Articles Related to Patient
Sigmoid Vaginoplasty in Patient with Complete Androgen Insensitivity: Technique and Outcomes
Androgen Insensitivity Syndrome (AIS), also known as testicular feminization, is a rare medical condition that has garnered increased attention in recent years due to evolving research and therapeutic approaches [1,2], as well as the psychological repercussions it has on patients and the risk of being associated not only with sex cord–stromal tumors but also with rare mesenchymal tumors [3]. AIS results from anomalies in the X chromosome and leads individuals with an XY genotype to exhibit various degrees
of female physical traits or complete feminine characteristics
Effect of “BEAUTYCOFFEE” on Body Weight A Pilot Study in Patients with Obesity
Background and Aims: Obesity and overweight are associated with a wide spectrum of morbid conditions, which contribute to high prevalence of disability and mortality worldwide. These conditions include the metabolic syndrome, cardio--
vascular and cerebro-vascular events, and fatty liver disease with the possible deterioration to liver fibrosis, cirrhosis and malignancy. Despite the wide variety of treatment options available, which include lifestyle modifications and medical and surgical interventions, obesity is still considered a worldwide pandemic, necessitating the search for additional treatment options. As caffeine exerts weight-reducing properties, we here studied the effect of Beautycoffee, a dietary supplement composed of black and green coffee arabica, together with herbal compounds, believed to be effective towards decreasing body
weight.
Assessment of Changes in Clinical Management of Cervical Cancer Patients in Light of New Staging Criteria
Objective: To assess the changes in the Current clinical management of cancer cervix patients as the new staging considers
radiological and pathological criteria for cervical cancer staging.
Methods: This retrospective study Retrospective collection of the Data from the medical records.
Results: Five hundred and nine Patients were registered for cervical cancer from Jan 2019 to December 2021. The average
age of patients treated was 53yrs. The patients' age distribution ( Table 2 ) was Less than one percent of patients below 30yrs,
31.4 percent, and 40.6 percent were in the 50 to 60 yrs range
A Case Report of Rapidly Progressing Amyotrophic Lateral Sclerosis in 31 Year Old Patient with Sympathovagal Imbalance
ALS is a fatal neurodegenerative condition characterized by degeneration of upper and lower motor neuron in cerebral cortex, cranial nerve nuclei and anterior horn cells of spinal cord. Three drugs are FDA approved, Riluzole, Edaravone and
AMX0035 (recently approved), which can only prolong survival time by 2-3 months.
Study to Find Clinical Characteristics of ABPA in Patients of Severe Bronchial Asthma and Its Relation with Serum Ige Level at Teriary Care Center North India
Allergic bronchopulmonary aspergillosis (ABPA) is an idiopathic inflammatory disease of the lung, characterized by an allergic inflammatory response to colonization of the airways by Aspergillus fumigatus or other fungi. Untreated
or inadequatetreatment may lead to poor outcome in patients. Raised level of serum IgE of more than 1000 IU/ML have
been considered as one if theimportant diagnostic criteria for ABPA, however relation of serum IgE withs severity ofdiseases is lacking. This study was conducted to find out level of serum IgE in patients ofABPA and to find out corelation of
Serum IgE with duration of symptoms and diseasesseverity.
Comparative Assessment of Chest X-ray Interpretations by AI Model and Radiologist Vs Pulmonologist in Predicting the Clinical Status of Covid-19 Pneumonia Patients
Pneumonia is most prevalent and acute respiratory disorder. Chest radiography is the gold standard to confirm
the clinical condition and the progress. The use of AI in diagnostic workflow proved to be useful. In this study, quantitative
assessment by the AI device is compared with the qualitative assessment by the radiologists.
Adherence to Antiretroviral Medication and Factors Affecting it Among HIV-- Positive Patients Receiving it at Adama General Hospital
Before the development of highly active antiretroviral medication, AIDS and related illnesses caused a great deal of suffering and death. All of the AIDS-related morbidities and mortality have considerably decreased thanks to modern medication, especially in industrialized nations. However, this accomplishment is still elusive in underdeveloped nations, particularly in those in sub-Saharan Africa. This failure can be attributed to a number of factors. Poverty, ignorance about the treatment, and inadequate therapy adherence are at the top of this list.
GMP-Compliant Production of a Fluorescent Antibody for in vivo Molecular Endoscopy in a Phase I/IIa Clinical Study in Inflammatory Bowel Disease Patients
Therapeutic response to anti-TNF antibody treatment in inflammatory bowel diseases is strongly influenced by transmembrane tumor necrosis factor (mTNF) expression in the intestinal mucosa. Fluorescent anti-TNF antibodies applied for in vivo molecular endoscopy have shown to be able to quantify mucosal mTNF expression in real-time and predict response to subsequent anti-TNF treatment in individual patients with Crohn’s.
Stroke Mimics: Diagnosis and Management of Patients with Suggestive Clinical Manifestations of Ischemic Stroke
Background and Purpose: Ischemic stroke is a treatable medical emergency. The diagnosis of stroke is mainly clinical and not always so obvious. Intravenous thrombolysis treatment with altepase IV and endovascular treatment have been proved as fist-line beneficial options for eligible patients who have acute ischemic stroke. However, approximately 30% of patients who experience an acute neurological deficit compatible with ischemic stroke fall into the category of "stroke mimics"
A rare case of levofloxacin-induced fatal hypoglycemia in a non-diabetic patient with the review of literature
Levofloxacin, a broad-spectrum, third-generation fluoroquinolone antibiotic, is rarely reported to cause life-threatening adverse effects, such as severe hypoglycemia resulting in coma. We report a rare case of hypoglycemia in an elderly non- diabetic patient induced by levofloxacin. A 61-year-old male patient was admitted with severe hypoglycemia. His past medical history revealed treatment with levofloxacin for pneumonia.
Short-Term Usage Time and Rate of CPAP Predict Long-Term CPAP Adherence in Patients with Obstructive Sleep Apnea
Objective: Obstructive sleep apnea (OSA) is a highly prevalent disease associated with various morbidities worldwide.
Although continuous positive airway pressure (CPAP) is the cornerstone of therapy, adherence to CPAP directly affects
its efficacy. Methods: We retrospectively investigated consecutive patients who were diagnosed with OSA and placed on CPAP the-
rapy within an approximate ten-year period. Using patient characteristics and short-term usage, the predictors of adhe-
rence to CPAP were evaluated.
Bilateral Palatal Necrotizing Sialometaplasia in Patient with Prurigo Nodularis: A Case Report
Necrotizing Sialometaplasia (NSM) is a rare, benign, self-limiting, inflammatory disease of mostly minor salivary gland
origin.
NSM can resemble a malignant lesion in its early disease course, both clinically and pathologically. Bilateral involvement
of the hard and soft palate by the lesion is a rare occurrence. NSM was first described as a reactive inflammatory process.
Since then, over 200 cases have been reported and has been added to the WHO classification of salivary gland tumours
under the tumour-like lesions. Here, we report a case of a 30-year-old male with bilateral NSM of both the hard and
soft palate, on a background history of prurigo nodularis. The patient was initially referred to an Oral and Maxillofacial
Department by his general practitioner for a palatal ulcer, concerning for oral malignancy. The ulcer was painless with a
well-demarcated border and necrotic base. Subsequent biopsy and histological examination confirmed necrotizing sialometaplasia with healing occurring within 5 weeks.
Machine Learning Prediction of Response towards Anti-VEGF Injections in Patients with DME: Prediction of Post-Injection CST
Diabetic macular edema (DME) has become one of the most potential complications that results in loss of vision in patients with
diabetic retinopathy. Treatment outcomes that have been predicted directly with advent of machine learning (ML) methods after
the initial anti-vascular endothelial growth factor (anti-VEGF) injection, has become extremely vital in the management of DME.
Purpose: The aim of this study is to analyze the efficiency of the ML regression models which were developed and validated to predict the possible post-injection central subfield thickness (CST) value and distant vision best corrected visual acuity (DV BCVA)
in eyes with DME before the anti-VEGF injection is administered at either treatment initiation or during treatment monitoring.
Methods: This retrospective study was conducted in Medical Research Foundation, Chennai, India from January 2010 to
December 2020. The model development emphasized on an ensemble ML system consisting of four ML models that were
developed and trained independently using the clinical parameters to predict the post injection CST value. The dataset
consisting of 906 patients with total of 1874 samples [Optical coherence tomography (OCT) images and clinical parameters] were divided into trained and test set, and the model was validated on test dataset. The predicted CST values was then
compared against the respective sample’s post injection actual CST value. The comparative results were measured in terms
of Correlation Coefficient and Mean Absolute Relative Error (MARE).
Results: On evaluation, we found that Support Vector Regression (SVR) with linear kernel performed best among the
other models with four different scenarios in term of both CST and DVBCVA prediction with correlation coefficient of
0.65, 0.73, 0.75, 0.85 and 0.83, 0.87, 0.89 and 0.92 respectively.
Malignant Scalp Tumors: Retrospective Analysis of 1000 Patients.
Background: Limited data on large cohort of patients with malignant tumors of the scalp are available in the literature. The
aim of this study was to review a large cohort of patients with malignant scalp tumors to determine epidemilogy, tumor
characteristics of this region and treatment.
Materials and Method: A retrospective review of patients with malignant scalp tumors diagnosed histopathologically
between 2005 and 2021 was performed. Demographic features and tumor characteristics were analyzed.
Results: A total of 1080 patients (M: F 3,5:1) were treated and followed up for a mean period of 42 months (12-120
months). Age at diagnosis ranged from 12 to 98 years. Most malignant scalp tumors (95,1%) occurred in those 50 years
or older and in bald patients (87%). Basal cell carcinomas (59,2%), squamous cell carcinomas (32,2%) and melanomas
were the most common histologic types. Incidence was highest on the frontal of temporal region (66,1%). Recurrence was
frequently in squamous and basal cell carcinomas but uncommon in melanoma.
Conclusions: Tumors of the scalp accounted about 8,01 % of all skin cancers. Tend to be basal and squamous cell carcinomas, many of which occur in the temporal and frontal region of bald men. The outlook for patients with scalp tumor is
positive, although we suggest excision margins of at least 3-4 mm and continued clinical vigilance is warranted given their
higher recurrence rates.
Elexacaftor/Tezacaftor/Ivacaftor Improves Glycemic Control in Pediatric Patients with Cystic Fibrosis-Related Diabetes
Cystic fibrosis (CF) is an inherited disorder caused by genetic mutations encoding the cystic fibrosis transmembrane conductance regulator (CFTR) protein. Elexacaftor/tezacaftor/ivacaftor (ELX/TEZ/IVA) is a CFTR modulator shown to improve lung function in certain patients with CF. We undertook this study to determine its effects on glycemic outcomes in pediatric patients with cystic fibrosis-related diabetes (CFRD). We reviewed the medical records and identified two subjects, referred to as subject A and subject B, with CFRD on insulin therapy at Duke University Hospital between 2019-2020 who were on treatment with ELX/TEZ/IVA for at least one year. The mean hgbA1C pre- and post- treatment was 5.65% (5.6-5.7) and 5.05% (5.0-5.1) respectively with a mean reduction of 0.6% (p value 0.01). Improvement in hgbA1C occurred in the absence of increased insulin requirements, subject B remained on a similar insulin regimen whereas subject A was able to come off insulin completely. In addition, improvements in BMI z-score were seen in both groups with a mean BMI z-score of -0.30 pre-treatment (-0.71-0.11) and z-score of +0.28 post-treatment (0.11-0.45).
Editorial Board Members Related to Patient
Ann Gaba
Assistant Professor
City University of New York
United States
City University of New York
United States
LAUREN BERKOW
Associate Professor
Division of Neuroanesthesia
Department of Anesthesiology and Critical Care Medicine
Johns Hopkins University
United States
Division of Neuroanesthesia
Department of Anesthesiology and Critical Care Medicine
Johns Hopkins University
United States
Riyadh Khudhair Lafta Al-Juboori
Professor
College of Medicine
Mustansiriya University
Iraq
College of Medicine
Mustansiriya University
Iraq
Massimo Caputo
Professor
Congenital Cardiac Surgery
Bristol Heart Institute
United Kingdom
Congenital Cardiac Surgery
Bristol Heart Institute
United Kingdom
WILLIAM B. SILVERMAN
Clinical Professor of Internal Medicine
Department of Gastroenterology and Hepatology
University of Iowa Carver College of Medicine
United States
Department of Gastroenterology and Hepatology
University of Iowa Carver College of Medicine
United States
Omar Abd El Sadek El Meligy
Professor
Pediatric Dentistry
King Abdulaziz University
Saudi Arabia
Pediatric Dentistry
King Abdulaziz University
Saudi Arabia
Sanja Ilic
Assistant Professor
Department of Human Nutrition
The Ohio State University
United States
Department of Human Nutrition
The Ohio State University
United States
Luis Ulloa
Associate Professor
Department of Surgery
Rutgers New Jersey Medical School
United States
Department of Surgery
Rutgers New Jersey Medical School
United States
BRUCE D CHESON
Professor of Medicine
Division of Hematology and Oncology
Georgetown University Hospital
United States
Division of Hematology and Oncology
Georgetown University Hospital
United States
Zhiyuan Li
Professor
Laboratory of Ion Channels Research
Guangzhou Institute of Biomedicine and Health
Chinese Academy of Sciences
China
Laboratory of Ion Channels Research
Guangzhou Institute of Biomedicine and Health
Chinese Academy of Sciences
China