Articles Related to EI
On Features and Measures of Psychological Wellbeing
Low levels of psychological wellbeing pose considerable burdens on society in terms of mortality, unemployment, absenteeism, medications, social services, morbidity, and in-out patients’ costs. Early detection and preventive treatments may
help to reduce costs and improve quality of life. Researchers have proposed several measures and tried to identify new
measures of psychological wellbeing, but there is not a universally accepted measure, and all the existing ones have their
own limitations. This paper discusses research results focusing on behavioral, psychological, social, demographic features
and biomarkers of psychological wellbeing and mental disorders associated with low psychological wellbeing levels. The
features which are addressed in the paper are categorized into three groups: affecting features, features for therapy and
detecting features. This categorization is described and defended.
Radiation Dose to Oesophagus in Breast Cancer Patients Receiving Radiation Therapy: A Retrospective Study
Background: Breast cancer is the most common cancer in women worldwide. Management of Breast cancer requires multidisciplinary team approach (viz, Surgery, Chemotherapy, Radiation therapy, Hormonal therapy & Targeted therapy). Radiotherapy reduces the risk of breast cancer mortality for women after breast conserving surgery and for women after mastectomy for node-positive disease. One of the organs at risk in breast cancer therapy is esophagus. As such, there is potential to expose greater volumes of esophagus to radiation. This may result in increased frequency and severity of acute radiation esophagitis during treatment.
Aims and Objectives: To evaluate dosimetric parameters such as mean dose (Dmean) maximum dose (Dmax) which may influence the incidence and severity of esophagitis in breast cancer patients receiving radiotherapy.
Material and Methods: Treatment plans of post mastectomy patients who had already received adjuvant RT of dose 50 Gy in 25 # over 5 weeks to the chest wall along with Supraclavicular field (SCF) using 3-Dimensional Conformal Radiation Therapy (3D CRT) and Intensity Modulated Radiation Therapy (IMRT) were selected. Mean dose (Dmean) and maximum dose (Dmax) to esophagus was assessed.
Results: Dosimetric parameters assessed are Dmean and Dmax. Dmean assessed up to less than or equal to 11Gy and Dmax assessed upto less than or equal to 34Gy. The average of Dmean in this study is 8.34Gy which is within normal limits of prescribed dose. The mean Of Dmax in this study is 24.80Gy which is in limits of prescribed dose.
Conclusion: Increased dose to esophagus in observed when IMRT is used especially when supraclavicular or internal mammary nodes are involved. Routine contouring of esophagus and planning accordingly may reduce oesophageal dose and acute oesophageal toxicity.
Detection of a Rheumatic Factor (RF,) Anti- Cyclic Citrullinated Peptides (Anti CCP) Antibodies and C- Reactive Protein (CRP) in Diagnosis and Prognosis of Rheumatoid Arthritis
Introduction: Rheumatoid arthritis ( RA)is an autoimmune and inflammatory disease. It is characterized by arthrosynovitis with resultant joint destruction . So, an early clinical diagnosis along with simple serological tests like anti CCP antibodies, C –reactive protein ( CRP) and Rheumatoid factor (RF) play an important role .An attempt was made to study and compare these parameters in OPD and IPD RA patients in our hospital setup, VMMC and Safdarjung Hospital , New Delhi.
Aims and Objectives: To study the role of RF , Anti-CCP antibodies and CRP in early detection and prognosis of Rheu- matoid arthritis.
Materials and Methods: A Total of 440 samples were studied from January 2018 to December 2020 (3years). Correlation between Rheumatoid factor(RF) ,anti CCP antibodies and CRP in suspected RA patients from various departments like PMR , Orthopaedics , Medicine, Obstetrics and Gynaecology and Paediatrics was attempted. RF and CRP was performed using latex agglutination test and anti CCP antibody by ELISA.
Results and Conclusion: Of 440 samples tested, all the factors were positive in 87 patients . Anti CCP and RF alone was seen in 32 patients. RF and CRP positive in 49 patients, RF alone in 22 patients. In 250 patients all the tests were negative. So, Anti CCP along with RF and CRP showed a better positive predictive value in patients of Rheumatoid arthritis. But positivity of these parameters even in patients who lack sign and symptoms also aids in better diagnosis, treatment and prognosis.
Forensic Examination of Heroin and Its Cutting Agents
In order to successfully counter the ever-growing drug problem, there is an increasing need, to identify conspiracy links and trafficking routes and to gather background intelligence concerning both the number of sources of drugs and whether those sources are within a country or are “internationally” based and also the points of distribution and distribution networks. A scientific tool to complement routine law enforcement investigative work in this field is the characterization and impurity profiling and cutting agents of seized drugs. Drug characterization studies have shown that it is possible to link samples, to classify material from different seizures into groups of related samples and to identify the origin of samples. Such information can be used for evidential (judicial, court) purposes or it can be used as a source of intelligence to identify samples that may have a common origin or history.
Development of SARS-Cov-2 Circulating Immune Complex Candidate, (CRCx) as A New Promising Vaccine Eliciting Broad Immune Response.
There is a need to develop a universal vaccine that can boost immunity to coronaviruses if some modifications in their structure occur. This is what we are dealing with nowadays: a virus that can mutate its structure, while immunity is standing still in facing the virus. We report on preclinical trials of CRCx 3 and CRCx 2 vaccine candidates in inducing an elevated level of positive neutralizing antibodies as well as a cellular immune response in an animal model to provide protection against SARS-CoV-2. Highly efficient protection against SARS-CoV-2 was obtained with three-dose immunization using 0.25 ml of CRCx vaccine with a 25-mm needle at 7-day intervals between successive injections. In addition, CRCx vaccine candidates exhibit efficient productivity and good genetic stability for vaccine manufacture. These results support the further evaluation of CRCx in a clinical trial.
An Accidental Intrathecal Injection of Tranexamic Acid: A Never Miss Event
Several factors have been identified as contributing to medical errors such as labels, appearance, and location of ampules. In this paper, inadvertent intrathecal Injection of tranexamic acid has resulted from similarities in appearance between tranexamic acid and heavy bupivacaine 0.5% ampoules. The patient experienced severe itching in the gluteal region followed by generalized myoclonic seizures after accidental intrathecal administration of tranexamic acid.
Benefits and Health Risks Associated with Energy Booster Drinks: A Review Study
There are several energy drinks available in the market such as Red Bull, Sting, Rebound, Power Up! Triple X Energy Drink, and so on. After the Red Bull drink was introduced in the market in1990s, Energy drinks started to gain popularity and afterwards it became a common name especially among teenagers and young adults [1]. Most energy drinks are caffeinated nonindulgent beverages that are professed to give an additional increase in energy for day-by-day work, increase alertness, and improve athletic performance and mood. There are even certain shreds of evidence present to substantiate these claims, but the effects of these drinks on mental and physical health cannot be neglected. There are reports of adverse events such as insomnia, anxiety, cardiovascular events, seizures, tachycardia, type-2 diabetes, and even death are associated with the consumption of these drinks [2]. This review will focus on energy drinks, their ingredients, health risks associated with these drinks, and will also suggest some recommendations such as changes in marketing, providing education to children regarding adverse effects of these drinks, and further research should be carried out in this domain.
Evaluation of Infectious and Malignant Complications in Elderly Renal Transplant Recipients Receiving Alemtuzumab Compared to Basiliximab
The choice of induction immunosuppression can affect several outcomes after kidney transplant (KTx). We aimed to evaluate infectious and malignant complications between alemtuzumab and basiliximab in elderly KTx recipients. Patients ≥ 65 years old who received alemtuzumab or basiliximab induction for their primary KTx from 2006 – 2018 were included.
Characterizing the Etiologies of Seizures and Cortical Myoclonic Activity in Covid-19 Patients and their Impact on Outcomes
Systematic literature review was conducted. Criteria included seizures, status epilepticus, and/or CMA developing prior to or during hospitalization, with concomitant COVID-19. COVID-19 severity was dichotomized into mild and severe cases, based on severity of respiratory symptoms. Good outcome was defined as discharge without severe deficits
and/or return to near baseline.
Treatment of Erdheim-Chester Disease with High Dose Pegylated IFN-α: a Case Report and Literature Review
Erdhein-chester disease is a rare non-Langerhans histocytes that can involve multiple systems, with bone involvement as the most common. We reports a 39-year-old female who visited the hospital due to pain in both lower limbs, combined with clinical manifestations, imaging, and laboratory tests, Erdhein-Chester disease was prelimi narily diagnosed. The diagnosis was confirmed by the presence of BRAF V600E mutation and tissue cells on biopsy of the right tibia. We discussed the disease based on literature review, aiming to improve the understanding of clinicians.
Factors Influencing Overweight and Obesity in Nurses: A Systematic Review and Meta-Analysis
WHO reports a high global prevalence of overweight and, which is prevalent among nurses and results in poorer health, work productivity and patient care. Existing studies have established the relationships between multiple demographic and work-related factors and overweight and obesity, but no review investigated which factors are associated
with overweight and obesity in nurses.
The Pharyngeal Muscle Trainer for the Therapy of Primary Snoring -An innovative therapy approach
Snoring is a concomitant of sleeping. This phenomenon is not only considered annoying, but also often taboo because it affects the privacy of those affected. In addition, however, snoring can be the cause of sometimes life-threatening diseases, such as hypertension, stroke and myocardial infarction.
Buschke-Lowenstein Tumor of the Vulva: A Case Report
Buschke-Lowenstein tumor or giant condyloma acuminata is a rare disorder of the external genitalia, belonging to the
group of verrucous carcinomas, and usually affects immunocompromised men. Human Papillomavirus (HPV) 6 and 11
are potentially involved in the pathophysiology. A detailed questioning, a rigorous clinical examination and complementary imaging are important to establish an accurate lesion assessment and an adapted management. Wide surgical excision
is the treatment of choice.
A Case of Frosted-Branch Angiitis Associated with Poststreptococcal Uveitis Syndrome
The case was a 7-year-old girl who had complained of bilateral blurry vision for 1 week. Five weeks earlier, she suffered from a flu-like episode with fever, sore throat, and skin rash, and received an irregular dose of oral amoxicillin for 4 days after a diagnosis of scarlet fever. Our clinical examination revealed bilateral panuveitis with frosted-branch angiitis.
Characteristic Human Scent Compounds Trapped on Natural and Synthetic Fabrics as analyzed by SPME-GC/MS
The collection of human odor volatiles is of interest to forensic applications as a path to investigate canine scent discriminations in
legal investigations. A study using a selected array of previously identified human odor compounds has been conducted to determine
the retention and release capabilities of five (5) natural and synthetic fabric types, cotton (mercerized fabric and gauze matrix),
polyester, rayon and wool.
Anodic Oxidation of Titanium in Sulphuric Acid and Phosphoric Acid Electrolytes
Anodisation of pure titanium has been carried out in sulphuric and in phosphoric acid solutions at potentials ranging from 50 to 150V. The SEM and AFM morphological analysis indicates that, within this potential range, oxidation in sulphuric acid solution produces better developed mesoporous oxide layers.
Preparation of Large Area Anodic Alumina Membranes and their Application to Thin Film Fuel Cell
The design of an electrochemical reactor for the preparation of self-supported comparatively thin (up to 10 μm) and large area (up to 50 cm2) anodic alumina membranes is described allowing growth of porous alumina at high applied potential (up to 150 V) without burning.
Editorial Board Members Related to EI
Hironao Wakabayashi
Assistant Professor
Department of Biochemistry & Biophysics
University of Rochester
United States
Department of Biochemistry & Biophysics
University of Rochester
United States
CARMEN CASTANEDA SCEPPA
Associate Professor
Department of Health Sciences
Bouvé College of Health Sciences
Northeastern University
United States
Department of Health Sciences
Bouvé College of Health Sciences
Northeastern University
United States
Elena Kolomietz
Assistant Professor
Department of Pathology and Lab Medicine
University of Toronto
Canada
Department of Pathology and Lab Medicine
University of Toronto
Canada
Yi-Wen Liu
Professor
Department of M icrobiology, Immunology and Biopharmaceuticals
National Chiayi University
Taiwan
Department of M icrobiology, Immunology and Biopharmaceuticals
National Chiayi University
Taiwan
Li-Ru Zhao
Associate Professor
Department of Neurosurgery SUNY Upstate Medical University
United States
Department of Neurosurgery SUNY Upstate Medical University
United States
