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Articles Related to Pharma

Stability Indicating Method Development and Validation for the Determination of Armodafinil in Pharmaceutical Tablet Dosage Form by RP-HPLC

The present research deals with the development of a stability indicating reverse phase HPLC with PDA detector method for the determination of Armodafinil Agilent XDB-C18, 150×4.6mm, 5µm or Equivalent column. The present research deals with the development of a stability indicating reverse phase HPLC with PDA detector method for the determination of Armodafinil Agilent XDB-C18,
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Bioequivalence Study of Donepezil 10 mg Orally Disintegrating Tablets in Healthy Thai Volunteers Under Fasting Conditions

Donepezil is a potent, selective, noncompetitive and reversible inhibitor of acetylcholinesterase, commonly used for the treatment of Alzheimer’s disease. The form of orally disintegrating tablets (ODTs) is a good alternative dosage form for patients who have a difficulty in swallowing conventional tablets or capsules.
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How Nurse Education Impacts Her Career?

A great proportion of healthcare services need high-quality medication and nursery. For high-quality nursery needs best nurses and their education. Gradually, different types of nursery education systems can impact their life and career. In the future, more parameters can be used for judging the quality and promotion of nurses. This editorial addresses different educational efforts for their progresses in medical knowledge promotion, technical capability improvement and salary promotion.
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Comparative Bioequivalence Studies of Pantoprazole 40 mg Delayed-Release Tablet Formulations in Healthy Thai Volunteers

Pantoprazole is a H+,K+-ATPase enzyme inhibitor for the treatment of acid-related gastrointestinal diseases. The Government Pharmaceutical Organization (GPO), Thailand had developed Pantoprazole GPO® (pantoprazole 40 mg delayed-release tablets) as a generic substitute for the corresponding innovator product, CONTROLOC® 40 mg.
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Bioequivalence of Two Efavirenz/Emtricitabine/Tenofovir Disoproxil Fumarate 600/200/300 mg Fixed-Dose Combination Tablets in Healthy Thai Male Volunteers under Fasting Conditions

Fixed-dose combination tablet formulation of efavirenz/emtricitabine/tenofovir disoproxil fumarate 600/200/300 mg is an antiretroviral therapy comprising one non-nucleoside reverse-transcriptase inhibitor and two nucleoside reverse-transcriptase inhibitors to control human immunodeficiency virus infection.
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Pharmacokinetics Bridging Study of a 400 Mg Extended Release Formulation of the Novel Fumaric Acid Ester PPC-06 (Tepilamide Fumarate) in Healthy Male Volunteers

Tepilamide fumarate (PPC-06) is a new, patented prodrug of monomethyl fumarate (MMF), belonging to the fumaric acid esters (FAEs) class of drugs. The efficacy and safety of a 400 mg PPC-06 dose administered twice daily, achieved thus far through concomitant intake of two tablets of 200 mg, was demonstrated previously in two Phase 2 clinical trials on patients with moderate to severe chronic plaque-type psoriasis.
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Bioequivalence Evaluation of Two Clopidogrel Immediate Release Tablet Formulations in Healthy Thai Volunteers Under Fasting Conditions

Clopidogrel is used for acute coronary syndrome and prevention of atherothrombotic events. To improve clinical outcomes, patient adherence to treatment is necessary. However, continuous use of branded product may cause economic burden to patients and healthcare system. The Government Pharmaceutical Organization (GPO), Thailand had developed a generic product of clopidogrel to reduce cost of treatment and improve accessibility to medicines for Thai people.
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Charles Bonnet Syndrome: Rapid Resolution of Visual Hallucinations with Low Dose Risperidone

Charles Bonnet syndrome (CBS) comprises of complex visual hallucinations secondary to visual impairment in the presence of preserved cognition. Age related macular degeneration and other factors causing visual deterioration lead to visual hallucinations in 10-15% of patients. Sensory deprivation and social isolation are risk factors for development of CBS. The distressing hallucinations are underreported by patients and to date there are no robust evidence based guidelines to manage these hallucinations. Since visual hallucinations are associated with multiple psychiatric disorders as well, these patients are often referred to mental health providers. Here, we present the case of CBS development after macular degeneration. Rapid and sustained resolution of visual hallucinations and associated distress was observed with low dose Risperidone.
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Bioequivalence between Two Tablets of Levetiracetam in Healthy Subjects under Fasting Condition

Bioavailability of two formulations containing levetiracetam 750 mg film-coated tablets was compared in a fasting bioequivalence study. The study was single dose, randomized, open label, and two-period crossover, with Brazilian healthy subjects, males and nonpregnant females. Blood samples were taken for 36 hours after drug administration and plasmatic concentrations were determined using a validated HPLC-MS/MS method. Confidence intervals (CI90%) for the peak plasma concentration (Cmax) and area under the concentration-time curve (AUC0-t) were determined by calculating LN-transformed data. The ratios and 90% CI for the geometric mean test/reference were 97.41% (91.45- 103.75%) for Cmax and 99.77% (97.07- 102.54%) for AUC0-t.
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Bioequivalence Study of Olanzapine 5 mg Orally Disintegrating Tablet Formulations in Healthy Thai Volunteers under Fasting Conditions

A comparative randomized, single dose, two-way crossover, open label study was carried out to assess bioequivalence and tolerability of test (ZOLAN GPO®) and reference (Zyprexa Zydis®) products of olanzapine 5 mg orally disintegrating tablets for interchange ability in the same quality and safety.
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A Bioequivalence Study of Two Formulations of Rosuvastatin

Aim of this study was to compare the bioavailability of two tablet formulations containing Rosuvastatin: Rosuvastatin tablets 40 mg manufactured by MacLeods Pharmaceuticals Ltd. (marketed in Italy with the brand name Exorta®) and CRESTOR® 40 mg tablets marketed by Astra Zeneca.
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A Bioequivalence Study of Two Formulations of Levetiracetam

This study was conducted to compare the bioavailability of 1000 mg levetiracetam film-coated tablet, marketed in Italy as Italept®, with Keppra® coated tablet.
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Dose-Dependent Pharmacokinetics of Ropivacaine in Anesthetized Rabbits: Absence of Changes in Protein Binding

The primary objectives of this study were to investigate the in vivo pharmacokinetics and in vitro plasma protein binding of ropivacaine at the concentration range observed after intravenous administration of different doses in anesthetized rabbits.
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The Dose and its Acute Toxicology: A Systematic Review Article in the First Phase of Experimental Pharmacology

Hundreds and thousands of acute toxicity studies are conducted in experimental pharmacology with assumption hypothesis every year. It is usually concluded with inadequately validated data during the period of investigation within 24 hours.
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Pharmacokinetics of a 1,000 mg Disintegrating Aspirin Tablet Formulation

Migraine is a global disorder and considerably affecting people`s quality of life. Treatments include nonsteroidal anti-inflammatory drugs-containing medicinal products among whom acetylsalicylic acid-containing Aspirin® has been proven effectively to relief migraine headache. Early treatment is recommended for patients with migraine attacks.
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Editorial Board Members Related to Pharma

ADRIAN M. BARANCHUK

Associate Professor
Department of Biomedical and Molecular Sciences
Queen’s University
Canada

Emmanuel O. Akala

Professor
Department of Pharmaceutics
Howard University Institutional Animal Care
United States

R. SURESHKUMAR

Assistant professor
Department of Pharmaceutics
JSS College of Pharmacy
India

Natasa Skalko-Basnet

Professor
Department of Pharmacy
University of Tromso
Norway

Ahmed S. Zidan

Associate Professor
Department of Pharmaceutics and industrial pharmacy
Zagazig University
Egypt

David Ilki Min

Professor
Pharmacy Practice and Administration
Western University of Health Sciences
United States

Antonio Sanchez-Pozo

Professor
Department of Biochemistry and Molecular Biology II
University of Granada
Spain

Tanveer Ahmed Khan

Lecturer in Pharmacy
Department of Basic Medical Sciences
Faculty of Pharmacy
Hajvery University
Pakistan

Daniela Iannazzo

University Researcher
Department of Electronic Engineering, Industrial Chemistry and Engineering
University of Messina
Italy

Ahed J Alkhatib

Researcher
Department of Forensic science and Toxicology
Jordan University of Science and Technology
Jordan
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