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Articles Related to Therapy

Complete Clinical Response after Induction Chemotherapy Followed by Chemoradiotherapy in Nasopharyngeal Carcinoma: Impact on Oncologic Outcomes

Objective: Concomitant chemoradiation (RCT) represents the standard of care for locally-advanced nasopharyngeal carcinoma (NPC).Nevertheless induction chemotherapy (IC) followed by RCT is currently an attractive approach. Some trials showed a survival benefit of this therapeutic strategy. The aim of this study was to analyze complete clinical response (CCR) after IC and to assess its impact on disease control and survival.
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Three Stages of Evolution in the Treatment of Acute Ischemic Stroke: Stroke Unit Care, Intravenous Thrombolysis and Endovascular Therapy

Ischemic stroke is the most frequent cause of disability in adults in the world and its treatment remains a challenge. The care management of stroke patients in organized stroke units has improved and various revascularization approaches have emerged during the past decades. Stroke patients cared in organized stroke units are more likely to survive, to return home and to be functional independency. It is recommended that all patients with stroke, regardless of age, should be cared in a stroke unit. Intravenous thrombolysis with recombinant tissue plasminogen activator delivered within 4.5 hours after symptom onset is the only approved and effective medical therapy in patients with acute ischemic stroke.
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Group Psychotherapy with Ethnoracially Diverse OEF/OIF/OND Veterans Presenting with Comorbid Psychopathology: A Transdiagnostic Clinical Forensic Paradigm

The comorbid psychopathology that is well-established in ethnoracially diverse OEF/OIF/OND veterans also often coincides with other problems (e.g., legal and social). To mitigate the clinical side of these types of difficulties, the Veteran Administration Health Care Systems offers a wide range of mental health services. This article draws on an evidenced-based literature review to explore factors that are relative to delivering group psychotherapy in light of the entwined clinical and forensic matters sometimes confronting diverse veterans.
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Compliance in the Duration of Administration of Anticancer Chemotherapy: Comparative Study of Two Different Administration Modalities (PVC versus IVAD)

Objective: To evaluate the compliance of chemotherapy administration duration by comparing the peripheral venous catheter (PVC) route with the implantable venous access device (IVAD).Keywords: Chemotherapy; Gravity perfusion; Peripheral venous; Implantable venous access deviceIntroduction Methods: This was a retrospective study that analyzed 566 cycles of chemotherapy administered by PVC at the Cancer Unit of Yalgado Ouédraogo University Hospital and 258 cycles administered by IVAD at the Oncology Department of Treichville University Hospital in Abidjan. We compared the differences between the programmed duration of chemotherapy and the actual duration of administration according to the two routes of administration.
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Group Psychotherapy with Ethnoracially Diverse OEF/OIF/OND Veterans Presenting with Comorbid Psychopathology: A Clinical Forensic Paradigm

The comorbid psychopathology that is well-established in ethnoracially diverse OEF/OIF/OND veterans also often coincides with other problems (e.g., legal and social). To mitigate the clinical side of these types of difficulties, the Veteran Administration Health Care Systems offers a wide range of mental health services. This article draws on an evidenced based literature review to explore factors that are relative to delivering group psychotherapy in light of the entwined clinical and forensic matters sometimes confronting diverse veterans.
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Primary Osteosarcoma of the Nasal Fossa: An Exceptional Presentation

Sarcomas of the head and neck are very rare accounting for approximately 1% of all head and neck neoplasms. Primary osteosarcomas of the nasal cavity are less than 0.5% of the osteosarcomas occur in this location. Because of the rarity of this presentation, we report a case of a 54 year old male with primary osteosarcoma arising de novo from the nasal cavity, presented with left epistaxis and bilateral nasal obstruction.
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Irrational Anti-Retroviral Therapy Prescription among Children Under 15 Years in Eastern Uganda

Highly Active Anti-Retroviral Therapy (HAART) has transformed HIV/AIDS into a manageable chronic illness with HIVinfected children having near-normal growth milestones as a result of virologic control and immunologic reconstitution.
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The Evaluation of Functional Mobility Chronic Hemiparetics Submitted to Group Physiotherapy in the Training Circuit Format

Objective: To evaluate the functional mobility of chronic hemiparesis sufferers who undergo 12 weeks of GPCT. IntroductionMethod: We selected 10 chronic hemiparetic patients, aged 21 or over with a medical referral and one-sided hemiparesis with an injury time of ≥12months, capable of walking with or without help and having the ability to perform walking tests. Interviews to collect personal data were conducted, which were then evaluated by Time up & go (TUG) which recorded the time taken for the patient to stand up from a chair, walk 3 meters, return and sit constituting the initial assessment (AV1) and after 12 weeks of intervention with GPCT the final evaluations were taken (AV2).
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Dosimetric Evaluation of Total Body Irradiation (TBI) Treatment by Volumetric Modulated Arc Therapy (VMAT) on the Coach

To compare three different types of volumetric modulated arc therapy (VMAT) planning techniques using Elekta Versa HD lineer accelerator to deliver total body irradiation (TBI) treatment on the coach and to evaluate the feasibility of VMAT planning technique for TBI treatment.
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Utility of Serum Bilirubin Screening during the First 24-Hours Following Birth of Pre-Term Neonates <35 Weeks’ Gestation

Neonates with severe hyperbilirubinaemia are at increased risk for neurological morbidity. Risk factors for early onset hyperbilirubinaemia include prematurity, red cell haemolysis and birth trauma. As most neonates are asymptomatic and clinical evaluation in detecting early jaundice limited, clinical practice guidelines at the Royal Women’s Hospital recommend a serum bilirubin (SBR) level in the first 24 hours following birth for neonates <35 weeks’ gestation. Our audit aims to describe the utility of SBR screening in this population
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The Use of Cardiac Resynchronization Therapy in Cancer Patients with Heart Failure

Investigate the use of cardiac resynchronization therapy (CRT) in cancer patients with heart failure (HF); assess factors associated with ischemic and non-ischemic HF. Many newer cancer therapies are cardiotoxic; thus, the incidence of HF has been increasing in this high-risk patient population. CRT has beneficial effects on morbidity, mortality, and left ventricular function in patients with non-ischemic cardiomyopathy, yet cancer patients and survivors who develop severe HF and are eligible for CRT often does not receive it.
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Evaluating the Effect of Oprelvekin on Cardiac Repolarization in Subjects with Chemotherapy-Induced Thrombocytopenia: An Observational Chart Review of a Phase 2 Clinical Trial in Laredo, Texas

This study tested for the cardiac effects of Oprelvekin, recombinant human interleukin-11, a thrombopoietic growth factor, in patients afflicted with chemotherapy-induced thrombocytopenia (platelet count<50,000 cells/ul). Chart-reviews of patients fulfilling the inclusion criteria of: 18-75 yrs of age, non-myeloid malignancy, with adequate hematologic, hepatic and renal parameters and normal electrocardiograms that were enrolled in this phase 2 trial were analyzed. Patients of child-bearing potential agreed to be on a reliable form of birth control for the duration of the study. Results on 4 patients suggest that Oprelvekin does not cause atrial nor ventricular arrhythmia, a rare severe cardiac side effect, in treating patients with chemotherapy-induced thrombocytopenia.
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Equines as Tools Vs Partners: A Critical Look at the Uses and Beliefs Surrounding Horses in Equine Therapies and Argument for Mechanical Horses

Horses have their own unique status as therapy animals due to their function in both physical and psychotherapies. Current models of Equine Assisted Activities and Therapies (EAAT) utilize horses for a range of physical, psychological and learning therapies to benefit humans, often referring to horses as therapeutic “partners”. To fulfill certification requirements for existing models of EAAT, practitioners are required to study equine behavior through the belief systems currently modeled in the natural horsemanship community. Despite requiring knowledge in horse behavior, studies and anecdotal evidence suggests that horses used in EAAT commonly display confusion or escape behaviors, “burn out” and/or display signs of depression. These behaviors could be a result of contradictions in the interpretation of equine behavior within the natural horsemanship practices or a lack of understanding and utilization of equine learning theory within the context of EAAT.
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Palmoplantar Malignant Melanoma in the Brazzaville University Hospital

Palmoplantar Malignant Melanoma (PPMM) is a tumor that arises from the melanocytes of the palmoplantar location. It is usually curable when treated surgically if diagnosed early. Objective: To assess the clinical presentation and treatment outcome of PPMM in Brazzaville Patients and Methods: This is a cross sectional study of thirteen years (January 1998-December 2011). 121 patients with PPMM who received the 3 treatment types were included: Surgery, chemotherapy and combination of surgery and chemotherapy.
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Immune Checkpoint and Ovarian Cancer

Many scientists and biotechnology companies had given up on the idea of cancer immunotherapy in 1990s. Almost a decade after first detection of T cell suppression effect of CTLA4 the identity of its antibody was established. While they are found effective in many cancers including melanoma, lung cancer etc. immune checkpoint inhibitors have lent an important measure to manage recurrent and refractory ovarian cancer. This subject needs constant updating specially for students of ovarian cancer who are looking at this avenue of cure with much hope.
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Editorial Board Members Related to Therapy

David Ilki Min

Professor
Pharmacy Practice and Administration
Western University of Health Sciences
United States

ION S. JOVIN

Associate Professor
Department of Medicine
Virginia Commonwealth University
United States

Suling Liu

Professor
School of Life Sciences
University of Science & Technology
China

ANNABELLA VITALONE

Assistant Professor
Department of Physiology and Pharmacology
University of Rome
Itlay

Lili Chen

Associate Professor
Department of Radiation Oncology
Fox Chase Cancer Center
United States

Huan-Zhang Zhu

Professor
State Key Laboratory of Genetic Engineering
Fudan University
China

Chang Ming Charlie Ma

Professor
Department of Radiation Oncology
Fox Chase Cancer Center
United States

Ren-Ke Li

Professor
Laboratory Medicine and Pathobiology
University of Toronto
Canada

Ming Tan

Associate Professor
Mitchell Cancer Institute
United States

Maythem M Saeed

Adjunct Professor
Department of Radiology
School of Medicine
University of California
United States
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