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Articles Related to Therapy

Tomotherapy Treatment of Chronic Lymphocytic Leukemia and Ocular Lymphoma

A sixty-five-years-old male patient with history of non-Hodgkin’s lymphoma of the right orbit and a fifty-years-old female patient with chronic lymphocytic leukemia with peripheral lymphocytosis were treated on TomoTherapy. In the first case, a 1 cm beam was used for planning a delivery of 30.6 Gy in 17 fractions with a sequential boost of 9 Gy in 5 fractions. Tumor involvement of the ipsilateral lens and lacrimal gland in the planning target volume necessitated a compromise between preserving patient’s vision and delivery of tumoricidal dose to the target. In the second case, 30 Gy in 20 fractions delivery was planned with a 2.5 cm beam. The tumor extended anteriorly and this technique allowed sparing more orbital tissue and required a high modulation factor.
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Envisioning Molecular Network of Obesity by Omics Stratification

To date, Obesity is considered prime concern of public health with multi-dimensional factors engaged in metabolic discrepancy that is rooted from multifactorial causes (i.e., environmental intoxication or genetic abnormality), and the unmet landscape of health care system seeks for therapeutic or preventive measures. Compelling evidence support Omics as strategic tool of systemic biology is benefit to define wiring of molecular circuit in metabolic malfunction and evaluation of metabolic modulator such as synthetic drugs, stem cell replacement, and natural secondary metabolites from various resources.
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An Observational Chart Review of a Comparison of Generic to Reference Liposome-Encapsulated Doxorubicin Hydrochloride in Subjects with Epithelial Ovarian Carcinoma Who Have Failed Platinum-Based Chemotherapy

This study tested for the effects of generic liposome-encapsulated doxorubicin hydrochloride (generic doxorubicin) compared to reference-pegylated liposomal doxorubicin hydrochloride (reference doxorubicin) as a treatment for patients afflicted with epithelial ovarian carcinoma whose disease has progressed after platinum-based chemotherapy. Chart-reviews of actual patients enrolled in a community-based NIH trial suggest that both generic and reference liposomal doxorubicin hydrochloride (HCl) are equally effective as treatment for ovarian cancer carcinoma.
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First Step Monotherapy with Lower Dosage of Propranolol at Complicated Infantil Hemangiamo

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Cognitive-Behavioral Psychotherapy, a Group Psycho-Educational Workshop and a Workshop for Caregivers of Sexually-Abused Children: a Case Study of Two Mexican Male Children

It has been reported that a large percentage of men and women had experiences of sexual abuse during childhood the effects of which are determined by factors such as age, gender, characteristics of the experience, and cultural aspects, among others. In Mexico, only a limited number of sexual abuse cases are reported to the relevant authorities and even fewer receive adequate care and treatment. This article presents an evaluation of the effectiveness of an individualized cognitive-behavioral treatment involving a group psychoeducational workshop and a workshop for caregivers of two Mexican male children who had experienced sexual abuse. Clinical and cognitive evaluations, pre- and post-test treatment, and follow-up one-and-a-half years later were made. Differences between the two participants were found in all three evaluation periods. Various factors associated with these results are discussed.
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Mechanisms of Resistance to Kinase Inhibitors and Strategies to Prevent the Development of Drug Resistance

Targeting mutant proteins and associated signaling pathways of driver oncogenes by small molecule kinase inhibitors (KIs) are a promising strategy of cancer therapy. However, despite the initial success of treatment, KIs often become ineffective as intrinsic and acquired resistance. This article reviews the English-language literature to explore the underlying mechanisms of drug resistance and to present a challenge for developing drugs to overcome resistance. Mechanisms of acquired resistance include 1) the selection of pre-existing subclones with other mutations, 2) the emergence of secondary mutations in the target kinase domain, 3) upregulation of kinases both within the same kinase family and their related kinase families, as well as activation of alternative bypass pathways, 4) epithelial-mesenchymal transition, 5) overexpression of pro-survival Bcl-2 family proteins and 6) drug efflux mechanisms. Currently available methods are to obtain tumor biopsy samples at recurrence or progression if the tumor lesion is accessible to a biopsy and to use the second- and third-generation KIs based on the individual need of each patient. Furthermore, recent computational challenges provide design principles to prevent the development of drug resistance. In conclusion, we provide an overview of the postulated resistance mechanisms and highlight the future direction of computational structure-based design of new potent KIs.
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Former Effective Immunotherapy without Adverse Events of Inoperable Epithelial Ovarian Cancers and a Prospect for the Immune Prophylaxis

Current cancer treatments by immune checkpoint blockades are limited due to severe adverse events caused by alteration of the immune system required for homeostasis of normal tissues. Common cancer chemotherapy alters the quality of patients’ lives. Platinum-based treatment can lead to severe neurotoxicity with chronic debilitation. Additionally, survival of patients with epithelial ovarian cancers (EOCs) has remained poor despite extensive cytoreductive surgery, high dose chemotherapy, checkpoint blockades and immunotherapies effective in some other types of cancer. The pathobiology of EOC cancer stem cells (CSCs) is not well understood. Observations demonstrate that EOCs exhibit in vivo two distinct CSC types - perivascular diploid CSCs dividing asymmetrically with the help of the host suicidal CD8+ T cells, and haploid CSCs at the cancer abdominal surface originating from meiosis I cytokinesis of bulk surface cancer cells. The perivascular CSCs contribute to the cancer cell bulk and, via left ovary venous blood, can cause EOC liver metastases. Haploid CSCs released from the bulk cancer surface cause the common pelvic and abdominal EOC spread. Former elimination of the host antibodies blocking T cell effectors by intermittent doses of cyclophosphamide exhibiting significant immunomodulatory anticancer effects, facilitation of the immune system reactivity against alloantigens of cancer cells by blood transfusions, and augmentation of anticancer immunity by bacterial toxins, resulted during the subsequent treatment-free period into rejection of inoperable EOCs without any adverse events during the treatnment. To help prevent cancer relapses, patients treated for advanced primary epithelial cancers should be considered as candidates for continuously stimulating immune anticancer activity by treatments such as daily metformin and weekly lentinan consumptions.
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Effect of Cold Wet sheet Pack on Body Temperature among Healthy Individuals - Result of a Single Arm Study

Hydrotherapy, as the name suggests is the most ancient method of treating diseases by using water in its various forms. The use of water for therapy has been around for hundreds of years. The cold wet sheet pack is one of the common hydrotherapy techniques used for reducing body weight. There have been no documented studies conducted to scientifically evaluate this effect. This study is an attempt to examine the effect of cold wet sheet pack on body temperature. Application of cold wet sheet pack for particular duration increases the body temperature by utilization of calories thus may leads to reduction of bodyweight. Thirty healthy volunteers were randomly selected from medical students enrolled in a naturopathic programme. The participants were of both sexes aged between 18 and 25 years under normal Body mass index (18.5-25). A cold (20 oC± 1 oC) wet sheet pack has given to each of the participants for one hour duration. The outcome measures were resting blood pressure, body temperature and pulse rate. 30 Participants were successfully completed the study, all participants have shown a raise in body temperature after intervention which was statistically significant (P=0.003). There is no significant change in blood pressure and pulse rate. Also there was a week positive correlation between body mass index and body temperature. A cold wet sheet pack for one hour has shown a raise in body temperature, which indicate that the cold wet sheet pack have a role in reducing body weight by utilizing the calories. However, these observations are based on a short term single arm pre-post design on healthy students. A cold wet sheet pack has been demonstrated in this study to have a significant effect in increasing body temperature and shows perspiration by utilization of calories. Large scale randomized control trials in obese patients over a longer period are warranted to conform the results which was uncovered in this study.
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Complete Clinical Response after Induction Chemotherapy Followed by Chemoradiotherapy in Nasopharyngeal Carcinoma: Impact on Oncologic Outcomes

Objective: Concomitant chemoradiation (RCT) represents the standard of care for locally-advanced nasopharyngeal carcinoma (NPC).Nevertheless induction chemotherapy (IC) followed by RCT is currently an attractive approach. Some trials showed a survival benefit of this therapeutic strategy. The aim of this study was to analyze complete clinical response (CCR) after IC and to assess its impact on disease control and survival.
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Three Stages of Evolution in the Treatment of Acute Ischemic Stroke: Stroke Unit Care, Intravenous Thrombolysis and Endovascular Therapy

Ischemic stroke is the most frequent cause of disability in adults in the world and its treatment remains a challenge. The care management of stroke patients in organized stroke units has improved and various revascularization approaches have emerged during the past decades. Stroke patients cared in organized stroke units are more likely to survive, to return home and to be functional independency. It is recommended that all patients with stroke, regardless of age, should be cared in a stroke unit. Intravenous thrombolysis with recombinant tissue plasminogen activator delivered within 4.5 hours after symptom onset is the only approved and effective medical therapy in patients with acute ischemic stroke.
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Group Psychotherapy with Ethnoracially Diverse OEF/OIF/OND Veterans Presenting with Comorbid Psychopathology: A Transdiagnostic Clinical Forensic Paradigm

The comorbid psychopathology that is well-established in ethnoracially diverse OEF/OIF/OND veterans also often coincides with other problems (e.g., legal and social). To mitigate the clinical side of these types of difficulties, the Veteran Administration Health Care Systems offers a wide range of mental health services. This article draws on an evidenced-based literature review to explore factors that are relative to delivering group psychotherapy in light of the entwined clinical and forensic matters sometimes confronting diverse veterans.
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Compliance in the Duration of Administration of Anticancer Chemotherapy: Comparative Study of Two Different Administration Modalities (PVC versus IVAD)

Objective: To evaluate the compliance of chemotherapy administration duration by comparing the peripheral venous catheter (PVC) route with the implantable venous access device (IVAD).Keywords: Chemotherapy; Gravity perfusion; Peripheral venous; Implantable venous access deviceIntroduction Methods: This was a retrospective study that analyzed 566 cycles of chemotherapy administered by PVC at the Cancer Unit of Yalgado Ouédraogo University Hospital and 258 cycles administered by IVAD at the Oncology Department of Treichville University Hospital in Abidjan. We compared the differences between the programmed duration of chemotherapy and the actual duration of administration according to the two routes of administration.
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Group Psychotherapy with Ethnoracially Diverse OEF/OIF/OND Veterans Presenting with Comorbid Psychopathology: A Clinical Forensic Paradigm

The comorbid psychopathology that is well-established in ethnoracially diverse OEF/OIF/OND veterans also often coincides with other problems (e.g., legal and social). To mitigate the clinical side of these types of difficulties, the Veteran Administration Health Care Systems offers a wide range of mental health services. This article draws on an evidenced based literature review to explore factors that are relative to delivering group psychotherapy in light of the entwined clinical and forensic matters sometimes confronting diverse veterans.
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Primary Osteosarcoma of the Nasal Fossa: An Exceptional Presentation

Sarcomas of the head and neck are very rare accounting for approximately 1% of all head and neck neoplasms. Primary osteosarcomas of the nasal cavity are less than 0.5% of the osteosarcomas occur in this location. Because of the rarity of this presentation, we report a case of a 54 year old male with primary osteosarcoma arising de novo from the nasal cavity, presented with left epistaxis and bilateral nasal obstruction.
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Irrational Anti-Retroviral Therapy Prescription among Children Under 15 Years in Eastern Uganda

Highly Active Anti-Retroviral Therapy (HAART) has transformed HIV/AIDS into a manageable chronic illness with HIVinfected children having near-normal growth milestones as a result of virologic control and immunologic reconstitution.
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Editorial Board Members Related to Therapy

ION S. JOVIN

Associate Professor
Department of Medicine
Virginia Commonwealth University
United States

David Ilki Min

Professor
Pharmacy Practice and Administration
Western University of Health Sciences
United States

MICHAEL P. SHERMAN

Professor Emeritus
Department of Child Health
Division of Neonatology
University of California-Davis School of Medicine
United States

Jae Hwa Kim

Professor
Department of Orthopedics
CHA Bundang Medical Center
CHA University
Korea

GAVIN PAUL SACKS

Associate Professor
Department of Obstetrics & Gynecology
University of New South Wales
Australia

Olga S. Latinovic

Assistant Professor
Institute of Human Virology
University of Maryland School of Medicine
United States

Domenico Rubello

Doctor
Director Department of Imaging Rovigo
General Hospital in Veneto
Italy

WEN ZHOU

Associate Faculty
Women's Health Faculty
Columbia University
United States

P. S. SURESH

Assistant Professor
Department of Bio-Sciences
Mangalore University
India

Inbo Han

Associate professor
Department of Neurosurgery
CHA University
South Korea
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