Articles Related to Colonic Polyps
Exhaled Volatile Organic Compounds in Patients with Colonic Polyps
Background: Exhaled Volatile Organic Compounds (E-VOCs) may help to early detection of colonic polyps
Objective: Assess whether a new ambulatory device is able to detect specific E-VOCs in patients recently diagnosed with colonic polyps.
Material and Methods: All data were collected during routine consultations for Small Intestinal Bowel Overgrowth. A breath test was performed by X-PID 9500®.
Results: 203 patients older than 45 years of age were included. 31patients (15.3%) reported colonic polyps. 74 patients presented with gastroduodenal or jejunal (GDJ) liquid at ultrasound examination despite fasting.
96 patients (47.3%) exhaled numerous E-VOCs with a retention time between 12 to 45s (E-VOCs 12 to 45s). All patients of the polyp group exhaled E-VOCs 12 to 45s.
69 patients with GDJ liquid exhaled E-VOCS 12 to 45s. 11 patients out of these 69 cases (15.9%) present with polyps. 27 patients exhaled E-VOCs 12 to 45s and did not have GDJ, 20 of whom (74.1%) presented with polyps.
When GDJ liquid is not objectivized after fasting, the sensitivity of the E-VOCs 12 to 45s to identify patients with colonic polyps is equal to 100.0% and the specificity is 93.6%. The positive predictive value is 74.1% and the negative predictive value is 100%.
Conclusion: After fasting, X-PID 9500® is able to detect E-VOCs associated with colonic polyps, when GDJ liquid is excluded.