The currently available anti HIV agents have several drawbacks such as short half life, low bioavailability, poor CNS penetration and
retention, hepatic first pass metabolism, undesirable side effects and frequent dosing regimen.
The development of effective drug delivery approaches for the treatment of AIDS and HIV infection is a global challenge. The advent
of multidrug, highly active antiretroviral therapy (HAART), have increased the life span of HIV-infected patients.