Articles Related to Nerve injury
Investigation of Neuroprotective Effects of Ripasudil in Mechanic Optic Nerve Injury Model
Purpose: We aimed to create mechanic optic nerve injury model in rats and investigate the neuroprotective effects of
ripasudil on retinal ganglion cells.
Study Design: Experimental study
Methods: Mechanic optic nerve injury model was created in the right eyes of male Wistar rats (n=15). Rats were divided
into three groups: glaucoma model with sham treatment (group1) and 20 µM intravitreal ripasudil treatment (group 2)
and 50 µM intravitreal ripasudil treatment (group 3). Treatment was applied intravitreally and rats were sacrificed at the
end of 4 weeks. Glial fibrillary acidic protein (GFAP), Brn-3a antibody,anti- Iba1 was examined by immunohistochemistry.
Results: The number of Brn-3a positive RGC in the mechanical optic nerve injury model was 5.33 ± 2.08 (min: 3, max: 7)
in sham group, 10.25 ± 2.63 (min: 8, max: 14) in 20 µM group and 16.75 ± 5.43 (min:9, max: 21) in 50 µM group (p <0.05).
GFAP positive RGC counts were recorded as 24.33 ± 2.08 (min: 22, max: 26) in sham group, 16.75 ± 1.70 (min: 15, max:
19) in 20 µM group and 13.00 ± 4.08 (min:10 , max: 19) in 50 µM group (p <0.05). Ripasudil treatment also decreased Iba1
expression in the retina of mechanic optic nerve injury groups. In addition, ripasudil treatment prevented apoptotic cell
death by increasing Bcl-xL protein expression and preserved Tfam protein expression in the retina.
Conclusions: Our experimental study has shown that ripasudil is neuropreotective in mechanical optic nerve injury
model.
Proximity of the Sciatic Nerve in Relation to the Posterior Approach to the Hip, and its Relationship to Femoral Head Size
The posterior approach to the hip joint involves operating in close proximity to the sciatic nerve. Iatrogenic injury to the sciatic nerve has been reported to occur in 0.6 - 1.9% of cases [1]. Stretching, transection or suturing of the nerve may occur during access or while closing the capsule and short external rotators to the hip.
