Articles Related to Leptin Receptor

Introduction: Obesity is a multifactorial condition influenced by environment and genetic factors. Controlling appetite and satiety involves complex interactions between the hypothalamus, which is responsible for homeostasis regulation energy, and hormones that regulate appetite including leptin and ghrelin. Leptin plays an important role in the regulation of food intake and energy expenditure, generating an increase in energy burning and decreasing food intake. And ghrelin is directly involved in the regulation of short-term energy balance. Objectives: To verify frequency, biochemical profile and Body Mass Index (BMI) variations according to SNPs in LEPR and GHRL gene. Subjects and Methods: 163 both genders subjects were classified into Study Group (SG): 103 subjects with obesity; Control Group (CG): 60 non-obese. Blood samples were collected to perform DNA extraction and biochemical profile analysis. Statistical significance was established at p < 0.05. Results: The genotype and allele frequency were similar between groups for both polymorphisms. The _/A genotype of the GHRL rs696217 polymorphism was associated to increased BMI in SG compared CG (p = 0.003) and increased triglycerides (TG) and very low density lipoprotein (VLDLc) values in CG (p < 0, 05). The _/A genotype was also associated with increased fasting glucose compared to CC genotype only in CG (p = 0.031). Considering the LEPR rs1137101 polymorphism, AA genotype subjects presented higher BMI compared to _/G genotype subjects (p = 0.024). No difference between biochemical profile variables related to LEPR rs1137101 polymorphism was found. Conclusion: AA genotypes of the LEPR rs1137101 polymorphism and _/A of the GHRL rs696217 polymorphism suggest being risk factors for BMI and the latter is associated with fasting glucose, VLDLc and TG variation.

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