Articles Related to Paroxysmal
Late Cerebellar Vermis Metastasis of Breast Cancer Presenting as Pseudo-Benign Paroxysmal Positional Vertigo
Benign paroxysmal positional vertigo (BPPV) is a common peripheral vestibular disease; however intracranial lesions can mimic it. Intractable, not self-limiting paroxysmal positional vertigo sustained by intracranial tumors is called malignant paroxysmal positional vertigo (MPPV) while, when radiological imaging shows vascular cerebellar vermis lesions and there are atypical findings on the Dix-Hallpike maneuver, we speak about pseudo-benign paroxysmal type (pseudo-BPPV).
Chromosomal Aberrations and HMGA2 Expression in Paroxysmal Nocturnal Hemoglobinuria
Somatic, inactivating PIGA mutations in haematopoietic stem cells, followed by an unknown autoimmune selection process in favor of
the mutated clone, are thought to be important events in the pathogenesis of paroxysmal nocturnal hemoglobinuria (PNH). Recently,
a second clonal event involving the HMGA2 gene was reported in some PNH cases, and over expression of this gene was postulated to
promote proliferation of the mutated clone.
Vasculitis Associated with Chronic Lymphocytic Leukemia
A patient is present who has chronic lymphocytic leukemia (CLL) and developed a vasculitis involving the skin and large vessels along with immune complex mediated glomerulosclerosis. Both vasculitis and immune complex nephritis are rare manifestations of CLL.