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Articles Related to Target

Evaluation of Characterization Results of Ru, Sb And V_Doped Sno2 Coatings Deposited by Using Produced and Commercial Targets

Ruthenium, Antimony and Vanadium doped and undoped tin oxide (SnO2) thin films were prepared by the R.F. Sputtering method. At the beginning of the thin film production studies, pellets were formed by pressing the filled and undoped tin oxide powders in the laboratory environment. The purpose of creating these pellets is to replace commercially purchased target material that acts as the coating material in the sputter coating device. The aim of the study is to use these pellets instead of this commercial target due to its disadvantages such as long lead time and expensiveness, and thus to produce easier, more diverse and high quality thin films. This study includes the synthesis of pure and doped thin films of tin oxide semiconductor material, which has a wide band gap and attracts attention with its wide spread use thanks to this feature, subjecting it to annealing process under different temperatures and times, and structural and morphological characterization studies: XRD, SEM, AFM, XPS, UV-Vis Spectrophotometer and Nano-hardness machine. The study showed that doped and undoped tin oxide films showed similar properties to similar studies seen in the literature, so that the pellets formed in the laboratory environment functioned. No major structural difference was observed in the films produced as a result of the use of pellets and target. As a result of the findings of the study, it has been seen that it is a preliminary study for the investigation of gas sensing properties.
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Rapid Peak Alignment for MALDI-TOF Lipid Analysis

The ability to measure structural and functional alterations in cellular and tissue lipids with small footprint, accessible instrumentation has sparked interest in their role in disease pathology. However, various lipidomic analytical tools tend to be cumbersome and time-consuming. A rapid, accurate, and straight forward peak alignment software routine would greatly facilitate the analysis of large datasets, such as those produced by matrix assisted laser desorption ionization-time of flight mass spectrometry (MALDI-TOF MS). Herein, we describe a novel Rapid Peak Alignment Method (RPAM) which allows untargeted analysis of lipids expressed in brain white matter following chronic ethanol exposure in an established experimental model. The RPAM outputs data comparable to manual peak alignments but the processing time requires only 90 minutes instead of 8-10 hours. This method is readily adapted to a broad range of models, tissue types, and human diseases.
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HIV Screening Scenarios and Targets to Achieve 90% Sero-Status Knowledge Over 2021-2025 in Morocco – Pioneer Use Case of the Goals HIV Testing Strategies Model in a Concentrated Epidemic

Morocco applied the Goals testing model, projecting alternative testing scale-up scenarios, varying coverage targets for 13 adult populations. The model was calibrated using program service delivery, spending and surveillance data (2015-2019), integrated bio-behavioural surveys, and national HIV estimates. It projects annual diagnoses by target group from undiagnosed prevalence and testing coverage, allowing for HIV-infected people self-selecting for testing, retesting and transitions between groups. Scenarios were evaluated for knowledge status improvement and cost, focusing on 2023-2025.
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The Effect of Surfactant Compound Sprays on the Rate of Adsorption on Different Target Surfaces

The first operation of adsorption on leaf surfaces in spray is drop sticking. In the water wettability of the surfaces, the sticking of the drops has a great importance.
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Discovery of Potent Drug Candidates of Adhatoda vasica Against Target Proteins IL- 4 and IL- 13 of Asthma – An in Silico

Bronchial-Asthma, Adhatoda-vasica, In-Silico, IL- 13, IL- 4
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Comparative Simulation Study of Direct and Indirect Target Production of 99Mo with Linear Accelerator at SAMEER

When high energy electron beam falls on a high Z target it generates bremsstrahlung photons which can be used to produce 99Mo from 100Mo using photo-neutron (γ, n) reaction. Two different approaches are studied to carry out photo-neutron reaction. First, a converter target approach in which photons are generated in a high Z target of tungsten using (e,γ) reaction and then (γ, n) reaction in 100Mo for 99Mo production. Second, a direct target approach wherein 30 MeV electrons hit directly onto 100Mo target to carry out both (e, γ) and (γ, n) reactions in the 100Mo target itself. GEANT4 simulation gives photons and neutrons fluxes and their angular distributions from both the approaches, which are then used to calculate activity of 99Mo. The study shows that for very thin 100Mo target of about 0.1 radiation length converter target shows better activity whereas, for any thickness beyond it the direct target approach is found to be more efficient. For 30 MeV and 10 kW beam falling on 100Mo target with 1.4 radiation length, direct target approach is found to be more efficient. Therefore, after improvising the geometry of 100Mo target in the case of direct target method an increased specific activity is obtained through GEANT4 simulation.
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Target Joint “New Concept of Identification”

The hallmark of hemophilia is hemarthrosis. All efforts must be made to early diagnose joint bleeding as soon as it occurs and treat it not later than within 2 h of onset by infusing the appropriate clotting factor. This will prevent the accumulation of blood in the joint as well as inflammation and a potential hemophilic arthropathy. Recurrent bleeding prevents the joint from regaining its range of motion, muscle strength, and normal appearance. These changes become permanent, leading eventually to osteoarthritis. A bleeds joint requires urgent and comprehensive management, especially in young patients, if permanent damage is to be prevented.
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Recent Advancements Involving Immunoliposomes to Target Breast Cancer

Breast cancer is caused by genetic abnormalities resulting in uncontrolled growth of breast cells, and is the most commonly diagnosed cancer amongst women. The clinical use of liposomal-based drugs to treat solid tumors such as breast cancer has been shown to improve the overall pharmacological properties of otherwise “unencapsulated” cytotoxic agents.
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Novel Computational Model of the Brain Water Metabolism: Introducing an Interdisciplinary Approach

Brain water metabolism ensures the processes of cellular communication, the transit of the signaling molecules, neurotransmitters, cytokines, and substrates, participates in the clearance of pathogenic metabolites. Many neurological conditions that present serious clinical problems arise from the altered fluid flow (e.g. Alzheimer’s disease, idiopathic normal pressure hydrocephalus, migraine, traumatic brain injury and stroke).
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Sequence Variant in the TRIM39-RPP21 Gene Readthrough is Shared Across a Cohort of Arabian Foals Diagnosed with Juvenile Idiopathic Epilepsy

Juvenile idiopathic epilepsy (JIE) is a self-limiting neurological disorder with a suspected genetic predisposition affecting young Arabian foals of the Egyptian lineage. The condition is characterized by tonic-clonic seizures with intermittent post-ictal blindness, in which most incidents are sporadic and unrecognized. This study aimed to identify genetic components shared across a local cohort of Arabian foals diagnosed with JIE via a combined whole genome and targeted resequencing approach: Initial whole genome comparisons between a small cohort of nine diagnosed foals (cases) and 27 controls from other horse breeds identified variants uniquely shared amongst the case cohort.
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Targeted Killing of Streptococcus mutans in Biofilms by a Pheromone Guided Antimicrobial Peptide HP30

Streptococcus mutans is a leading cariogenic pathogen of dental caries worldwide. Clinically, eliminating S. mutans from dental biofilms using antibiotics is not practical, because these agents indiscriminately kill other members of the resident flora, leading to ecological disruption and other negative clinical consequences. To develop target-specific antimicrobials, we evaluated several fusion peptides and identified a new peptide HP30 that showed a high selectivity for targeted killing of S. mutans.
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Twenty Five Years of Drug Discovery at the University of California Targeting Kinetoplastid Parasites

This review summarizes 25 years of screening compounds against three major kinetoplastid parasites, Trypanosoma brucei, Trypanosoma cruzi, and Leishmania spp. The work was carried out at two University of California campuses by a consortium of scientists. The history of this effort is summarized beginning with DARPA and NIAID TDRU projects. The compound collections that were screened came from both academic and industry sources.
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Liquid Biopsy in Advanced Gastric Malignancy and Molecular Targeted Therapy; a Case Report and Update Pertaining Anti HER2-Neu Therapy

Human epidermal growth factor receptor 2 (HER2) is responsible for the pathogenesis and poor outcomes of several types of cancers, including advanced gastric and gastroesophageal junction cancer. Molecular-targeted drugs on the other hand, such as trastuzumab, prolong overall survival and progression-free survival in HER2-positive gastric cancer. The purpose of the case report is to evaluate the impact of delivering trastuzumab in advanced gastric cancer with concomitant HER2 mutation and amplification.
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Predicting Multi-Drug Inhibition Interactions based on Signaling Networks and Single Drug Dose-Response Information

Inhibiting multiple pathways/targets with combination drug therapies is widely used to maximize therapeutic benefit in many diseases. Therapeutic success can often be improved by concurrently and/or sequentially inhibiting multiple pathways/targets by combining drugs with different mechanisms of action.
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A Non-Contact Passive Approach for the Effective Collection of Target Explosive Volatiles for Canine Training Aid Development

The use of real explosive materials for canine training involves inherent dangers, toxicity risks exposure, and often limited availability of the training material all of which may affect the reliable training of canine teams. For this reason, the development of a training aid suitable for daily operations is beneficial to provide safe and effective explosive detection training that can provide for enhanced detection capabilities.
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Editorial Board Members Related to Target

BADER MUBARAK W. AL-JAEID

Faculty of Pharmacy
King Abdulaziz University
Saudi Arabia

Frank C. Barone

Professor
Department of Neurology
SUNY Downstate Medical Center
United States

Martin Michaelis

Professor of Molecular Medicine
Centre for Molecular Processing and School of Biosciences
University of Kent
United Kingdom

Yun Dai

Associate Professor
Department of Medicine
Virginia Commonwealth University
United States

Daniel Lacorazza

Associate Professor
Departments of Pathology and Immunology
Baylor College of Medicine
United States

Jason J. Guo

Associate Professor
Center for Drug Discovery
Northeastern University
United States

IRENE HATSU

Assistant Professor
Department of Human Science
The Ohio State University
United States

Younes Chorfi

Associate Professor
Department of Veterinary Biomedicine
University of Montreal
Canada

Yanyan Li

Assistant Professor
Department of Health and Nutrition Sciences
Montclair State University
United States

Anuradha Ratna

Department of Medicine
University of Massachusetts Medical School
USA
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