Articles Related to PPH
Assessment of Antioxidant and Antineoplastic Activities Blumea Lacera (Burn. F) Leaves
Blumea lacera (Burn. f.) DC. (Family: Asteraceae) is an important member of Bangladeshi natural plant resource and it is an herbaceous weed locally known as Kukursunga. Different parts of this plant are used traditionally to cure various diseases. But detail study on the antioxidant and antineoplastic potentials of Blumea lacera leaves, has not yet been done. Aim of this study is to examine the antioxidant and antineoplastic properties and quantify the different type of phytochemical content of the methanolic extract of leaves of Blumea lacera (MELB). MELB contained a rich polyphenol, flavonol, flavonoid and proanthocyanidins. MELB showed moderate cytotoxic effect against Artemia salina (brine shrimp nauplii) where its LD50 values was 66.12 μg/ml. In vitro antioxidant assay, MELB exhibited a remarkable capacity to scavenge the tested reactive species. MELB scavenged DPPH with an IC50 of 33.64 μg/mL and 42.69 μg/mL, respectively. In vivo antineoplastic assay, MELB significantly (P<0.05) decreased viable cell count and increased the survival time of EAC cell bearing mice. Hematological profiles were also restored significantly (P<0.05) to normal levels in MELB treated mice as compared to untreated EAC control mice. In addition, fluorescence microscopic view of EAC cells derived from MELB-treated group showed apoptotic characteristics in treated cells compared to untreated EAC control. our findings suggest that methanolic extract of Blumea lacera leaves(MELB) might be a potential agent with antioxidant properties for prevention of cancer and has the merit for further investigation in isolating its active constituents.
A Novel Neuroprotective and Antioxidative Efficacy of a Unique Combination of Standardized Huperzia serrata, Convolvulus pluricaulis and Celastrus paniculatus Extracts
Physical and environmental stress in conjunction with hectic lifestyle and unhealthy food habits are the major cause of diverse neurodegenerative disorders. Oxidative neuronal injury and acetylcholine deficiency have a major impact on learning and memory retention. Most of the treatment strategies are based on the improvement of cholinergic function in the brain and one of the emerging therapeutic targets is to enhance the acetylcholine level in the brain. Standardized botanical extracts including Huperzia serrata (1% Huperzine A, CogniUp), Convolvulus pluricaulis (SP) and Celastrus paniculatus (JY) have been demonstrated to attenuate brain function by serving as a natural acetylcholinesterase (AChE) inhibitor.
Management, Clinical Course and Treatment Outcome of Postpartum Uterine Atony
By reporting a case series from a referral hospital we aimed to determine the treatment options and outcomes of one of the serious complications of the labour uterine atony refractory to the medical treatment. In this study, a total of 58 postpartum uterine atony cases refractory to uterotonic treatment and managed with intrauterine balloon tamponade, B-Lynch suture, internal iliac artery ligation or hysterectomy was a retrospectively analyzed. Initially, thirty two cases managed with intrauterine Bakri balloon tamponade and six B-Lynch compression sutures alone, in eight cases both procedures were done together. Eight cases managed with internal iliac artery ligation and four hysterectomies. Our success rate with intrauterine Bakri balloon tamponade, B-Lynch compression suture and internal iliac artery ligation were 84.4%, 83.3%, 75% respectively in stopping postpartum haemorrhage regarding uterine atony and the most successfull rate was obtained with the Bakri balloon tamponade in the combination with B-Lynch compression suture 87.5%. The median estimated blood loss was 2018ml, intraoperative median hemoglobin was 5.8 mg/dl and the median amount of blood transfused was five units, the median volume
infused into balloon was 285ml; balloon was in place for a median duration of 36 hours. In 6 cases Bakri balloon tamponade with or without B-Lynch compression sutures failed to stop haemorrhage and hysterectomy required. In two patients Asherman’s syndrome and infertility, in two patients’ amenore were developed and uterine prolapse was observed in 2 patients, one of which was uterine necrosis. No maternal mortality was observed.
Phyto-Nutrient Diversity in Morinda Citrifolia L. Genotypes of Andaman Islands, India
The Indian mulberry or Noni (Morinda citrifolia L.) is one of the emerging sources of natural antioxidants for herbal and pharmaceutical industry. The genus Morinda has more than 150 species in which M. citrifolia is identified as most important for health and economic point of view. Present study revealed significant (p < 0.05) diversity in 33 genotypes of M. citrifolia from Andaman and Nicobar Islands (India) for phyto-constituents. The promising genotypes viz. FRG-14, JGH-5, TRA-1, TRA-2 and HD-6 were identified for commercial uses. Correlation analysis in M. citrifolia germplasm showed strong correlation between carotenoids and ascorbic acid (r2 =0.973; p<0.05), tannin (r2 =0.598; p<0.05), flavonoids (r2 =0.691; p<0.05) and phenol (r2 =0.598; p<0.05). The genotypes showed wide range for antioxidant capacity which showed positive correlation with carotenoids (r2 =0.335; p<0.05), flavonoids (r2 =0.249; p<0.05) and Cu (r2 =0.953; p<0.05), Mn (r2 =0.953; p<0.05) and Mg (r2 =0.582; p<0.05). The diversity analysis is useful for designing breeding strategies for phyto-nutrient rich genotypes for better recovery in health products.
Effects of Oxytocin and Carbetocin on Haemostatic Variables in Pregnant Women after Cesarean Section
Uterine atony is the first cause of haemorrhage at delivery. To prevent post partum major bleeding uterotonic prophylactic drugs are commonly used after caesarean section. Few studies showed an haemostatic activation after oxytocin infusion while no data are available on carbetocin.