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Articles Related to Therapy

Positive Efficiency of Combine Immunotherapy in Immunocompromised Girls with Recurrent Nonspecific Chronic Vulvovaginitis

Nonspecific chronic vulvovaginites (NCVV) are a frequent clinical sign of immune deficiency, especially in young girls. The established problems with the functioning of various parts of the immune system (IS) in this pathology dictate the need to include immunomodulatory therapy into the complex. The developed program of combined immunotherapy for immunocompromised girls allows reducing the severity and duration of exacerbation of NCVV, their frequency against the background of a significant reduction in ARVI incidence. Positive clinical effects were observed with underlying restoration in IS functioning. A protective effect was obtained (observation in a catamnesis for 1 year): the duration of a clinically safe period increased from 6 to 11-11.5 months per year.
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Gene Therapy in Sickle Cell Disease

Sickle cell disease is a prevalent and severe monogenic disorder resulting from a homozygous missense mutation in the β-globin gene that leads to polymerization of hemoglobin S. Clinical manifestations of the disease can be critical with considerable morbidity and mortality. One treatment option for the disease is bone marrow transplantation. However this method is restricted to the patients with an appropriately matched donor. Gene therapy by either gene insertion or gene editing, utilizing patient’s own cell is a primary therapeutic option to cure sickle cell disease. However, very less clinical trials have been performed with genetic therapy for treating Sickle cell disease (SCD). Since a couple of decades significant progress has been made in the area of gene therapy for treating monogenic hemoglobin disorders. Numerous therapies are currently in clinical trial stages or in preclinical stages. The safety and efficacy of gene therapy has been greatly improved with the initial use of γ-retrovirus vectors, followed by next-generation lentivirus vectors, and latest gene editing techniques. Although the clinical interpretation of gene therapy has been successful, it involves some limitations including complex cellular abnormalities, inadequate transgene expression, and challenges in achieving effective and persistent inhibition of polymerization of hemoglobin S. This review intends to discuss gene therapy strategies specific to Sickle cell disease, present state of the field, and current status of the gene therapy clinical trials.
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Novel Evidences of Extracorporeal Shockwave Therapy for Spasticity

Spasticity is defined as ‘a disorder of sensorimotor control, resulting from an upper motor neuron (UMN) lesion, presenting as intermittent or sustained involuntary activation of muscles’. It is characterized by increased involuntary velocity-dependent tonic stretch reflexes (muscle tone) with exaggerated tendon jerks, resulting from hyper-excitability of the stretch reflex. In the recent years,a range of non-pharmacological interventions has been used to manage spasticity. Among the novel of all therapies, extracorporeal shock wave therapy (ESWT) is attractive for many researchers since the noninvasive, easy application after well training and afety property. Moreover, the evidences of regeneration of musculoskeletal tissues made ESWT more interesting than other novel therapies.This article will show the evidences, practical clinical use and precaution to guide treating for the clinicians in the novel therapy of ESWT for spasticity. The review of the scientific evidences including methodology components and main results of ESWT treatment on upper limb and lower limb muscles affected by post-stroke spasticity are demonstrated. However, reducing spasticity alone without addressing the negative components of the upper motor neuron syndrome will limit meaningful recovery. A combination of rehabilitation techniques is needed to facilitate functional improvements.
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Recent Advancements Involving Immunoliposomes to Target Breast Cancer

Breast cancer is caused by genetic abnormalities resulting in uncontrolled growth of breast cells, and is the most commonly diagnosed cancer amongst women. The clinical use of liposomal-based drugs to treat solid tumors such as breast cancer has been shown to improve the overall pharmacological properties of otherwise “unencapsulated” cytotoxic agents.
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Cisplatin-Gemcitabine Related Cardiomyopathy in Non-Small Cell Lung Cancer NSCLC Patient: A Case Study

Gemcitabine is a pyrimidine analog and cisplatin is a platinum agent, they are usually combined to form a chemotherapeutic doublet used to treat different types of oncological cancers, including non-small cell lung cancer (NSCLC). Although these agents are not known to cause such events, few cases related to possible cardiotoxicity side effects have been reported ; including angina, chronic heart failure, arrhythmias, and cardiac ischemia. A 52-year-old African male presented with Stage IV lung adenocarcinoma metastatic to the bone, pleura and lymph node, EGFR wild type. Patient has a history of hypertension, diabetes, and atrial fibrillation and on rate control medications. He was treated initially with cisplatin-gemcitabine, after which he developed cardiomyopathy.
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Novel Computational Model of the Brain Water Metabolism: Introducing an Interdisciplinary Approach

Brain water metabolism ensures the processes of cellular communication, the transit of the signaling molecules, neurotransmitters, cytokines, and substrates, participates in the clearance of pathogenic metabolites. Many neurological conditions that present serious clinical problems arise from the altered fluid flow (e.g. Alzheimer’s disease, idiopathic normal pressure hydrocephalus, migraine, traumatic brain injury and stroke).
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Impact of Myocardial Revascularization on the Range of Joint Motion of the Superior and Inferior Members

The surgical procedure for myocardial revascularization (MRI) may compromise chest stability, compliance and range of motion (ROM) of the shoulder joint due to sternotomy and knee joint due to saphenectomy.To evaluate the impact of myocardial revascularization surgery on upper and lower limb ROM
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A Health Model Based on the Clinical Practice of Manual Therapists

Introduction: The evolution of health models occurred along with the changes of the definition of health and rehabilitation but it is still unknown the predominant model of health that fits the clinical practice of physiotherapists who work in manual therapy. Aim(s): Creation of a questionnaire to assess the health model that fits the clinical practice of physiotherapists and after application,
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Monotherapy versus Combination Therapy for the Treatment of Pseudomonas Aeruginosa in Cystic Fibrosis Patients

Infection with Pseudomonas aeruginosa in cystic fibrosis (CF) patients is a strong contributor to respiratory failure and associated mortality. Bacteria colonizing a cystic fibrosis lung commonly form biofilms that greatly contribute to increased antibiotic resistance and hypermutability. Antimicrobial treatment in these cases can be either through the use of a single agent (monotherapy) or through a combination of agents (combination therapy).
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Use of Electroconvulsive Therapy (ECT) in Hysterical Catatonia: Case Reports of Two Women, One Young and One Elderly

A 62-years-old female patient with a diagnosis of conversion disorder and somatization disorder and a 20-years-old female patient with a diagnosis of conversion disorder were treated on electroconvulsive therapy. Electroconvulsive therapy was performed in 8 sessions with anaesthesia. 62-years-old patient began to recover after the sixth session of electroconvulsive therapy once every two days. Complete remission in catatonic symptoms also sustained during follow-up. The catatonic symptoms of the 20-years-old patient were completely terminated after the second session of the ECT once every two days. The treatments were completed in 8 sessions.
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Postural Impairment of Adults and Adolescents Cerebral Palsy Inpatients at the Retaguarda Hospital of Ribeirão Preto-SP

Introduction: Cerebral Palsy (CP) is a condition that described a group of permanent movement and postural development disorders, leading to activity limitations as a result of non-progressive distress during foetal or infant brain development. The non-pregressive distress is frequently associated to sensation, perception, cognition, communication and behavioural disorders, by epilepsy or by secondary muscle distress.
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Efficacy and Safety of Moxifloxacin-Enhanced versus Standard Sequential Eradication Therapy for Treating Helicobacter pylori Infection among Tobacco Smokers

The therapeutic failure rate of eradication therapy for Helicobacter pylori (Hp) is increasing due to bacterial resistance; tobacco smoking can increase such a rate even more. We explored the role of adding moxifloxacin to the standard sequential eradication therapy for Hp in decreasing the therapeutic failure rate among the tobacco smokers.
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Tomotherapy Treatment of Chronic Lymphocytic Leukemia and Ocular Lymphoma

A sixty-five-years-old male patient with history of non-Hodgkin’s lymphoma of the right orbit and a fifty-years-old female patient with chronic lymphocytic leukemia with peripheral lymphocytosis were treated on TomoTherapy. In the first case, a 1 cm beam was used for planning a delivery of 30.6 Gy in 17 fractions with a sequential boost of 9 Gy in 5 fractions. Tumor involvement of the ipsilateral lens and lacrimal gland in the planning target volume necessitated a compromise between preserving patient’s vision and delivery of tumoricidal dose to the target. In the second case, 30 Gy in 20 fractions delivery was planned with a 2.5 cm beam. The tumor extended anteriorly and this technique allowed sparing more orbital tissue and required a high modulation factor.
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Envisioning Molecular Network of Obesity by Omics Stratification

To date, Obesity is considered prime concern of public health with multi-dimensional factors engaged in metabolic discrepancy that is rooted from multifactorial causes (i.e., environmental intoxication or genetic abnormality), and the unmet landscape of health care system seeks for therapeutic or preventive measures. Compelling evidence support Omics as strategic tool of systemic biology is benefit to define wiring of molecular circuit in metabolic malfunction and evaluation of metabolic modulator such as synthetic drugs, stem cell replacement, and natural secondary metabolites from various resources.
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An Observational Chart Review of a Comparison of Generic to Reference Liposome-Encapsulated Doxorubicin Hydrochloride in Subjects with Epithelial Ovarian Carcinoma Who Have Failed Platinum-Based Chemotherapy

This study tested for the effects of generic liposome-encapsulated doxorubicin hydrochloride (generic doxorubicin) compared to reference-pegylated liposomal doxorubicin hydrochloride (reference doxorubicin) as a treatment for patients afflicted with epithelial ovarian carcinoma whose disease has progressed after platinum-based chemotherapy. Chart-reviews of actual patients enrolled in a community-based NIH trial suggest that both generic and reference liposomal doxorubicin hydrochloride (HCl) are equally effective as treatment for ovarian cancer carcinoma.
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Editorial Board Members Related to Therapy

HONG-NERNG HO

Professor
Department of Obstetrics and Gynecology
National Taiwan University
Taiwan

Huatao Guo

Assistant Professor
Department of Molecular Microbiology and Immunology
University of Missouri School of Medicine
United States

ANNABELLA VITALONE

Assistant Professor
Department of Physiology and Pharmacology
University of Rome
Itlay

WEN ZHOU

Associate Faculty
Women's Health Faculty
Columbia University
United States

Mohammad Khayatzadeh Mahani

Assistant Professor of Occupational Therapy
Staff member of Occupational Therapy department
Ahvaz Jundishapoor University of Medical Sciences
Iran

Tamer Atif Mohamed Dawod

Associate Professor
Faculty of Medicine
Mansoura University
Egypt

Miyuru Chandradasa

Department of Psychiatry
University of Kelaniya
Sri Lanka

Ozlem Altindag

Department of Physical Medicine and Rehabilitation
University of Gaziantep
Turkey

Martin A. Katzman

Clinic Director and Staff Psychiatrist
START Clinic for Mood and Anxiety Disorders
Canada

Catherine Ortega

Department of Physical Therapy
University of Texas Health Science Center At San Antonio
USA
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