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Articles Related to Rel

Cocoa Butter Intake Regulates Gut Immunity through the Release and Transport of IL-1β, IL-6 and IL-10: Activation of Negative Feedback Control System with Inflammatory and Anti-Inflammatory Cytokines

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Piriformospora indica: in Relation with Nitrogen and Phosphorus Uptake Mitigate the Effect of Drought and Heavy metal Ions in Plants

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Leptin Receptor Gene Variant Rs1137101 and Ghrelin Gene Variant Rs696217 are Associated with Body Mass Index in Brazilian Population: A Case-Control Study

Introduction: Obesity is a multifactorial condition influenced by environment and genetic factors. Controlling appetite and satiety involves complex interactions between the hypothalamus, which is responsible for homeostasis regulation energy, and hormones that regulate appetite including leptin and ghrelin. Leptin plays an important role in the regulation of food intake and energy expenditure, generating an increase in energy burning and decreasing food intake. And ghrelin is directly involved in the regulation of short-term energy balance. Objectives: To verify frequency, biochemical profile and Body Mass Index (BMI) variations according to SNPs in LEPR and GHRL gene. Subjects and Methods: 163 both genders subjects were classified into Study Group (SG): 103 subjects with obesity; Control Group (CG): 60 non-obese. Blood samples were collected to perform DNA extraction and biochemical profile analysis. Statistical significance was established at p < 0.05. Results: The genotype and allele frequency were similar between groups for both polymorphisms. The _/A genotype of the GHRL rs696217 polymorphism was associated to increased BMI in SG compared CG (p = 0.003) and increased triglycerides (TG) and very low density lipoprotein (VLDLc) values in CG (p < 0, 05). The _/A genotype was also associated with increased fasting glucose compared to CC genotype only in CG (p = 0.031). Considering the LEPR rs1137101 polymorphism, AA genotype subjects presented higher BMI compared to _/G genotype subjects (p = 0.024). No difference between biochemical profile variables related to LEPR rs1137101 polymorphism was found. Conclusion: AA genotypes of the LEPR rs1137101 polymorphism and _/A of the GHRL rs696217 polymorphism suggest being risk factors for BMI and the latter is associated with fasting glucose, VLDLc and TG variation.
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Relation between Osteocalcin and Metabolic Profils in Overweight Men: Comparison of Aerobic and Resistance Trainings

Objectives: Recent studies have shown that exercise by affecting bones causes the release of hormones that are effective in regulating blood glucose, lipid profile and preventing vascular calcification. The present study aims to Comparison effect of aerobic and resistance exercises on Osteocalcin and Metabolic Profils in Overweight men. Methods: total of 33 overweight healthy men (BMI 29 = 67.96 ± 0.96 and age 33.2 ± 2.23) were randomly assigned into three groups: control (n = 11), aerobic (n = 11) and resistance exercise (n = 11) groups. The training program was conducted for 8 weeks, 3 sessions per week for the training groups. Body compositions parameters (weight, body fat percent, BMI) were analyzed, osteocalcin and blood biochemical parameters were assessed from fasting blood samples before and after 8-week exercise programme. Results: Body fat, BMI and body weight reduction following exercise (P<0/05), significantly increased serum Osteocalcin (P<0/05, baseline vs Post exercise) and blood biochemical parameters significantly changes (P < 0/05). Increase in osteocalcin had a negative correlation with changes in body composition, as well as HOMA-IR and HDL, LDL not significantly (all P > 0/05). Conclusion: Aerobic and Resistance exercise cause to changes in body weight, body fat, BMI, as well as the increase level of osteocalcin and improvement of glucose metabolism and lipid profiles. However, the difference between the two training groups was not statistically significant.
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Elexacaftor/Tezacaftor/Ivacaftor Improves Glycemic Control in Pediatric Patients with Cystic Fibrosis-Related Diabetes

Cystic fibrosis (CF) is an inherited disorder caused by genetic mutations encoding the cystic fibrosis transmembrane conductance regulator (CFTR) protein. Elexacaftor/tezacaftor/ivacaftor (ELX/TEZ/IVA) is a CFTR modulator shown to improve lung function in certain patients with CF. We undertook this study to determine its effects on glycemic outcomes in pediatric patients with cystic fibrosis-related diabetes (CFRD). We reviewed the medical records and identified two subjects, referred to as subject A and subject B, with CFRD on insulin therapy at Duke University Hospital between 2019-2020 who were on treatment with ELX/TEZ/IVA for at least one year. The mean hgbA1C pre- and post- treatment was 5.65% (5.6-5.7) and 5.05% (5.0-5.1) respectively with a mean reduction of 0.6% (p value 0.01). Improvement in hgbA1C occurred in the absence of increased insulin requirements, subject B remained on a similar insulin regimen whereas subject A was able to come off insulin completely. In addition, improvements in BMI z-score were seen in both groups with a mean BMI z-score of -0.30 pre-treatment (-0.71-0.11) and z-score of +0.28 post-treatment (0.11-0.45).
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Prevalence of Significant Ocular Surface Symptoms and Its Relation to Polypharmacy Among In-Patients in A General Internal Medicine Department

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Evaluation of System Usability Scale as A Marker of Non-Human Computer Interface’s Usability: A Sanitizer Container-Based Study

The use and the production of sanitizers have increased in the post-pandemic situation to prevent the further spread of COVID-19. Usability assessment of sanitizer containers is essentially required to evaluate the effectiveness, efficiency, and satisfactory use of the sanitizer containers. This study aimed to evaluate the system usability scale (SUS) as a marker of perceived usability of non-human computer interfaces, such as - sanitizer containers. The perceived usability of three types of sanitizer containers was evaluated using SUS. The authors have measured the reliability, convergent, and discriminant validity to evaluate SUS as a marker of usability of sanitizer containers. The result showed that SUS lacks convergent validity though it has a higher reliability coefficient. Thus, this is not the best measure of usability for non-human computer interfaces like-sanitizer containers. The SUS was applied on the flip cap, finger-pressure pump, and spray-type sanitizer containers. The finger-pressure pump container has exhibited a higher SUS score than others. The results of this study have given an idea about the usability of three different kinds of sanitizer containers. This research provides an overview of the application of SUS on non-Human computer interfaces like sanitizer containers. This study provides limitations like lack of convergent validity and ideas to overcome common method bias.
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Therapy-related Myeloid Neoplasms after Pediatric Solid Cancer in a Single Reference Cancer Center in Brazil

Pediatric cancer overall survival has increased due to improvements in treatment. However, long-term adverse effects are a challenge for this population. Secondary myeloid neoplasm (MN) is one of the complications of solid tumor treatment. Therapy-related myeloid neoplasms (t-MN), therapy-related acute myeloid leukemia (t-AML), and therapy-related myelodysplastic syndrome (t-MDS) are the most common events. The aim of this study was to report a large pediatric sample and the relevance of t-MN after pediatric solid tumor therapy. We conducted a retrospective study between 2000-2016 in a cohort of pediatric patients treated for solid tumors who developed a secondary MN by medical records review and analysis. Seven from 2178 pediatric patients who were previously treated for solid tumors, were diagnosed with t-MN in a reference cancer center in Brazil. The median age at primary tumor diagnosis was 12.8 years old. Osteosarcoma, atypical primitive neuroectodermal tumor (PNET), Ewing sarcoma, and retinoblastoma were the most frequent solid tumors associated with t-MN. Three patients had a story of familiar cancer, and one patient with osteosarcoma had Li-Fraumeni syndrome confirmed. The median latency period to secondary MN was ten months and the prevalence rate was 0.32%. Two patients developed t-MDS and five, t-AML. All these patients received cytotoxic agents’ high doses that may have been associated with t-MN development. t-MN initial control, as well as unfavorable cytogenetic abnormalities, may have contributed to the poor outcome. We described the rarity of t-MN related to previous solid tumor therapy in a large pediatric sample in a Brazilian Cancer Center and their poor prognosis.
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Selection of Disease Modifying Treatment (DMT) Relates to Patient’s DecisionMaking Competence in MS

Background: In Multiple Sclerosis, more efficient disease modifying treatment (DMT) are often accompanied by higher risks and side effects. Selecting the optimal DMT demands from patients and doctors therefore a complex decision-making process weighing risks and benefits. Patients and doctors often prefer to share responsibility when making these treatment decisions, but this shared decision-making model requests decision-making competence on both sides. The aim of our online study was to investigate whether patients’ decision-making competence relates to DMT selection. Method: 197 patients participated in the online survey, advertised by two patient organizations. Patients reported their DMT and who decided for or against a DMT: their neurologist, themselves, or both. We measured decision-making competence with two tasks from the Adult Decision-Making Competence Battery (A-DMC), the ability to follow decision rules and the consistency of risk perception. Perceived impairment of the disease was measured with Patient Determined Disease Steps (PDDS). Results: The ability to follow decision rules varied with the potency of the DMT. Patients receiving basic DMT were better able to follow decision rules compared to patients receiving medium DMT. Patients who did not take any DMT stated more frequently that this decision was their own choice and independent of their doctor’s advice. Conclusions: If patients without DMT decided against this treatment on their own behalf, doctors and caregivers potentially have to strengthen their effort to reach out to the patient and to ensure the decision is well taken.
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A Retrospective Analysis of 25 cases of Addisons Disease Caused by Adrenal Tuberculosis in Tibet and Review of Related Literature

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Diabetic Retinopathy, Classification And Clinical Impact

Introduction: Diabetic retinopathy maybe defined as the presence and characteristic evolution of typical retinal micro-vascular lesions to an patient with diabetes. DR usually manifests as a gradual, painless progression of vision loss; however, visual loss may occur with vitreous hemorrhage or macular edema. Aims: To ascertain the prevalence of diabetic retinopathy (DR) based on the duration of the diabetes mellitus (DM) and to compare it with data from relevant literature and other referent clinics. This exploratory research was conducted to evaluate the clinical experience of DR, its impact of the other disease and health related quality of life. Material and methods: In this study are included the patients with diabetes mellitus type I insulin dependent (DMID) and diabetes mellitus type II non-insulin dependent (DMNID). The duration of diabetes in the examined patients varied from 5 till 30 years. We have applied examination by ophthalmoscope, slit lamp bio-microscopy with Volk and Goldman lens, optical coherence tomography - OCT as well as fluorescent angiography - FAG. Have been included for focus groups (n = 450) the treated patients with DR, from December 2016 - 2020. Results: Participants described a range of evaluate symptoms and clinical impact. In suffering for a period of 5 years, the prevalence of DR is 12.5%. In diabetic patients suffering over 30 years, the prevalence of DR is over 90.5 %. After the test of PDR impact the comlications results by the X2 -test, the difference was found to be statistically significant for p<0.05.
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A Tunisian Patient with CLCN2-Related Leukoencephalopathy

CLCN2 related leukoencephalopathy (CC2L OMIM#: 615651) is a recently identified rare disorder, caused by autosomal recessive mutations in CLCN2 gene, leading to the dysfunction of its encoded CLC-2 chloride channel protein with characteristic brain MRI features of leukoencephalopathy
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Correlation between Overall Survival and Quality of Life in Patients with Esophageal Cancer: A Comparison between Radiation and Chemoradiation

Desirable treatment options for inoperable esophageal cancer considering not only overall survival (OS) but also quality of life (QOL) during the entire clinical course remain unclear. We evaluated OS and QOL during the clinical course of patients with inoperable esophageal cancer undergoing chemoradiation or radiation. Forty-four patients with inoperable esophageal cancer between 2015 and 2020 were included in this retrospective study.
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Study on Prescribing Pattern of Antibiotic used for Urinary Tract Infection in Tertiary Care Teaching Hospital: A Preliminary Antibiotic Stewardship Programme

Urinary tract infection is defined as the presence of microorganism in the urine that cannot be accounted by contamination. First line treatments for UTI are antibiotics. Antibiotic stewardship is the coordinated intervention designed to improve and measure the appropriate use of antibiotic agents, by promoting the selection of optimal antibiotic drug regimen including dosing, duration of therapy and route of administration.
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Spine Osteonecrosis Related to Sickle Cell Disease

Analyze the clinical profile of the spine with osteonecrosis in sickle cell disease. 610 patients were followed-up in this study between 2000 and 2017. 98 osteonecrosis were identified, 48 in the lumbar spine, 40 in the thoracic spine and 10 in both spine segments. We analyzed sex, age, genotype, and pain. Magnetic resonances and radiographs of the spine were performed.
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Synthesis of BaTiO3 Nanowires via Anodic Aluminum Oxide Template Method Assisted by Vacuum-and-Drop Loading

In this paper, we report on the synthesis of BaTiO3 nanowires via the anodic aluminum oxide template method. To fill in the precursors of BaTiO3 into anodic aluminum oxide templates, the vacuum and drop loading method developed in our previous study was used. Ba(CH3COO)2 (barium acetate) and C12H28O4Ti (tetraisopropyl orthotitanate) were used as Ba and Ti sources, respectively. Anodic aluminum oxide membranes with the through-hole diameter of ~200 nm were used as the template for BaTiO3 nanowires.
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Editorial Board Members Related to Rel

Anthony Joseph Berdis

Assistant Professor
Departments of Chemistry and Biology
Cleveland State University
United States

Nathan Newman

Associate Professor of Athletic Training
Athletic Training Program Director
Drake University
USA

Suman Sirimulla

Assistant Professor
Department of Basic Sciences
St. Louis College of Pharmacy
St. Louis, MO
United States.

Ashraf Eljedi

Associate Professor of International Public Health
Faculty of NUrsing
The Islamic University of Gaza
Palestine

Roy G Beran

Professor
Department of Neurology
University of New South Wales
Australia

MASAYOSHI YAMAGUCHI

Professor
Department of Hematology and Medical Oncology
Emory School of Medicine
Emory University
United States

DAVID R. BLACK

Professor Emeritus
Department of Health and Kinesiology
Purdue University
United States

BADER MUBARAK W. AL-JAEID

Faculty of Pharmacy
King Abdulaziz University
Saudi Arabia

Zuhair Muhi-eldeen

Professor
Department of Medicinal chemistry
Petra University
Jordan

CHIA-YI KUAN

Associate Professor
Department of Pediatrics
Center for Neurodegenerative Disease
Emory University School of Medicine
United States
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