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Articles Related to Pharma

Phyto-Nutrient Diversity in Morinda Citrifolia L. Genotypes of Andaman Islands, India

The Indian mulberry or Noni (Morinda citrifolia L.) is one of the emerging sources of natural antioxidants for herbal and pharmaceutical industry. The genus Morinda has more than 150 species in which M. citrifolia is identified as most important for health and economic point of view. Present study revealed significant (p < 0.05) diversity in 33 genotypes of M. citrifolia from Andaman and Nicobar Islands (India) for phyto-constituents. The promising genotypes viz. FRG-14, JGH-5, TRA-1, TRA-2 and HD-6 were identified for commercial uses. Correlation analysis in M. citrifolia germplasm showed strong correlation between carotenoids and ascorbic acid (r2 =0.973; p<0.05), tannin (r2 =0.598; p<0.05), flavonoids (r2 =0.691; p<0.05) and phenol (r2 =0.598; p<0.05). The genotypes showed wide range for antioxidant capacity which showed positive correlation with carotenoids (r2 =0.335; p<0.05), flavonoids (r2 =0.249; p<0.05) and Cu (r2 =0.953; p<0.05), Mn (r2 =0.953; p<0.05) and Mg (r2 =0.582; p<0.05). The diversity analysis is useful for designing breeding strategies for phyto-nutrient rich genotypes for better recovery in health products.
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Evaluating the Effect of Oprelvekin on Cardiac Repolarization in Subjects with Chemotherapy-Induced Thrombocytopenia: An Observational Chart Review of a Phase 2 Clinical Trial in Laredo, Texas

This study tested for the cardiac effects of Oprelvekin, recombinant human interleukin-11, a thrombopoietic growth factor, in patients afflicted with chemotherapy-induced thrombocytopenia (platelet count<50,000 cells/ul). Chart-reviews of patients fulfilling the inclusion criteria of: 18-75 yrs of age, non-myeloid malignancy, with adequate hematologic, hepatic and renal parameters and normal electrocardiograms that were enrolled in this phase 2 trial were analyzed. Patients of child-bearing potential agreed to be on a reliable form of birth control for the duration of the study. Results on 4 patients suggest that Oprelvekin does not cause atrial nor ventricular arrhythmia, a rare severe cardiac side effect, in treating patients with chemotherapy-induced thrombocytopenia.
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Bioanalytical Method for Pamabrom (Determined as 8-Bromotheophylline) and its Application to a Pharmacokinetic Study

Pamabrom is a common over-the-counter mild diuretic that is often used in combination with acetaminophen and other drugs for the treatment of menstrual pain. It consists of a 1:1 ratio mixture of 8-bromotheophylline and 2-amino-2-methyl-1-propanol. A bioanalytical method for pamabrom, determined as 8-bromotheophylline, was developed and validated using reverse-phase HPLC coupled with UV detection.
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Bioequivalence between Generic Rasagiline (As Tartrate) and Rasagiline (As Mesylate)

The objective of the study was to compare bioavailability of 1 mg rasagiline (as tartrate) immediate release tablets and Azilect® 1 mg immediate release tablets.
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Challenges in the Pharmacological Management of Non Hodgkin’s Lymphoma in Children in the Maintenance Phase of Therapy at Kenyatta National Hospital

Non Hodgkin’s lymphoma is an extremely chemo sensitive with a five year event free survival of greater than 90% in developed countries and a one year survival rate of 40-50% in developing countries.
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Bioanalytical Method Development and Validation of Ferrum in Rabbit Plasma Samples by Derivatised Reverse Phase Liquid Chromatography and Application to Pharmacokinetic Study

Iron is an important component of hemoglobin, in addition to other positive roles like proper growth and development of humans and for growing of fetus in pregnancy women. Iron deficiency anemia is more prevalent among vegetarian than non vegetarians.
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Health Food and Traditional Chinese Medicine in China

Like a drug for a purpose of treating or preventing a disease, a health food has to be scientifically evaluation and officially approved before it legally is marketed in China.
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Bioequivalence Study of Two Oral-Capsule Formulations of Omeprazole 20 mg in Combination with Sodium Bicarbonate in Healthy Mexican Adult Volunteers

In Mexico, the immediate-release formulation of omeprazole 20 mg in combination with 1100 mg of sodium bicarbonate (oral capsules) is indicated for patients over 18 years for the treatment of gastritis, reflux, heartburn and the sensation of emptiness caused by the excessive acid production.
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An Introduction to the Approaches of Novel Drug Delivery Systems for Acquired Immune Deficiency Syndrome (AIDS)

The currently available anti HIV agents have several drawbacks such as short half life, low bioavailability, poor CNS penetration and retention, hepatic first pass metabolism, undesirable side effects and frequent dosing regimen.
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Bioequivalence Study of Two Oral-Capsule Formulations of Pregabalin 300 mg in Healthy Mexican Adult Volunteers

Pregabalin is a ligand for the alpha-2-delta subunit of voltage-gated calcium channels in the central nervous system. It has anticonvulsant, analgesic, and anxiolytic activity. The bioequivalence of a test formulation was evaluated with respect to its corresponding reference drug formulation of oral pregabalin 300 mg, administered as a capsule. This randomized-sequence, single-dose, single-blind, two-period crossover design under fasting conditions was done on 25 healthy Mexican adult subjects including both genders. There was a seven-day washout period.
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Investigating the Double-Peak Phenomenon in Oral Pharmacokinetics of Eurycoma Longifolia quassinoids in Lipid-Based Solid Dispersion

13α(21)-Epoxyeurycomanone (EP) and eurycomanone (EN), the polar quassinoids of Eurycoma longifolia extract (TAF2) formulated as a lipid-based solid dispersion (TAF2-SD) to increase sperm count for oligospermic infertility, displayed improvement of oral pharmacokinetics and bioavailability in rats over the non-formulated TAF2 extract.
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Researches on the Pharmacological Effects of Eicosapentaenoic Acid

Fish oils are the most common source of omega-3 polyunsaturated fatty acids (n-3 PUFAs), mainly eicosapentaenoic acid (EPA). It has been pointed out protective effects and beneficial effects of EPA on body weight reduction, heart health, blood lipid profile, cardiovascular diseases and other diseases. Based on its biological activities, EPA may be developed to a complementary and alternative medicine through further research. In this paper, the pharmacological effects of EPA were summarized by reviewing the recent related literatures.
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Orally Disintegrating Tablets: A Short Review

This article summarizes the advantages of orally disintegrating tablets (ODTs) as well as critical issues during evaluation of ODTs such as bioequivalence and challenges and limitations of ODTs and finally present and the future of ODTs. ODTs have received everincreasing demand and the field has become a rapidly growing area in the pharmaceutical industry.
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Pharmacokinetics, Biotransformation, Distribution and Excretion of Empagliflozin, a Sodium-Glucose Co-Transporter (SGLT 2) Inhibitor, in Mice, Rats, and Dogs

The metabolism, pharmacokinetics, excretion and distribution of a sodium-glucose co-transporter (SGLT 2) inhibitor, empagliflozin, were studied in mice, rats and beagle dogs following a single oral or intravenous administration of [14C]-empagliflozin. Empagliflozin was well absorbed in all species after oral administration.
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Review on Pharmacological Activities of the Peptides from Scorpion Buthus Martensii Karsch

In China, the scorpion Buthus martensii Karsch is used as functional food and medicinal materials. The scorpion, scorpion venoms and their extracts are effective in treating a variety of nervous system diseases such as epilepsy, apoplexy pains and facial paralysis.
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Editorial Board Members Related to Pharma

Norio Yasui-Furukori

Associate Professor
Department of Neuropsychiatry
Hirosaki University School of Medicine
Japan

Sunliang Cui

Visiting Professor
Department of pharmaceutics
College of Pharmaceutical Sciences
Zhejiang University
China

Allan Siegel

Professor
Department of Neurology & Neurosciences
Rutgers University
United States

ADRIAN M. BARANCHUK

Associate Professor
Department of Biomedical and Molecular Sciences
Queen’s University
Canada

Henry H. Y. Tong

Professor
School of Health Sciences
Macao Polytechnic Institute
Macau

Shi J. Liu

Professor
Department of Pharmaceutical Sciences
University of Arkansas for Medical Sciences
United States

UMA D PALANISAMY

Associate Professor
Department of Biomedical Science
Jeffrey Cheah School of Medicine and Health Sciences
Monash Universtiy
Malaysia

Douglas Wilson

Professor
School Medicine Pharmacy and Health
Durham University
UK

Mohamed Eddouoks

Professor
Faculty of Sciences and Techniques Errachidia
Moulay Ismail University
Morocco

David Paul Richman

Professor
Department of Neurology and Center for Neuroscience
University of California
United States
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