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The Use of Gingipain DNA Vaccine Against Virulence of Porphyromonas Gingivalis: A Literature Review

Porphyromonas gingivalis (P. gingivalis) is a primary etiologic agent of generalized aggressive and chronic forms of periodontitis. It releases toxins called ‘gingipains’.Gingipains, (Arginine-and Lysine-specific cysteine proteinases) are proteases that are critical virulence factors in progression of periodontitis and degradation of cytokines expressed during inflammation. HRgpA and RgpB (products of two distinct but related genes) induce vascular permeability by activation of the kallikrein/kinin pathway and activating the blood coagulation system which in turn induces gingival crevicular fluid production and progression of inflammation leading to alveolar bone loss.
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A Review on Antioxidant, Anti-Inflammatory and Gastroprotective Abilities of Mango (Magnifera indica) Leaf Extract and Mangiferin

Mango (Mangifera indica Linn.) trees have been cultivated and grown in Southern and Eastern India for thousands of years and have slowly spread all over the world. For over 4,000 years various parts of mango trees including leaf and fruit pulp have been extensively used in Ayurvedic and Unani medicines.
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The 2015 Dutch Food-Based Dietary Guidelines on Alcohol Consumption - A Critical Review

Background: Recently the Dutch Health Council has issued a revised alcohol guideline stating: Do not drink alcohol, or if any only drink one glass daily. The current guidelines are intended to obtain the lowest disease burden of the most burdensome diseases in The Netherlands. The current paper aims to estimate the overall impact of alcohol consumption on these diseases.
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Prevention of Peri-Implantitis: A Narrative Review

With the discovery of osseointegration and advancement in dental materials dental implants provide superior support, stability and retention for prosthetic replacement of missing teeth than any available prosthetic option. But with the use of implants, an associated biological complication of peri-implant disease is seen in 48% of cases. Hence, this review aims to summarize the risk factors associated with peri-implantits and highlights current prevention strategies available and those to be further researched to minimise the incidence and severity of peri-implant disease and enhance longevity of implants.
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Non Ige Mediated Cows Milk Protein Allergy Presenting with Generalized Edema: Case Report and Review of the Literature

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Caenorhabditis elegans (C. elegans) Used as a Whole Model Organism to Identify New Anti-Infectives Therapeutic Agent for MRSA Pathogens - A Review Paper

Methicillin-resistant Staphylococcus aureus (MRSA) is one of the greatest fears with the number of serious infections on human health regarding antibiotic resistance. It causes a wide range of infections and bacteremia, ranging from inconsequential superficial skin infections, wound suppuration, even pneumonia or deep-seated tissue infections, which may lead to sepsis and fatalities.
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The Effect of Bundled Interventions on Prevention of Hospital Acquired Clostridium Difficile Infection: An Integrative Review

Hospitalized patients are at an increased risk for acquiring Clostridium Difficile Infection (CDI). Increased virulence of C. difficile strains and increased use of antimicrobials have led to an increase of CDI cases that are more difficult to treat (CDC, 2013). Proper hand hygiene techniques, room cleaning, and equipment cleaning are not consistently being followed by healthcare workers, leading an increased spread of CDI between hospitalized patients. The purpose of this integrative review was to determine the best evidencebased methods to reduce hospital-acquired CDI rates. The evidence reviewed supports the implementation of a multifaceted approach including: (a) proper hand hygiene practices, (b) adequate and appropriate surface cleaning practices, (c) compliance to contact isolation procedures, and (d) strengthening of an existing antimicrobial stewardship committee to reduce hospital-acquired CDI rates.
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Oral Health in Asthmatics: A Review

Asthma is a chronic inflammation of airway tract characterized by airway obstruction and hyper responsiveness presenting with symptoms of wheezing, coughing, chest tightness and dyspnoea. It is a serious health issue with the worldwide occurrence. Antiasthmatic drugs have unfavorable effects on oral health causing dental caries, xerostomia, dental erosion, periodontal disease and orofacial deformities. This review concludes that asthma drastically affects oral health but preventive measures can help to improve quality of life.
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Trends in Thyroid Malignancies in Accra Ghana: A Retrospective Histopathological Review in the Department of Pathology (1994-2013), Korle-Bu Teaching Hospital

Malignancies of the thyroid gland are common in certain parts of the world. In Ghana there are no available data on the trends and gender characteristics of thyroid malignancies (TMs). The aim of this retrospective study was to determine the trends and gender characteristics of TMs in the Department of Pathology.
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Osteoid Osteoma of the Ribs - Is Image Intensifier or Bone Scintigraphy a Mandatory Diagnostic Tool - A Case report with Review of Literature

Osteoid osteoma (OO) is a benign bone tumour. In 1935, the jaffe reported it first. The fifty percent of OOs occur in long bones of the lower extremities but it may affect any bone. Only 1 % OOs affects the ribs and surgical excision was reported only in 14 cases in the literature. Complete surgical excision is the standard treatment method for osteoid osteoma is complete surgical excision which is reserved for the patients not responding to conservative treatment. In this report, we present a case of osteoid osteoma of the posterior part of the shaft of the sixth rib affecting a 30-year-old male, who had presented with symptoms of severe pain over the affected area and underwent surgical resection. Excised rib segment showed no osteosclerotic lesion on X-ray so immediately extended resection of the sixth rib was done. Here we have tried to evaluate the importance of the presence of the skeletal scintigraphy or C Arm image intensifier intraoperatively by comparing our experience with the available literature.
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An Observational Chart Review of a Comparison of Generic to Reference Liposome-Encapsulated Doxorubicin Hydrochloride in Subjects with Epithelial Ovarian Carcinoma Who Have Failed Platinum-Based Chemotherapy

This study tested for the effects of generic liposome-encapsulated doxorubicin hydrochloride (generic doxorubicin) compared to reference-pegylated liposomal doxorubicin hydrochloride (reference doxorubicin) as a treatment for patients afflicted with epithelial ovarian carcinoma whose disease has progressed after platinum-based chemotherapy. Chart-reviews of actual patients enrolled in a community-based NIH trial suggest that both generic and reference liposomal doxorubicin hydrochloride (HCl) are equally effective as treatment for ovarian cancer carcinoma.
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Mucinous Adenocarcinoma of the appendix with Retroperitoneal and Pelvic Bone Extension - A Case Report and Literature Review

The Appendiceal mucocele (AM) was considered as a rare dilation of the appendiceal lumen. Four different types of AMs are defined according to the cause of obstruction, for both benign and malignant, including retention cysts, epithelial hyperplasia, mucinous cystadenoma, and mucinous cystadenocarcinoma.
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Two Novel Cases of Marfan Syndrome with FBN1 whole Gene Deletion: Laboratory Assay and Cases Review

Background: Marfan syndrome is a hereditary disorder of connective tissue mainly characterized by abnormalities in the cardiovascular, skeletal and ocular systems. It is most frequently due to heterozygous point mutations in the FBN1 gene located on chromosome 15q21.1 and coding for fibrillin-1 protein. Over 3000 FBN1 mutations have been reported in the FBN1 Universal Mutation Database, among these FBN1 large rearrangements account for <2%. Several studies have shown that 15q deletions encompassing the whole FBN1 gene are associated with Marfan syndrome and FBN1 haploinsufficiency is involved in the pathogenesis of the disease. Since now 19 cases of FBN1 entire deletion have been already described.
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All-On-Four Concept in Implant Dentistry: A Literature Review

implantIntroductionThe implant technology developed as the all-on-four concept is offered as an alternative to conventional implant applications. In the all-on-four technique, 4 implants are placed in the interforaminal region in the mandible and in the pre-maxillary region in total edentulism cases. This application is based on the placement of two of these implants to the anterior region so as to be perpendicular to the occlusal plane, and on the placement of two implants to the posterior region so as to be inclined 30-45o. These implants are ensured to function by making immediate fixed complete denture over them. The patient is administered with permanent fixed full arch restoration 3 months later. The reduction of surgical procedures and the functioning of immediate dentures are important by means of this system. The purpose of this study is to compile the clinical and research articles regarding the all-on-four implant concept, to determine the basic principles of this concept, and to present the advantages and disadvantages of the method. The all-on-four concept can be an alternative and potential treatment method especially in atrophic edentulous jaws, its routine clinical practices can be performed, but it is necessary to increase long-term clinical controlled studies.
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The Role of Nanotechnology in Semiconductor Industry: Review Article

Nanotechnology is now the key area of technology to create and manipulate materials at the nanometre (nm or 10-9 m) scale either by bottom up from single groups of atoms to bulk matter or by top down which is reducing bulk materials to a group of atom. Now a days it is being used or considered for use for fabricating and constructing many efficient electronic devices which have extremely large surface area to volume ratio, this makes a large number of surface or interfacial atoms, resulting in more surface dependent material properties specially this technology is used in semiconductor industry or solar cell industry.
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Editorial Board Members Related to Review

J Vernon Odom

Professor
Department of Ophthalmology
West Virginia University
United States

Thiam Chye LIM

Associate Professor
Department of Surgery
National University of Singapore
Singapore

Peter Schemmer

Professor
Department of General -, Visceral- and Transplant Surgery
University Hospital of Heidelberg
Germany

Seyed Fakhreddin

Department of Seafood Processing
Faculty of Marine Sciences
Tarbiat Modares University
Iran

Boxun Hu

Assistant Research Professor
Center for Clean Energy Engineering
University of Connecticut
USA

Bernd Schierwater

Research Associate
labs of Stephen Dellaporta
Yale University
United States

Bulang Gao

Professor
Department of Medical Research
Hebei Medical University
China

Rammurti T. Kamble

Professor of Medicine
Baylor College of Medicine
United States

Shigemi Matsuyama

Associate Professor
Division of Hematology/Oncology
School of Medicine
Case Western Reserve University

United States

JACQUES MARESCAUX

Professor
Department of Surgery
Research Institute Against Digestive Cancer
France
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