Articles Related to MOU

This study investigates the natural radioactivity levels in the Abha and Al-Baha region, a mountain range with a variety of rock types, ranging from calcareous to granitic. Thirty rock samples were collected, 15 from the Abha mountains and 15 from the Al-Baha mountains

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Penicillin and streptomycin are the most commonly used to prevent bacterial infection or contamination in cell culture. However, the role of Penicillin-streptomycin on inducing mouse embryonic stem cells(mESCs) to differentiate into cardiomyocytes is unclear. To illustrate the mechanism of penicillin-streptomycin on inducing mESCs differentiation into cardiomyocytes, we firstly investigated mESCs differentiation into cardiomyocytes by the traditional method. The time- space expressions of cardiac-specific genes were detected by real-time PCR and western blotting at 8 different time-points over a period of 36 days. Furthermore, action potentials were measured by patch clamp for mESC-derived cardiomyocytes. Embryonic bodies through hanging drop method, were incubated with penicillin-streptomycin (P/S) at different concentrations (1×PBS, 1×, 2×, 5×), and then, the number of cardiomyocytes and expression levels of myocardial marker proteins were detected by flow cytometry, cellular immunofluorescence, and western blotting, respectively. We found that the SSEA-1 of mESC presented green fluorescence, and H.E. staining showed karyoplasmic ratio >>1. Besides, TNNI3, TNNT2, ACTN2 and MYL-2v were clearly visible by cellular immunofluorescence. Furthermore, the ACTN2 positive cells rate of 2× and 5× groups were remarkably higher than that in Cntl (1×PBS) group and 1× group (10 Units/mL penicillin; 10 μg/mL streptomycin), as well as the expressions of GATA4, MYL-2v, TNNI3, ACTN2

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Background: Limited data on large cohort of patients with malignant tumors of the scalp are available in the literature. The aim of this study was to review a large cohort of patients with malignant scalp tumors to determine epidemilogy, tumor characteristics of this region and treatment. Materials and Method: A retrospective review of patients with malignant scalp tumors diagnosed histopathologically between 2005 and 2021 was performed. Demographic features and tumor characteristics were analyzed. Results: A total of 1080 patients (M: F 3,5:1) were treated and followed up for a mean period of 42 months (12-120 months). Age at diagnosis ranged from 12 to 98 years. Most malignant scalp tumors (95,1%) occurred in those 50 years or older and in bald patients (87%). Basal cell carcinomas (59,2%), squamous cell carcinomas (32,2%) and melanomas were the most common histologic types. Incidence was highest on the frontal of temporal region (66,1%). Recurrence was frequently in squamous and basal cell carcinomas but uncommon in melanoma. Conclusions: Tumors of the scalp accounted about 8,01 % of all skin cancers. Tend to be basal and squamous cell carcinomas, many of which occur in the temporal and frontal region of bald men. The outlook for patients with scalp tumor is positive, although we suggest excision margins of at least 3-4 mm and continued clinical vigilance is warranted given their higher recurrence rates.

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Chronic pilonidal sinus disease, an acquired benign affliction too many across the globe but in the very few follows through to malignant transformation. We report an unusual case of a large squamous cell carcinoma arising from a chronic pilonidal sinus, its successful surgical excision and detailed documentation of wound healing with the assistance of a negative pressure wound therapy dressing. For large sacrococcygeal wounds we evidence that secondary intention healing via NPWT is a valid initial alternative to reconstructive surgery with a good cosmetic outcome and the option for early ambulation.

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This study aims at describing the CT imaging findings and role of multidetector computed tomography (MDCT) in evaluation of squamous cell carcinoma of buccal mucosa and its staging. The imaging findings in squamous cell carcinoma (SCC) of the oral cavity allow the radiologist to accurately determine the extent and staging of disease thereby help clinicians plan appropriate treatment.

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Huntington’s Disease is associated with motor behavior deficits that are lessened by few therapeutic options. This preliminary study tested if pharmacological inhibition of α/β-hydrolase domain containing 6 (ABHD6), a multifunctional enzyme expressed in the striatum, rescues behavioral deficits in HdhQ200/200 mice.

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To study the prevalence, clinico-pathological profile and survival outcome of oral squamous cell carcinoma in young patients (<40 years).

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The main objective of the present work was to study the population trend of the Seychelles scale, Icerya seychellarum (Westwood) (Hemiptera: Monophlebidae) on guava trees at Abu-Suwair district in Ismailia Governorate, Egypt during two consecutive years (2018-19). The results showed that insect population was recorded on guava trees all the year round and has three peaks of seasonal activity per year i.e., June, August/September and November.

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The wind instruments are the musical instruments most likely to cause oral lesions, because their use involves the involvement of anatomical structures of the oral and perioral cavity. The purpose of this literature review was to assess the impact of wind instruments on the oral condition of musicians. Scientific articles indexed in the databases Pubmed, Lilacs, Scielo, Cochrane and also in Google Scholar were evaluated. Publications from 1935 to 2020 were included and the following descriptors were applied: wind musicians and oral conditions, wind musicians and periodontal conditions, wind musicians and occlusal disorders.

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Hand-Foot-and-Mouth Disease (HFMD) is an epidemic childhood illness caused by enteroviruses including enterovirus A71 (EVA71), coxsackievirus A16 (CV-A16) and coxsackievirus A6 (CV-A6). This disease mainly affects children under 5 years of age, causing typical skin rash such as papulovesicular rash on the palms, feet, and mouth. However, atypical clinical signs may include eruption in others anatomic sites, palmar and plantar desquamation and onychomadesis. Severe complications including encephalitis, myocarditis or meningitis can occur.

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Tumours of the parapharyngeal space are rare (less than 1% of head and neck tumours). They are of various etiologies, but pleomorphic adenomas from the parotid gland, nerve tumours and paragangliomas of the vagus nerve account for more than two thirds of cases.

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Squamous cell carcinoma of the external auditory canal may masquerade as an infective process causing late diagnosis. A delay in treatment as a result of missed diagnosis would carry a poor prognosis as the disease progresses to an advanced stage. We present a case of a man with history of chronic otorrhea, who developed left sided otalgia associated with hearing loss. otoscopic examination shows a mass in her left ear and pus discharge which was initially treated as an infection. The biopsy of the mass was proven to be squamous cell carcinoma. High index of suspicion is necessary when encountering patients presenting with a mass in the ear canal with prior history of chronic otorrhea or cholesteatoma. Proper tissue biopsy is crucial. Early diagnosis is required for better prognosis for the patient.

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Candida, a commensal of the oral and the vaginal cavity, sometimes turns invasive, in immunosuppressed individuals. The resultant lesion, known as invasive or aggressive candidiasis, can be extremely refractory to treatment. This is a case report of an ulcero proliferative lesion in the hard palate that mimicked an intra-oral neoplasm. The clinical picture was confused by the fact that the patient was a chain smoker, and also because the initial MRI images were strongly suggestive of an invasive malignancy. When clinical and radiological signs exactly mimic a malignancy, the picture is confusing.

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This case report presents an unusual variant of generalized aggressive periodontitis that was managed by nonsurgical therapy which included the use of a novel tooth gel. Also, a brief review of the literature is offered as context for this unusual clinical case. The patient, a 40-year old Caucasian female, presented with advanced bone loss involving all teeth, intense inflammation of the attached gingiva and little obvious supra- or subgingival biofilm and dental calculus. Presence of systemic disease, high levels of periodontal microbial pathogens and IL-1α and IL-1β polymorphisms were evaluated and all determined to be negative. Gingival biopsy resulted in a diagnosis of nonspecific inflammation. Treatment consisted of 2- and 3-month intervals for periodontal maintenance appointments and eventually the introduction of an activated edathamil-based tooth gel. Over the subsequent 4-years the patient’s periodontal status stabilized as manifested by no further loss of tooth supporting bone, a reduction in the percentage of periodontal pockets of 4-6 mm depth and a reduction in the percentage of sites exhibiting bleeding upon periodontal probing. The significance of this case report is to emphasize that, even in cases of severe generalized aggressive periodontitis, nonsurgical periodontal therapy can be effective. In addition, it appears that a novel tooth gel containing activated edathamil is effective at reducing gingival inflammation with a concomitant reduction in percent of sites that bleed on periodontal probing.

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Squamous cell carcinoma of the gallbladder is rarely reported, comprises less than 1% of all gall bladder cancer and portends a worse prognosis than the more common adenocarcinoma. We report a 80-year-old female who presented with acute onset epigastric pain. She was operated on based on a presumptive diagnosis of acute on top of chronic cholecystitis with cholelithiasis according to clinical and ultrasonographic findings. Histopathological examination of the thickened wall of the gallbladder revealed well to moderately differentiated keratinized squamous cell carcinoma invading full wall thickness and infiltrating the liver. Further examinations revealed no other primary site for the tumour. Gallbladder cancer should be considered as part of the differential diagnosis in elderly patients presenting with cholecystitis.

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The collection of human odor volatiles is of interest to forensic applications as a path to investigate canine scent discriminations in legal investigations. A study using a selected array of previously identified human odor compounds has been conducted to determine the retention and release capabilities of five (5) natural and synthetic fabric types, cotton (mercerized fabric and gauze matrix), polyester, rayon and wool.

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