Articles Related to HOMA
Intravascular Large B-Cell Lymphoma, an Updated Review
Intravascular large B-cell lymphoma (IVBCL) is a rare but aggressive form of non-Hodgkin lymphoma. It is characterized by the malignant proliferation of lymphocytic tumor cells in the lumens of capillaries, small arterioles, and post-capillary venules. There exists two clinical variants: the Asian variant and the Western variant. The former is associated with neurologic and dermatologic signs and symptoms, whereas the latter often presents with splenomegaly, jaundice, and hemophagocytes. Lymphadenopathy is uncommon, and patients typically have nonspecific symptom
Profile of Adult Lymphomas in Sub-Saharan Africa: A Monocentric Study of Histoimmunochemical Aspects
A total of 26 NHL patients (56.5%) and 20 LH cases (43.5%), aged 32-11 and 51-18 years respectively, were selected. Polyadenopathy was noted in 95% of cases of HL and 73.1% of cases of NHL (p=0.002). Patients were at Ann Arbor Stage II-IV in 80% of cases for the NHL and 70% of cases for LH (p: 0 ,317). Type B-Cell NHL entities were Diffuse Large Cell B Lymphoma (34.6%), Follicular Lymphoma (15.4%), Mantle Lymphoma (7.7%), Lymphocytic Lymphoma (7.7%), and Malt Lymphoma (3.8%). The NHL was type T-Cell in 30.8% of cases including 19.2% of anaplastic lymphoma. The HL were classic (80%) and nodular lymphocyte predominant Hodgkin lymphoma (20%). Specific treatment was performed in 82.6% of cases, 28.9% of which were immunochemotherapy. Remission was noted in 52.4% of NHL patients and 70.3% of those with HL.
Small Cell Variant of Anaplastic Large Cell Lymphoma Presenting As Leukaemia: A Case Report and Review of Literature
Anaplastic large cell lymphoma with a small cell pattern is a rare T-cell lymphoma. This condition is frequently seen in young patients and should be considered in patients presenting with leucocytosis and constitutional symptoms. We report a case of small cell variant (SCV) of ALCL in a 68 year old man diagnosed by ALK immunohistochemistry (IHC) and cytogenetic analysis. The limitations of using only morphology in diagnosing this rare variant, has also been emphasised.
Optical Coherence Tomography Angiography for Choroidal Neovascularization and Subretinal Fibrosis in Pseudoxanthoma Elasticum
Pseudoxanthoma elasticum (PXE) is characterized by a progressive fragmentation and calcification of elastic fibers in connective tissue and when Bruch membrane (BM) is affected ocular modifications can be found. Recently, Optical coherence tomography-angiography (OCT-A) contribute to a better comprehension of lesions in PXE.
Tomotherapy Treatment of Chronic Lymphocytic Leukemia and Ocular Lymphoma
A sixty-five-years-old male patient with history of non-Hodgkin’s lymphoma of the right orbit and a fifty-years-old female patient with chronic lymphocytic leukemia with peripheral lymphocytosis were treated on TomoTherapy. In the first case, a 1 cm beam was used for planning a delivery of 30.6 Gy in 17 fractions with a sequential boost of 9 Gy in 5 fractions. Tumor involvement of the ipsilateral lens and lacrimal gland in the planning target volume necessitated a compromise between preserving patient’s vision and delivery of tumoricidal dose to the target. In the second case, 30 Gy in 20 fractions delivery was planned with a 2.5 cm beam. The tumor extended anteriorly and this technique allowed sparing more orbital tissue and required a high modulation factor.
Gingival Stimulation: An Important Metabolic Regulator?
This study aimed to determine whether a relationship exists between gingival stimulation and the levels of leptin, ghrelin, insulin and glucose, which are important regulators of energy homeostasis. Blood samples for ghrelin, leptin, glucose and insulin were taken from 15 male volunteers (mean age 25.5±2.3 years; mean body mass index 24.4±2.79 kg/m2), who did not brush their teeth for one day, after a 12 h-long overnight fasting and before standard breakfast (0 min) and thereafter at 30, 60, 120 and 180 min after breakfast. After toothbrushing after dinner and after a 12 h-long overnight fasting, blood samples were taken again before standard breakfast (0 min) and then after at the same time points following tooth brushing.A significant reduction was found in the leptin levels measured at 0, 30, 60, 120 and 180 min after tooth brushing (p < 0.005). The ghrelin levels also declined at these time points but were significant at 0, 30 and 120 min (p < 0.05). Despite the reduced insulin levels at 120 and 180 min after tooth brushing (p < 0.05), no significant change was observed in the glucose levels.
Lymphoma Complicating IBD Immunomodulator Therapy: A Reminder to be Vigilant
Patients with Inflammatory Bowel Disease (IBD) not responding to steroid treatment should be considered for immunomodulator therapy. The risk of lymphoma in IBD patients treated with immunomodulators is a well-documented but rare complication and remains a subject of controversy. Here, we present two patients treated successfully in outpatient clinics on thiopurine immunomodulators who were admitted within weeks of each other with a diagnosis of lymphoma.
Clinical Utility of Triglyceride: HDL-Cholesterol Ratio as a Surrogate Marker of Inflammation in Pediatric Obesity
The prognostic utility of the triglyceride: HDL-cholesterol (TG:HDL-C) ratio, a marker for insulin resistance, is unknown among high-risk children and adolescents. We examined the clinical utility of TG:HDL-C ratio as a marker of insulin resistance and chronic inflammation in obese youth.
Challenges in the Pharmacological Management of Non Hodgkin’s Lymphoma in Children in the Maintenance Phase of Therapy at Kenyatta National Hospital
Non Hodgkin’s lymphoma is an extremely chemo sensitive with a five year event free survival of greater than 90% in developed countries and a one year survival rate of 40-50% in developing countries.
Anterior Mediastinal Pseudo-Tumor Tuberculosis: Should We Settle for This Diagnosis?
Mr M.Y., 32 years old, presented since 5 months Dyspnea associated with a productive cough, in a context of night sweats and encrypted weight loss 5 kg in 3 months and who has consulted in a different formation other than ours.
An Effective Treatment Regimen for Warts in Cattle
The study was aimed to evaluate the potency and for advocation of a homeopathic drug regimen against warts. Sixty six cattle of variable age presented with warts on skin, eyelids, ears, muzzle, udder and external genitals.
How Should we Screen Overweight and Obese Adolescents for Risk of Type 2 Diabetes in Large Public Health Initiatives?
To develop a valid method to identify insulin resistance (IR) in overweight and obese adolescents without requiring a fasting blood sample.
Editorial Board Members Related to HOMA
Markus Müschen
Professor
Department of Laboratory Medicine
University of California, San Francisco
United States
Department of Laboratory Medicine
University of California, San Francisco
United States
Robert H. Rosenwasser
Professor
Department of Neurological Surgery
Thomas Jefferson University
United States
Department of Neurological Surgery
Thomas Jefferson University
United States
QINGSHENG WANG
Assistant Professor
Department of Chemical Engineering
Oklahoma State University
United States
Department of Chemical Engineering
Oklahoma State University
United States
RONALD R. THRASHER
Assistant Professor
School of Forensic Sciences
Oklahoma State University
United States
School of Forensic Sciences
Oklahoma State University
United States
Luca Arcaini
Assistant Professor
Department of hematology
University of Pavia School of Medicine
Italy
Department of hematology
University of Pavia School of Medicine
Italy
Jana Barlic-Dicen
Assistant Professor
Department of Cell Biology
University of Oklahoma Health Sciences Center
United States
Department of Cell Biology
University of Oklahoma Health Sciences Center
United States
Edralin A Lucas
Associate Professor
Department of Nutritional Sciences
Oklahoma State University
United States
Department of Nutritional Sciences
Oklahoma State University
United States
Mohammed A. Gomaa
Professor
Department of Otorhinolaryngology
Minia University
Egypt
Department of Otorhinolaryngology
Minia University
Egypt
BRUCE D CHESON
Professor of Medicine
Division of Hematology and Oncology
Georgetown University Hospital
United States
Division of Hematology and Oncology
Georgetown University Hospital
United States
RAJNISH S. DAVE
Associate Scientist
Department of Neuroscience
Temple University
United States
Department of Neuroscience
Temple University
United States