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Articles Related to DM

Evaluation of Calcitriol Administration Against Apoptotic Markers in Ischemic Stroke

Background: Ischemic stroke is one of the most dangerous health issues that leads to neuronal cell death through various mechanisms including, inflammation, oxidative stress, and apoptosis. Calcitriol (1,25(OH)2D3) play an important role against ischemic stroke. Objective: The aim of this study was evaluating the effects of 1,25(OH)2D3 administration on the activity of Calpain 1, Caspase 3, and JNK apoptotic proteins. Materials and Methods: In this clinical trial study, 38 eligible patients were recruited and then were divided into two control and experimental groups. A single oral dose of 10μg 1,25(OH)2D3 was given to experimental group and 4ml of blood samples were collected from all subjects. After isolation of leukocytes from blood samples of patients, flow cytometry was used to investigate the proteins expression of Calpain 1, Caspase 3, and JNK. Results: Our data revealed that the activity of Calpain1, Caspase 3 and JNK were significantly decreased after the administration of 1,25(OH)2D3 in ischemic stroke. Conclusion: Based on our findings, calcitriol (1,25(OH)2D3) could be considered as a protective approach against ischemic stroke by reducing the activity of apoptotic proteins.
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Radiation Dose to Oesophagus in Breast Cancer Patients Receiving Radiation Therapy: A Retrospective Study

Background: Breast cancer is the most common cancer in women worldwide. Management of Breast cancer requires multidisciplinary team approach (viz, Surgery, Chemotherapy, Radiation therapy, Hormonal therapy & Targeted therapy). Radiotherapy reduces the risk of breast cancer mortality for women after breast conserving surgery and for women after mastectomy for node-positive disease. One of the organs at risk in breast cancer therapy is esophagus. As such, there is potential to expose greater volumes of esophagus to radiation. This may result in increased frequency and severity of acute radiation esophagitis during treatment. Aims and Objectives: To evaluate dosimetric parameters such as mean dose (Dmean) maximum dose (Dmax) which may influence the incidence and severity of esophagitis in breast cancer patients receiving radiotherapy. Material and Methods: Treatment plans of post mastectomy patients who had already received adjuvant RT of dose 50 Gy in 25 # over 5 weeks to the chest wall along with Supraclavicular field (SCF) using 3-Dimensional Conformal Radiation Therapy (3D CRT) and Intensity Modulated Radiation Therapy (IMRT) were selected. Mean dose (Dmean) and maximum dose (Dmax) to esophagus was assessed. Results: Dosimetric parameters assessed are Dmean and Dmax. Dmean assessed up to less than or equal to 11Gy and Dmax assessed upto less than or equal to 34Gy. The average of Dmean in this study is 8.34Gy which is within normal limits of prescribed dose. The mean Of Dmax in this study is 24.80Gy which is in limits of prescribed dose. Conclusion: Increased dose to esophagus in observed when IMRT is used especially when supraclavicular or internal mammary nodes are involved. Routine contouring of esophagus and planning accordingly may reduce oesophageal dose and acute oesophageal toxicity.
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Clodronate : A Potential DMOAD in Osteoarthtitis

Osteoarthritis is an inflammatory-degenerative joint disease that affects the osteochondral unit with the concomitant intervention of the immune system; this causes pain and progressive functional limitation. With a varied and complex etiopathogenesis, Osteoarthritis has a subtle outcome and an inexorable evolution towards joint deformity. The therapeutic approach makes use of non-pharmacological and pharmacological aids. Pharmacological therapy consists of symptomatic drugs that act on acute and especially chronic pain, in an attempt to decrease the incidence of any structural damage to the cartilage and subchondral bone. If the anti-resorptive drugs cure the subchondral-epiphyseal osteometabolic pathology, the interventions on the cartilage have not produced important and well evaluable results, even after prolonged therapies. This contribution analyzes the profile of Clodronate, used for the treatment of subchondral bone edema in Osteoarthritis, regarding its potential protective effects in cartilage, like DMOADs.
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Selection of Disease Modifying Treatment (DMT) Relates to Patient’s DecisionMaking Competence in MS

Background: In Multiple Sclerosis, more efficient disease modifying treatment (DMT) are often accompanied by higher risks and side effects. Selecting the optimal DMT demands from patients and doctors therefore a complex decision-making process weighing risks and benefits. Patients and doctors often prefer to share responsibility when making these treatment decisions, but this shared decision-making model requests decision-making competence on both sides. The aim of our online study was to investigate whether patients’ decision-making competence relates to DMT selection. Method: 197 patients participated in the online survey, advertised by two patient organizations. Patients reported their DMT and who decided for or against a DMT: their neurologist, themselves, or both. We measured decision-making competence with two tasks from the Adult Decision-Making Competence Battery (A-DMC), the ability to follow decision rules and the consistency of risk perception. Perceived impairment of the disease was measured with Patient Determined Disease Steps (PDDS). Results: The ability to follow decision rules varied with the potency of the DMT. Patients receiving basic DMT were better able to follow decision rules compared to patients receiving medium DMT. Patients who did not take any DMT stated more frequently that this decision was their own choice and independent of their doctor’s advice. Conclusions: If patients without DMT decided against this treatment on their own behalf, doctors and caregivers potentially have to strengthen their effort to reach out to the patient and to ensure the decision is well taken.
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A Java Software for Randomized Phase II Clinical Cancer Trial Designs

Traditionally, a typical phase II trial has been conducted using a single-arm design recruiting patients only to the experimental therapy to be compared with a historical control. Due to a small sample size and heterogeneity of patient population, the patient characteristics of the patients in a new phase II trial is often different from that of the selected historical control, so that the single-arm phase II trial may lead to biased conclusions. A randomized phase II trial can resolve such problems by randomizing patients between an experimental arm and a control arm. We propose a software package for designing and analyzing randomized phase II trials. We develop a user-friendly Java software that will help us find optimal two-stage phase II trial designs. Although the programs accommodate trial designs based on various statistical methods and different types of early stopping rules, the main part of our paper is focused on randomized phase II trials based on Fisher’s exact test with futility and superiority early stopping values. If users enter input parameter values, the software generates a graphical output displaying all efficient two-stage designs. Minimax, optimal, and admissible designs are highlighted as good designs, but users can select any of the displayed designs. When the circle representing a design is clicked, all the specifics of the selected design are displayed. Fisher’s test is an exact method whose critical values depend on the total number of responders from two arms. So, the computations required to search for optimal randomized multi-stage phase II trial designs based on Fisher’s exact test is very heavy. By using efficient algorithms, our software provides output at almost real time speed
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PSII Photosystem Protection by Soil Amendment with Biochar and Adequate Nitrogen Fertilizer Availability Attenuate Cadmium Induced-Photoinhibition and Phytotoxicity in Solanum Lycopersicon

The aim of this research was to assess the biochar ability to protect the photosynthesis process face to Cd contamination, especially, when nitrogen fertilizer was added at adequate amount. Culture of tomato seedlings was conducted on pots containing soil added with different portion of biochar (0, 3.5 and 7%) and nitrogen (3 or 6g NH4NO3). Irrigation was done by water (control condition) or Cd solution (150µM). Data showed that regardless presence of Cd, synchronously addition of high nitrogen fertilizer (6g) and biochar (7%) in the culture medium resulted in fresh matter production, photosynthetic pigment (Chlorophyll a) and mineral elements content enhancement. Similar observation was shown concerning the mineral nutrition (nitrogen, phosphorus and potassium contents).
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Early Predictive Value of MR-proADM in Critically Ill Patients with Covid-19: An Observational Study in the Emergency Department

Since December 2019, the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic has reached catastrophic proportions. Many patients required admission to the intensive care units (ICU), stressing the capacity of public health systems. The workload in the emergency departments (ED), especially the ICU, has dramatically increased, creating a pressing need to optimize resources through risk stratification for critically ill COVID-19 patients.
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Anthropometric Measures of Obesity to Predict Mortality using Edmonton’s Obesity Staging System, among Young Sudanese Females at Khartoum Locality, Sudan

Obesity is considered a serious health hazard. It predisposes the individual to many disorders, such as diabetes and heart disease, it shortens the life span, and it complicates childbirth and surgery. This study was a cross-sectional study conducted in health centers at Khartoum locality during November 2018- January 2019; aimed to predict mortality among a young female Sudanese population enrolled in health centers.
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Hyponatremia as Parameter in Admission and Discharge Disability of Stroke Survivors, Babol, North of Iran

Stroke is one of the most common neurological diseases, research on risk factors except classical ones has been going on and hyponatremia is one of these
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Pattern of Injuries in Patients Admitted to the Emergency Department of Alexandria Main University Hospital and its Relation to Substance Use

Injuries are one of the most important causes of morbidity and mortality among the non-communicable diseases. They also represent a big economic burden in countries worldwide. Substance abuse and injuries both are dangerous phenomena in all countries. The relation between addiction and injuries is obscure, and what occurs first is the question. The aim of this work was to determine the pattern of injuries in patients attended to the emergency department of Alexandria Main University Hospital and its relation to substance use.
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Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis in Twin Sisters after Ibuprofen Administration. New Insights in Pathogenesis and Literature Review

Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are closely-related, severe, acute life-threatening, drug-induced skin and mucosal disorders with a high mortality rate or long-term damages. These medical conditions are considered a delayed, typeIV hypersensitivity reaction and can be triggered by drugs, infections and malignancies.
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Diencephalon-Mesencephalon Dysplasia, with Dysplastic Basal Ganglia, and Midline Fusion, a Case Report of Novel Appearances

Diencephalic-mesencephalic junction dysplasia is a rare malformation characterized by a poorly defined junction between the diencephalon and the mesencephalon, associated with a characteristic butterfly-like contour of the midbrain on axial Magnetic resonance imaging (MRI) sections (butterfly sign). This condition may be variably associated with other brain malformations, including callosal abnormalities and supratentorial developmental hydrocephalus. We report one newborn with third-trimester fetal ultrasound (US) showing ventriculomegaly. After full-term delivery, the baby had microcephaly and generalized hypotonia, and MRI undertaken at age of 5 days, showed features of diencephalic-mesencephalic junction dysplasia (DMJD). The hypothalamic-midbrain fusion and midbrain butterfly sign could have been seen on fetal MRI, thus allowing for the prenatal diagnosis of DMJD, with implications for the surgical management of hydrocephalus and parental counseling.
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Impaired Driving Associated with the Synthetic Cannabinoid 5F-ADB

Synthetic marijuana compounds are more potent than ∆9-tetrahydrocannabinol (∆9-THC) and are known to produce a wide variety of clinical symptoms including cardiac toxicity, seizures, and death. Erratic driving by a 45 y/o male was witnessed in the fall of 2017 and roadside evaluation of the driver by the responding law enforcement officer concluded that the driver was intoxicated. Comprehensive analysis of the cigarettes by gas chromatography-mass spectrometry detected the synthetic cannabinoid 5-fluoro-ADB (5F-ADB or 5F-MDMB-PINACA). Validated forensic liquid chromatography-tandem mass spectrometry (LC-MS/MS) methods were used to detect the 5-fluoro ADB metabolite 7 (26.37 ng/mL) in the driver’s blood sample. No other drugs were detected. This case report is one of the first to conclusively show that designer synthetic cannabinoids, commonly referred to as “K2” and “Spice”, can significantly impair driving at relatively low concentrations.
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Acute Disseminated Encephalomyelitis (ADEM): Short Term Motor Outcome of Hospital Admitted Patients

Introduction: Among the neuroinflammatory disorder of CNS, Acute Disseminated Encephalomyelitis (ADEM) is a multifocal, subacute or acute onset disease that has got current interest of neurologists for its better outcome. Very few studies have been carried out on ADEM particularly in adults of our country. So we performed the study to describe short term motor outcome of hospital admitted ADEM patients.
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Interrelation between Fluoride Content in Drinking Water and Dental Caries Prevalence Measured with DMF and ICDAS in Senegal

This study aimed to establish a correlation between the dental caries prevalence measured with the DMFT and ICDAS indexes and the rate of fluorine content in drinking water. A national dental caries prevalence data measured with ICDAS and DMFT indexes at several thresholds were correlated with the fluoride content of drinking water in several regions of Senegal. The dental caries prevalence was calculated based, distinctively, on the DMFT and ICDAS criteria. The variation of the rate of fluorine content in the drinking water of different regions was calculated according to the WHO reference rate. When the DMFT index is used, the dental caries prevalence correlates with the rate of fluor content in drinking water. But, when dental caries prevalence is measured with ICDAS, our results show that the rate of fluorine contained in drinking water does not affect the decayed teeth prevalence.
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Editorial Board Members Related to DM

Alain L Fymat

President/CEO and Professor
International Institute of Medicine and Science
Rancho Mirage
California
USA

Avinash Shankar

Chairman
National Institute of Health & Research
Warisaliganj (Nawada), Bihar
India

Sue Hudson Duran

Professor
Auburn University
United States

Scott Asbill

Professor of Pharmaceutics
College of Pharmacy & Health Sciences
Campbell University
United States

Jyotsna Sharman

Assistant Professor
Department of Health and Human Performance
Radford University
United States

Eugene S. Kim

Associate Professor
Department of Surgery
University of Southern California
United States

Mohammad Al-Haggar

Professor
Department of Pediatrics & Neurogenetics
Faculty of Medicine
Mansoura University
Egypt

J Vernon Odom

Professor
Department of Ophthalmology
West Virginia University
United States

Khue Vu Nguyen

Professor
Department of Medicine and Pediatrics
University of California, San Diego, School of Medicine, San Diego
California, USA

MATEJ TRAPECAR

Assistant Professor
National Forensic Laboratory
Slovenia
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