Articles Related to LDH

Pediatric cancer overall survival has increased due to improvements in treatment. However, long-term adverse effects are a challenge for this population. Secondary myeloid neoplasm (MN) is one of the complications of solid tumor treatment. Therapy-related myeloid neoplasms (t-MN), therapy-related acute myeloid leukemia (t-AML), and therapy-related myelodysplastic syndrome (t-MDS) are the most common events. The aim of this study was to report a large pediatric sample and the relevance of t-MN after pediatric solid tumor therapy. We conducted a retrospective study between 2000-2016 in a cohort of pediatric patients treated for solid tumors who developed a secondary MN by medical records review and analysis. Seven from 2178 pediatric patients who were previously treated for solid tumors, were diagnosed with t-MN in a reference cancer center in Brazil. The median age at primary tumor diagnosis was 12.8 years old. Osteosarcoma, atypical primitive neuroectodermal tumor (PNET), Ewing sarcoma, and retinoblastoma were the most frequent solid tumors associated with t-MN. Three patients had a story of familiar cancer, and one patient with osteosarcoma had Li-Fraumeni syndrome confirmed. The median latency period to secondary MN was ten months and the prevalence rate was 0.32%. Two patients developed t-MDS and five, t-AML. All these patients received cytotoxic agents’ high doses that may have been associated with t-MN development. t-MN initial control, as well as unfavorable cytogenetic abnormalities, may have contributed to the poor outcome. We described the rarity of t-MN related to previous solid tumor therapy in a large pediatric sample in a Brazilian Cancer Center and their poor prognosis.

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Treating childhood obesity is time-consuming and inconclusive exercise; children suffering dominantly in later years are more likely to grow up to be obese adults.

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Childhood obesity is a growing problem facing the developed world. This manuscript reports user experiences of the TreCLifeStyle mHealth app to bring about behavioural change.

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Generalized pustular psoriasis (GPP) is an acute and uncommon form of psoriasis, representing about 3% of all psoriasis cases. Triggers may include streptococcical infections, emotional stress, vaccinations and exposure to medications such as penicillin. Systemic therapy is often necessary for GPP, since it may rapidly evolve, leading to significant and potentially fatal complications. Here, we describe the case of a 5-year-old male presenting with diffuse erythema, confluent scaly plaques and painful pustules localized on the trunk and limbs. Systemic manifestations such as fever, general lymphadenopathy and arthritis were also observed. To date, no standardized treatment guideline exists for infantile acute generalized pustular psoriasis. Our patient responded successfully to cyclosporine treatment within 4 weeks without any side effects. Thus, cyclosporine could be considered a useful agent in cases of pediatric GPP, keeping in mind its side effect profile in child population.

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Severe early childhood caries (S-ECC) is an aggressive form of tooth caries in preschool children. New different bacteria were defined as associated with S-ECC. The aim of this study was to analysis the role of Scardovia wiggsiae and the other cariogenic microorganisms in S-ECC in Turkish children. Two same-sized groups of children were enrolled in the study: the first group consisted of 40 children with S-ECC (mean-age:52.93±11.5months), and the second group consisted of 40 caries-free children (mean-age:49.43±12.47months). The numbers of mutans streptococci, lactobacilli and yeasts were examined by culturing techniques, while the presences of S. wiggsiae, Streptococcus mutans, Streptococcus sobrinus, Actinomyces gerencseriae, Veillonella parvula, Fusobacterium nucleatum were examined by using 16S rRNA-based PCR technique in plaque samples. The prevalence of S. wiggsiae, S. mutans, A. gerencseriae, V. parvula and the numbers of mutans streptococci, lactobacilli, yeasts were found significantly high (P<0.05) in SECC. Also, the presence of S. wiggsiae with either S. mutans, A. gerencseriae, V. parvula or F. nucleatum were associated (P<0.01) with S-ECC. Understanding the effects of bacteria on initiation and progression of S-ECC will also help to improve protective and preventive treatments.

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The prevalence of obesity is on the increase worldwide due to changes in diet and physical activity patterns. Childhood obesity is now a major public health challenge in advanced economies. Obesity in childhood tends to persist into adulthood and to predispose to non-communicable diseases. There is little data on childhood obesity and its correlates and determinants in sub-Saharan Africa. A cross-sectional study was carried out using simple random sampling technique to select 260 junior high school children aged 11-15 years from six basic schools (n=768) from three different socioeconomic (low, middle, high) areas of Accra, the capital city of Ghana.

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Childhood obesity is epidemic in the United States, but low levels of physical activity and high levels of screen time are modifiable risk factors. An activity meter (AM) program, that utilizes an interactive child-focused website and measures the amount and intensity of physical activity, may promote activity and decrease BMI.The current study tests the feasibility of using an AM program with child-caregiver pairs in a primary care setting. We hypothesize that participants would rate the system as easy to use, would be motivated with their engagement in physical activity, and would continue to use and recommend to others. We hypothesize the AM system would increase children’s physical activity levels and decrease engagement in screen time over the study period. We also measure changes in participants’ body mass index (BMI).Prospective study assessing ease of use and satisfaction with the AM program post-intervention and comparing physical activity and BMI changes in children and caregivers from pre- and post-intervention over a 4-month period.

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Headache is among the main pediatric symptom and the physicians should meet the diagnostic criteria of the International Headache Society. In a cross-sectional study, during August 2015 to August 2016, the types of headaches and the sociodemographic profile of patients between 4 and 18 years of age were evaluated. The headache patients were previously diagnosed and followed at the Pediatric Neurology Service of Salvador, according to established criteria. The study was approved by Research Ethics Committee and it was carried out with the application of a specific questionnaire. In the overall study population (N = 58) were detected: primary headache migraine type that incapacitated the daily activities in 34/58 (58.6%) and the socioeconomic profile showed the family income below two salaries (in Real currency) in 38/58 (65.5%) of the population. As observed in adults, the headaches constitute a disabling diagnosis and it is impactful in the development of activities of daily living in the age group of this study, corroborating the literature on the importance of early diagnosis and therapy.

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Homocysteine is a parameter that plays an important role for diagnosing several diseases mainly cardiovascular diseases. In this study, the first time reference values for homocysteine levels detected in healthy Golden Retriever, Terrier, German Shepherd and Labrador Retriever breeds of dogs play an important role in the prognosis of many diseases.

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In Morocco, through the finding of the Casablanca population-based registry, all cancers are estimated at 35000 new cases par year and 3.2% are aged less or equal 20 years.

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Previous research has demonstrated that HIV risk practices often differ based on gender and on whether or not people experienced sexual abuse during their formative (i.e., childhood and adolescence) years. The interaction of these two factors, which is the focus of this paper, has received limited attention.

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Preeclampsia is clinically defined by hypertension and proteinuria, with or without pathologic edema that occurs after 20 weeks’ gestation, but can also present up to 4-6 weeks post-partum. Worldwide, incidence of preeclampsia is 5-14 percent of all pregnancies, while severe preeclampsia can develop to about 25 percent of all cases of preeclampsia.

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Congenital dyserythropoietic anemia type III (CDA III) can be caused by mutation in KIF23. CDA III differs from CDA I and II in the sense that secondary hemochromatosis has not been reported. However, we have observed elevated serum ferritin in a CDA III family.

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As stunting in early postnatal life is prudent in developing countries, investigating its long term effect on adult blood pressure is necessary.

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We hypothesized that quantitative tandem mass spectrometry-based proteomics, incorporating rapid microwave and magnetic sample preparation (M2 proteomics), might enable relative protein expression to be correlated to childhood B-precursor acute lymphoblastic leukemia (B-ALL) cytogenetic subtypes, corresponding to low-risk (ETV6-RUNX1) and high-risk (MLL-R) subtypes.

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