Articles Related to MB
Leveraging Electronic Medical Records for Legal Compliance and Improved Reimbursement Efficiency
Background and Objective: Septic shock remains an impatient cause of morbidity and mortality. Early restitution of the circulation improve tissue oxygen delivery and increase survival. This study is a prospective randomized single center study its
main objective is to investigate the therapeutic value of hypertonic saline in patients with septic shock.
Methods: Fifty-two critically ill patients admitted with septic shock divided into two groups, the first group received isotonic saline (control group) starch, while the second received hypertonic saline 5%.
In-vitro Regeneration in Maize (Zea Mays L.) from Mature Embryo
Maize is an economically important crop worldwide. As the world population increases, there is a great need to develop
high yielding and stress resistant maize varieties. To provide a future platform for maize improvement, we tested mature embryos as alternative explants for the regeneration of three economically important maize inbred lines: CML331, CML442
and CML444.
The Efficiency and Safety of a Resveratrol and Alpha Lipoic Acid Combination in the Prevention of Gestational Diabetes Related Complications: A Retrospective Clinical Trial
Gestational diabetes mellitus (GDM) is associated with an increased maternal and fetal risk of complications. Other than
lifestyle modifications and diet, little prevention can be done towards this maternal complication. Through a preclinical approach and a retrospective clinical trial, we investigated the effects of maternal supplementation with a nutraceutical composition based on resveratrol (RSV) and alpha-lipoic acid (ALA) on insulin resistance and GDM status
Trends and Day-of-the-Week Effects Decomposition in the Mean and Dispersion in the Number of Subjects Testing Positive for COVID-19 in the UK in 2020
COVID-19 pandemic is a global threat, where the rate of infection with Severe Acute Respiratory Syndrome
Coronavirus 2 (SARS-CoV-2) increases exponentially, and the spread of the virus from person to person is very fast.
Fitting models for COVID-19 counts receive a great attention, and modelling the dispersion of COVID-19 counts
helps measuring the spread of the disease in a population and evaluating the intervention
Comparative Assessment of De Novo Genome Assemblers for Generating Eukaryotic Primary Genome Assembly from Short Reads
Ameya Santhosh, Rani Alex, Vikas Vohra (2023) Comparative Assessment of De Novo Genome Assemblers for Generating Eukaryotic Primary Genome Assembly from Short Reads. J Comp Sys Bio 6(1): 101
Explorations of the Combined Effects of Surface Energy, Initial Stress and Nonlocality on the Dynamic Behaviour of Carbon Nanotubes Conveying Fluid Resting on Elastic Foundations in a Thermo-Magnetic Environment
The vibrations of carbon nanotubes under the influences of various internal and external forces have been subjects of interests
for some years. These researches have not really considered the effects of surface energy and initial stress which are very
important from both material and mechanical aspects of views. Therefore, the current study presents the simultaneous
impacts of surface energy, initial stress and nonlocality and other various parameters on the nonlinear vibration of carbon
nanotube hot fluid-conveying resting on elastic foundations in a magnetic environment. The derived equations governing the
behaviours are solved using Galerkin’s decomposition-Adomian decomposition method is adopted to explore the concurrent
impacts of surface elasticity, initial stress, residual surface tension and nonlocality on the nonlinear vibration of singlewalled carbon conveying nanotube resting on linear and nonlinear elastic foundation and operating in a thermo-magnetic
environment
A Case Report of Rapidly Progressing Amyotrophic Lateral Sclerosis in 31 Year Old Patient with Sympathovagal Imbalance
ALS is a fatal neurodegenerative condition characterized by degeneration of upper and lower motor neuron in cerebral cortex, cranial nerve nuclei and anterior horn cells of spinal cord. Three drugs are FDA approved, Riluzole, Edaravone and
AMX0035 (recently approved), which can only prolong survival time by 2-3 months.
Incessant Supraventricular Tachycardia in a Newborn Treated with Combined Antiarrhythmic Drug Therapy
Supraventricular tachycardia is the most common type of tachyarrhythmia seen in childhood. First-line treatments (adenosine, esmolol-propranolol, digoxin, electrical cardioversion) usually suppress tachycardia, but rarely tachycardia is resistant and requiring Class IC and/or Class III agents, such as amiodarone, sotalol, propafenone, and flecainide.
CCR5 Promoter SNP Genotype in HIV Seropositive Infants on Combination Antiretroviral Therapy in Uganda: Association with Virological Failure
According to the UNAIDS 2022 report, 52% of the HIV positive children between 0-14 years were able to access treatment and of these 68% attain viral suppression. CCR5 promoter genotype specifically single nucleotide polymorphisms have been linked to modulate patient virological status. However, the few studies that have studied the association in infants have utilized allele-specific PCR a genotypic method limited to detecting already known SNPs. By using Sanger sequencing, we explored the association taking into account novel mutations.
Adherence to Antiretroviral Medication and Factors Affecting it Among HIV-- Positive Patients Receiving it at Adama General Hospital
Before the development of highly active antiretroviral medication, AIDS and related illnesses caused a great deal of suffering and death. All of the AIDS-related morbidities and mortality have considerably decreased thanks to modern medication, especially in industrialized nations. However, this accomplishment is still elusive in underdeveloped nations, particularly in those in sub-Saharan Africa. This failure can be attributed to a number of factors. Poverty, ignorance about the treatment, and inadequate therapy adherence are at the top of this list.
Antiradical and Antibacterial Activities of The Ethanolic Extract of Terminalia Avicennioides Guill. and Perr. (Combretaceae) from Chad
Oxidative stress associated with bacterial infections, are recognized as being a key factor in the appearance and complications of many chronic pathologies. To help overcome these difficulties, herbal remedies are one of the alternatives for the development of traditionally improved drugs. The objective of this work is to evaluate the antiradical and antibacterial activities of the ethanolic extract of the bark of the trunk of Terminalia avicennioides. Plant used in traditional medicine in Chad in the treatment of infectious diseases.
Penicillin-Streptomycin Induces Mouse Embryonic Stem Cells Differentiation into Cardiomyocytes through MAPK signal pathway
Penicillin and streptomycin are the most commonly used to prevent bacterial infection or contamination in cell culture. However, the role of Penicillin-streptomycin on inducing mouse embryonic stem cells(mESCs) to differentiate into cardiomyocytes is unclear. To illustrate the mechanism of penicillin-streptomycin on inducing mESCs differentiation into cardiomyocytes, we firstly investigated mESCs differentiation into cardiomyocytes by the traditional method. The time- space expressions of cardiac-specific genes were detected by real-time PCR and western blotting at 8 different time-points over a period of 36 days. Furthermore, action potentials were measured by patch clamp for mESC-derived cardiomyocytes. Embryonic bodies through hanging drop method, were incubated with penicillin-streptomycin (P/S) at different concentrations (1×PBS, 1×, 2×, 5×), and then, the number of cardiomyocytes and expression levels of myocardial marker proteins were detected by flow cytometry, cellular immunofluorescence, and western blotting, respectively. We found that the SSEA-1 of mESC presented green fluorescence, and H.E. staining showed karyoplasmic ratio >>1. Besides, TNNI3, TNNT2, ACTN2 and MYL-2v were clearly visible by cellular immunofluorescence. Furthermore, the ACTN2 positive cells rate of 2× and 5× groups were remarkably higher than that in Cntl (1×PBS) group and 1× group (10 Units/mL penicillin; 10 μg/mL streptomycin), as well as the expressions of GATA4, MYL-2v, TNNI3, ACTN2
Climate Change: Effects and Adaptation Strategies Among Orange Fleshed Sweet potato (ofsp) Farmers in Anambra East and West Local Government in Anambra State, Nigeria
The study investigated the effects of climate change and adaptation strategies among Orange Fleshed Sweet potato (OFSP)
farmers in Anambra East and West local government in Anambra State, Nigeria. The specific objectives of the study were to
assess the sources of information on climate change by the farmers, determine the causes of climate change in the study
area, ascertain the perceived effects of climate change on OFSP farmers, assess the adaptation strategies used by the farmers
and identify constraints to climate change adaptation strategies.
Investigation of Neuroprotective Effects of Ripasudil in Mechanic Optic Nerve Injury Model
Purpose: We aimed to create mechanic optic nerve injury model in rats and investigate the neuroprotective effects of
ripasudil on retinal ganglion cells.
Study Design: Experimental study
Methods: Mechanic optic nerve injury model was created in the right eyes of male Wistar rats (n=15). Rats were divided
into three groups: glaucoma model with sham treatment (group1) and 20 µM intravitreal ripasudil treatment (group 2)
and 50 µM intravitreal ripasudil treatment (group 3). Treatment was applied intravitreally and rats were sacrificed at the
end of 4 weeks. Glial fibrillary acidic protein (GFAP), Brn-3a antibody,anti- Iba1 was examined by immunohistochemistry.
Results: The number of Brn-3a positive RGC in the mechanical optic nerve injury model was 5.33 ± 2.08 (min: 3, max: 7)
in sham group, 10.25 ± 2.63 (min: 8, max: 14) in 20 µM group and 16.75 ± 5.43 (min:9, max: 21) in 50 µM group (p <0.05).
GFAP positive RGC counts were recorded as 24.33 ± 2.08 (min: 22, max: 26) in sham group, 16.75 ± 1.70 (min: 15, max:
19) in 20 µM group and 13.00 ± 4.08 (min:10 , max: 19) in 50 µM group (p <0.05). Ripasudil treatment also decreased Iba1
expression in the retina of mechanic optic nerve injury groups. In addition, ripasudil treatment prevented apoptotic cell
death by increasing Bcl-xL protein expression and preserved Tfam protein expression in the retina.
Conclusions: Our experimental study has shown that ripasudil is neuropreotective in mechanical optic nerve injury
model.
The Combined Effect of 2,4-Epibrassinolide and Chilling Stress on Tomato Cultivars Differing in Maturity
Low temperature (but above-freezing) during germination and early seedling growth of chilling-sensitive crop is one of the most significant limiting factors in the productivity. 2,4-Epibrassinolide (24-EB) is one of the most active forms of brassinosteroids are multifunctional plant hormones that can regulate development and respond to abiotic stresses. The effect of seed-pretreatment with 24-EB (12.5 μg/L) on photosynthetic characteristics, membrane permeability, lipid peroxidation and antioxidant activities under chilling stress were investigated in tomato (Lycopersicon esculentum Mill.) cultivars: Kulon (early ripening) and Yakhont (mid-early). Results showed that the use of 24-EB led to more pronounced changes in the pigment composition in Yakhont in the absence of a stress factor, whereas in Kulon under chilling stress (2 o C for 24 h). 24-EB pretreatment minimized the damage to cell membranes in tomato plants caused by chilling stress. The tolerance to chilling stress in Yakhont was higher than Kulon (by electrolyte leakage and content of malondialdehyde assay). Under these conditions, oxidative processes in plants of Yakhont did not show significant difference. We have not established the effect of 24-EB on the level of low molecular weight antioxidants in tomato cultivars (measured by inhibition of 2,2-diphenyl-1-picrylhydrazyl free radical method). The antioxidant activity of leaf extracts in Yakhont was
twice as high as in Kulon under all experimental conditions (with/without 24-EB, 22/2 o C). It was concluded that the less pronounced reaction of plants of Yakhont to the use of 24-EB and chilling stress is due to their genetically determined higher cold resistance than that of Kulon.
Preparation of Large Area Anodic Alumina Membranes and their Application to Thin Film Fuel Cell
The design of an electrochemical reactor for the preparation of self-supported comparatively thin (up to 10 μm) and large area (up to 50 cm2) anodic alumina membranes is described allowing growth of porous alumina at high applied potential (up to 150 V) without burning.
Fabrication and Luminescence of Anodic Alumina with Incorporated Vanadyl Citrate Chelate Anions
Anodic aluminum oxide doped with vanadyl citrate chelate complex anions was formed by a two-step self-organized anodization in 2 wt. % sulfuric acid containing 0.04 M V2O5 and 0.08 M citric acid at voltage range 13-23 V, and at 0 and 15 oC. The combination of two temperatures and at least four voltages (depending on the applied temperature) was applied as the operating conditions of anodization.
Editorial Board Members Related to MB
JING LIN
Associate Professor
Department of Pediatrics
The Icahn School of Medicine at Mount Sinai
United States
Department of Pediatrics
The Icahn School of Medicine at Mount Sinai
United States
Leonardo Roever
Research Assistant
Department of Clinical Research
Federal University of Uberlandia
Uberlandia
Brazil
Department of Clinical Research
Federal University of Uberlandia
Uberlandia
Brazil
Emmanouil Malandrakis
Department of Ichthyology and Aquatic Environment
University of Thessaly
Greece
University of Thessaly
Greece
Jamie I. Baum
Assistant Professor
Department of Food Science
University of Arkansas
United States
Department of Food Science
University of Arkansas
United States
SAYED M. HASSAN
Senior Research Scientist and Director
CAIS Lab. for Environmental Analysis
Center for Applied Isotope Studies
The University of Georgia
USA
CAIS Lab. for Environmental Analysis
Center for Applied Isotope Studies
The University of Georgia
USA
RICHARD JOHN CURE
Associate Professor
Warwick Medical School
University of Warwick
England
Warwick Medical School
University of Warwick
England
Ashraf Youssef Nasr
Associate professor
Department of Anatomy & Embryology
Zagazig University
Egypt
Department of Anatomy & Embryology
Zagazig University
Egypt
LUIS CLAUDIO NASCIMENTO DA SILVA
Department of Parasitary Biology
Ceuma University
Rua dos Castanheiros Jardim Renascença 65075120 - São Luís
Brazil
Ceuma University
Rua dos Castanheiros Jardim Renascença 65075120 - São Luís
Brazil
Syed Mohammed Shamsul Islam
Lecturer
Computing and Security
School of Science
Edith Cowan University
Australia
Computing and Security
School of Science
Edith Cowan University
Australia
Arvind Chhabra
Assistant Professor
Department Of Medicine
University of Connecticut Health Center
United States
Department Of Medicine
University of Connecticut Health Center
United States