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Articles Related to Osteogenesis imperfecta

Atypical Femur Fracture Nonunion in a Patient with Osteogenesis Imperfecta

Here, we present a 43-year-old male with osteogenesis imperfecta (OI) with previously placed intramedullary growing rods that sustained an atypical femur fracture (AFF) following long-term bisphosphonate use. He additionally experienced a non-traumatic ipsilateral femoral neck fracture that was successfully managed with operative stabilization. Despite previous reports following successful conservative management for AFF in patients with OI, nonunion developed requiring osteotomy and surgical stabilization.
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Descriptive Study of Exposure to Inhalation Zanamivir and Pregnancy-Related Outcomes

The Health Improvement Network (THIN) provided data from UK General Practitioners (GPs) for 144 pregnant women who were prescribed zanamivir and 144 age- and date-matched untreated comparators with no recorded diagnosis of influenza. Groups were assessed for baseline characteristics, treatment-emergent diagnoses in the mother, pregnancy outcomes and congenital malformations diagnosed in the offspring within 28 days of birth.
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