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Effects of Gabapentin Enacarbil on Cortical Arousals, Heart Rate, Blood Pressure and Anterior Tibialis EMG Responses Associated with PLMs in Restless Legs Syndrome

Objective: This study was conducted to investigate the effects of gabapentin enacarbil (GEn) on sleep EEG, heart rate (HR), blood presssure, anterior tibialis EMG activity (PLMs power) and subjective complaints in subjects with moderate to severe RLS and disturbed sleep. Methods: This was a single site, single-blind, placebo run-in, fixed dose single group polysomnography (PSG) study. Eligible subjects (age 24-66 years) were treated with placebo for one week and GEn (600 mg/day) for 4 weeks. Two in-laboratory PSGs were collected for adaptation and baseline at the end of the placebo run-in period and for re-adaptation and efficacy assessment at the end of the 4-week treatment period. The primary endpoint was the difference in PSG derived cortical arousal intensity (arousal scale, 0-9) associated with PLMs between 4 weeks of treatment with GEn and placebo. Secondary endpoints included changes in HR responses (ΔHR), nocturnal systolic blood pressure (SBP) changes (>10 mmHg) secondary to PLMs and PLMs power. Other PSG and subjective measures were assessed. Results: Of 20 subjects enrolled, 18 completed the study. Subjects treated with GEn did not show significant improvements in cortical arousal intensity and ΔHR. However, subjects showed reduced PLMs power (p= 0.013) and associated reductions in nocturnal SBP per hour of sleep (p= 0.041) GEn showed significant improvement in other PSG parameters and subjective endpoints. Conclusion: The data suggests that GEn reduces the frequency and power of PLMs and the corresponding SBP changes in subjects with RLS. Despite reducing the total number of PLM associated arousals and nocturnal HR, the study did not demonstrate consistent effects of GEn on cortical arousal intensity and corresponding HR changes associated with PLMs. Clinical Trial Registration: ClinicalTrials.gov identifier: NCT02424695
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Gliomatosis Cerebri: A Case Report

Background: Gliomatosis cerebri is a rare primary brain tumor that can have extensive infiltration into the brain parenchyma. It can affect any age group and often has poor clinical outcomes. Given its unique pathology, presentation and treatment can be challenging to recognize and efficaciously treat
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Port State Control: A Risk of The International Spread Of COVID-19 Disease on Board Ships?

The emergency committee said the spread of COVID-19 can be halted through early detection, isolation, prompt treatment and implementation of a robust contact traceability system.
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Potential COVID-19 Therapeutics: A Perspective on Pharmacological Properties and Safety

There are no guidelines for pharmacological treatment of COVID-19 disease, but several drugs are being tested every day in search of an optimal therapeutic strategy. The drugs that have been tested, so far, include some antiviral drugs such as danoprevir, favipiravir, darunavir, nelfinavir, remdesivir, umifenovir and the combination lopinavir/ritonavir. Others are drugs targeting inflammatory mediators such as meplazumab, siltuximab, tocilizumab, azithromycin and corticosteroids. Also included in this array of tested drugs are those with pleiotropic actions against SARS-CoV-2 infection like chloroquine/hydroxychloroquine, ivermectin and nitazoxanide, postulated as inhibitors of several phases of virus life cycle. Upon diagnosis of SARS-CoV-2 infection, it is pertinent to embark on a treatment approach based on potential antiviral options, adequately managed under proper medical situation. We suggest that, in addition to the antiviral option efforts, drugs targeting inflammatory mediators should be considered.
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A Case Report: Delayed Onset Urinary Tract Injury after Laparoscopic Hysterectomy

Lower urinary tract injury in hysterectomy is rare, but once it occurs, the consequence can be deteriorating. We experienced late onset urinary tract injury that developed as late as 15 days after laparoscopic hysterectomy. The objective of this case report is to alert all gynecological laparoscopists that such late onset complication may happen to any of patients.
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Solitary Adrenal Metastasis: A Case Report of Aberrant Behavior of Prostate Cancer

A Caucasian male with prostate cancer under androgen deprivation therapy after radiotherapy for a locally advanced lesion. Positron emission tomography/Computed Tomography revealed an adrenal lesion. The mass was removed, and histopathological examination showed adenocarcinoma of prostatic origin. Prostate-specific antigen decreased dramatically after adrenalectomy
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A Chronic Myeloid Leukemia Case Showing Spontaneous Ph-positive Clone Regression and Bone Marrow Hypoplasia after a Short Treatment with Dasatinib

Dasatinib is an orally bioavailable second generation TKI, more potent than imatinib. Bone marrow aplasia or hypoplasia secondary to TKI therapy is an uncommon adverse event. We report here the first case of chronic myeloid leukemia in chronic phase shortly treated with dasatinib that developed a prolonged bone marrow hypoplasia with concomitant response on the hematological disease with gradual improvement of the cytogenetic and molecular response after dasatinib discontinuation, without use of any other TKI therapy.
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Characterizing the Etiologies of Seizures and Cortical Myoclonic Activity in Covid-19 Patients and their Impact on Outcomes

Systematic literature review was conducted. Criteria included seizures, status epilepticus, and/or CMA developing prior to or during hospitalization, with concomitant COVID-19. COVID-19 severity was dichotomized into mild and severe cases, based on severity of respiratory symptoms. Good outcome was defined as discharge without severe deficits and/or return to near baseline.
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A Case Report of Peripheral Giant Cell Granuloma

Peripheral giant cell granuloma (PGCG) is a rarely seen benign lesion at soft oral tissue. In this report, the patient had a history of central giant cell granuloma at the left mandibular posterior region. The lesion was excised two years ago. Patient was consulted to our hospital for soft tissue growth at right maxillary anterior region. Excisional biopsy was planned and the lesion was examined histopathologically. Giant cell reparative granuloma was described and routine examination was advised to the patient
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A Novel Coenzyme Q8A Mutation in a Case with Juvenile-Onset Coenzyme Q10D4: Case Report and Literature Review

Primary coenzyme Q10 deficiency-4 (CoQ10D4) is an autosomal recessive disorder characterized by childhood-onset of cerebellar ataxia and exercise intolerance. Molecular pathology responsible for clinical findings is mitochondrial respiratory chain dysfunction. The main clinical manifestation involves early-onset exercise intolerance, progressive cerebellar ataxia and movement disorders. Some affected individuals develop seizures and have mild mental impairment, indicating variable severity.
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The Efficiency of Functional Activated Carbon Non-woven Fabric Filters for Fine Dust Reduction

Particulate matter (PM) concentrations are significantly higher in urban railway tunnels (178.1 μg/m3) than in metropolitan areas (49 μg/m3). Nitrogen oxide (NOx) concentrations, which are a direct cause of lung disease, have been found to exceed the atmospheric standard of the Ministry of Environment in tunnels in Korea. Dust generated by trains is scattered at high speed along tunnels, making filtration difficult. The development of filters that can be used in tunnels is urgently required. In this study, the results of using an activated carbon filter (ACF) were analyzed and compared with the laboratory-scale PM adsorption using functional activated carbon non-woven fabric filters (Cerebasel, Cerecore) that can be manufactured in Korea. The fine PM concentration, filter depth, and flow rate in the tunnel were the experimental variables. We compared PM concentrations before and after the filter experiments, and calculated the PM removal efficiency to determine the optimal conditions.
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Treatment of Erdheim-Chester Disease with High Dose Pegylated IFN-α: a Case Report and Literature Review

Erdhein-chester disease is a rare non-Langerhans histocytes that can involve multiple systems, with bone involvement as the most common. We reports a 39-year-old female who visited the hospital due to pain in both lower limbs, combined with clinical manifestations, imaging, and laboratory tests, Erdhein-Chester disease was prelimi narily diagnosed. The diagnosis was confirmed by the presence of BRAF V600E mutation and tissue cells on biopsy of the right tibia. We discussed the disease based on literature review, aiming to improve the understanding of clinicians.
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Disseminated Blastomycosis: A Case Report

Blastomycosis is known for its propensity to mimic other illnesses, which often leads to incorrect or delayed treatment. Here we present a case report of a patient working in Wisconsin who was misdiagnosed as Tuberculosis since he was an Indian. The patient was not evaluated on endemic grounds for Blastomyces where he was working for couple of years. After he developed skin lesions along with increased shortness of breath, lesions were evaluated which showed large yeast cells resembling Blastomyces. The treating pulmonologist evaluated his occupational history and was revealed with endemicity for Blastomyces.
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Tooth Size Discrepancy among Different Malocclusion Groups in a Libyans Sample

Tooth Size Discrepancy (TSD) forms part of the initial diagnosis and is considered when formulating a treatment plan for the individual patient. The present research aimed at determining the extent and prevalence in a representative orthodontic population in Libya, to determine the prevalence of tooth size discrepancies (TSDs) in orthodontic population among different malocclusion groups.
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PSII Photosystem Protection by Soil Amendment with Biochar and Adequate Nitrogen Fertilizer Availability Attenuate Cadmium Induced-Photoinhibition and Phytotoxicity in Solanum Lycopersicon

The aim of this research was to assess the biochar ability to protect the photosynthesis process face to Cd contamination, especially, when nitrogen fertilizer was added at adequate amount. Culture of tomato seedlings was conducted on pots containing soil added with different portion of biochar (0, 3.5 and 7%) and nitrogen (3 or 6g NH4NO3). Irrigation was done by water (control condition) or Cd solution (150µM). Data showed that regardless presence of Cd, synchronously addition of high nitrogen fertilizer (6g) and biochar (7%) in the culture medium resulted in fresh matter production, photosynthetic pigment (Chlorophyll a) and mineral elements content enhancement. Similar observation was shown concerning the mineral nutrition (nitrogen, phosphorus and potassium contents).
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Anodic Porous Alumina Array for Cyanine Fluorophore Cy3 Confinement

Self-organized anodic porous alumina films with hexagonal pore lattice have attracted a considerable attention for biological arrays and confinement of various organic probes dyes in solutions. A molecular structure with axial symmetry in bis-heterocyclic indole chains and conjugate system, such as cyanine fluorophore Cy3 dye, was investigated here with respect to its fluorescence when loaded in the anodic alumina pores.
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Anodizing for Design and Function

Two basic reactions occur during the anodizing of aluminum: 1) the aluminum is consumed and 2) an oxide grows. By accepting this statement as true, the anodizing process can be viewed as a corrosion process, and anodizing can be modeled using the Tafel Equation. Anodizing process parameters of electrolyte chemistry and concentration, temperature, aluminum substrate resistance and current density are presented as they relate to the Tafel Equation and how they impact the anodic aluminum oxide structure and properties. Understanding this relationship is consequent in making anodizing an engineering process, one that enables tuning the structure such that it yields distinct characteristics to fulfill design and application requirements.
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Recent Developments in Human Odor Detection Technologies

Human odor detection technologies have drawn attention due to the wide possibility of potential applications they open up in areas such as biometrics, criminal investigation and forensics, search for survivors under rubble, and security checkpoint screening. Gas chromatography/mass spectrometry (GC/MS) has been the most successful and powerful analytical approach developed to date for human odor analysis, and hundreds of human odorants have been identified using this tool.
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Electronic-nose Applications in Forensic Science and for Analysis of Volatile Biomarkers in the Human Breath

The application of electronic-nose (E-nose) technologies in forensic science is a recent new development following a long history of progress in the development of diverse applications in the related biomedical and pharmaceutical fields. Data from forensic analyses must satisfy the needs and requirements of both the scientific and legal communities. The type of data collected from electronic-nose devices provides a means of identifying specific types of information about the chemical nature of evidentiary objects and samples under investigation using aroma signature profiles of complex gaseous mixtures containing volatile organic compounds (VOCs) released from manufactured products and parts of the human body. E-nose analyses also provide useful qualitative information about the physicochemical characteristics and metabolic conditions of human subjects without the need for time-consuming analyses to identify all chemical components in human-derived volatile mixtures.
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Analysis of Sweat Simulant Mixtures using Multiplexed Arrays of DNA-Carbon Nanotube Vapor Sensors

Carbon nanotube (NT) based electronic vapor sensors were tested against synthetic sweat solutions, consisting of 13 volatile organic compounds (VOCs) in saline, in order to probe the device ability to analyze and differentiate vapors derived from complex biological samples.
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Characteristic Human Scent Compounds Trapped on Natural and Synthetic Fabrics as analyzed by SPME-GC/MS

The collection of human odor volatiles is of interest to forensic applications as a path to investigate canine scent discriminations in legal investigations. A study using a selected array of previously identified human odor compounds has been conducted to determine the retention and release capabilities of five (5) natural and synthetic fabric types, cotton (mercerized fabric and gauze matrix), polyester, rayon and wool.
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The Effects of the Film Thickness and Roughness in the Anodization Process of Very Thin Aluminum Films

The anodization of aluminum foils having micrometer thickness is a common process and results in hexagonally self-ordered alumina membranes. However, anodic aluminum oxide (AAO) membranes fabricated from nanometer-thin films present new challenges to the anodization process, since aluminum films adheres poorly on supporting substrates and the smoothness of the film is highly related to the kind of substrate.
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Anodic Oxidation of Titanium in Sulphuric Acid and Phosphoric Acid Electrolytes

Anodisation of pure titanium has been carried out in sulphuric and in phosphoric acid solutions at potentials ranging from 50 to 150V. The SEM and AFM morphological analysis indicates that, within this potential range, oxidation in sulphuric acid solution produces better developed mesoporous oxide layers.
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Fabrication of Ordered Arrays of Anodic Aluminum Oxide Pores with Interpore Distance Smaller than the Pitch of Nano-pits formed by Ion Beam Etching

We investigated a method for preparation of ordered nanopore arrays with the interpore distance of 60 nm by guided self-organization of anodic aluminum oxide with a prepatterned array of pits in the starting Al film.
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Preparation of Large Area Anodic Alumina Membranes and their Application to Thin Film Fuel Cell

The design of an electrochemical reactor for the preparation of self-supported comparatively thin (up to 10 μm) and large area (up to 50 cm2) anodic alumina membranes is described allowing growth of porous alumina at high applied potential (up to 150 V) without burning.
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Fabrication of Vertical Cu2ZnSnS4 Nanowire Arrays by Two-Step Electroplating Method into Anodic Aluminum Oxide Template

Vertical Cu2ZnSnS4 (CZTS) nanowire arrays have been synthesized via two-step electroplating method into anodized aluminum oxide template. For deposition of CZTS nanowires, anodized aluminum oxide (AAO) was used as the growth mask for the growth of the nanowires. AAO templates with hole sizes of 70 nm in diameter were used in the experiments.
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Fabrication and Luminescence of Anodic Alumina with Incorporated Vanadyl Citrate Chelate Anions

Anodic aluminum oxide doped with vanadyl citrate chelate complex anions was formed by a two-step self-organized anodization in 2 wt. % sulfuric acid containing 0.04 M V2O5 and 0.08 M citric acid at voltage range 13-23 V, and at 0 and 15 oC. The combination of two temperatures and at least four voltages (depending on the applied temperature) was applied as the operating conditions of anodization.
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Synthesis of BaTiO3 Nanowires via Anodic Aluminum Oxide Template Method Assisted by Vacuum-and-Drop Loading

In this paper, we report on the synthesis of BaTiO3 nanowires via the anodic aluminum oxide template method. To fill in the precursors of BaTiO3 into anodic aluminum oxide templates, the vacuum and drop loading method developed in our previous study was used. Ba(CH3COO)2 (barium acetate) and C12H28O4Ti (tetraisopropyl orthotitanate) were used as Ba and Ti sources, respectively. Anodic aluminum oxide membranes with the through-hole diameter of ~200 nm were used as the template for BaTiO3 nanowires.
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Editorial Board Members Related to RT

Marc Poirot

Research Director at INSERM
Cancer Research Center of Toulouse
University of Toulouse
France

GAVIN PAUL SACKS

Associate Professor
Department of Obstetrics & Gynecology
University of New South Wales
Australia

CODY P. COYNE

Professor
Department of Basic Science
Mississippi State University
United States

Richa Arora

Assistant Professor
Nizam's Institute of Medical Sciences
India

AYMAN ELTAIRY MAHMOUD MAHDY

Associate Professor
Division of Urology
University of Cincinnati
United States

Amer A Taqa

Professor
Head in Dental Basic Science
Mosul University
IRAQ

PATRICIA LANEE WEI DENNING

Associate Professor
Department of Pediatrics
Emory University Medical School
United States

Chunying Li

Assistant Professor
Department of Biochemistry and Molecular Biology
Wayne State University School of Medicine
United States

Mohamed Abdo Rizk

Professor
Department of Internal Medicine and Infectious Diseases
Mansoura University
Egypt

JIANYE GE

Assistant Professor
Department of Forensics and Investigative Genetics
University of North Texas Health Science Center
United States
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