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Articles Related to PEP

Monoclonal Antibodies for the CIGB-552 Antitumor Synthetic Peptide Quantification

The CIGB-552 peptide is a synthetic peptide that exerts cytotoxic effect on tumor cells. Thus, CIGB-552 peptide quantification in patient samples is crucial for assessing the treatment efficacy. Therefore, this study describes the generation and characterization of monoclonal antibodies (mAb) directed against the CIGB-552 peptide to be used in a quantification assay in further pharmacokinetic studies in humans. In this sense, the CIGB.552-H294 mAb specificity was evidenced only against the CIGB-552 peptide and a metabolite of 17 amino acids resulting from the CIGB-552 peptide degradation detected in mouse sera.
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Proteomic Analysis in Response to Germination in Ceiba pentandra (Kapok) Seeds

1-D, 2-D gel electrophoresis, mass spectrometry and bioinformatics analysis were established and utilized to examine the changes in protein expressions associated with germination of Ceiba pentandra seeds.The change in protein pattern was analysed by 1-D and 2-D gel electrophoresis for better separation and to ascertain the pattern of protein mobilization during germination.
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Immunogenicity of Multiple Antigenic Peptides (MAP) Based on B and T cell Epitopes of E2 Glycoprotein of Chikungunya Virus in Murine System

Chikungunya is a viral disease caused by positive sense single stranded RNA virus. High fever, myalgia, arthralgia, body rashes are the characteristic features of Chikungunya transmitted by Aedes mosquitoes. We aim to demonstrate that dominant epitopes of envelope E2 protein can be used for diagnostic purposes as well as vaccine design. Multiple Antigenic Peptide (MAP) approach was used based on B and T cell epitopes of E2 protein. Humoral and cell mediated responses were studied in outbred and inbred H-2d mice. Different groups of mice were immunized intramuscularly with or without adjuvant (CpG ODN and murabutide) in PLGA microspheres. MAP entrapped in microspheres with CpG ODN showed highest IgG peak titer (2,98,000) with IgG subclass, mostly IgG2a/2b distribution. MAP’s antisera showed significant immunoreactivity with individual peptides. During thymidine incorporation assay for T cells, all the MAPs showed high lympho-proliferative response. Cytokine profile was dominated by Th1 and Th17 response. Thus, all the MAPs showed high humoral and cell mediated response with CpG/ murabutide adjuvant. MAP’s antisera showed significant in vitro neutralization of CHIKV strain in vero cells.
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Gingival Stimulation: An Important Metabolic Regulator?

This study aimed to determine whether a relationship exists between gingival stimulation and the levels of leptin, ghrelin, insulin and glucose, which are important regulators of energy homeostasis. Blood samples for ghrelin, leptin, glucose and insulin were taken from 15 male volunteers (mean age 25.5±2.3 years; mean body mass index 24.4±2.79 kg/m2), who did not brush their teeth for one day, after a 12 h-long overnight fasting and before standard breakfast (0 min) and thereafter at 30, 60, 120 and 180 min after breakfast. After toothbrushing after dinner and after a 12 h-long overnight fasting, blood samples were taken again before standard breakfast (0 min) and then after at the same time points following tooth brushing.A significant reduction was found in the leptin levels measured at 0, 30, 60, 120 and 180 min after tooth brushing (p < 0.005). The ghrelin levels also declined at these time points but were significant at 0, 30 and 120 min (p < 0.05). Despite the reduced insulin levels at 120 and 180 min after tooth brushing (p < 0.05), no significant change was observed in the glucose levels.
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Biological Effect Tetra-Branched Anti-TNF-Peptide and Coating Ratio-Dependent Penetration of the Peptide-Conjugated Cerium3/4+ Cation-Stabilized Gamma-Maghemite Nanoparticles into Rat Inner Ear after Transtympanic Injection Visualized By MRI

Jing.Zou@staff.uta.fi
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Field Evaluation and Use of a Non Commercial Peptide Enzyme Immunoassay for Human Immunodeficiency Virus Serotyping in Abidjan (Ivory Coast)

In West Africa, where Human Immunodeficiency Viruses 1 and 2 (HIV-1 and HIV-2) co-circulate, serological assays allowing the reliable serotyping of HIV infection are needed.
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Targeted Killing of Streptococcus mutans in Biofilms by a Pheromone Guided Antimicrobial Peptide HP30

Streptococcus mutans is a leading cariogenic pathogen of dental caries worldwide. Clinically, eliminating S. mutans from dental biofilms using antibiotics is not practical, because these agents indiscriminately kill other members of the resident flora, leading to ecological disruption and other negative clinical consequences. To develop target-specific antimicrobials, we evaluated several fusion peptides and identified a new peptide HP30 that showed a high selectivity for targeted killing of S. mutans.
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Small-Intestinal-Bacterial-Overgrowth-in-Children-with-Functional-Dyspepsia-and-Duodenal-Ulcer-Disease

Helicobacter pylori (HP) infection is present in more than the half of the world population. Most individuals are infected during early childhood; in developing countries, 50% of children are infected by the age of 5 years [1,2]. Studies suggest the main etiological role of HP infection in development of chronic gastroduodenal pathology and the formation of its most severe forms in patients of different age groups. However, not all infected people exhibit diseases associated with this bacterium. In addition, pathogenic mechanisms of duodenal ulcer disease (DUD) in childhood remain not fully understood.
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Community Perception towards Traditional Healers and Health Centers on Management of Dog Bites and its Relation with Veterinary Public Health Activities

A survey was conducted to investigate whether the community uses traditional healers or modern health centers after exposure to dog bites and veterinary public health responses on the issues in Arba Minch, Ethiopia. Two stage cluster and simple random sampling procedures were employed to select inhabitants and other target study population for this study.
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Nuts and Body Weight - An Overview

Since obesity and overweight became health issues, tree nuts became considered as unhealthy, due to their high fat content. Their high energy density has been pointed as a major factor in body weight gain.
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Adipogenesis in Obesity is Modulated by IP6 in Peanuts through Activation of the Nuclear Receptors (PPARs)

Increased life style changes have led to global epidemic of obesity. The global prevalence of obesity protracts to increase, with devastating consequences for overall health. Thus by exploring novel beneficial properties of natural products and their scientific indications are the need of the hour and can bring about a whole new revolution in nutraceutical industries and health care sectors.
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Stability Analysis of Human Islet Amyloid Polypeptide and Its Mutated Oligomeric Forms

Human islet amyloid polypeptide (hIAPP), a 37 residue peptide hormone is an ingenious factor in pancreatic amyloid deposits found in cases with type-2 diabetes. Its aggregation into small toxic oligomeric species is presumed to be the reason for cells debilitation and demise in case of diabetic patients.
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In Vitro Models to Study Candida Albicans Biofilms

Biofilm is a common mode of fungal growth in clinical infection and Candida albicans is one of the species that are the most frequently associated with biofilm infection which has a significant impact on morbidity and mortality. In the mode of biofilm, C. albicans tends to display high resistance to body immunity and antimicrobial agents.
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Effects of Pioglitazone on the Electrocardiogram in the Goto-Kakizaki Type 2 Diabetic Rat Heart

Cardiovascular complications are the major cause of morbidity and mortality in diabetic patients. Pioglitazone (PIO) is used for the treatment of type 2 diabetes mellitus and there is some evidence that it may improve ventricular function in diabetic patients.
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Review on Pharmacological Activities of the Peptides from Scorpion Buthus Martensii Karsch

In China, the scorpion Buthus martensii Karsch is used as functional food and medicinal materials. The scorpion, scorpion venoms and their extracts are effective in treating a variety of nervous system diseases such as epilepsy, apoplexy pains and facial paralysis.
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Editorial Board Members Related to PEP

Bakhtiar Affendi Rosdi

Senior Lecturer
School of Electrical and Electronic Engineering
Universiti Sains Malaysia
Malaysia

Jack Ho Wong

School of Biomedical Sciences
Chinese University of Hong Kong
Hong Kong

Fa-Yun Che

Associate Professor
Department of Pathology
Albert Einstein College of Medicine
United States

Frank Portugal

Associate Professor
Department of Biology
The Catholic University of America
United States

Alireza Jahan-mihan

Assistant Professor
Department of Nutrition and Dietetics
University of North Florida
United States

JOHN EVANS

Professor
Department of Obstetrics and Gynaecology
University of Otago
New Zealand

TIMUCIN UGURLU

Associate Professor
Department of Pharmaceutical Technology
Marmara University
Turkey

Ngai Sai Ming

Associate Professor
School of Life Sciences
The Chinese University of Hong Kong
Hong Kong

Anuradha Ratna

Department of Medicine
University of Massachusetts Medical School
USA

ASIF ALI

Assistant Professor
Academy of Scientific & Innovative Research (AcSIR)
India
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