The pathogenic potential of Fusobacterium nucleatum and its significance in infections has gained new interest. This retrospective study assessed the epidemiology of patients with infections and culture isolated F. nucleatum at two county hospitals in Houston, Texas. Clinical, epidemiological and microbiological data were obtained from the electronic medical record for both Ben Taub General Hospital and Lyndon B. Johnson Hospital from January 1, 2002 to December 31, 2011.