Articles Related to Heart

Objective: This study was conducted to investigate the effects of gabapentin enacarbil (GEn) on sleep EEG, heart rate (HR), blood presssure, anterior tibialis EMG activity (PLMs power) and subjective complaints in subjects with moderate to severe RLS and disturbed sleep. Methods: This was a single site, single-blind, placebo run-in, fixed dose single group polysomnography (PSG) study. Eligible subjects (age 24-66 years) were treated with placebo for one week and GEn (600 mg/day) for 4 weeks. Two in-laboratory PSGs were collected for adaptation and baseline at the end of the placebo run-in period and for re-adaptation and efficacy assessment at the end of the 4-week treatment period. The primary endpoint was the difference in PSG derived cortical arousal intensity (arousal scale, 0-9) associated with PLMs between 4 weeks of treatment with GEn and placebo. Secondary endpoints included changes in HR responses (ΔHR), nocturnal systolic blood pressure (SBP) changes (>10 mmHg) secondary to PLMs and PLMs power. Other PSG and subjective measures were assessed. Results: Of 20 subjects enrolled, 18 completed the study. Subjects treated with GEn did not show significant improvements in cortical arousal intensity and ΔHR. However, subjects showed reduced PLMs power (p= 0.013) and associated reductions in nocturnal SBP per hour of sleep (p= 0.041) GEn showed significant improvement in other PSG parameters and subjective endpoints. Conclusion: The data suggests that GEn reduces the frequency and power of PLMs and the corresponding SBP changes in subjects with RLS. Despite reducing the total number of PLM associated arousals and nocturnal HR, the study did not demonstrate consistent effects of GEn on cortical arousal intensity and corresponding HR changes associated with PLMs. Clinical Trial Registration: ClinicalTrials.gov identifier: NCT02424695

View complete article: PDF  |  Full-text

Anti-streptolysin O (ASO) titer assists for the diagnosis of streptococcal infections and their sequele. Normal value of Anti-streptolysin O titer is not available for Ethiopian populations. These studies establishes and compare the normal reference value in Rheumatoid Heart Disease (RHD) and in apparently healthy children.

View complete article: PDF  |  Full-text

Obesity is a multisystemic disease. It is a coronary risk factor, that promotes or is associated with other components such as hypertension, diabetes, dyslipidemia, etc.

View complete article: PDF  |  Full-text

Obesity has been linked to autonomic dysfunction, which is thought to be one of the main contributors for hypertension, cardiac remodelling and death. The aim of the present study was to investigate stress related changes in autonomous function in subjects at high risk for obesity (Restrained eaters). 33 healthy women aged 18-30 years were recruited through advertisement in local newspapers. Classification in restrained and unrestrained eaters was done according to norm tables from the German version of the Three Factor Eating Questionnaire. Participants were exposed to the Trier Social Stress Test, a standardized laboratory stressor. As an indicator of autonomous function the measurement of heart rate was performed. Restrained eaters did not respond with a significant increase in heart rate after stress. The results are interpreted with respect to consequences for nutritional intake and stress coping.

View complete article: PDF  |  Full-text

Congenital heart disease is the most common congenital disorder in newborns represents a major cause of perinatal death. The prevalence of these malformations is still unrecognized in Tunisia because of the lack of a national register. The aim of this study was describe the epidemiological and clinical aspects of the heart diseases with neonatal diagnosis in Tunisia.

View complete article: PDF  |  Full-text

In the past decade, finite element modeling of complete heart valves has greatly aided evaluation of heart valve surgery, design of bioprosthetic valve replacements, and general understanding of healthy and abnormal cardiac function. Such a model must be based on an accurate description of the mechanical behavior of the valve material. It is essential to calculate velocity/displacement, geometrical indices and strain rate/strain at a component level that is to work at the cellular level.

View complete article: PDF  |  Full-text

Autonomic nervous system involvement in subjects practicing Yoga has rarely been studied and has shown conflicting results. Our main purpose was to assess the effect of Yoga on autonomic function of group of subjects practicing Yoga regularly in comparison with another group with normal control subjects by measuring the frequency gain response of the two groups. Other aim of this study was to determine wither the duration of Yoga practicing correlated with measures of heart rate variability signal (HRV) using approximate entropy index (ApEn).

View complete article: PDF  |  Full-text

Investigate the use of cardiac resynchronization therapy (CRT) in cancer patients with heart failure (HF); assess factors associated with ischemic and non-ischemic HF. Many newer cancer therapies are cardiotoxic; thus, the incidence of HF has been increasing in this high-risk patient population. CRT has beneficial effects on morbidity, mortality, and left ventricular function in patients with non-ischemic cardiomyopathy, yet cancer patients and survivors who develop severe HF and are eligible for CRT often does not receive it.

View complete article: PDF  |  Full-text

In developed countries, around 3-5% of the people could be identified as chronic complex patients, and they are increasingly at risk of atrial fibrillation (AF) and cognitive impairment. The main objective of this study was to present the current findings on the association between AF and cognitive impairment and mortality risk among chronic complex outpatients (CCP). A multicenter and prospective cohort study of mortality incidence was carried out from 1 January 2013 to 30 September 2016 in a sample of 932 adult patients registered as CCP. To predict hazard ratios, mean survival time, and survival probabilities, a multivariate Cox regression was used.

View complete article: PDF  |  Full-text

Several studies have suggested that Insertion/Deletion polymorphism of ApoB gene is associated with obesity, dyslipidemia, diabetes and coronary heart disease (CHD).

View complete article: PDF  |  Full-text

The incidence of complete heart block following Glenn’s shunt is not known. Complete heart block may occur immediately after surgery or early in the postoperative period and also may occur many months or years after surgery.

View complete article: PDF  |  Full-text

Accidental hypothermia is a potentially life-threatening situation that involves a debilitated patient and is a result of environmental exposure.

View complete article: PDF  |  Full-text

There could be progressive changes in hemodynamic and autonomic parameters causing cardiovascular damage from lean to morbid obesity. We aim to study resting and reactivity of hemodynamic and autonomic parameters to physical and mental stress in lean, overweight and obese subjects of the Oman Family Study (OFS).

View complete article: PDF  |  Full-text

As stunting in early postnatal life is prudent in developing countries, investigating its long term effect on adult blood pressure is necessary.

View complete article: PDF  |  Full-text

Acquired heart diseases such as myocarditis, cardiomyopathies and rheumatic heart diseases are important non-communicable diseases responsible for morbidity and mortality in children.

View complete article: PDF  |  Full-text