Articles Related to MS

Anaplasma marginale is the etiological agent of bovine anaplasmosis, one of the most prevalent tick-borne diseases of cattle in tropical and subtropical regions that causes significant economic losses to cattle industry. Cattle that survive infection remain persistently infected for life. Immunity against A. marginale infection seems to require both humoral and cellular mechanisms. Antibodies against A. marginale neutralize bacteria by interacting with Major Surface Proteins (MSPs). For this reason, MSPs are believed to be one of the best candidate antigens for vaccine development. Research carried out in the last few years has helped us to understand the antigenic composition of A. marginale and to develop new potential vaccine formulations. Desirable bovine anaplasmosis vaccine must induce protective immunity as well as prevent infection and transmission

View complete article: PDF  |  Full-text

Ameya Santhosh, Rani Alex, Vikas Vohra (2023) Comparative Assessment of De Novo Genome Assemblers for Generating Eukaryotic Primary Genome Assembly from Short Reads. J Comp Sys Bio 6(1): 101

View complete article: PDF  |  Full-text

A cross sectional survey on socio economic and health status among randomly selected rag pickers in the dump site of Mekelle city was done during 2020. The study showed that all rag pickers were 19 to 25 years old males; 60% of them were educated up to secondary level

View complete article: PDF  |  Full-text

Justificative: This trial was conducted in order to register a new generic product of Rivaroxaban. Objective: To evaluate the bioequivalence of rivaroxaban formulations manufactured by Eurofarma Laboratórios S/A and the reference drug, Xarelto (Bayer) under fasting and fed conditions. Methods: Three randomized, open label, balanced, 2 treatments, 4 periods, 2 sequences, single dose, full replicate, crossover studies in 48 healthy adult human subjects under fed and fasting conditions for rivaroxaban 10 mg and 20 mg. Rivaroxaban concentrations in plasma were determined using a validated HPLC-MS/MS method.

View complete article: PDF  |  Full-text

Covid-19 caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which hit the world in December 2019 is one of the worst medical emergencies people have ever encountered. Human angiotensin I converting enzyme 2 (ACE2) is the entry path of this virus to the host that regulates the renin-angiotensin-aldosterone system (RAAS). Hypothesis: Susceptibility to SARS-CoV-2 infection may be affected by ACE rs4646994 and ACE2 rs2285666 polymorphisms.

View complete article: PDF  |  Full-text

The transdermal drug delivery system is technique that provides drug through the intact skin. Skin penetration enhancement techniques have been developed to increase the bioavailability of drug substance. These review describes various transdermal patches available in market, types of patches, basic components, polymer used in formulation. The novel drug delivery method do well and complete with those already on the market the main problem that requires consideration include device design and safety, efficacy, ease of handling and economical. Transdermal drug delivery system represent the most attractive method among these because of its low rejection rate, magnificent, ease of administration and better convenience and compliance with patient. This review article provide an overview of transdermal drug delivery system contains various innovative dosage forms. In comparison transdermal patch are effective due to its easy to apply and non-invasive.

View complete article: PDF  |  Full-text

Despite Taiwan’s title as one of the most efficient recycling systems, individual recycling habits contribute to these efficient recycling systems. Despite Taiwan’s successful strategy of demolishing waste through incineration, improper recycling at a grassroots level, such as students’ municipal solid waste recycling habits, result in recycling contamination, and improper waste recycling could lead to the release of toxic fumes into the atmosphere. This study compares the recycling practices and recycle bin setups of a public school and a private international school to determine important factors that could contribute to decreasing waste recycled improperly. The results show that immediate feedback if a student recycled improperly as well as clear recycling signs were essential factors to decrease recycling mistakes.

View complete article: PDF  |  Full-text

Matrix-assisted laser desorption/ionization time of flight mass spectrometry (MALDI-TOF MS) has become a widely used technique for the rapid, accurate, durable, economical, and trustworthy method for identification of bacteria, mycobacteria and fungal pathogens in the microbiology laboratory.

View complete article: PDF  |  Full-text

Objective: The purpose of this study was to compare the bioavalability between the two 80 mg Valsartan Tablets formulations and to evaluate the bioequivalence of Reference and Test formulations of Valsartan Tablets 80 mg in Healthy adult chinese Male and Female subjects under Fasting and Fed condition.

View complete article: PDF  |  Full-text

This paper covers the validation and measurement uncertainty evaluation of an ICP-AES method for bismuth mass fraction determination in bismuth sulfide thin films. Plasma view at radial mode and the wavelength were monitored for bismuth at 223.061 nm. Following AFNOR (Association Française de Normalisation) Norm NFT 90-210 (2009), a regression equation was calculated using single element bismuth standard solution prepared in the same matrix as samples. The linear range was between 0.2 and 2.0 mg L−1. Limits of detection (LOD) and quantification (LOQ) were calculated as 0.03 and 0.12 mg L−1, respectively. Recovery percentages were ranging between 91 and 109 %. Accuracy was found to be adequate. Estimated expanded uncertainty according to both GUM and EURACHEM guides was 3.1 %.

View complete article: PDF  |  Full-text

The term mucoadhesion can be defined as a phenomenon of interfacial molecular attractive forces in the layer of surface of a biological membrane and the natural or synthetic polymer, which allows the polymer to the adhere the surface of that membrane for an extended as well prolonged period of time. Since the last four decades, the conception of mucoadhesion has achieved a important precious interest in the various fields of pharmaceutics

View complete article: PDF  |  Full-text

The Government of Ghana recognizes the importance of wetlands as a habitat for wildlife, in the maintenance of the water table, mitigation of flood conditions, and water purification. Wetlands resources are also known to be of socio-economic importance and have been harvested for construction poles, fuel-wood, timber for furniture, and craftwork

View complete article: PDF  |  Full-text

View complete article: PDF  |  Full-text

Aim: Palm oil processing generally generates lots of wastewater (palm oil mill effluent), this is usually discharged into the environment in the untreated form and subsequently causes several environmental issues. There is therefore need to isolate microorganisms that can be used to clean up the palm oil contaminated environment especially the soil. Methods and Results: Palm oil contaminated soil was obtained from Oba Adeyemi palm oil mill in Oyo, Oyo State, Nigeria, other soil samples which were purposely contaminated with palm oil, were obtained from Ajayi Crowther University Oyo, Oyo State. Isolation, characterization and identification of microorganisms were carried out using morphological and biochemical characterization. The isolates were preliminarily screened for lipolytic activities, this was confirmed by growth on the mineral salt medium after 7 days, signifying hydrolysis. One of the prominent isolates was further identified by sequences analysis of 16S rRNA genes. Forty-one bacterial isolates were identified, which included species of Bacillus (80 %), Pseudomonas (20 %) in the oil mill contaminated soil sample and Bacillus spp. (100 %) in the purposely contaminated soils. Twenty-nine fungal isolates including species of Aspergillus, Oidiodendron, Geotrichum, Penicillum, Saccharomyces were isolated with Aspergillus fumigatus having the highest frequency of occurrence (37.5 %) in artificially contaminated soil and Saccharomyces spp. having the highest frequency of occurrence (91 %) in palm oil contaminated soil from the palm oil mill. Sequencing of the 16S rRNA of one of the prominent isolates showed that it was identified as MN607220 Saccharomyces cerevisae. All the bacterial and fungal isolates had lipolytic activities except Bacillus mycoides and Oidiodendron sp. respectively. Nine of the ten Saccharomyces sp. had lipolytic activities. Conclusion: These screened organisms could therefore be employed for the cleanup of palm oil contamination in the environment. Significance and Impact of Study: Thereby ridding the environment of possible toxic effects especially in areas of need like Malaysia

View complete article: PDF  |  Full-text

Many students suffer from the sound of air conditioners and others suffer from light intensity in classroom. The air conditioners and light intensity affect the efficiency and quality of education. Urduino is used a lot in industrial areas because there is a lot of noise pollution. Additionally, it can be used in high traffic regions as well as to monitor noise in different parts of the city. It can also be used in education systems to monitor the noise in classrooms. The purpose of this study was to monitor the noise in classrooms by Arduino Nano that interfaced with a Sound Sensor. A study was conducted to determine the ambient sound and light intensity of a convenience sample at school during September, October and November 2021. Six classrooms’ samples corresponding to hourly fractions of the average sample broken down into the following periods: from 10:00 am to 2:50 pm. Sound levels were measured to assess acoustic conditions. Light levels were measured to assess light conditions. Each classroom from 1 to 6 was tested the ambient sound intensity and light using an Arduino. Noise varies with time and place. The sound level varies between 27.5 dB and 65 dB with the average sound level in the classrooms was 43.53 dB greater than recommended sound level limit of 35 dB. The light intensity varies between 62.50 lux and 208.5 lux. The average light levels around the recommended 300 lux. Everyone emphasized the quality of using the device to measure the noise level in the classroom. The use of the device leads to monitor the noise of the air conditioner or replacing it. The device has the potential to significantly change the noise pollution monitoring system at school. Researchers recommend all students and authorities the importance of the Arduino.

View complete article: PDF  |  Full-text

The results are presented of obtaining anodic aluminum oxide with an ordered pore arrangement by employing two anodizing modes - galvanostatic mode and combined (galvanostatic + potentiostatic) mode, at high values of the current density and voltage. Use has been made of an oxalate electrolyte and a complex electrolyte comprising oxalic acid and phosphoric acid. Scanning electron microscopy has been used to investigate the surface morphology of the barrier and porous layers and to determine pore sizes and inter-pore distance.

View complete article: PDF  |  Full-text

Self-organized anodic porous alumina films with hexagonal pore lattice have attracted a considerable attention for biological arrays and confinement of various organic probes dyes in solutions. A molecular structure with axial symmetry in bis-heterocyclic indole chains and conjugate system, such as cyanine fluorophore Cy3 dye, was investigated here with respect to its fluorescence when loaded in the anodic alumina pores.

View complete article: PDF  |  Full-text

Two basic reactions occur during the anodizing of aluminum: 1) the aluminum is consumed and 2) an oxide grows. By accepting this statement as true, the anodizing process can be viewed as a corrosion process, and anodizing can be modeled using the Tafel Equation. Anodizing process parameters of electrolyte chemistry and concentration, temperature, aluminum substrate resistance and current density are presented as they relate to the Tafel Equation and how they impact the anodic aluminum oxide structure and properties. Understanding this relationship is consequent in making anodizing an engineering process, one that enables tuning the structure such that it yields distinct characteristics to fulfill design and application requirements.

View complete article: PDF  |  Full-text

Human odor detection technologies have drawn attention due to the wide possibility of potential applications they open up in areas such as biometrics, criminal investigation and forensics, search for survivors under rubble, and security checkpoint screening. Gas chromatography/mass spectrometry (GC/MS) has been the most successful and powerful analytical approach developed to date for human odor analysis, and hundreds of human odorants have been identified using this tool.

View complete article: PDF  |  Full-text

Carbon nanotube (NT) based electronic vapor sensors were tested against synthetic sweat solutions, consisting of 13 volatile organic compounds (VOCs) in saline, in order to probe the device ability to analyze and differentiate vapors derived from complex biological samples.

View complete article: PDF  |  Full-text

The collection of human odor volatiles is of interest to forensic applications as a path to investigate canine scent discriminations in legal investigations. A study using a selected array of previously identified human odor compounds has been conducted to determine the retention and release capabilities of five (5) natural and synthetic fabric types, cotton (mercerized fabric and gauze matrix), polyester, rayon and wool.

View complete article: PDF  |  Full-text

The anodization of aluminum foils having micrometer thickness is a common process and results in hexagonally self-ordered alumina membranes. However, anodic aluminum oxide (AAO) membranes fabricated from nanometer-thin films present new challenges to the anodization process, since aluminum films adheres poorly on supporting substrates and the smoothness of the film is highly related to the kind of substrate.

View complete article: PDF  |  Full-text

Anodisation of pure titanium has been carried out in sulphuric and in phosphoric acid solutions at potentials ranging from 50 to 150V. The SEM and AFM morphological analysis indicates that, within this potential range, oxidation in sulphuric acid solution produces better developed mesoporous oxide layers.

View complete article: PDF  |  Full-text

We investigated a method for preparation of ordered nanopore arrays with the interpore distance of 60 nm by guided self-organization of anodic aluminum oxide with a prepatterned array of pits in the starting Al film.

View complete article: PDF  |  Full-text

The design of an electrochemical reactor for the preparation of self-supported comparatively thin (up to 10 μm) and large area (up to 50 cm2) anodic alumina membranes is described allowing growth of porous alumina at high applied potential (up to 150 V) without burning.

View complete article: PDF  |  Full-text

Vertical Cu2ZnSnS4 (CZTS) nanowire arrays have been synthesized via two-step electroplating method into anodized aluminum oxide template. For deposition of CZTS nanowires, anodized aluminum oxide (AAO) was used as the growth mask for the growth of the nanowires. AAO templates with hole sizes of 70 nm in diameter were used in the experiments.

View complete article: PDF  |  Full-text

Anodic aluminum oxide doped with vanadyl citrate chelate complex anions was formed by a two-step self-organized anodization in 2 wt. % sulfuric acid containing 0.04 M V2O5 and 0.08 M citric acid at voltage range 13-23 V, and at 0 and 15 oC. The combination of two temperatures and at least four voltages (depending on the applied temperature) was applied as the operating conditions of anodization.

View complete article: PDF  |  Full-text

In this paper, we report on the synthesis of BaTiO3 nanowires via the anodic aluminum oxide template method. To fill in the precursors of BaTiO3 into anodic aluminum oxide templates, the vacuum and drop loading method developed in our previous study was used. Ba(CH3COO)2 (barium acetate) and C12H28O4Ti (tetraisopropyl orthotitanate) were used as Ba and Ti sources, respectively. Anodic aluminum oxide membranes with the through-hole diameter of ~200 nm were used as the template for BaTiO3 nanowires.

View complete article: PDF  |  Full-text