Articles Related to Hyperglycaemia
Hypoglycemic Potential of Ziziphus spina-christi Fruit on Alloxan induced Hyperglycemic Rats
Hyperglycaemia is a key symptom in diabetes mellitus associated with long term damages, dysfunction and eventually failure of organs, especially the eyes, kidneys, nerves, heart and blood vessels. This study is to evaluate the hypoglycaemic potential of orally administered aqueous and ethanol extracts of Zyziphus spina-christ fruit on alloxan induced hyperglycaemic Wistar rats.
The plant was extracted using maceration using aqueous and 80% ethanol as extraction solvents. Qualitative phytochemical analysis was done. An in vitro assessment of both aqueous and ethanol extract to demonstrate hypoglycaemic activity via inhibition of alpha amylase enzyme and alpha glucosidase enzymes were done. Total of 45 albino rats were used in the study of both sexes divided in 9 groups. Group 1: normal control group, group 2: diabetic control group, group 3: positive control group (metformin 300mg/kg), group 4-6: (150mg/kg, 300mg/kg and 600mg/kg) aqueous extract and group 7-9: (150mg/kg, 300mg/kg and 600mg/kg) ethanol extract. Groups were compared using one way ANOVA for significant differences and Dunnet’s posthoc test was deployed were differences exit. Data were represented as mean ± SEM and p value <0.005
The aqueous and ethanol extract yielded 35.59%% and 46.68% respectively. Phytochemical analysis revealed the presence of alkaloids, flavonoids, terpenoids, tannins, Saponins, Saponins glycosides, steroids, Phytosteroids, carbohydrate and volatile oil. An in vitro assessment of aqueous and ethanol extract demonstrated hypoglycaemic activity via inhibition of both alpha amylase enzyme and alpha glucosidase enzymes. The percentage inhibition of alpha amylase was presented as IC50 of 0.14, 0.19 and 0.58 for the acarbose, ethanol extract and aqueous extract respectively. Alpha glucosidase inhibition was represented by the IC50 of 0.7mg/ml, 0.9mg/ml and 0.7mg/ml for acarbose, ethanol extracts and aqueous extracts. The aqueous and ethanol extracts significantly decrease the blood glucose level. Elevation of cholesterol and LDL was seen in diabetic control group.
The results from the studies showed that Ziziphus spina-Christi fruit aqueous and ethanol extracts has an anti-hyperglycaemic potential which is not a dose dependent both in Vitro and in Vivo. Ziziphus spina-Christi fruit aqueous and ethanol extract also causes a significant reduction in cholesterol level.
How Blood Glucose Relevance with Falooda Ice Cream Loving?
The amount of glucose or sugar that is present in our blood is termed as blood glucose, normal value of it’s should be 5.4 or 5.6 mmol/ L in humans. Mainly two types of blood glucose are discussed hyperglycemia high amount of sugar and hypoglycemia low amount of sugar. Falooda ice cream is a sweet and delicious so it also contains too much sugar that is necessary for our health and maintaing blood glucose level but by eating too much it can cause hyperglycemia. Hyperglycemia may damage eyes, blood vessels and kidneys. There is significant relation between falooda ice cream loving and blood glucose.