Articles Related to Hemoglobin
Effectiveness of a Brief Diabetes Risk Assessment Instrument for Detecting Undiagnosed Type 2 Diabetes Among High-Risk Ethnic Communities in West Africa
With the growing burden of type 2 diabetes (T2D) and associated health, social, and economiccosts in sub-Saharan Africa, tools are needed to assess T2D risks rapidly, allowing for targeted early intervention. The objective of this study was to assess the effectiveness of a brief diabetes risk assessment instrument for detecting undiagnosed Type 2 Diabetes among high-risk ethnic communities in Benin, West Africa.
Falsely Low HbA1c Unmasking a Latent HbE Defec
The current case report illustrates role of vigilant laboratory services that helped in unmasking asymptomatic HbE variant in a middle aged known diabetic woman who came as an outdoor patient and on subsequent HbA1c testing was found to have lower value -2.9 %. It triggered extensive workup after looking for common causes and an electrophoresis of
Hemoglobin revealed HbE variant.
Hemoglobin SC Disease with COVID-19 Presenting with Multiple Infarcts and Acute Splenic Sequestration Crises
Hb SC disease is a type of hemoglobinopathy that can be viewed as a hybrid of hemoglobin S and C. In this disorder there is co-inheritance of one Hbs gene and one HbC gene resulting in a milder phenotype than sickle cell anemia (SCA). Whereas SCA clinical features have been extensively studied, very few studies have been dedicated specifically to HbSC disease as most cases are reported to be silent or of mild severity. As the pandemic continues to evolve with the novel Sars-CoV-2 virus we have learned it can lead to thrombotic complications which could be fatal if not detected early. Of those requiring admission to the intensive care unit, most carry multiple comorbidities (hypertension, diabetes mellitus etc.) leading to worse clinical outcomes. Here, we present a case of a young adult patient with silent hemoglobin SC disease who tested positive for SARS-CoV-2 leading to multiple infarcts, splenic sequestration and respiratory failure. The concurrence of a hemoglobinopathy and COVID-19 should warrant heightened clinical suspicion for unusual outcomes. Hence, providers must remain vigilant while treating any patient with any hemoglobinopathy in the setting of COVID-19.
Oxygen Balance Homeostasis and Tissue Metabolic Score (TMS) of Patients in Emergency and Critical Care Medicine
Patients admitted to the emergency room or intensive care units (ICUs) need real-time monitoring of body oxygen balance. As of today, the availability of monitoring devices that provide real-time data on tissue level of oxygen homeostasis is very limited. The involvement of mitochondrial dysfunction in many pathological states such as stroke, sepsis or heart failure is calling for a real-time evaluation of this intracellular organelle. In order to avoid the deterioration of the most vital organs in the body (brain and heart), we are proposing to monitor a less vital organ, such as the urethral wall, that serves as an early warning signal for the deterioration of body oxygen balance.
Gene Therapy in Sickle Cell Disease
Sickle cell disease is a prevalent and severe monogenic disorder resulting from a homozygous missense mutation in the β-globin gene that leads to polymerization of hemoglobin S. Clinical manifestations of the disease can be critical with considerable morbidity and mortality. One treatment option for the disease is bone marrow transplantation. However this method is restricted to the patients with an appropriately matched donor. Gene therapy by either gene insertion or gene editing, utilizing patient’s own cell is a primary
therapeutic option to cure sickle cell disease. However, very less clinical trials have been performed with genetic therapy for treating Sickle cell disease (SCD). Since a couple of decades significant progress has been made in the area of gene therapy for treating monogenic hemoglobin disorders. Numerous therapies are currently in clinical trial stages or in preclinical stages. The safety and efficacy of gene therapy has been greatly improved with the initial use of γ-retrovirus vectors, followed by next-generation lentivirus vectors, and latest gene editing techniques. Although the clinical interpretation of gene therapy has been successful, it involves some limitations including complex cellular abnormalities, inadequate transgene expression, and challenges in achieving effective and persistent inhibition of polymerization of hemoglobin S. This review intends to discuss gene therapy strategies specific to Sickle cell disease, present state of the field, and current status of the gene therapy clinical trials.
Investigation of Homocysteine Levels in Healthy Dogs
Homocysteine is a parameter that plays an important role for diagnosing several diseases mainly cardiovascular diseases. In this study, the first time reference values for homocysteine levels detected in healthy Golden Retriever, Terrier, German Shepherd and Labrador Retriever breeds of dogs play an important role in the prognosis of many diseases.
Clinical Utility of Triglyceride: HDL-Cholesterol Ratio as a Surrogate Marker of Inflammation in Pediatric Obesity
The prognostic utility of the triglyceride: HDL-cholesterol (TG:HDL-C) ratio, a marker for insulin resistance, is unknown among high-risk children and adolescents. We examined the clinical utility of TG:HDL-C ratio as a marker of insulin resistance and chronic inflammation in obese youth.
Orodental Considerations in Thalassemia Patients
Thalassemia is one of the most common genetic disorders worldwide and presents a major public health problem and social challenge in parts where the frequency is high. The symptoms of the disorder are modulated by various environmental, racial and genetic factors. Therefore, dental specialists are obligated to have knowledge towards the nature of the disorder and its effect on dental health. Cooperation with a hematologist is recommended in every dental treatment.
Severe Bone Marrow Suppression Associated with Use of Clopidogrel
A 60 year-old male presented with fever, malaise, and myalgias. The patient was admitted 3 weeks prior for acute coronary syndrome, underwent coronary stent placement, and was started on clopidogrel.
The Impact of Repeated Hb A2 Measurements on β-Thalassemia Trait Diagnosis
Hemoglobin A2 (Hb A2) is a minor component of the hemoglobin present in normal adult red blood cells, accounting for 1.5-3.5% of the total hemoglobin in healthy individuals.
A One-Year Hospital Based Prospective Study of Sickle Cell Disease from One Capital Area of Kuwait by HPLC
Haemoglobinopathies are inherited disorders of haemoglobin synthesis that are responsible for significant morbidity and mortality all over the world.
How Should we Screen Overweight and Obese Adolescents for Risk of Type 2 Diabetes in Large Public Health Initiatives?
To develop a valid method to identify insulin resistance (IR) in overweight and obese adolescents without requiring a fasting blood sample.
Congenital Dyserythropoietic Anemia Type III and Primary Hemochromatosis; Coexistence of Mutations in KIF23 and HFE
Congenital dyserythropoietic anemia type III (CDA III) can be caused by mutation in KIF23. CDA III differs from CDA I and II in the sense that secondary hemochromatosis has not been reported. However, we have observed elevated serum ferritin in a CDA III family.
Chromosomal Aberrations and HMGA2 Expression in Paroxysmal Nocturnal Hemoglobinuria
Somatic, inactivating PIGA mutations in haematopoietic stem cells, followed by an unknown autoimmune selection process in favor of
the mutated clone, are thought to be important events in the pathogenesis of paroxysmal nocturnal hemoglobinuria (PNH). Recently,
a second clonal event involving the HMGA2 gene was reported in some PNH cases, and over expression of this gene was postulated to
promote proliferation of the mutated clone.
Glucose Testing and Lifestyle Counseling of Obese and Overweight Patients: A Survey of Primary Care Physicians in the United States
In the United States (U.S.), the costs for health care and lost productivity due to diagnosed diabetes has increased from $174 billion in 2007 to $245 billion in 2012, making it one of the fastest growing public health burdens. Nearly 26 million adults have diabetes, and another 79 million have prediabetes, a condition that increases the risk for developing type 2 diabetes. Clearly to reduce the costs and improve health, preventing diabetes must be a priority.
Editorial Board Members Related to Hemoglobin
Jonathan Scott Harrison
Professor
Division of Hematology/Medical Oncology University of Missouri
United States
Division of Hematology/Medical Oncology University of Missouri
United States
