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Articles Related to Therapy

Periodontal Maintenance Therapy and Generalized Aggressive Periodontitis: Brief Review of the Literature and Case Report

This case report presents an unusual variant of generalized aggressive periodontitis that was managed by nonsurgical therapy which included the use of a novel tooth gel. Also, a brief review of the literature is offered as context for this unusual clinical case. The patient, a 40-year old Caucasian female, presented with advanced bone loss involving all teeth, intense inflammation of the attached gingiva and little obvious supra- or subgingival biofilm and dental calculus. Presence of systemic disease, high levels of periodontal microbial pathogens and IL-1α and IL-1β polymorphisms were evaluated and all determined to be negative. Gingival biopsy resulted in a diagnosis of nonspecific inflammation. Treatment consisted of 2- and 3-month intervals for periodontal maintenance appointments and eventually the introduction of an activated edathamil-based tooth gel. Over the subsequent 4-years the patient’s periodontal status stabilized as manifested by no further loss of tooth supporting bone, a reduction in the percentage of periodontal pockets of 4-6 mm depth and a reduction in the percentage of sites exhibiting bleeding upon periodontal probing. The significance of this case report is to emphasize that, even in cases of severe generalized aggressive periodontitis, nonsurgical periodontal therapy can be effective. In addition, it appears that a novel tooth gel containing activated edathamil is effective at reducing gingival inflammation with a concomitant reduction in percent of sites that bleed on periodontal probing.
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The In Vitro Evaluation of Calcium and Bioactive Glass Based Pulp Capping Materials

Vital pulp preservation in the treatment of deep caries is challenging due to sealing issue. The aim of this study was to compare the physicochemical properties and radiopacity of various light curing pulp capping materials. In this study, SEM-EDS analysis and the radiopacity of four different pulp capping materials including ThereCal LC, Biner LC, Calci Plus LC, and Activa-Bioactive were evaluated. Each material was characterized by scanning electron microscopy (SEM) and chemical composition of each material was analyzed by energy dispersive x-ray spectroscopic (EDS) analysis. The diskshaped specimens (8 mm diameter and 1 mm thickness) were prepared from each material and exposed to a digital x-ray along with an aluminum step wedge for the radiopacity assay. The statistical analysis was performed with ANOVA and Duncan’s post-hoc test.
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Control and Learning Motor in Depression From The Relationship Physiotherapy-Mental Health

The mental health as field of action for the physiotherapists is an important challenge that implies formation and investigation. The alterations of the mental health on a global scale are nowadays a problem of public health that it makes necessary that the professionals of the area of the health have a deeper knowledge on the topic to act of way adapted from the prevention and intervention.
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Commitment to the Quality of Global Life and Emotional Function of Women with Cancer in Chemotherapy

To evaluate the quality of life and the impairment of the emotional function of women with breast cancer under chemotherapeutic treatment, in relation to sociodemographic and clinical characteristics. Observational, longitudinal, and analytical research; conducted between 2013 to 2015 with 67 women in three stages of chemotherapy treatment in a public referral teaching hospital in Paraná. Two questionnaires, one for socio-demographic and clinical data, and the Quality of Life Questionnaire-C30 were used for data collection.
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Profile Clinical, Epidemiological of Patients Subject to Sedestation in Intensive Care Unit

The sedestation is defined as an act of sitting is a useful therapy for physiotherapy, have reported pulmonary effects ranging from increased lung compliance to improvement in oxygenation. There is lack of this study as a single therapy in critically ill patients, showing still not well defined.
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Positive Efficiency of Combine Immunotherapy in Immunocompromised Girls with Recurrent Nonspecific Chronic Vulvovaginitis

Nonspecific chronic vulvovaginites (NCVV) are a frequent clinical sign of immune deficiency, especially in young girls. The established problems with the functioning of various parts of the immune system (IS) in this pathology dictate the need to include immunomodulatory therapy into the complex. The developed program of combined immunotherapy for immunocompromised girls allows reducing the severity and duration of exacerbation of NCVV, their frequency against the background of a significant reduction in ARVI incidence. Positive clinical effects were observed with underlying restoration in IS functioning. A protective effect was obtained (observation in a catamnesis for 1 year): the duration of a clinically safe period increased from 6 to 11-11.5 months per year.
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Gene Therapy in Sickle Cell Disease

Sickle cell disease is a prevalent and severe monogenic disorder resulting from a homozygous missense mutation in the β-globin gene that leads to polymerization of hemoglobin S. Clinical manifestations of the disease can be critical with considerable morbidity and mortality. One treatment option for the disease is bone marrow transplantation. However this method is restricted to the patients with an appropriately matched donor. Gene therapy by either gene insertion or gene editing, utilizing patient’s own cell is a primary therapeutic option to cure sickle cell disease. However, very less clinical trials have been performed with genetic therapy for treating Sickle cell disease (SCD). Since a couple of decades significant progress has been made in the area of gene therapy for treating monogenic hemoglobin disorders. Numerous therapies are currently in clinical trial stages or in preclinical stages. The safety and efficacy of gene therapy has been greatly improved with the initial use of γ-retrovirus vectors, followed by next-generation lentivirus vectors, and latest gene editing techniques. Although the clinical interpretation of gene therapy has been successful, it involves some limitations including complex cellular abnormalities, inadequate transgene expression, and challenges in achieving effective and persistent inhibition of polymerization of hemoglobin S. This review intends to discuss gene therapy strategies specific to Sickle cell disease, present state of the field, and current status of the gene therapy clinical trials.
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Novel Evidences of Extracorporeal Shockwave Therapy for Spasticity

Spasticity is defined as ‘a disorder of sensorimotor control, resulting from an upper motor neuron (UMN) lesion, presenting as intermittent or sustained involuntary activation of muscles’. It is characterized by increased involuntary velocity-dependent tonic stretch reflexes (muscle tone) with exaggerated tendon jerks, resulting from hyper-excitability of the stretch reflex. In the recent years,a range of non-pharmacological interventions has been used to manage spasticity. Among the novel of all therapies, extracorporeal shock wave therapy (ESWT) is attractive for many researchers since the noninvasive, easy application after well training and afety property. Moreover, the evidences of regeneration of musculoskeletal tissues made ESWT more interesting than other novel therapies.This article will show the evidences, practical clinical use and precaution to guide treating for the clinicians in the novel therapy of ESWT for spasticity. The review of the scientific evidences including methodology components and main results of ESWT treatment on upper limb and lower limb muscles affected by post-stroke spasticity are demonstrated. However, reducing spasticity alone without addressing the negative components of the upper motor neuron syndrome will limit meaningful recovery. A combination of rehabilitation techniques is needed to facilitate functional improvements.
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Recent Advancements Involving Immunoliposomes to Target Breast Cancer

Breast cancer is caused by genetic abnormalities resulting in uncontrolled growth of breast cells, and is the most commonly diagnosed cancer amongst women. The clinical use of liposomal-based drugs to treat solid tumors such as breast cancer has been shown to improve the overall pharmacological properties of otherwise “unencapsulated” cytotoxic agents.
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Cisplatin-Gemcitabine Related Cardiomyopathy in Non-Small Cell Lung Cancer NSCLC Patient: A Case Study

Gemcitabine is a pyrimidine analog and cisplatin is a platinum agent, they are usually combined to form a chemotherapeutic doublet used to treat different types of oncological cancers, including non-small cell lung cancer (NSCLC). Although these agents are not known to cause such events, few cases related to possible cardiotoxicity side effects have been reported ; including angina, chronic heart failure, arrhythmias, and cardiac ischemia. A 52-year-old African male presented with Stage IV lung adenocarcinoma metastatic to the bone, pleura and lymph node, EGFR wild type. Patient has a history of hypertension, diabetes, and atrial fibrillation and on rate control medications. He was treated initially with cisplatin-gemcitabine, after which he developed cardiomyopathy.
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Novel Computational Model of the Brain Water Metabolism: Introducing an Interdisciplinary Approach

Brain water metabolism ensures the processes of cellular communication, the transit of the signaling molecules, neurotransmitters, cytokines, and substrates, participates in the clearance of pathogenic metabolites. Many neurological conditions that present serious clinical problems arise from the altered fluid flow (e.g. Alzheimer’s disease, idiopathic normal pressure hydrocephalus, migraine, traumatic brain injury and stroke).
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Impact of Myocardial Revascularization on the Range of Joint Motion of the Superior and Inferior Members

The surgical procedure for myocardial revascularization (MRI) may compromise chest stability, compliance and range of motion (ROM) of the shoulder joint due to sternotomy and knee joint due to saphenectomy.To evaluate the impact of myocardial revascularization surgery on upper and lower limb ROM
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A Health Model Based on the Clinical Practice of Manual Therapists

Introduction: The evolution of health models occurred along with the changes of the definition of health and rehabilitation but it is still unknown the predominant model of health that fits the clinical practice of physiotherapists who work in manual therapy. Aim(s): Creation of a questionnaire to assess the health model that fits the clinical practice of physiotherapists and after application,
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Monotherapy versus Combination Therapy for the Treatment of Pseudomonas Aeruginosa in Cystic Fibrosis Patients

Infection with Pseudomonas aeruginosa in cystic fibrosis (CF) patients is a strong contributor to respiratory failure and associated mortality. Bacteria colonizing a cystic fibrosis lung commonly form biofilms that greatly contribute to increased antibiotic resistance and hypermutability. Antimicrobial treatment in these cases can be either through the use of a single agent (monotherapy) or through a combination of agents (combination therapy).
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Use of Electroconvulsive Therapy (ECT) in Hysterical Catatonia: Case Reports of Two Women, One Young and One Elderly

A 62-years-old female patient with a diagnosis of conversion disorder and somatization disorder and a 20-years-old female patient with a diagnosis of conversion disorder were treated on electroconvulsive therapy. Electroconvulsive therapy was performed in 8 sessions with anaesthesia. 62-years-old patient began to recover after the sixth session of electroconvulsive therapy once every two days. Complete remission in catatonic symptoms also sustained during follow-up. The catatonic symptoms of the 20-years-old patient were completely terminated after the second session of the ECT once every two days. The treatments were completed in 8 sessions.
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Editorial Board Members Related to Therapy

Amolak Singh

Professor
Department of Radiology
University of Missouri Health Care
United States

Guoshun Wang

Associate Professor
Department of Microbiology, Immunology and Parasitology
LSU Health New Orleans
United States

KRZYSZTOF KOSTRO

Professor
Department of Epizootiology and Clinic of Infectious Diseases
Lublin University
Poland

Chang Ming Charlie Ma

Professor
Department of Radiation Oncology
Fox Chase Cancer Center
United States

Mohammad Khayatzadeh Mahani

Assistant Professor
`Occupational Therapy department
Ahvaz Jundishapoor University of Medical Sciences
Iran

Arif Gulzar

Department of Material Science and Chemical Engineering
Harbin Engineering University
China

Nils Ole Schmidt

Neurosurgeon
Department of Neurosurgery
University Medical Center Hamburg-Eppendorf
Germany

Suling Liu

Professor
School of Life Sciences
University of Science & Technology
China

Massimo Dominici

Assistant Professor
Head Laboratory of Cell Biology and Advanced Cancer Therapies
Department of Medical and Surgical Sciences for Children & Adults
University Hospital of Modena and Reggio Emilia
Italy

MICHAEL P. SHERMAN

Professor Emeritus
Department of Child Health
Division of Neonatology
University of California-Davis School of Medicine
United States
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