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Articles Related to EMA

Biomaterials Characterization for Orthopedic Orthoses: a Systematic Revi

The term biomaterial is used for materials used in medical implants, extracorporeal and disposable devices, and must have compatible biological, physical, chemical and mechanical characteristics for use in humans. Objective: to identify and characterize the biomaterials used for the preparation of orthopedic orthoses.
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The Dose and its Acute Toxicology: A Systematic Review Article in the First Phase of Experimental Pharmacology

Hundreds and thousands of acute toxicity studies are conducted in experimental pharmacology with assumption hypothesis every year. It is usually concluded with inadequately validated data during the period of investigation within 24 hours.
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The Efficiency and Specificity of Matrix Gel Method from the Forensic Point of View, in Determination of ABO Blood Grouping and Rhesus Factor

In today’s crime investigation world determination of ABO blood grouping is still a very vital and effective precess in the field of forensic crime scenes. This investigation involves the identification of blood group, on the clothes (Accuse, Victim, injured, Complainer) collected from the scene of crime, and its cross comparision with the blood sample send by medical officer. Hence for this purpose total of 200 cases were included in the study having the samples of blood of accuse, victim, injured, complainer consisting of male and female... The determination of ABO/Rh factor was performed by conventional tube method and matrix gel card. The comparison of both techniques shows a very comparative result. As the red blood cells are sensitized with antibody will get agglutinate in the presence of anti human reagent in the matrix gel card and this will be trapped in the gel column this helps for easy analysis of blood group. However spin tube method is an operator-dependent assay, and is more susceptible to handling errors, the results are not more objective. The matrix gel card method requires Small sample volumes, and gives standardized performance with technical ease, and is with ready automation, and increased biosafety; all these factors have made this technology advantageous. In both techniques the reaction strength for ABO grouping and Rh factor is mainly govern by agglutination reaction intensity between red blood cells and anti-human reagent.
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Global Analysis of an Epidemic Mathematical Model in A Chemostat

In this paper, a mathematical five-dimensional dynamical system involving an SVEIR model of infectious disease transmission in a chemostat is proposed. A profound qualitative analysis is given. The analysis of the local and global stability of equilibrium points is carried out. It is proved that if R>1, then the disease-persistence (endemic) equilibrium is globally asymptotically stable. However, if 1≤R, then the disease-free equilibrium is globally asymptotically stable in R5.
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Profile of Newborns with Bone Metabolic Disease in a Neonatal Intensive Therapy Unit

This is a retrospective and documental study with a quantitative approach, performed at the NICU of a reference hospital in Fortaleza, from November 2016 to January 2017, whose sample consisted of 30 medical records. The following variables were analyzed: weight, gestational age (GI), weight / GI adequacy, gender, Apgar score, BDM associated morbidities, ventilator support, parenteral nutrition (NTP), medicines, physiotherapeutic assistance and blood biochemical analysis. The variables were analyzed by Microsoft Excel® 2016 to obtain absolute and percentage data.
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Drinking Patterns and Fluid Intake in the Settings Workplace and University: A Systematic Review

The effect of an adequate fluid consumption is well-known and its relevance for the maintenance and promotion of health cannot be denied. Previous work indicates that daily demands and work exposures, i.e. related to stress, may have an impact on drinking patterns. To date, only few studies have investigated workers’ and students’ fluid consumption and drinking patterns, as well as their impact on different outcomes. However, a review that combines previous findings and current knowledge about workers’ and students’ likely fluid consumption has not been published yet. Therefore, we conducted a systematic literature review on drinking patterns in the settings workplace and university.
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Immunohistochemical Localization of LH Receptors in Canine Splenic Hemangiosarcoma

Gonad removal has been implicated as a risk factor for the development of canine hemangiosarcoma. With gonad removal, there is a loss of negative feedback to the anterior pituitary, resulting in persistently elevated concentrations of luteinizing hormone (LH). LH receptors can be found in gonadal and extragonadal tissues, including the bladder and skin. The aim of this study was to investigate if LH receptors were expressed in canine splenic hemangiosarcoma. Splenic tumor samples submitted to the Oregon State Veterinary Diagnostic Laboratory from referring veterinarians were with routine immunohistochemical methods. In addition, survival time following hemangiosarcoma diagnosis was obtained from the referring veterinarians. Five of the eight splenic hemangiosarcomas (62.5 %) were positive for LH receptor expression. LH receptor cellular localization in splenic hemangiosarcoma was cytoplasmic and granular, similar to the positive control canine skin sections (Figure 1C). There was no positive staining in the negative controls. LH receptor is expressed in a proportion of HSAs but further study need to be done to assess the significance of this finding.
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Castleman’s Disease: a Diagnosis to Eliminate in Cases of Cervical Lymphadenopathy

Castleman’s disease is due to a lymphoproliferative disorder by the polyclonal proliferation of B cells inside lymphoid organ.Two types exist: the localized form which is usually benign and multicentric form which is more severe. The main risk is the development of lymphoma. Our aim is to report a case of a 18 years old man patient. Her medical history was unremarkable. She presented with a localized form on the right side of neck lymph node. After the ablation of the nodes,none relapse was noticed.
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New Technologies of Crystallization of Sucrose as Fundamental Factor of Increase in Economic Efficiency of Sugar Branch

In recent years sugar industry of the Russian Federation violently develops, showing positive effect in development of finished product. The modern crystallization of sucrose is based on two fundamental processes: periodic and continuous boiling of sugar massecuites. A traditional (typical) crystallization of sugar for these years undergone serious modernization as from the point of view of the technology, and equipment.
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High Glucose Modulates Responsiveness to Estrogens of Human Derived Female Cultured Osteoblasts and in Osteoblastic Cell Lines

Human female- derived osteoblast- like cells in culture (hObs) and the cell lines (SaOS2 and hFOB) express mRNAs involved in bone biology and physiology such as estrogen receptor α (ERα) and α (ERα), vitamin D receptor (VDR), 1α, 25 (OH) vitamin D3 hydroxylase (1OHase) and 12 and 15 lipoxygenases (12LO and 15LO). These mRNAs are modulated by estrogenic compounds. Since the skeletal protective effects of estrogens are not discernible in diabetic women, we tested the estrogenic modulations of these parameters in cells grown in growth medium containing high glucose (HG; 9.0g/L; 44mM) compared to normal glucose (NG; 4.5g/L; 22mM). HG significantly increased DNA synthesis (DNA) and creatine kinase specific activity (CK). Stimulations of DNA but not of CK by estradiol-17β (E2), by 4, 4’, 4’’-[4-propyl-(1H)-pyrazol-1, 3, 5- triyl] tris-phenol (PPT; ERa specific agonist), or by 2, 3-bis (4-hydroxyphenyl)-propionitrile (DPN; ER β specific agonist), were modulated by HG. HG Itself up regulated the expression of mRNA of 12LO and 15LO and to less extent ERβ and VDR, but had no effect on ERα and 1OHase mRNA expression. The different hormonal treatments modulated the expressions of VDR, 1OHase, 12LO and 15LO mRNAs which were reduced in HG, whereas the induction of their products 1α, 25 dihydroxy-vitamin D3 (1,25D) and 12- and 15- hydroxyeicosatetraenoic acid (12 and 15 HETE) were only slightly affected by HG. The exact mechanism of HG effects on bone cell responses and its relationship to human bone physiology is not yet clear.
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Is there Correlations among SLEDAI, Pro-Inflammatory Biomarkers and Urine NGAL in SLE?

Systemic Lupus Erythematosus (SLE) is a chronic autoimmune inflammatory disease. Several indexes can measure SLE activity, and Systemic Lupus Erythematosus Disease Activity Index (SLEDAI) is one of them. The aim was to associate SLEDAI with inflammatory biomarkers present in serum (C3, C4, CH50, C-reactive protein, and creatinine), proteinuria (urine 24h) and urine NGAL in SLE patients. This study included 43 SLE patients who were arranged in two groups according to the value of SLEDAI. One group, SLEDAI 0-4 (n=25), included SLE patients with low activity, and the other group, SLEDAI >4 (n=18), included SLE patients form moderate to high activity. Level of urine NGAL (uNGAL) was determined by ELISA, and the data were analyzed using GraphPad Prism 5.
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A Traumatic Context Can Hide a Sexual Rape

Aeric syndrome during a multiple trauma reflects the severity of this latter, which made mention to extra thoracic or intra thoracic lesion. This requires a good diagnostic and therapeutic strategy. We report the case of a young patient admitted to emergency in an array of closed multiple traumas where the etiological diagnosis was rare and unknown. This case highlights that a careful questioning and a good examination in admission can reveal earlier the diagnosis, the thing that was not well led in our case, because the patient was mute, anxious, and not cooperating making unnoticed rape history.
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Effect of Operator-Related Factors on Failure Rate of Orthodontic MiniImplants (OMIS) used as Temporary Anchorage Devices (TAD); Systematic Review

A search was performed through electronic databases; PubMed, EMBASE searched via ScienceDirect and Cochrane Library. Reference lists were limited to English papers ranging from 2012 to 2018. Eligibility criteria were defined by considering the (PICOS) question patients who received OMIs for orthodontic anchorage. Inclusion and exclusion criteria were performed independently by two authors.
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A Systematic Review Caenorhabditis Elegans (C. Elegans) - A Host Model Organism to Study Drug-Induced Responses to the Effects of Stimulant and Depressant Drugs

Although there are many researches on drug of abuse behavior using C. elegans as model organism, the precise targets and mechanism shared by C. elegans accompanied with behavioral responses to substance misuse is still scarce. This alternative model for rodents and other animal organism has been used to investigate genetic mechanism and specific genes coding drug-induced behavioral response. However, there is very few papers reported to summarize and analyze findings from original researches to identify target/genes underpinning responses to drug addiction.
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Non Ige Mediated Cows Milk Protein Allergy Presenting with Generalized Edema: Case Report and Review of the Literature

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Editorial Board Members Related to EMA

Jason X. Cheng

Assistant Professor
Department of Pathology, Hematopathology
University of Chicago
United states

Matthias Clauss

Associate Professor
Department of Medicine
Indiana University
United States

ADRIAN M. BARANCHUK

Associate Professor
Department of Biomedical and Molecular Sciences
Queen’s University
Canada

Hamidah Ibrahim

Professor
Faculty of Computer Science and Information Technology
Universiti Putra Malaysia
Malaysia

Patrick Ilg

Associate Professor
Department of Mathematics and Statistics
University of Reading
United Kingdom

Efimia Papadopoulou-Alataki

Assistant professor
Aristotle University of Thessaloniki
Papageorgiou Hospital
Greece

PREET M. CHAUDHARY

Professor
Department of Medicine
University of Southern California
United States

Lawrence Gettleman

Professor
Department of Restorative Dentistry and Biomaterials
University of Texas
United States

Clemente Maia S. Fernandes

Professor
Sao Paulo State University
Araraquara, Sau Paulo
Brazil

CHRIS CONSTANTINOU

Professor
Department of Urology
Stanford University Medical School
United States
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