Articles Related to Synthetic cannabinoid
Synthetic marijuana compounds are more potent than ∆9-tetrahydrocannabinol (∆9-THC) and are known to produce a wide variety of clinical symptoms including cardiac toxicity, seizures, and death. Erratic driving by a 45 y/o male was witnessed in the fall of 2017 and roadside evaluation of the driver by the responding law enforcement officer concluded that the driver was intoxicated. Comprehensive analysis of the cigarettes by gas chromatography-mass spectrometry detected the synthetic cannabinoid 5-fluoro-ADB (5F-ADB or 5F-MDMB-PINACA). Validated forensic liquid chromatography-tandem mass spectrometry (LC-MS/MS) methods were used to detect the 5-fluoro ADB metabolite 7 (26.37 ng/mL) in the driver’s blood sample. No other drugs were detected. This case report is one of the first to conclusively show that designer synthetic cannabinoids, commonly referred to as “K2” and “Spice”, can significantly impair driving at relatively low concentrations.
Synthetic cannabinoids (SCs) present a multitude of problems in terms of maintaining up-to-date methods of detection. They are novel psychoactive substances originally synthesized for medical use and research purposes. Abuse has demonstrated a variety of effects ranging from euphoria to aggressive behavior and death. The marketing, similar naming, and described pharmacological interactions create the dangerous and false perception that SCs are similar to, or the same as, tetrahydrocannabinol in cannabis products
NMR Assignment of N-(1-adamantyl)-1-pentyl-1H-indazole-3-carboxamide Seized as Herbal Incense for the First Time in Italy
The synthetic cannabinoid, N-(1-adamantyl)-1-pentyl-1H-indazole-3-carboxamide, known also as AKB48 and/or APINACA, has been detected for the first time in herbal incense seized in Italy. Its structural characterization has been performed through gas chromatography-mass spectrometry (GC-MS) and high-resolution nuclear magnetic resonance (NMR) analysis. In order to favor an easier and faster identification of AKB48 in future investigations, NMR assignments in deuterated methanol and chloroform is also reported.