 12 Jeddah Primary Health Centers (JPHCCs). Data was collected using a structured questionnaire consisting of socio-demographic factors, eating habits (EHs), PA, and perceived barriers to a maintenance of healthy weight maintenance. Body mass index (BMI) and waist circumference (WC) data also were obtained.
Editorial Board Members Related to Center
Mohsen Meydani
Professor
Friedman School of Nutrition Science and Policy
Tufts University
United States
Friedman School of Nutrition Science and Policy
Tufts University
United States
Farnad Imani
Professor
Department of Anesthesiology
University Iran University of Medical Sciences
Iran
Department of Anesthesiology
University Iran University of Medical Sciences
Iran
Murali S. Rao
Professor & Chair
Department of Psychiatry and Behavioral Sciences
Loyola University Chicago
USA
Department of Psychiatry and Behavioral Sciences
Loyola University Chicago
USA
Jing-Huei Lee
Professor
Department of Biomedical, Chemical, and Environmental Engineering
University of Cincinnati
United States
Department of Biomedical, Chemical, and Environmental Engineering
University of Cincinnati
United States
Jean-François Desaphy
Associate Professor
Department of Pharmacy & Drug Sciences
University of Bari
Italy
Department of Pharmacy & Drug Sciences
University of Bari
Italy
Robert Luk
Associate Professor
Department of Computing
Hong Kong Polytechnic University
Hong Kong
Department of Computing
Hong Kong Polytechnic University
Hong Kong
Ki Baik Hahm
Professor
Cancer Prevention Research Center
CHA University
Korea
Cancer Prevention Research Center
CHA University
Korea
Bonghee Lee
Professor
Lee Gil Ya Cancer and Diabetes Institute
Gachon University
Korea
Lee Gil Ya Cancer and Diabetes Institute
Gachon University
Korea
Peter L. Bordi
Associate Professor
School of Hospitality Management
Pennsylvania State University
United States
School of Hospitality Management
Pennsylvania State University
United States
Kell Mortensen
Professor
Niels Bohr Institute
University of Copenhagen
Denmark
Niels Bohr Institute
University of Copenhagen
Denmark