Articles Related to Retina
Investigation of Neuroprotective Effects of Ripasudil in Mechanic Optic Nerve Injury Model
Purpose: We aimed to create mechanic optic nerve injury model in rats and investigate the neuroprotective effects of
ripasudil on retinal ganglion cells.
Study Design: Experimental study
Methods: Mechanic optic nerve injury model was created in the right eyes of male Wistar rats (n=15). Rats were divided
into three groups: glaucoma model with sham treatment (group1) and 20 µM intravitreal ripasudil treatment (group 2)
and 50 µM intravitreal ripasudil treatment (group 3). Treatment was applied intravitreally and rats were sacrificed at the
end of 4 weeks. Glial fibrillary acidic protein (GFAP), Brn-3a antibody,anti- Iba1 was examined by immunohistochemistry.
Results: The number of Brn-3a positive RGC in the mechanical optic nerve injury model was 5.33 ± 2.08 (min: 3, max: 7)
in sham group, 10.25 ± 2.63 (min: 8, max: 14) in 20 µM group and 16.75 ± 5.43 (min:9, max: 21) in 50 µM group (p <0.05).
GFAP positive RGC counts were recorded as 24.33 ± 2.08 (min: 22, max: 26) in sham group, 16.75 ± 1.70 (min: 15, max:
19) in 20 µM group and 13.00 ± 4.08 (min:10 , max: 19) in 50 µM group (p <0.05). Ripasudil treatment also decreased Iba1
expression in the retina of mechanic optic nerve injury groups. In addition, ripasudil treatment prevented apoptotic cell
death by increasing Bcl-xL protein expression and preserved Tfam protein expression in the retina.
Conclusions: Our experimental study has shown that ripasudil is neuropreotective in mechanical optic nerve injury
model.
Optical Coherence Tomography Angiography for Choroidal Neovascularization and Subretinal Fibrosis in Pseudoxanthoma Elasticum
Pseudoxanthoma elasticum (PXE) is characterized by a progressive fragmentation and calcification of elastic fibers in connective tissue and when Bruch membrane (BM) is affected ocular modifications can be found. Recently, Optical coherence tomography-angiography (OCT-A) contribute to a better comprehension of lesions in PXE.
A Case with Vitreomacular Traction Developing Complications after Intravitreal Perfluoropropane Injection
A sixty-year-old woman with no remarkable systemic disease came to our clinic due to blurred vision of right eye for one month. The best corrected visual acuity (BCVA) was 0.2 in the right eye, while intraocular pressure, anterior segment, and optic disc of right eye were all normal. Optical coherence tomography (OCT) was arranged, which showed VMT in right eye.
Introduction of Stem Cells in Ophthalmology
Stem cells are relatively undifferentiated, with unlimited proliferative ability; self-renewal capability and also they can
differentiate into specialized cells. Somatic stem cells in adult organisms are responsible for regenerating and self-renewing tissue.
Many different stem cell types reside in the eye.
Closed Traumatic Avulsion of Extensor Digitorium Communis and Extensor Indicis Proprius of Index Finger at the Musculotendinous Junction
Closed traumatic rupture of extensor tendons of the fingers at the musculotendinous is rare. In fact the common sites of a closed rupture are distal attachment at the distal phalanx as well as at the attachment of the central slip at the base of the middle phalanx.
The Updated International Veterinary Anatomical and Embryological Nomenclatures
The international nomenclature of the anatomical, histological and embryological terms is known as Nomina Anatomica Veterinaria (N.A.V.), Nomina Histologica Veterinaria (N.H.V.) and Nomina Embryologica Veterinaria (N.E.V.).
Editorial Board Members Related to Retina
Christophe P. Ribelayga
Associate Professor
Ophthalmology & Visual Science
The University of Texas Health Science Center
USA
Ophthalmology & Visual Science
The University of Texas Health Science Center
USA
Li Cai
Associate Professor
Department of Biomedical Engineering
Rutgers University
United States
Department of Biomedical Engineering
Rutgers University
United States
GIUSTI CRISTIANO
Professor
Department of Ophthalmology
University Hospital “Campus Bio-Medico”
Italy
Department of Ophthalmology
University Hospital “Campus Bio-Medico”
Italy
Walter J. Lukiw
Professor
Neurology, Neuroscience and Ophthalmology
Louisiana State University
United States
Neurology, Neuroscience and Ophthalmology
Louisiana State University
United States
Ronald E.P. Frenkel
Voluntary Professor of Ophthalmology
Bascom Palmer Eye Institute
University of Miami School of Medicine
United States
Bascom Palmer Eye Institute
University of Miami School of Medicine
United States
Janet Liversidge
Professor
School of Medicine and Dentistry
University of Aberdeen Institute of Medical Sciences
United Kingdom
School of Medicine and Dentistry
University of Aberdeen Institute of Medical Sciences
United Kingdom
Baha’ N. Noureddin
Professor and Chairman
Department of Ophthalmology
The American University of Beirut
Lebanon
Department of Ophthalmology
The American University of Beirut
Lebanon