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Gestational diabetes mellitus (GDM) is associated with an increased maternal and fetal risk of complications. Other than lifestyle modifications and diet, little prevention can be done towards this maternal complication. Through a preclinical approach and a retrospective clinical trial, we investigated the effects of maternal supplementation with a nutraceutical composition based on resveratrol (RSV) and alpha-lipoic acid (ALA) on insulin resistance and GDM status

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In the last decade, neurodegenerative diseases (such as Alzheimer's disease, Parkinson's disease, and various forms of Dementia) have become a challenging problem facing contemporary society, placing on it a strong economic, social, and healthcare burden. Despite huge and long-lasting efforts, the progress in solving these problems remains unsatisfactory

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Malnutrition is a major challenge in caring for critically ill children. Therefore we aimed to assess the nutritional status in critically ill pediatrics. Methods: This is a prospective observational study carried out on180 children admitted into Pediatric Intensive Care Unit (PICU) of Menoufia University Hospital. Clinical examination performed including anthropometric measurement, screening for malnutrition risk using Pediatric Yorkhill Malnutrition Score (PYMS) and determination of disease severity by Pediatric Risk of Mortality score (PRISM)

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Allergic bronchopulmonary aspergillosis (ABPA) is an idiopathic inflammatory disease of the lung, characterized by an allergic inflammatory response to colonization of the airways by Aspergillus fumigatus or other fungi. Untreated or inadequatetreatment may lead to poor outcome in patients. Raised level of serum IgE of more than 1000 IU/ML have been considered as one if theimportant diagnostic criteria for ABPA, however relation of serum IgE withs severity ofdiseases is lacking. This study was conducted to find out level of serum IgE in patients ofABPA and to find out corelation of Serum IgE with duration of symptoms and diseasesseverity.

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Using longitudinal data that tracks bulimic behavior among young girls (National Heart, Lung, and Blood Institute Growth and Health Study), we examine (1) whether the persistence in bulimia nervosa (BN) can be attributed to slow learning about the deleterious health effects of BN or if it reflects tolerance formed from an addiction; and 2) whether bulimic behavior is consistent with addiction criteria as stated in the Diagnostic and Statistical Manual of Mental Disorders DSM-IV. To address the endogeneity of past behavior, we use instrumental variables, and show that past BN positively and significantly impacts current BN after controlling for individual heterogeneity. When accounting for BN ”stock,” the parameter estimates of past behavior are not negative, which casts doubt on the importance of learning. Making the case for treating BN as an addiction has important policy implications. First, it suggests that the timing of educational policy and treatment is crucial: preventive educational programs aimed at instructing girls about the deleterious health effects of BN, as well as treatment interventions, will be most effective if provided in the early stages. Second, it would put those exhibiting BN on more equal footing (from a treatment reimbursement perspective) with individuals with drug or alcohol addictions.

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Aim of this work is to observe some epidemiological pattern related heart pathology like pericarditis and myocarditis in last decades and the toxicological effect played by various WRC wireless communication radiations as described by scientific literature. All this related the class age distribution of some Rare ADR by various covid-19 vaccines like Pericarditis and miocarditis (more frequent in young) and the use of electronic device WCR among the subpopulation. Of interest to observe that sars cov-2 spike protein, derivates and WCR are able to affect the heart as showed by literature in direct or indirect way. What information can be obtained studing this phenomena?

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Background and Purpose: Escherichia coli (E. coli) is one of the multidrug-resistant pathogens, producing extendedspectrum beta-lactamase enzymes. Molecular typing of this pathogen can be useful for determining the source of dissemination and transfer of resistance and virulence genes of these isolates. Considering the significance of infection in children, in this study, we examined the stool flora of children (<10 years) to show the characteristics and clonal relationship of the isolates.

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The study reports on improved order selection ergonomics, feedback delivery, productivity, and worker satisfaction by replacing a wireless handheld device system with a voice feedback system. ‘Order selectors’ at a dairy manufacturing plant are tasked with selecting dairy products for store orders (e.g. grocery stores, convenience stores). In the new voice feedback system, workers listened to instructions via a headset and spoke directly into a microphone, receiving immediate voice feedback.

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Introduction: Obesity is a multifactorial condition influenced by environment and genetic factors. Controlling appetite and satiety involves complex interactions between the hypothalamus, which is responsible for homeostasis regulation energy, and hormones that regulate appetite including leptin and ghrelin. Leptin plays an important role in the regulation of food intake and energy expenditure, generating an increase in energy burning and decreasing food intake. And ghrelin is directly involved in the regulation of short-term energy balance. Objectives: To verify frequency, biochemical profile and Body Mass Index (BMI) variations according to SNPs in LEPR and GHRL gene. Subjects and Methods: 163 both genders subjects were classified into Study Group (SG): 103 subjects with obesity; Control Group (CG): 60 non-obese. Blood samples were collected to perform DNA extraction and biochemical profile analysis. Statistical significance was established at p < 0.05. Results: The genotype and allele frequency were similar between groups for both polymorphisms. The _/A genotype of the GHRL rs696217 polymorphism was associated to increased BMI in SG compared CG (p = 0.003) and increased triglycerides (TG) and very low density lipoprotein (VLDLc) values in CG (p < 0, 05). The _/A genotype was also associated with increased fasting glucose compared to CC genotype only in CG (p = 0.031). Considering the LEPR rs1137101 polymorphism, AA genotype subjects presented higher BMI compared to _/G genotype subjects (p = 0.024). No difference between biochemical profile variables related to LEPR rs1137101 polymorphism was found. Conclusion: AA genotypes of the LEPR rs1137101 polymorphism and _/A of the GHRL rs696217 polymorphism suggest being risk factors for BMI and the latter is associated with fasting glucose, VLDLc and TG variation.

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Objectives: Recent studies have shown that exercise by affecting bones causes the release of hormones that are effective in regulating blood glucose, lipid profile and preventing vascular calcification. The present study aims to Comparison effect of aerobic and resistance exercises on Osteocalcin and Metabolic Profils in Overweight men. Methods: total of 33 overweight healthy men (BMI 29 = 67.96 ± 0.96 and age 33.2 ± 2.23) were randomly assigned into three groups: control (n = 11), aerobic (n = 11) and resistance exercise (n = 11) groups. The training program was conducted for 8 weeks, 3 sessions per week for the training groups. Body compositions parameters (weight, body fat percent, BMI) were analyzed, osteocalcin and blood biochemical parameters were assessed from fasting blood samples before and after 8-week exercise programme. Results: Body fat, BMI and body weight reduction following exercise (P<0/05), significantly increased serum Osteocalcin (P<0/05, baseline vs Post exercise) and blood biochemical parameters significantly changes (P < 0/05). Increase in osteocalcin had a negative correlation with changes in body composition, as well as HOMA-IR and HDL, LDL not significantly (all P > 0/05). Conclusion: Aerobic and Resistance exercise cause to changes in body weight, body fat, BMI, as well as the increase level of osteocalcin and improvement of glucose metabolism and lipid profiles. However, the difference between the two training groups was not statistically significant.

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Cystic fibrosis (CF) is an inherited disorder caused by genetic mutations encoding the cystic fibrosis transmembrane conductance regulator (CFTR) protein. Elexacaftor/tezacaftor/ivacaftor (ELX/TEZ/IVA) is a CFTR modulator shown to improve lung function in certain patients with CF. We undertook this study to determine its effects on glycemic outcomes in pediatric patients with cystic fibrosis-related diabetes (CFRD). We reviewed the medical records and identified two subjects, referred to as subject A and subject B, with CFRD on insulin therapy at Duke University Hospital between 2019-2020 who were on treatment with ELX/TEZ/IVA for at least one year. The mean hgbA1C pre- and post- treatment was 5.65% (5.6-5.7) and 5.05% (5.0-5.1) respectively with a mean reduction of 0.6% (p value 0.01). Improvement in hgbA1C occurred in the absence of increased insulin requirements, subject B remained on a similar insulin regimen whereas subject A was able to come off insulin completely. In addition, improvements in BMI z-score were seen in both groups with a mean BMI z-score of -0.30 pre-treatment (-0.71-0.11) and z-score of +0.28 post-treatment (0.11-0.45).

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The use and the production of sanitizers have increased in the post-pandemic situation to prevent the further spread of COVID-19. Usability assessment of sanitizer containers is essentially required to evaluate the effectiveness, efficiency, and satisfactory use of the sanitizer containers. This study aimed to evaluate the system usability scale (SUS) as a marker of perceived usability of non-human computer interfaces, such as - sanitizer containers. The perceived usability of three types of sanitizer containers was evaluated using SUS. The authors have measured the reliability, convergent, and discriminant validity to evaluate SUS as a marker of usability of sanitizer containers. The result showed that SUS lacks convergent validity though it has a higher reliability coefficient. Thus, this is not the best measure of usability for non-human computer interfaces like-sanitizer containers. The SUS was applied on the flip cap, finger-pressure pump, and spray-type sanitizer containers. The finger-pressure pump container has exhibited a higher SUS score than others. The results of this study have given an idea about the usability of three different kinds of sanitizer containers. This research provides an overview of the application of SUS on non-Human computer interfaces like sanitizer containers. This study provides limitations like lack of convergent validity and ideas to overcome common method bias.

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Pediatric cancer overall survival has increased due to improvements in treatment. However, long-term adverse effects are a challenge for this population. Secondary myeloid neoplasm (MN) is one of the complications of solid tumor treatment. Therapy-related myeloid neoplasms (t-MN), therapy-related acute myeloid leukemia (t-AML), and therapy-related myelodysplastic syndrome (t-MDS) are the most common events. The aim of this study was to report a large pediatric sample and the relevance of t-MN after pediatric solid tumor therapy. We conducted a retrospective study between 2000-2016 in a cohort of pediatric patients treated for solid tumors who developed a secondary MN by medical records review and analysis. Seven from 2178 pediatric patients who were previously treated for solid tumors, were diagnosed with t-MN in a reference cancer center in Brazil. The median age at primary tumor diagnosis was 12.8 years old. Osteosarcoma, atypical primitive neuroectodermal tumor (PNET), Ewing sarcoma, and retinoblastoma were the most frequent solid tumors associated with t-MN. Three patients had a story of familiar cancer, and one patient with osteosarcoma had Li-Fraumeni syndrome confirmed. The median latency period to secondary MN was ten months and the prevalence rate was 0.32%. Two patients developed t-MDS and five, t-AML. All these patients received cytotoxic agents’ high doses that may have been associated with t-MN development. t-MN initial control, as well as unfavorable cytogenetic abnormalities, may have contributed to the poor outcome. We described the rarity of t-MN related to previous solid tumor therapy in a large pediatric sample in a Brazilian Cancer Center and their poor prognosis.

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In this paper, we report on the synthesis of BaTiO3 nanowires via the anodic aluminum oxide template method. To fill in the precursors of BaTiO3 into anodic aluminum oxide templates, the vacuum and drop loading method developed in our previous study was used. Ba(CH3COO)2 (barium acetate) and C12H28O4Ti (tetraisopropyl orthotitanate) were used as Ba and Ti sources, respectively. Anodic aluminum oxide membranes with the through-hole diameter of ~200 nm were used as the template for BaTiO3 nanowires.

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