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Articles Related to SPE

Artisanal Cannabis in Young and Adults Patients with Treatment Resistant Epilepsy: Prospective, Observational, Open-Label Study in Argentina

Background: A third of patients with epilepsy have a drug-resistant form. We aimed to observed whether addition of artisanal cannabis to existing anti-epileptic treatment would be safe, and efficacious in young and adults with drug-resistant epilepsy. Methods: Patients (aged 12-51 years) with severe, intractable epilepsy, who were receiving stable doses of antiepileptic drugs before study entry, were enrolled in an expanded-access programme at our epilepsy centre.
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Some New Results on Overdispersed Models for the Human Sex Ratio Data

We have presented in this paper alternative computation to arrive at results obtained in Lindsey and Altham (1998) on the use of the beta-binomial, the double binomial and the multiplicative binomial models to the Human Sex Ratio data. Our procedure estimates fewer parameters and thus the goodness-of-fit test statistics computed here are based on more d.f. The results obtained, using SAS PROC NLMIXED agree with those presented in the Lindsey et al. paper.
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A Retrospective Evaluation of Joint Endoprosthesis Infections and Depending Costs

Joint endoprosthesis are standard treatment in orthopedic surgery, but the risk of infection represents a major drawback for elderly patients with comorbidities. Therefore, we investigated joint endoprosthesis infections in Germany (2005-2012) focusing on elderly patients. We extrapolated infection related costs to estimate the burden for the health care system.
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Protection and Valuation of Mediterranean Species: The Role of Aquaculture

The Mediterranean Sea is catalogued worldwide as one of the 25 “hot spots” in terms of biological diversity [1]. However, it hosts many threatened species including turtles, marine mammals, rays and sharks, with chondrichthyans being the group exposed to the highest risk, with 42% of the species living under some type of threat [2]. On the other hand, a third of the other species studied in these waters, are not under any apparent risk [3].
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Analysis of antibody by Real-Valued Special Functions

Along with the rapid development of genetic engineering technology and antibody engineering technology, the humanized monoclonal antibody has been rapidly developed and gradually replaces the rat sourced monoclonal antibody. In this paper, we establish two new logarithmically completely monotonic functions involving the real-valued special functions according to two preferred interaction geometries, necessary and sufficient conditions are presented for one of them to be logarithmically completely monotonic. As a consequence, a sharp inequality involving the real-valued special functions is deduced to solve the problems of genetically engineered antibody.
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A Framework for Speaker Recognition System

An individual’s voice holds the characteristics to identify that individual uniquely. Automatic Speaker Recognition (ASR) is a technique for recognizing an individual by his/her voice. Controlling access privileges and forensic is the major application areas of Speaker recognition systems. To develop a robust speaker recognition system it is required that the system is able to provide acceptable performance with several operating conditions.
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Individual and Contextual Aspects Associated with Malocclusion in Brazilian Adolescents

Analytical cross-sectional study using data from the SB Brazil 2010. The dependent variable was malocclusion (absent, set, severe, very severe). Independent variables were classified into: individual (socio-demographic, oral health problems; education, utilization of dental services; self-perception, impact on activities) and contextual (Family Financial Grant, National Health System Development Index (IDSUS), Human Development Index (HDI) and interaction of Gross National Product (GNP) with fluoridated water). A multilevel analysis was executed.
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Trends in Thyroid Malignancies in Accra Ghana: A Retrospective Histopathological Review in the Department of Pathology (1994-2013), Korle-Bu Teaching Hospital

Malignancies of the thyroid gland are common in certain parts of the world. In Ghana there are no available data on the trends and gender characteristics of thyroid malignancies (TMs). The aim of this retrospective study was to determine the trends and gender characteristics of TMs in the Department of Pathology.
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Detection of the host-specific Bacterioides and Bifidobacteriumsaeculare markers in surface water in Hanam, Vietnam with real-time PCR

The microbiological quality of coastal or river waters can be affected by faecal pollution from human or animal sources. Contamination of fresh produce with pathogenic bacteria can be attributed directly or indirectly to the raw wastewater (domestic, industrial effluents, human and animal excrement). This includes water sources that are routinely used for crop irrigation and produce washing. An efficient MST (Microbial Source Tracking) toolbox consisting of several host-specific markers would, therefore, be valuable for identifying the origin of the faecal pollution in the environment and thus for effective resource management and remediation. As a result, the need for expanding from traditional techniques to molecular methods has been highly recommended.
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The Specific Composition of Micromycetes Contaminants of Children Foods in Syria and there Toxigenic Activity

For the investigation of micromycetes-contaminants in children foods and their toxigenic activity, 173 samples of children foods traded in local markets in al-Hasakah governorate -northeastern Syria- were collected and tested during the period (2011-2012). The tested samples were included in 4 food groups: oily seeds (35 samples), potato & maize chips (53 samples), biscuits (45 samples) and powdered milk & sugars (40 samples).The Sample investigation was undertaken in the plant diseases laboratory in Al-Qamishli Agricultural Research Center. The results of the analysis showed that most of the samples tested were contaminated with fungi in varying degrees ranged between 1× 10² and 5×10⁷ spore / gram of food substance. Only 2.3% of the samples tested exceeded 10⁴ spore / gram of food substance.
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Endothelial Cells May Have Tissue-Specific Origins

Endothelial heterogeneity reflects many functions performed by endothelial cells (ECs) in various tissues. However, the origin of this heterogeneity is unclear. Here, we report that tissue-specific ECs in lungs, brain, and liver co-expressed the lineage markers of their coordinating tissue-specific cells at very early stages. Specifically, we found that the pulmonary EC population was significantly suppressed after pulmonary epithelial-specific (Nkx2.1-Cre mediated) deletion of fetal liver kinase-1 (Flk1). Together, the results suggest that tissues-specific ECs may originate from the same progenitor cells as tissue-specific cells.
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Former Effective Immunotherapy without Adverse Events of Inoperable Epithelial Ovarian Cancers and a Prospect for the Immune Prophylaxis

Current cancer treatments by immune checkpoint blockades are limited due to severe adverse events caused by alteration of the immune system required for homeostasis of normal tissues. Common cancer chemotherapy alters the quality of patients’ lives. Platinum-based treatment can lead to severe neurotoxicity with chronic debilitation. Additionally, survival of patients with epithelial ovarian cancers (EOCs) has remained poor despite extensive cytoreductive surgery, high dose chemotherapy, checkpoint blockades and immunotherapies effective in some other types of cancer. The pathobiology of EOC cancer stem cells (CSCs) is not well understood. Observations demonstrate that EOCs exhibit in vivo two distinct CSC types - perivascular diploid CSCs dividing asymmetrically with the help of the host suicidal CD8+ T cells, and haploid CSCs at the cancer abdominal surface originating from meiosis I cytokinesis of bulk surface cancer cells. The perivascular CSCs contribute to the cancer cell bulk and, via left ovary venous blood, can cause EOC liver metastases. Haploid CSCs released from the bulk cancer surface cause the common pelvic and abdominal EOC spread. Former elimination of the host antibodies blocking T cell effectors by intermittent doses of cyclophosphamide exhibiting significant immunomodulatory anticancer effects, facilitation of the immune system reactivity against alloantigens of cancer cells by blood transfusions, and augmentation of anticancer immunity by bacterial toxins, resulted during the subsequent treatment-free period into rejection of inoperable EOCs without any adverse events during the treatnment. To help prevent cancer relapses, patients treated for advanced primary epithelial cancers should be considered as candidates for continuously stimulating immune anticancer activity by treatments such as daily metformin and weekly lentinan consumptions.
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Assessment of the Efficacy, Safety and Cost-Effectiveness of Micafungin Compared to Caspofungin and Low Dose Liposomal Amphotericin B for the Treatment of Candidaemia and Clinically Diagnosed Invasive Candidiasis: A Retrospective Audit

Despite several studies having highlighted that candidaemia and invasive fungal disease (IFD) are associated with high mortality and increased costs, there are currently few published studies which provide an insight into real-life practice of invasive candidal diseases. In a medium-sized district general hospital in the UK we sought to compare the efficacy, safety and treatment cost of micafungin versus caspofungin and low dose of liposomal amphotericin B (L-AmB) 1mg/kg/day for the treatment of confirmed candidaemia or clinically diagnosed invasive fungal disease (CDIFD). In the present retrospective audit, a total of 126 patients with candidaemia or CDIFD were reviewed from hospital records and 94 were included in our audit.
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Retrospective Analysis of 185 Occurrences of Clinical Neurological Signs in 181 South American Camelids

Medical records of each occurrence of neurologic signs in 181 South American Camelids admitted on 185 occasions (90 alpacas and 95 llamas) were evaluated. Age ranged from 0 days to 20 years, but 70.5% of cases were ≥ 1 year old. Specific clinical diagnosis was achieved by cerebrospinal fluid analysis (CSF), radiographs, computed tomography, laboratory testing, or necropsy in 74% of cases. 54% of cases survived; 46% of cases died or were euthanized. The most common diagnosis (31%) was parasitic myelopathy/encephalopathy (PME). CSF eosinophilia ≥10% was found in 85% of parasitic spinal migrations but only in 55% of intracranial migrations, and 73% had increased protein in CSF. There was a seasonal bias for PME with 79% of cases occurring between October and March. Survival of PME cases was 77% for spinal migration but only 7% when intracranial migration occurred. The most common diagnoses, excluding PME, were infectious disease (15%) and trauma (12%). Most trauma cases involved the cervical spine of which 50% survived.
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Does the Level of Chlamydia Serology Titre Correlate to the Degree of Tubal Disease at Laparoscopy? A Retrospective Controlled Study

In order to detect if there is any correlation between the level of total and specific Chlamydia serology titre and the degree of tubal disease at laparoscopy in sub fertile women and to compare the results with a control group. A retrospective controlled clinical study was conducted in a hospital setting (both inpatient and outpatient clinic). A total of hundred and twenty two sub fertile women who underwent laparoscopy/tubal surgery in the period between January 2011-January 2014 were included. This included 40 women with positive Chlamydia Trachomatis specific titre (group 1), 40 with positive Chlamydia serology total titre only (group 2) and 42 women with negative Chlamydia serology titre (control group). Chlamydia serology titre was measured by ELISA. The differentiated Chlamydia specific titres were measured using Microscopic Immunofluorescence Assay (MIF) to determine the immunity status. The Chlamydia Trachomatis IgG titres were classified for the purpose of the study into normal (<1/16), Mild (1/16), Moderate (1/32), and severe (>=1/64). Laparoscopic grading of tubal disease was performed into grades 1-3 according to the severity of the tubal damage which was compared to the Chlamydia titre. Pearson`s correlation test was used as a descriptive measure.
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Introduction to the special issue on ‘Nanostructures by Valve Metal Anodization’

With this special issue of JMSN we are pleased to present significant contributions to a fascinating topic in the field of materials nanostructing, which is the anodization of valve metals. By this treatment porous oxides of controlled geometry can be grown on the respective metal surfaces. To date, aluminum (Al) has been used most often, as confirmed in this special issue where nine out of ten contributions deals with its anodization.
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Recent Developments in Human Odor Detection Technologies

Human odor detection technologies have drawn attention due to the wide possibility of potential applications they open up in areas such as biometrics, criminal investigation and forensics, search for survivors under rubble, and security checkpoint screening. Gas chromatography/mass spectrometry (GC/MS) has been the most successful and powerful analytical approach developed to date for human odor analysis, and hundreds of human odorants have been identified using this tool.
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Characteristic Human Scent Compounds Trapped on Natural and Synthetic Fabrics as analyzed by SPME-GC/MS

The collection of human odor volatiles is of interest to forensic applications as a path to investigate canine scent discriminations in legal investigations. A study using a selected array of previously identified human odor compounds has been conducted to determine the retention and release capabilities of five (5) natural and synthetic fabric types, cotton (mercerized fabric and gauze matrix), polyester, rayon and wool.
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Anodic Oxidation of Titanium in Sulphuric Acid and Phosphoric Acid Electrolytes

Anodisation of pure titanium has been carried out in sulphuric and in phosphoric acid solutions at potentials ranging from 50 to 150V. The SEM and AFM morphological analysis indicates that, within this potential range, oxidation in sulphuric acid solution produces better developed mesoporous oxide layers.
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Preparation of Large Area Anodic Alumina Membranes and their Application to Thin Film Fuel Cell

The design of an electrochemical reactor for the preparation of self-supported comparatively thin (up to 10 μm) and large area (up to 50 cm2) anodic alumina membranes is described allowing growth of porous alumina at high applied potential (up to 150 V) without burning.
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Fabrication and Luminescence of Anodic Alumina with Incorporated Vanadyl Citrate Chelate Anions

Anodic aluminum oxide doped with vanadyl citrate chelate complex anions was formed by a two-step self-organized anodization in 2 wt. % sulfuric acid containing 0.04 M V2O5 and 0.08 M citric acid at voltage range 13-23 V, and at 0 and 15 oC. The combination of two temperatures and at least four voltages (depending on the applied temperature) was applied as the operating conditions of anodization.
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Editorial Board Members Related to SPE

Xueqin Gao

Department of Orthopaedic Surgery
University of Texas Health Science Center
USA

Jayasimha Rao

Associate Professor
Jefferson College of Health Sciences
Department of Medicine
USA

Massimo Caputo

Professor
Congenital Cardiac Surgery
Bristol Heart Institute
United Kingdom

Gyorgy Nagy

Associate Professor
Faculty of Medicine
Semmelweis University
Hungary

Abdelwahab Omri

Professor
Department of Chemistry and Biochemistry
Laurentian University
Canada

Marcela Claudia Pagano

Institute of Exact Sciences
Federal University of Minas Gerais
Brazil

Francisco R Breijo-Marquez

Research director
Department of Clinical & Experimental Cardiology
East Boston University
USA

Monique Mancuso

Researcher
Coastal Marine Environment Institute (IAMC)
National Research Council (CNR)
Italy

RICHARD ROBESON

Adjunct Professor of Practice - Bioethics
Dept. of Communication Bioethics Faculty
Wake Forest University
USA

Fayez M. Bany-Mohammed

Clinical Professor
Department of Pediatrics
University of California
United States
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