Articles Related to LOD
Clodronate : A Potential DMOAD in Osteoarthtitis
Osteoarthritis is an inflammatory-degenerative joint disease that affects the osteochondral unit with the concomitant intervention of the immune system; this causes pain and progressive functional limitation. With a varied and complex etiopathogenesis, Osteoarthritis has a subtle outcome and an inexorable evolution towards joint deformity. The therapeutic
approach makes use of non-pharmacological and pharmacological aids. Pharmacological therapy consists of symptomatic
drugs that act on acute and especially chronic pain, in an attempt to decrease the incidence of any structural damage to the
cartilage and subchondral bone. If the anti-resorptive drugs cure the subchondral-epiphyseal osteometabolic pathology,
the interventions on the cartilage have not produced important and well evaluable results, even after prolonged therapies.
This contribution analyzes the profile of Clodronate, used for the treatment of subchondral bone edema in Osteoarthritis,
regarding its potential protective effects in cartilage, like DMOADs.
An Insight into the Role of Spliceosomal Mutations in Myelodysplastic Syndromes
The identification of altered splicing signatures in Myelodysplastic Syndromes (MDS) could likely provide key markers for diagnosis, prognostication and development of novel therapeutics. This review presents an insight into role of spliceosomal gene mutations in the pathogenesis of MDS, emphasizing on their clinical and prognostic significance. We also discuss emerging studies delineating the functional consequences of these mutations and pointing towards the emergence of a new leukemogenic pathway involving spliceosomal dysfunction.
Congenital Dyserythropoietic Anemia Type III and Primary Hemochromatosis; Coexistence of Mutations in KIF23 and HFE
Congenital dyserythropoietic anemia type III (CDA III) can be caused by mutation in KIF23. CDA III differs from CDA I and II in the sense that secondary hemochromatosis has not been reported. However, we have observed elevated serum ferritin in a CDA III family.
Hemodynamic and Autonomic Reactivity to Mental and Physical Stress in Lean, Overweight and Obese Subjects
There could be progressive changes in hemodynamic and autonomic parameters causing cardiovascular damage from lean to morbid obesity. We aim to study resting and reactivity of hemodynamic and autonomic parameters to physical and mental stress in lean, overweight and obese subjects of the Oman Family Study (OFS).
Ascites Secondary to Compression of the Caudal Vena Cava by Liver Abscesses in a Cow
Ascites due to thrombosis of the caudal vena cava is relatively seldom in cattle. To our knowledge, there have been no reports of ascites secondary to compression of the caudal vena cava by liver abscesses. This case report describes the findings in a 3.7-year-old Brown Swiss cow with this disease.
Increased High Mobility Group Protein A2/SMAD3 Relates to Ovarian Cancer Progression
The high mortality associated with ovarian cancer is generally related to the development of drug-resistant disease. HMGA2 protein, a member of the high-mobility group AT-hook (HMGA) family of non-histone chromatin binding factors, is overexpressed in high-grade serous ovarian and tubal carcinomas, though little is known about its contribution to disease progression and drug resistance. We sought to assess whether compositional changes in HMGA2 production were associated with ovarian cancer progression.
Copper Deficiency Myeloneuropathy Mimicking Subacute Combined Degeneration Following Bariatric Surgery
Bariatric surgery (BS) is a potential cause for malabsorption resulting in nutritional deficiency-related neuropathies and myelopathy.
Amyloid beta precursor protein: forgotten facts of the most studied protein in the 21st Century*
The amyloid precursor protein (APP) is mainly known for being the precursor of the ß-amyloid peptide, which accumulates in plaques found in the brain of Alzheimer’s disease patients. Expression in different tissues and the degree of sequence identity among mammals indicate an essential and non-tissue specific physiological function.
Wet Granulation to Overcome Liquisolid Technique Issues of Poor Flowability and Compactibility: A Study to Enhance Glibenclamide Dissolution
The aim of this study is to apply wet granulation on liquisolid powders to overcome issues of poor powder flowability and compressibility especially with using high viscosity liquid vehicles. Different liquisolid formulations were made using three excipients where the effect of each excipient used in the dissolution of the model hydrophobic drug (Glibenclamide) was evaluated. The Glibenclamide tablets were formulated using PEG 400, Synperonic PE/L44 and Cremophor ELP, at a 10 %w/w in liquid vehicle drug concentration. The carrier (Avicel®PH102) was used followed by colloidal silicon dioxide (coating material) that converted the wet mixture into dry powder. Potato starch, 5%w/w, as a disintegrant was mixed with the mixture manually for 10 minutes and was finalized by adding 0.75% of magnesium stearate as a lubricant.
Microfilaria Causing Bone Marrow Failure
It is common to detect microfilariae in various cytological preparations, however there are very few case reports describing microfilariae in bone marrow aspirates. It is rarer to get bone marrow failure secondary to microfilaria in bone marrow. We report here a patient from Bihar, presented to us with prolonged fever and pancytopenia, bone marrow aspirate showed microfilaria. Treatment with DEC and albendazole resulted in prompt recovery.
Reduction of Bitterness and Enhancing Palatability of Cetirizine Oral Liquid Dosage Forms by Cyclodextrins
The aim of this manuscript is to study cyclodextrins (CDs) as a potential excipient to suppress bitterness and enhance palatability of pediatric liquid preparations for Cetirizine, an extremely bitter drug. Natural α, β and γ CDs; and β CD derivatives such as hydroxyl propyl (HP), randomly methylated (RM) and sulfobutyl ether (SBE) β-CDs were screened in different molar ratios of 1:1, 1:2 and 1:3 for their inhibition of the extremely bitter taste of Cetirizine using the human gustatory sensation test.
Topical Delivery System for Phytochemicals: Capsaicin and Capsicum Tincture
Capsaicin, an active ingredient of Capsicum fruit, is currently undergoing “revival” in the clinical management of pain. However, the choice of its formulation is rather limited to the use of “old-fashioned” tinctures and recently the patches. In an attempt to improve the therapeutic outcome and develop its skin-friendly formulation, we prepared the vesicle-based drug delivery system with capsaicin.
Development of a Stability Indicating UPLC-MS/MS Method for Rapid and Reliable Determination of Fenofibrate in Marketed Product (Lypanthyl® 200M) and Human Plasma
A reliable, fast, sensitive and selective Ultra Performance Liquid Chromatography-Tandem Mass Spectrometry (UPLC-MS/MS) method has been developed and validated for the determination of fenofibrate in marketed product (Lipanthyl) and human plasma. The chromatographic separation was performed on a reversed-phase Acquity®BEH C18 column (1.7 μm particle size, 50 mm x 2.1 mm ID) with an isocratic elution profile and mobile phase consisting of methanol and water (80:20, %, v/v). To achieve optimum chromatographic condition the influence of mobile phase composition and flow rate was investigated. The total chromatographic analysis time was as short as 2 min.
Recent Developments in Human Odor Detection Technologies
Human odor detection technologies have drawn attention due to the wide possibility of potential applications they open up in areas such as biometrics, criminal investigation and forensics, search for survivors under rubble, and security checkpoint screening. Gas chromatography/mass spectrometry (GC/MS) has been the most successful and powerful analytical approach developed to date for human odor analysis, and hundreds of human odorants have been identified using this tool.
Editorial Board Members Related to LOD
Julie Teruya-Feldstein
Director
Hematopathology
Immunohistochemistry Laboratory
United States
Hematopathology
Immunohistochemistry Laboratory
United States
Magdolna Csavas
Associate Professor
Department of Pharmaceutical Chemistry, Faculty of Pharmacy
University of Debrecen
Hungary
Department of Pharmaceutical Chemistry, Faculty of Pharmacy
University of Debrecen
Hungary
Baha’ N. Noureddin
Professor and Chairman
Department of Ophthalmology
The American University of Beirut
Lebanon
Department of Ophthalmology
The American University of Beirut
Lebanon
Jason X. Cheng
Assistant Professor
Department of Pathology, Hematopathology
University of Chicago
United states
Department of Pathology, Hematopathology
University of Chicago
United states
Ana Rita Ramalho Figueiras
Faculty of Pharmacy
University of Coimbra
Portugal
University of Coimbra
Portugal
CLAUDIO FOZZA
Aggregate Professor
Department of Biomedical sciences
University of Sassari
Italy
Department of Biomedical sciences
University of Sassari
Italy