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Articles Related to SAFE

Efficacy and Safety of Moxifloxacin-Enhanced versus Standard Sequential Eradication Therapy for Treating Helicobacter pylori Infection among Tobacco Smokers

The therapeutic failure rate of eradication therapy for Helicobacter pylori (Hp) is increasing due to bacterial resistance; tobacco smoking can increase such a rate even more. We explored the role of adding moxifloxacin to the standard sequential eradication therapy for Hp in decreasing the therapeutic failure rate among the tobacco smokers.
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The Efficacy and Safety of Prophylactic Fluconazole Prevent Invasive Fungal Infection in Preterm Very Low Birth Weight Infants: An Update Meta-analysis

We identified 8 eligible trials that enrolled 1392 infants. There was significant effect of prophylactic fluconazole on fungal colonization (RR, 0.31, 95%C1:-0.24 to 0.41; P<0.00001). Effect of prophylactic fluconazole on IFI in VLBW infants: RR: 0.42(95%CI 0.23 to 0.76; P=0.004.). However, prophylactic fluconazole did not reduce mortality in VLBW infants (RR 0.76, 95% CI 0.58 to 1.01; P = 0.06). Studies did not report significant adverse reactions.
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Comparative Study for Efficacy and Safety of Biosimilar Infliximab in Patients with Active Rheumatoid Arthritis on a stable Dose of Methotrexate

The present study evaluated the efficacy and safety of biosimilar infliximab in patients with active rheumatoid arthritis on a stable dose of methotrexate. Subjects were assigned randomly to either study infliximab or reference infliximab product in an approved dose of 3 mg/kg as an intravenous infusion at week 0, followed by similar doses at Weeks 2, 6 and 14. Primary efficacy endpoint was the proportion of subjects achieving ACR20 criteria at week 16 and secondary efficacy assessment included proportion of subjects achieving ACR20, ACR50 and ACR70 at week 16. In the open-label phase, all responders were followed till week 54. The non-responders entered a follow-up phase for immunogenicity and safety for an additional 3 months.
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Assessment of the Efficacy, Safety and Cost-Effectiveness of Micafungin Compared to Caspofungin and Low Dose Liposomal Amphotericin B for the Treatment of Candidaemia and Clinically Diagnosed Invasive Candidiasis: A Retrospective Audit

Despite several studies having highlighted that candidaemia and invasive fungal disease (IFD) are associated with high mortality and increased costs, there are currently few published studies which provide an insight into real-life practice of invasive candidal diseases. In a medium-sized district general hospital in the UK we sought to compare the efficacy, safety and treatment cost of micafungin versus caspofungin and low dose of liposomal amphotericin B (L-AmB) 1mg/kg/day for the treatment of confirmed candidaemia or clinically diagnosed invasive fungal disease (CDIFD). In the present retrospective audit, a total of 126 patients with candidaemia or CDIFD were reviewed from hospital records and 94 were included in our audit.
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Quadrivalent Human Papillomavirus Vaccine and the Young Ovary: Review of Safety Research Following Two Case Series of Premature Ovarian Insufficiency

The quadrivalent virus-like particle vaccine against human papillomavirus (QHPV) is a population vaccine targeting peri-pubertal girls and boys. Focus on evaluation of adolescent ovarian safety arises from cases in primary care and published case series describing the development of menstrual dysfunction and idiopathic premature ovarian insufficiency (POI) following QHPV vaccination. A structured review of QHPV vaccine safety studies was performed to answer the question ‘has the ongoing ovarian safety of this vaccine in adolescents been assessed?’ The design, size, and process of pre-licensing safety trials in relation to their capacity to assess ovarian function were reviewed.
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Safety of Permethrin and Pyriproxyfen in Dogs Treated With VetGuard Plus®

Ectoparasites are a continuous problem in small companion animals, and veterinary personnel and pet owners are constantly exposed to transferable residues when handling dogs treated with topical ectoparasiticides.
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Dietary Diversity Score: A Measure of Nutritional Adequacy or an Indicator of Healthy Diet?

At the time when the lack of indicators seemed to constrain appropriate child feeding in developing countries, dietary diversity score (DDS) emerged as a measure of nutritional adequacy that could close the gap. DDS refers to the number of food groups consumed in a given time, often in 24 hrs.
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Health Food and Traditional Chinese Medicine in China

Like a drug for a purpose of treating or preventing a disease, a health food has to be scientifically evaluation and officially approved before it legally is marketed in China.
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Biometric Template Protection

Biometric template offers a dependable approach to the trouble of user authentication in identity management structures. Various biometric technologies were developed and effectively deployed around the arena which includes fingerprints, face, iris, palm-print, hand geometry and signature.
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Bacteriological Quality of Milk in Raw Bovine Bulk Milk in the Selected Milk Collection Centers: Smallholder Dairy Processing Ethiopia

Cross-sectional study was conducted to examine and identify quality of raw bovine milk from in Arsi Zone and East Shewa Zone, in Oromia, Ethiopia. The purpose of the study was to assess hygienic practices during milking, milk collection and bacteriological quality of cow’s milk in Arsi and East Shewa Zones milk collection centers.
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Nuts and Body Weight - An Overview

Since obesity and overweight became health issues, tree nuts became considered as unhealthy, due to their high fat content. Their high energy density has been pointed as a major factor in body weight gain.
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Determining the Role of Hand Feeding Practices in Accidental Shark Bites on Scuba Divers

Shark-based ecotourism is significantly developing around the world, often without appropriate management of risk. This activity involves a risk of accidental bites on divers that can be quite severe or even fatal.
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Threat of Mosquito-Borne Human Viral Diseases

Mosquitoes, with its annoying behavior, are the worst enemy in human societies worldwide. To complicate matters, there are more than 3,500 species of mosquitoes existing globally
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Descriptive Study of Exposure to Inhalation Zanamivir and Pregnancy-Related Outcomes

The Health Improvement Network (THIN) provided data from UK General Practitioners (GPs) for 144 pregnant women who were prescribed zanamivir and 144 age- and date-matched untreated comparators with no recorded diagnosis of influenza. Groups were assessed for baseline characteristics, treatment-emergent diagnoses in the mother, pregnancy outcomes and congenital malformations diagnosed in the offspring within 28 days of birth.
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Impact of Training Programme on Knowledge and Perception of Primary Health Care (PHC) Workers on Nutrition Component of Safe Motherhood Initiative in South-West Nigeria

One of the core components of Safe Motherhood Initiatives (SMI) is nutrition, yet only few studies have considered this adequately. The goal of this intervention study was to evaluate the effect of training programme on knowledge and perception of PHC health workers on nutrition components of SMIs.
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Editorial Board Members Related to SAFE

LAUREN BERKOW

Associate Professor
Division of Neuroanesthesia
Department of Anesthesiology and Critical Care Medicine
Johns Hopkins University
United States

Lucia Gutierrez Bayard

Associate Professor
Department of Radiation Oncology
Hospital Universitario Puerta del Mar
Spain

MATEJ TRAPECAR

Assistant Professor
National Forensic Laboratory
Slovenia

YUNBO LI

Professor
Department of Pharmacology
Campbell University School of Osteopathic Medicine
United States

VILMA E. ORTIZ

Associate Anesthetist
Department of Anesthesia, Critical Care & Pain Medicine
Massachusetts General Hospital
United States

Mohammad Obaidat

Assistant Professor
Food Safety and Zoonotic Diseases
Jordan University of Science and Technology
Jordan

TANYA D. GRAHAM

Professor
Veterinary Pathologist
South Dakota State University
United States

Lela Bakanidze

Professor
Georgian Biosafety Association
Europe

Suresh Valiyaveettil

Associate Professor
Department of Chemistry
National University of Singapore
Singapore

Maria Ioannou

Senior Lecturer
University of Huddersfield
United Kingdom
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