Articles Related to Chitosan

Paracoccidioidomycosis (PCM) is a systemic disease caused by thermo- dimorphic fungi of Paracoccidioides genus that is endemic in several Latin American countries. The treatment for this disease can be performed with different drugs. In general, it is a long duration treatment that aims the control of the clinical manifestations. Even after treatment, the patient usually shows relapse and incapacitating sequelae, such as fibrosis and pulmonary emphysema.

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Terbinafine hydrochloride (TH) is first line drug against treatment of onychomycosis; which is the commonest fungal infection of nail plate. However, strong barrier property of nail plate restricts the effective topical treatment of onychomycosis. In this study, TH loaded solid lipid nanoparticles (SLNs) were prepared and subsequently incorporated into a gel system. SLNs were prepared by high pressure homogenization (HPH) technique using glyceryl monosterate (GMS), compritol 888ATO and a co-processed lipid. They were evaluated for particle size, polydispersity index, zeta potential, % entrapment efficiency (%EE), % drug loading (%DL), drug content and in-vitro drug release. Optimized SLNs were incorporated into chitosan gel and further evaluated for in-vitro drug release and ex-vivo antifungal study.

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In this paper we report our results on the green synthesis of nontoxic, stable, and small size gold nanoparticle suspensions. We used the single and two-beam laser to ablate a gold target submerged in deionized water containing chitosan or starch as the stabilizing agent. Since both chitosan and starch are biodegradable and biocompatible, use of these natural polymers for gold nanoparticle protection and stabilization does not introduce any environmental toxicity or biological hazards.

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In recent years many progress has been achieved in the biomedical and biopharmaceutical fields particularly in drug delivery and regenerative medicine. This has been possible thanks to the increased expertise in polymers chemistry as well as the advent of innovative techniques of materials manipulation that have lead to the production of new “smart” polymeric devices with peculiar propertiesable to selectively reach almost all areas of the human body, in the case of drug delivery systems, or to reduce the chemical-physical gap between human tissues and synthetic devices, in the case of tissue engineering.

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