Articles Related to LC

Background: Ischemic stroke is one of the most dangerous health issues that leads to neuronal cell death through various mechanisms including, inflammation, oxidative stress, and apoptosis. Calcitriol (1,25(OH)2D3) play an important role against ischemic stroke. Objective: The aim of this study was evaluating the effects of 1,25(OH)2D3 administration on the activity of Calpain 1, Caspase 3, and JNK apoptotic proteins. Materials and Methods: In this clinical trial study, 38 eligible patients were recruited and then were divided into two control and experimental groups. A single oral dose of 10μg 1,25(OH)2D3 was given to experimental group and 4ml of blood samples were collected from all subjects. After isolation of leukocytes from blood samples of patients, flow cytometry was used to investigate the proteins expression of Calpain 1, Caspase 3, and JNK. Results: Our data revealed that the activity of Calpain1, Caspase 3 and JNK were significantly decreased after the administration of 1,25(OH)2D3 in ischemic stroke. Conclusion: Based on our findings, calcitriol (1,25(OH)2D3) could be considered as a protective approach against ischemic stroke by reducing the activity of apoptotic proteins.

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Introduction: Mechanical disorganization of the bacterial biofilm is the cornerstone of the prevention of gingivitis and periodontitis periodontal diseases. The objective of this study was to evaluate the periodontal health of schoolchildren in Widou, Ferlo. Methodology: This was a descriptive, cross-sectional study of schoolchildren living in Widou in the centre of Ferlo. The survey was exhaustive and concerned the only school in the locality. The epidemiological data collected concerned oral hygiene practice, periodontal health and socio-demographic characteristics such as sex, age and educational level. The degree of hygiene was assessed by the Silness and Loe plaque index (Plaque Index); inflammation and bleeding on probing were assessed by the Loe and Silness gingival index (Gingival Index). Results: In a total of 126 schoolchildren, boys and girls were equally represented and the average age was 10 years +/- 2.16.Sixty-nine percent (69%) of the children examined did not use a toothbrush. Of these, more than 47% reported brushing 3 times a day. The plaque index mean value was 1.23 and 99.2% of the population had a moderate plaque control. The average gingival index was 0.96 and 80.2% of the sample had moderate gingival inflammation. Conclusion: The study showed a relatively low rate of toothbrush use in contrast to the tooth stick and a relatively high rate of periodontal index. Communication-based approaches to behaviour change in children are needed to improve periodontal health.

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In order to successfully counter the ever-growing drug problem, there is an increasing need, to identify conspiracy links and trafficking routes and to gather background intelligence concerning both the number of sources of drugs and whether those sources are within a country or are “internationally” based and also the points of distribution and distribution networks. A scientific tool to complement routine law enforcement investigative work in this field is the characterization and impurity profiling and cutting agents of seized drugs. Drug characterization studies have shown that it is possible to link samples, to classify material from different seizures into groups of related samples and to identify the origin of samples. Such information can be used for evidential (judicial, court) purposes or it can be used as a source of intelligence to identify samples that may have a common origin or history.

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The Aims: The retro-prospective clinical study was to compare these two methods of laparoscopic and classical cholecystectomy. To prove the postoperative benefits of laparoscopic treatment are, less pain, aesthetic aspect without surgical scarring and shorter hospital stay, faster return to social activities as well as more cost effective. Material and Methods: The operated patients, from January 2017 to December 2019 in the abdominal surgery ward in Gjilan. Important data for the study are taken from the operative list, history of the disease, adequate list compiled specifically for this study. The study included 389 patients with chronic calculous cholecystitis. Results: According to the results obtained for calculous diseases of the biliary system are predisposed persons with blood group O, Rh-positive, with 44.2%, followed by group A + with 29.5%, group B + with 14.7%. Other blood groups and Rh factors are below 6.5%. Statistical point of view is significant (p <0.05). The study analyzed, C-reactive protein (CRP) values in both research group (RG) and control groups (CG); CRP by gender; and by age group. RG recorded 76.9% of females with increased CRP values> 6, while 23.1% of males. The percentage difference in statistical terms is significant p <0.05. Conclusion: The results obtained have shown that there are no significant differences in the presentation of intra-operative complications in terms of gender and age, to both methods. Optimization measures for postoperative management of patients after laparoscopic cholecystectomy. Continuing education in laparoscopic surgery is important for successful management.

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An internist with an eagle’s eye can diagnose many hidden diseases through careful examination. One such hereditary metabolic disorder is Albright’s Hereditary Osteodystrophy (AHO). Characteristic presentations in an individual affected by AHO were short stature, obesity, mild mental retardation and brachydactyly especially of 4th and 5th digits, which are the phenotypic features of genetic mutation. Pseudohypoparathyroidism (PHP) is characterized by inability of the body to respond appropriately to parathormone, mainly characterized by hypocalcaemia, increased serum parathormone concentration, insensitivity to the biological activity of parathormone and hyperphosphatemia. AHO when seen in association with resistance to parathormone (PTH), it is called PHP. Here is a case report of 22-year-old female patient with AHO with distinctive physical characteristics who presented to us with recurrent hypocalcaemic tetan

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Candida infections of the gastrointestinal tract are rare and perforation caused by Candida infections is extremely rare. Herein, we present a case of duodenal perforation where laboratory culture revealed the growth of a fungus, Candida and the absence of H. pylori from a 51-year-old female who presented with an upper abdominal pain while performing her religious obligation in the month of Ramadan. The results suggest emergency exploratory laparotomy and the perforation discovered was repaired through omental patching. An antifungal agent, Fluconazole, was administered.

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There are several energy drinks available in the market such as Red Bull, Sting, Rebound, Power Up! Triple X Energy Drink, and so on. After the Red Bull drink was introduced in the market in1990s, Energy drinks started to gain popularity and afterwards it became a common name especially among teenagers and young adults [1]. Most energy drinks are caffeinated nonindulgent beverages that are professed to give an additional increase in energy for day-by-day work, increase alertness, and improve athletic performance and mood. There are even certain shreds of evidence present to substantiate these claims, but the effects of these drinks on mental and physical health cannot be neglected. There are reports of adverse events such as insomnia, anxiety, cardiovascular events, seizures, tachycardia, type-2 diabetes, and even death are associated with the consumption of these drinks [2]. This review will focus on energy drinks, their ingredients, health risks associated with these drinks, and will also suggest some recommendations such as changes in marketing, providing education to children regarding adverse effects of these drinks, and further research should be carried out in this domain.

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CLCN2 related leukoencephalopathy (CC2L OMIM#: 615651) is a recently identified rare disorder, caused by autosomal recessive mutations in CLCN2 gene, leading to the dysfunction of its encoded CLC-2 chloride channel protein with characteristic brain MRI features of leukoencephalopathy

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The present research deals with the development of a stability indicating reverse phase HPLC with PDA detector method for the determination of Armodafinil Agilent XDB-C18, 150×4.6mm, 5µm or Equivalent column. The present research deals with the development of a stability indicating reverse phase HPLC with PDA detector method for the determination of Armodafinil Agilent XDB-C18,

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Pantoprazole is a H+,K+-ATPase enzyme inhibitor for the treatment of acid-related gastrointestinal diseases. The Government Pharmaceutical Organization (GPO), Thailand had developed Pantoprazole GPO® (pantoprazole 40 mg delayed-release tablets) as a generic substitute for the corresponding innovator product, CONTROLOC® 40 mg.

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Succinylcholine (Sch) is usually given for intubation in suspected difficult airway due to its fast onset and short duration of action. We report a case of Masseter Muscle Rigidity (MMR) after giving Sch to a patient for lap cholecystectomy with difficult airway

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Antenatal alcoholization leads to a number of specific disorders in the offspring organism, grouped into the concept of fetal alcohol syndrome, which is included in the fetal alcohol spectrum disorders. The negative effects of alcohol on the developing fetal brain include structural abnormalities of the brain, neurological, behavioral and cognitive defects.

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A simple High-Performance Thin layer chromatography (HPTLC) method has been developed for determination of atenolol in human blood and viscera. The mobile phase was ethyl acetate, acetone, ethyl alcohol, ammonia solution in the ratio of 45:45:7:3. The densitometry scanning at 254 nm was found to be maximum absorption for standard atenolol. The standard and extracted atenolol from samples were detected by HPTLC and confirmed with authenticated spectra at 254 nm. The quantity of the atenolol determined to be 1.6 µg for viscera and 1.5 µg for blood sample.

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Clopidogrel is used for acute coronary syndrome and prevention of atherothrombotic events. To improve clinical outcomes, patient adherence to treatment is necessary. However, continuous use of branded product may cause economic burden to patients and healthcare system. The Government Pharmaceutical Organization (GPO), Thailand had developed a generic product of clopidogrel to reduce cost of treatment and improve accessibility to medicines for Thai people.

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Ethyl glucuronide (EtG) and ethyl sulfate (EtS) are markers for screening previous alcohol consumption and indicating recent drinking in cases of suspicion of driving under the influence of alcohol.

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Vertical Cu2ZnSnS4 (CZTS) nanowire arrays have been synthesized via two-step electroplating method into anodized aluminum oxide template. For deposition of CZTS nanowires, anodized aluminum oxide (AAO) was used as the growth mask for the growth of the nanowires. AAO templates with hole sizes of 70 nm in diameter were used in the experiments.

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