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Comparative Bioequivalence Studies of Pantoprazole 40 mg Delayed-Release Tablet Formulations in Healthy Thai Volunteers

Pantoprazole is a H+,K+-ATPase enzyme inhibitor for the treatment of acid-related gastrointestinal diseases. The Government Pharmaceutical Organization (GPO), Thailand had developed Pantoprazole GPO® (pantoprazole 40 mg delayed-release tablets) as a generic substitute for the corresponding innovator product, CONTROLOC® 40 mg.
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Succinylcholine Used for Difficult Airway Lead to Difficult Airway - A Case Report

Succinylcholine (Sch) is usually given for intubation in suspected difficult airway due to its fast onset and short duration of action. We report a case of Masseter Muscle Rigidity (MMR) after giving Sch to a patient for lap cholecystectomy with difficult airway
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Ultrastructure of the Frontal Cortex Neurons of 5-Day-Day Rats after Antenatal Alcoholization

Antenatal alcoholization leads to a number of specific disorders in the offspring organism, grouped into the concept of fetal alcohol syndrome, which is included in the fetal alcohol spectrum disorders. The negative effects of alcohol on the developing fetal brain include structural abnormalities of the brain, neurological, behavioral and cognitive defects.
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A Simple Method for the Quantification of Atenolol from the Forensic Human Blood and Visceral Samples by High Performance Thin Layer Chromatography

A simple High-Performance Thin layer chromatography (HPTLC) method has been developed for determination of atenolol in human blood and viscera. The mobile phase was ethyl acetate, acetone, ethyl alcohol, ammonia solution in the ratio of 45:45:7:3. The densitometry scanning at 254 nm was found to be maximum absorption for standard atenolol. The standard and extracted atenolol from samples were detected by HPTLC and confirmed with authenticated spectra at 254 nm. The quantity of the atenolol determined to be 1.6 µg for viscera and 1.5 µg for blood sample.
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Bioequivalence Evaluation of Two Clopidogrel Immediate Release Tablet Formulations in Healthy Thai Volunteers Under Fasting Conditions

Clopidogrel is used for acute coronary syndrome and prevention of atherothrombotic events. To improve clinical outcomes, patient adherence to treatment is necessary. However, continuous use of branded product may cause economic burden to patients and healthcare system. The Government Pharmaceutical Organization (GPO), Thailand had developed a generic product of clopidogrel to reduce cost of treatment and improve accessibility to medicines for Thai people.
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Relationship between Blood Ethanol Concentration, Ethyl Glucuronide and Ethyl Sulfate and Clinical Signs of Alcohol Intoxication

Ethyl glucuronide (EtG) and ethyl sulfate (EtS) are markers for screening previous alcohol consumption and indicating recent drinking in cases of suspicion of driving under the influence of alcohol.
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Voromonas Pontica Identified by Giemsa Staining and Anti-RhopH3 Protein Reactivity

Culture characteristics, routine staining for light microscopy and feeding behavior of Voromonas pontica Cavalier-Smith (American Type Culture Collection, ATCC 50640), a predatory free-living marine colpodellid, was investigated
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A Comparative Study of Different Blood Alcohol Concentration Effect on Handwriting

Handwriting is a visible speech which is not spoken but written. There are various internal and external factors that might cause variation in handwriting
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Separation and Detection of Monocrotophos by Chromatography Methods in Forensic Samples

Monocrotophos is a extremely hazardous organophosphate insecticide that is extensively used and easily accessible in India.
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Bioequivalence Study of Olanzapine 5 mg Orally Disintegrating Tablet Formulations in Healthy Thai Volunteers under Fasting Conditions

A comparative randomized, single dose, two-way crossover, open label study was carried out to assess bioequivalence and tolerability of test (ZOLAN GPO®) and reference (Zyprexa Zydis®) products of olanzapine 5 mg orally disintegrating tablets for interchange ability in the same quality and safety.
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Determination of N-Butylscopolamine in Human Plasma by Solid-Phase Extraction and UHPLC-ESI-MS/MS: Development, Validation and Application to a Bioequivalence Study

BioequivalenceA sensitive ultra performance liquid chromatography-electrospray ionization-tandem mass spectrometry (UHPLC-ESI-MS/MS) method for measurements of N-butylscopolamine in plasma was developed and validated. A SPE extraction was proposed for the clean up of plasma and N-butylscopolamine-d9 was added as internal standard. The analyses were carried out using a phenyl column and mobile phase of acetonitrile:
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A Novel Neuroprotective and Antioxidative Efficacy of a Unique Combination of Standardized Huperzia serrata, Convolvulus pluricaulis and Celastrus paniculatus Extracts

Physical and environmental stress in conjunction with hectic lifestyle and unhealthy food habits are the major cause of diverse neurodegenerative disorders. Oxidative neuronal injury and acetylcholine deficiency have a major impact on learning and memory retention. Most of the treatment strategies are based on the improvement of cholinergic function in the brain and one of the emerging therapeutic targets is to enhance the acetylcholine level in the brain. Standardized botanical extracts including Huperzia serrata (1% Huperzine A, CogniUp), Convolvulus pluricaulis (SP) and Celastrus paniculatus (JY) have been demonstrated to attenuate brain function by serving as a natural acetylcholinesterase (AChE) inhibitor.
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Impact of the Biofield Energy Treated Proprietary Novel Formulation on Memory and Cognition Function in Neuronal Cell

The current study was investigated for the in vitro cognitive effect of the Consciousness Energy Healing (The Trivedi Effect®) Treated novel proprietary test formulation in terms of acetylcholinesterase (AChE) inhibition, neuroprotection, and neurite outgrowth assays in two different neuronal cell-lines (SHS-Y5Y and PC-12 Cells). The test formulation divided into two parts; one part was received the Biofield Energy Treatment by Mr. Mahendra Kumar Trivedi and termed as the Biofield Energy Treated sample, while the other part was denoted as the untreated test sample.
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A Study on Chromatography Methods for the Separation and Detection of Certain Benzodiazepine Drug in Forensic Sample

Forensic Scientists are required to identify an ever increasing and more complex assortment of drugs and related compounds.
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Optimization of Pseudomonas aeruginosa for Chlorpyrifos Degradation using Response Surface Methodology

Chlorpyrifos is a hazardous organophosphate pesticide used worldwide thus its biodegradation is need of the time. In the present study 13 bacterial strains were isolated from collected soil samples of different agro climatic regions and out of them one bacterial strain was screened out as potent degrader of Chlorpyrifos on the basis of percentage degradation using high pressure liquid chromatography (HPLC).
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Fabrication of Vertical Cu2ZnSnS4 Nanowire Arrays by Two-Step Electroplating Method into Anodic Aluminum Oxide Template

Vertical Cu2ZnSnS4 (CZTS) nanowire arrays have been synthesized via two-step electroplating method into anodized aluminum oxide template. For deposition of CZTS nanowires, anodized aluminum oxide (AAO) was used as the growth mask for the growth of the nanowires. AAO templates with hole sizes of 70 nm in diameter were used in the experiments.
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Editorial Board Members Related to LC

Anthony Joseph Berdis

Assistant Professor
Departments of Chemistry and Biology
Cleveland State University
United States

Gordon L Fung

Professor
School of Medicine
University of California
United States

MALCOLM KENNETH ROBINSON

Assistant Professor
Department of Surgery
Brigham and Women's Hospital
Harvard Medical School
United States

David Paul Richman

Professor
Department of Neurology and Center for Neuroscience
University of California
United States

Mirosław Kwiatkowski

AGH University of Science and Technology
Faculty of Energy and Fuels
Poland

Loai Aljerf

Professor
Department of Basic Sciences
Faculty of Dental Medicine
Damascus University
Syria

Raghu Vannam

Scientist
Olon Ricerca Bioscience LLC
United States

Fatih Yalcin

Professor
Department of Cardiology
Johns Hopkins Medical Institutions
USA

Shiva Singh

Professor
University of Western Ontario
Canada

Sayed M. Hassan

Senior Research Scientist
University of Georgia
USA
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